Detailed information for compound 1156982

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.43 | Formula: C20H23N5O
  • H donors: 0 H acceptors: 3 LogP: 0.51 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1ncc(c1)CN1CCc2c(CC1)n(Cc1ccncc1)c(=O)cc2
  • InChi: 1S/C20H23N5O/c1-23-13-17(12-22-23)14-24-10-6-18-2-3-20(26)25(19(18)7-11-24)15-16-4-8-21-9-5-16/h2-5,8-9,12-13H,6-7,10-11,14-15H2,1H3
  • InChiKey: ZOFYYBUPYXVOLA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0068
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0727 0.0727
Onchocerca volvulus 0.0071 0.1522 1
Echinococcus multilocularis tumor protein p63 0.0326 0.8854 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Onchocerca volvulus 0.0071 0.1522 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0614 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0068 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.1522 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0068 0.0068
Echinococcus multilocularis thyroid hormone receptor alpha 0.0151 0.3833 0.4329
Onchocerca volvulus 0.0071 0.1522 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0007 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0068 0.0077
Entamoeba histolytica cysteine proteinase 2 0.0037 0.0534 0.1081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.1522 1
Brugia malayi steroid hormone receptor 0.002 0.0068 0.0068
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0021 0.0028
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0172 0.4425 0.6607
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0202 0.0228
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0614 0.0907
Brugia malayi beta-lactamase family protein 0.0039 0.0614 0.0614
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0614 0.0693
Leishmania major cysteine peptidase A (CPA) 0.0071 0.1522 0.1929
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0068 0.0068
Trypanosoma cruzi cysteine peptidase, putative 0.027 0.7242 0.9215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215
Brugia malayi beta-lactamase 0.0039 0.0614 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0068 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Leishmania major cathepsin L-like protease 0.027 0.7242 0.9215
Echinococcus multilocularis dna polymerase eta 0.0043 0.0727 0.0821
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 1 1
Loa Loa (eye worm) ctsf protein 0.0071 0.1522 0.1522
Plasmodium vivax vivapain-2 0.0071 0.1522 0.2159
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0007 0.0007
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0068 0.0097
Brugia malayi Cathepsin L-like precursor 0.0071 0.1522 0.1522
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1522 0.1929
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0614 0.0693
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0614 0.0907
Schistosoma mansoni hypothetical protein 0.0039 0.0597 0.085
Brugia malayi Cathepsin L-like precursor 0.0071 0.1522 0.1522
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0068
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0534 0.1081
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0068 0.0068
Schistosoma mansoni Smad4 0.0025 0.0202 0.0288
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.1111 0.1111
Echinococcus multilocularis lamin dm0 0.0031 0.0373 0.0422
Echinococcus multilocularis peptidase Clp (S14 family) 0.0172 0.4425 0.4997
Onchocerca volvulus 0.0047 0.0849 0.5369
Onchocerca volvulus 0.0071 0.1522 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0068 0.0097
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0021 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0021 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0614 0.0865
Loa Loa (eye worm) hypothetical protein 0.0047 0.0849 0.0849
Loa Loa (eye worm) hypothetical protein 0.0071 0.1522 0.1522
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0068 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.325 0.3671
Loa Loa (eye worm) hypothetical protein 0.0039 0.0614 0.0614
Mycobacterium tuberculosis Conserved protein 0.0039 0.0614 0.0907
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0068 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0534 0.3482
Mycobacterium tuberculosis Conserved protein 0.0039 0.0614 0.0907
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0614 0.0874
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215
Echinococcus granulosus smad 0.0025 0.0202 0.0228
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0039 0.0614 0.0614
Loa Loa (eye worm) cysteine protease 0.0071 0.1522 0.1522
Loa Loa (eye worm) hypothetical protein 0.0047 0.0849 0.0849
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.7859 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0727 0.0727
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Entamoeba histolytica hypothetical protein 0.0188 0.4884 1
Onchocerca volvulus 0.0039 0.0614 0.3755
Onchocerca volvulus 0.0071 0.1522 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0202 0.0288
Brugia malayi Cathepsin L-like precursor 0.0023 0.0159 0.0159
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0614 0.0907
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0068 0.0068
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0534 0.1081
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0663 0.0835
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Schistosoma mansoni smad1 5 8 and 0.0025 0.0202 0.0288
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.1111 0.1111
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0021 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0534 0.0672
Loa Loa (eye worm) hypothetical protein 0.0039 0.0614 0.0614
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0373 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0068 0.0068
Schistosoma mansoni cathepsin F (C01 family) 0.0071 0.1522 0.2167
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0021 0.0017
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0857 0.1221
Loa Loa (eye worm) hypothetical protein 0.0263 0.702 0.702
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0614 0.0874
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0068
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0614 0.0907
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0068 0.0077
Toxoplasma gondii cathepsin CPL 0.0071 0.1522 0.2159
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0159 0.0193
Brugia malayi ecdysteroid receptor 0.002 0.0068 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Onchocerca volvulus 0.0039 0.0614 0.3755
Onchocerca volvulus 0.0039 0.0614 0.3755
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0534 0.0672
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0849 0.1209
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0247 0.6569 0.8358
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0663 0.0835
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0021 0.0023
Echinococcus granulosus cathepsin L cysteine proteinase 0.0071 0.1522 0.1719
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0071 0.1522 0.2159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.1522 1
Trypanosoma cruzi cysteine peptidase, putative 0.027 0.7242 0.9215
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0849 0.1725
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0068 0.0077
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0071 0.1522 0.2159
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0037 0.0534 0.0761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0614 0.0614
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0021 0.003
Entamoeba histolytica hypothetical protein 0.0188 0.4884 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0263 0.702 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0071 0.1522 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.2082 0.2958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0047 0.0849 0.0849
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0263 0.702 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0037 0.0534 0.0761
Plasmodium falciparum cysteine proteinase falcipain 1 0.0037 0.0534 0.0752
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215
Mycobacterium ulcerans beta-lactamase 0.0039 0.0614 0.0865
Loa Loa (eye worm) hypothetical protein 0.0039 0.0597 0.0597
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0921 0.1163
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0663 0.0835
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.009 0.2082 0.2291
Onchocerca volvulus 0.0048 0.0857 0.5427
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0068 0.0077
Echinococcus granulosus tumor protein p63 0.0326 0.8854 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0358 0.05
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.1522 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Brugia malayi Smad1 0.0025 0.0202 0.0202
Brugia malayi Probable ClpP-like protease 0.0263 0.702 0.702
Schistosoma mansoni smad 0.0025 0.0202 0.0288
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0068 0.0077
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.3448 0.4383
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0068 0.0068
Leishmania major cathepsin L-like protease 0.0071 0.1522 0.1929
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0021 0.002
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0263 0.702 1
Leishmania major cathepsin L-like protease 0.0071 0.1522 0.1929
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0614 0.0773
Trypanosoma cruzi cruzipain precursor, putative 0.027 0.7242 0.9215
Echinococcus multilocularis cysteine protease 0.0071 0.1522 0.1719
Loa Loa (eye worm) hypothetical protein 0.0039 0.0614 0.0614
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.325 0.3671
Brugia malayi Cathepsin L-like precursor 0.0047 0.0849 0.0849
Brugia malayi intermediate filament protein 0.0031 0.0373 0.0373
Brugia malayi nuclear receptor NHR-88 0.002 0.0068 0.0068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0188 0.4884 0.5517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.1522 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.1522 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0021 0.0023
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0159
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0263 0.702 1
Entamoeba histolytica hypothetical protein 0.0188 0.4884 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.1522 1
Echinococcus granulosus cathepsin l1 0.0071 0.1522 0.1719
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0023 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0188 0.4884 0.6957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0068 0.0097
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0597 0.0597
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Brugia malayi Cathepsin L-like precursor 0.0071 0.1522 0.1522
Echinococcus multilocularis musashi 0.0031 0.0373 0.0422
Schistosoma mansoni lamin 0.0031 0.0373 0.0532
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0068 0.0068
Echinococcus granulosus cathepsin L cysteine protease 0.0037 0.0534 0.0604
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0534 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0068 0.0068
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0021 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0068 0.0068
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0021 0.009
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Loa Loa (eye worm) transcription factor SMAD2 0.0366 1 1
Brugia malayi MH1 domain containing protein 0.0025 0.0202 0.0202
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Onchocerca volvulus Cathepsin F homolog 0.0071 0.1522 1
Trypanosoma cruzi cysteine protease, putative 0.0037 0.0534 0.0672
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0068 0.0068
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0172 0.4425 0.5948
Brugia malayi MH2 domain containing protein 0.0025 0.0202 0.0202
Schistosoma mansoni ap endonuclease 0.0018 0.0007 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0614 0.0614
Schistosoma mansoni nuclear hormone receptor 0.002 0.0068 0.0097
Leishmania major cathepsin L-like protease 0.0071 0.1522 0.1929
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0202 0.0228
Brugia malayi nuclear hormone receptor 0.002 0.0068 0.0068
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0614 0.4007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0614 0.0614
Brugia malayi Cathepsin L-like precursor 0.0047 0.0849 0.0849
Onchocerca volvulus Cathepsin L homolog 0.0071 0.1522 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0263 0.702 1
Echinococcus granulosus intermediate filament protein 0.0031 0.0373 0.0422
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0373 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0068 0.0077
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0021 0.0021
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0068 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Brugia malayi MH2 domain containing protein 0.0025 0.0202 0.0202
Loa Loa (eye worm) beta-lactamase 0.0039 0.0614 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0614 0.4007
Leishmania major cathepsin L-like protease 0.0071 0.1522 0.1929
Leishmania major DNA polymerase eta, putative 0.003 0.0358 0.0447
Trypanosoma cruzi cysteine proteinase, putative 0.0037 0.0534 0.0672
Echinococcus granulosus dna polymerase kappa 0.0019 0.0021 0.0023
Echinococcus granulosus Smad4 0.0025 0.0202 0.0228
Mycobacterium ulcerans hypothetical protein 0.0039 0.0614 0.0865
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0068 0.0097
Echinococcus granulosus cathepsin l1 0.0047 0.0849 0.0958
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0614 0.0907
Echinococcus granulosus peptidase Clp S14 family 0.0172 0.4425 0.4997
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0068 0.0077
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0263 0.702 0.5
Schistosoma mansoni lamin 0.0031 0.0373 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0068 0.0068
Brugia malayi Cathepsin L-like precursor 0.0071 0.1522 0.1522
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0263 0.702 0.793
Trichomonas vaginalis esterase, putative 0.0039 0.0614 0.4007
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0614 0.4007
Schistosoma mansoni smad1 5 8 and 0.0025 0.0202 0.0288
Loa Loa (eye worm) fibroinase 0.0071 0.1522 0.1522
Leishmania major cathepsin L-like protease 0.0071 0.1522 0.1929
Onchocerca volvulus 0.0071 0.1522 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.3896 0.5816
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0021 0.0019
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0021 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0614 0.4007
Plasmodium vivax vivapain-1 0.0037 0.0534 0.0752
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0727 0.0917
Brugia malayi cathepsin L-like precursor 0.0047 0.0849 0.0849
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Leishmania major cathepsin L-like protease 0.027 0.7242 0.9215
Schistosoma mansoni cathepsin s 0.0023 0.0159 0.0226
Schistosoma mansoni ap endonuclease 0.0018 0.0007 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0071 0.1522 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0614 0.4007
Schistosoma mansoni intermediate filament proteins 0.0031 0.0373 0.0532
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0068 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0068 0.0068
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0071 0.1522 0.1522
Entamoeba histolytica cysteine proteinase, putative 0.0071 0.1522 0.3105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215
Schistosoma mansoni DNA polymerase eta 0.0043 0.0727 0.1036
Entamoeba histolytica cysteine proteinase, putative 0.0071 0.1522 0.3105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0068 0.0097
Echinococcus granulosus cysteine protease 0.0037 0.0534 0.0604
Entamoeba histolytica cysteine protease, putative 0.0071 0.1522 0.3105
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.3448 0.4383
Entamoeba histolytica hypothetical protein 0.0188 0.4884 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0068 0.0097
Schistosoma mansoni cathepsin F (C01 family) 0.0071 0.1522 0.2167
Schistosoma mansoni hypothetical protein 0.0131 0.325 0.463
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0263 0.702 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0068 0.0077
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0202 0.0202
Trypanosoma cruzi cysteine proteinase, putative 0.0037 0.0534 0.0672
Brugia malayi cathepsin F-like cysteine proteinase 0.0023 0.0159 0.0159
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0534 0.1081
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0068
Entamoeba histolytica cysteine proteinase 1, putative 0.0037 0.0534 0.1081
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0614 0.0865
Echinococcus multilocularis smad 0.0025 0.0202 0.0228
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Echinococcus granulosus FTZ F1 alpha 0.002 0.0068 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0068 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0614 0.0907
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0071 0.1522 0.1719
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0068 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215
Schistosoma mansoni transcription factor LCR-F1 0.0188 0.4884 0.6957
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0068 0.0068
Brugia malayi Cathepsin L-like precursor 0.0071 0.1522 0.1522
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0068 0.0068
Echinococcus multilocularis cathepsin L cysteine protease 0.0071 0.1522 0.1719
Loa Loa (eye worm) hypothetical protein 0.0047 0.0849 0.0849
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0263 0.702 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0357 0.0357
Mycobacterium ulcerans hypothetical protein 0.0154 0.3896 0.5545
Loa Loa (eye worm) Smad1 0.0025 0.0202 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0068 0.0068
Brugia malayi beta-lactamase family protein 0.0039 0.0614 0.0614
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0202 0.0228
Echinococcus granulosus dna polymerase eta 0.0043 0.0727 0.0821
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0358 0.0447
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0007 0.0008
Schistosoma mansoni coup transcription factor 0.002 0.0068 0.0097
Brugia malayi Cathepsin L-like precursor 0.0071 0.1522 0.1522
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0614 0.0865
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0068 0.0068
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0037 0.0534 0.0672
Plasmodium vivax unspecified product 0.0037 0.0534 0.0752
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.7859 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0857 0.0857
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0068 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0534 0.0672
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0534 0.0534
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0021 0.0019
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Onchocerca volvulus 0.0031 0.0373 0.2099
Onchocerca volvulus 0.0031 0.0373 0.2099
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.6694 1
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.1522 0.1522
Onchocerca volvulus 0.0071 0.1522 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0614 0.0773
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0263 0.702 0.793
Brugia malayi MH1 domain containing protein 0.0025 0.0202 0.0202
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0727 0.0917
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0068 0.0097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0188 0.4884 0.5517
Echinococcus multilocularis Smad4 0.0025 0.0202 0.0228
Plasmodium vivax vivapain-3 0.0037 0.0534 0.0752
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0373 0.0373
Echinococcus granulosus cathepsin l cysteine peptidase 0.0071 0.1522 0.1719
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0068
Toxoplasma gondii hypothetical protein 0.0047 0.0836 0.1182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0534 0.3482
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0263 0.702 1
Trypanosoma cruzi cysteine peptidase, putative 0.027 0.7242 0.9215
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0007 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.7859 1
Onchocerca volvulus Cathepsin L homolog 0.0071 0.1522 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0614 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0068 0.0068
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0263 0.702 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0159 0.0193
Schistosoma mansoni thyroid hormone receptor 0.0151 0.3833 0.5459
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.1522 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.1111 0.1111
Mycobacterium ulcerans lipase LipD 0.0039 0.0614 0.0865
Plasmodium vivax unspecified product 0.0023 0.0159 0.0216
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0068 0.0068
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.7859 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.2082 0.2958
Leishmania major cathepsin L-like protease 0.027 0.7242 0.9215
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0068 0.0077
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0021 0.0023
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.2082 0.2958
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0263 0.702 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0849 0.5556
Toxoplasma gondii hypothetical protein 0.009 0.2082 0.2958
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0068 0.0097
Leishmania major hypothetical protein, conserved 0.0039 0.0614 0.0773
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0202 0.0228
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0021 0.0017
Toxoplasma gondii ABC1 family protein 0.0039 0.0614 0.0865
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0172 0.4425 0.6607
Loa Loa (eye worm) hypothetical protein 0.0031 0.0373 0.0373
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.1522 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0849 0.5556
Trypanosoma brucei unspecified product 0.0019 0.0021 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0017
Echinococcus granulosus lamin 0.0031 0.0373 0.0422
Trypanosoma cruzi major cysteine proteinase, putative 0.0212 0.5582 0.7101
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0534 0.1081
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0068
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0202 0.0202
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0263 0.702 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.1111 0.1111
Echinococcus multilocularis cathepsin L 0.0037 0.0534 0.0604
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0071 0.1522 0.1719
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.3448 0.4383
Echinococcus granulosus lamin dm0 0.0031 0.0373 0.0422
Plasmodium vivax vivapain-2 0.0071 0.1522 0.2159
Echinococcus multilocularis cysteine protease 0.0071 0.1522 0.1719
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0614 0.0907
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0068 0.0077
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0068 0.0068
Schistosoma mansoni thyroid hormone receptor 0.0151 0.3833 0.5459
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0021 0.003
Leishmania major DNA polymerase eta, putative 0.0043 0.0727 0.0917
Echinococcus multilocularis cathepsin L cysteine protease 0.0071 0.1522 0.1719
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0663 0.0835
Echinococcus multilocularis lamin 0.0031 0.0373 0.0422
Echinococcus granulosus cathepsin L 0.0037 0.0534 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.1522 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0021 0.0021
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0614 0.0907
Entamoeba histolytica cysteine protease, putative 0.0037 0.0534 0.1081
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0202 0.0288
Plasmodium falciparum cysteine proteinase falcipain 3 0.0071 0.1522 0.2159
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0071 0.1522 0.1522
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0037 0.0534 0.0761
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0068 0.0068
Brugia malayi hypothetical protein 0.0188 0.4884 0.4884
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0068 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.027 0.7242 0.9215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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