Detailed information for compound 1157316

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 599.642 | Formula: C24H25N9O6S2
  • H donors: 5 H acceptors: 7 LogP: -0.35 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCn1nc(cc1N)c1ccc[n+](c1)CC1=C(C(=O)[O-])N2[C@H](SC1)[C@@H](C2=O)NC(=O)/C(=N/OC)/c1csc(n1)N
  • InChi: 1S/C24H25N9O6S2/c1-39-30-17(15-11-41-24(26)27-15)20(35)28-18-21(36)33-19(23(37)38)13(10-40-22(18)33)9-31-4-2-3-12(8-31)14-7-16(25)32(29-14)5-6-34/h2-4,7-8,11,18,22,34H,5-6,9-10H2,1H3,(H5-,25,26,27,28,29,35,37,38)/b30-17+/t18-,22-/m1/s1
  • InChiKey: KXXTUOUPRPOXKO-PLEZTBHSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0093 0.0093
Schistosoma mansoni C-fyn 0.0015 0.003 0.003
Echinococcus granulosus SHC transforming protein 3 0.0015 0.0033 0.0033
Echinococcus multilocularis tyrosine protein kinase Abl 0.0034 0.0197 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0093 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0549 0.0549
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1182 1 1
Brugia malayi protein-tyrosine kinase 0.0138 0.1077 0.1077
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1182 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0093 0.0093
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0093
Schistosoma mansoni cell polarity protein 0.0015 0.003 0.003
Trichomonas vaginalis CMGC family protein kinase 0.1182 1 1
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0793 0.6678 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0093 0.0093
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0015 0.0033 0.0033
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0015 0.003 0.003
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0095 0.0142
Echinococcus granulosus SH2 motif 0.0015 0.0033 0.0033
Entamoeba histolytica hypothetical protein 0.0015 0.003 0.003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0093 0.0093
Plasmodium vivax glycogen synthase kinase 3, putative 0.1182 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Echinococcus granulosus N chimaerin 0.0015 0.0033 0.0033
Onchocerca volvulus 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0251 0.0251
Schistosoma mansoni vav2 0.0015 0.0033 0.0033
Schistosoma mansoni ap endonuclease 0.0022 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0064
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0015 0.003 0.003
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0119 0.0119
Brugia malayi hypothetical protein 0.005 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Brugia malayi Protein kinase domain containing protein 0.002 0.007 0.007
Brugia malayi MH2 domain containing protein 0.0119 0.0917 0.0917
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0015 0.003 0.003
Echinococcus multilocularis tensin 0.0015 0.0033 0.0033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0093 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.003 0.003
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0549 0.0549
Onchocerca volvulus 0.0015 0.003 0.003
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0119 0.0178
Entamoeba histolytica unconventional myosin IB 0.0015 0.003 0.003
Echinococcus granulosus growth factor receptor bound protein 2 0.003 0.016 0.016
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0093 0.0093
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0152 0.1204 0.1204
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.0033 0.0033
Loa Loa (eye worm) variant SH3 domain-containing protein 0.003 0.016 0.016
Schistosoma mansoni tensin-related 0.0015 0.0033 0.0033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0095 0.0095
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.007 0.007
Echinococcus granulosus tyrosine protein kinase Lyn 0.0164 0.1301 0.1301
Onchocerca volvulus 0.0015 0.003 0.003
Echinococcus granulosus fch and double sh3 domains protein 2 0.0015 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0015 0.003 0.003
Entamoeba histolytica SH2-protein kinase domain containing protein 0.002 0.007 0.007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0095 0.0095
Echinococcus granulosus tyrosine kinase 0.002 0.007 0.007
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0016 0.0037 0.0037
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1182 1 1
Schistosoma mansoni nck2/grb4 0.003 0.016 0.016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Loa Loa (eye worm) SH2 domain-containing protein 0.0015 0.0033 0.0033
Brugia malayi nuclear receptor NHR-88 0.0022 0.0093 0.0093
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0015 0.003 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0119 0.0178
Echinococcus granulosus tyrosine protein kinase ABL1 0.002 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0067 0.0067
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0093 0.0093
Echinococcus multilocularis activin receptor type 0.0016 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0064
Brugia malayi Variant SH3 domain containing protein 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0093
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0064 0.0064
Echinococcus multilocularis NCK adaptor protein 0.003 0.016 0.016
Brugia malayi Variant SH3 domain containing protein 0.003 0.016 0.016
Entamoeba histolytica hypothetical protein 0.0015 0.003 0.003
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0015 0.003 0.003
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0152 0.1204 0.1204
Brugia malayi hypothetical protein 0.002 0.007 0.007
Echinococcus granulosus suppressor of cytokine signaling 7 0.0015 0.0033 0.0033
Echinococcus multilocularis signal transduction protein lnk realted 0.0015 0.0033 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0332 0.0332
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0093 0.0093
Echinococcus granulosus protein kinase shaggy 0.1182 1 1
Schistosoma mansoni Dab2-interacting protein-like 0.0015 0.003 0.003
Brugia malayi Tyrosine-protein kinase abl-1 0.0034 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0119
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.0033 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0023 0.0096 0.0096
Echinococcus granulosus tyrosine kinase 0.0138 0.1077 0.1077
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0064 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0093 0.0093
Brugia malayi nuclear hormone receptor 0.0022 0.0093 0.0093
Entamoeba histolytica protein kinase domain containing protein 0.1182 1 1
Entamoeba histolytica hypothetical protein 0.0015 0.003 0.003
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.007 0.007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0093 0.0093
Schistosoma mansoni signal transduction protein lnk-related 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0549 0.0549
Leishmania major hypothetical protein, conserved 0.0015 0.003 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0093 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0332 0.0332
Echinococcus multilocularis SH2 motif 0.0015 0.0033 0.0033
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0152 0.1204 0.1204
Brugia malayi Sex muscle abnormal protein 5 0.003 0.016 0.016
Onchocerca volvulus 0.002 0.007 0.007
Entamoeba histolytica BAR/SH3 domain containing protein 0.0015 0.003 0.003
Brugia malayi steroid hormone receptor 0.0022 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0093
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.1436 0.1436
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0015 0.0033 0.0033
Schistosoma mansoni SH2A 0.0015 0.0033 0.0033
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0015 0.003 0.003
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0033 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0016 0.0037 0.0037
Schistosoma mansoni protein kinase 0.0016 0.0037 0.0037
Brugia malayi Peripheral plasma membrane protein CASK 0.0015 0.003 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0119 0.0119
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0093 0.0093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0056 0.0083
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0332 0.0332
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0093 0.0093
Echinococcus multilocularis tensin 0.0015 0.0033 0.0033
Echinococcus multilocularis 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0034 0.0197 0.0197
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0549 0.0549
Brugia malayi protein-tyrosine kinase 0.0015 0.003 0.003
Echinococcus granulosus tyrosine protein kinase Src42A 0.0152 0.1204 0.1204
Loa Loa (eye worm) hypothetical protein 0.005 0.0332 0.0332
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0093
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0332 0.0332
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0034 0.0197 0.0197
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0015 0.003 0.003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0064 0.0064
Echinococcus multilocularis endophilin A3 0.0015 0.003 0.003
Toxoplasma gondii exonuclease III APE 0.0022 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0917 0.0917
Leishmania major protein kinase, putative 0.0016 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Brugia malayi SH2 domain containing protein 0.002 0.007 0.007
Onchocerca volvulus Putative cortactin 0.0015 0.003 0.003
Schistosoma mansoni dreadlocks/dock 0.0015 0.003 0.003
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0549 0.0549
Brugia malayi SH2 domain containing protein 0.0015 0.0033 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0004 0.0004
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0015 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0004 0.0004
Loa Loa (eye worm) TK/ABL protein kinase 0.002 0.007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.007 0.007
Leishmania major hypothetical protein, conserved 0.005 0.0332 0.0332
Brugia malayi Variant SH3 domain containing protein 0.0015 0.003 0.003
Echinococcus multilocularis tyrosine kinase 0.002 0.007 0.007
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0019 0.0064 0.0064
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0037 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0093 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0093
Loa Loa (eye worm) RNA binding protein 0.0076 0.0549 0.0549
Schistosoma mansoni tensin 0.0015 0.0033 0.0033
Echinococcus multilocularis expressed conserved protein 0.0015 0.0033 0.0033
Brugia malayi hypothetical protein 0.0032 0.018 0.018
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0095 0.0095
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1182 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0004 0.0004
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.0033 0.0033
Echinococcus granulosus tyrosine protein kinase Src64B 0.0152 0.1204 0.1204
Schistosoma mansoni GTPase activating protein 0.0015 0.0033 0.0033
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0119 0.0178
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Entamoeba histolytica protein kinase, putative 0.0015 0.003 0.003
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1182 1 1
Trypanosoma brucei protein kinase, putative 0.1182 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0093 0.0093
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0095 0.0095
Loa Loa (eye worm) TK protein kinase 0.0122 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0093 0.0093
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0015 0.003 0.003
Schistosoma mansoni formin binding protein and related proteins 0.0015 0.003 0.003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0093 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.003 0.016 0.016
Schistosoma mansoni dynamin-associated protein 0.0015 0.003 0.003
Echinococcus granulosus GPCR family 2 0.0019 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Echinococcus granulosus SH2 domain containing adapter protein F 0.0015 0.0033 0.0033
Schistosoma mansoni eps8-related protein 0.0015 0.003 0.003
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0015 0.0033 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0332 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0549 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0033 0.0033
Loa Loa (eye worm) SH2 domain-containing protein 0.0015 0.0033 0.0033
Brugia malayi Myosin tail family protein 0.0015 0.003 0.003
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0033 0.0033
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0152 0.1204 0.1204
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0064 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0015 0.0033 0.0033
Onchocerca volvulus 0.0015 0.0033 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0004 0.0004
Brugia malayi Variant SH3 domain containing protein 0.003 0.016 0.016
Echinococcus granulosus hypothetical protein 0.0015 0.0033 0.0033
Echinococcus granulosus tensin 0.0015 0.0033 0.0033
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0037 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0093 0.0093
Schistosoma mansoni tyrosine kinase 0.0152 0.1204 0.1204
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0095 0.0095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0412 0.0412
Loa Loa (eye worm) AGC/PKG protein kinase 0.0015 0.0033 0.0033
Plasmodium falciparum glycogen synthase kinase 3 0.1182 1 1
Onchocerca volvulus 0.0015 0.0033 0.0033
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0549 0.0549
Brugia malayi Src substrate cortactin 0.0015 0.003 0.003
Brugia malayi SRC-1 0.0152 0.1204 0.1204
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0015 0.0033 0.0033
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0093 0.0093
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0332 0.0332
Onchocerca volvulus 0.1182 1 1
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.003
Brugia malayi SH2 domain containing protein 0.0015 0.0033 0.0033
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0015 0.003 0.003
Brugia malayi SH2 domain containing protein 0.0015 0.0033 0.0033
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0015 0.003 0.003
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0015 0.003 0.003
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0015 0.0033 0.0033
Brugia malayi SH2 domain containing protein 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0549 0.0549
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0093 0.0093
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0027 0.013 0.013
Mycobacterium ulcerans haloalkane dehalogenase 0.0793 0.6678 1
Schistosoma mansoni run and tbc1 domain containing 0.0015 0.003 0.003
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0064 0.0064
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0095 0.5
Echinococcus multilocularis intersectin 2 0.0015 0.003 0.003
Brugia malayi tRNA modification GTPase TrmE family protein 0.0015 0.0033 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0033 0.0033
Brugia malayi Variant SH3 domain containing protein 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Onchocerca volvulus 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.0033 0.0033
Echinococcus granulosus tyrosine protein kinase Srms 0.002 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0093
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.003 0.003
Echinococcus multilocularis GPCR, family 2 0.0019 0.0064 0.0064
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.003 0.003
Giardia lamblia Kinase, CMGC GSK 0.1182 1 1
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0015 0.003 0.003
Brugia malayi Variant SH3 domain containing protein 0.0015 0.003 0.003
Onchocerca volvulus 0.0015 0.003 0.003
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0004 0.0004
Brugia malayi STAT protein, DNA binding domain containing protein 0.0015 0.0033 0.0033
Brugia malayi TAR-binding protein 0.0076 0.0549 0.0549
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0138 0.1077 0.1077
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0093 0.0093
Schistosoma mansoni suppressor of cytokine signaling 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0119
Echinococcus granulosus expressed conserved protein 0.0015 0.0033 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0412 0.0412
Loa Loa (eye worm) p53BP2 0.0015 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0019 0.0064 0.0064
Echinococcus multilocularis expressed protein 0.0015 0.003 0.003
Echinococcus granulosus tyrosine protein kinase shark 0.002 0.007 0.007
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0332 0.0332
Echinococcus multilocularis growth factor receptor bound protein 2 0.003 0.016 0.016
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0093 0.0093
Onchocerca volvulus 0.0026 0.0127 0.0127
Brugia malayi hypothetical protein 0.0012 0.0004 0.0004
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0034 0.0197 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0093 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.007 0.007
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0096 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0064
Entamoeba histolytica SH2 domain containing protein 0.0015 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0041 0.0251 0.0251
Echinococcus granulosus NCK adaptor protein 0.003 0.016 0.016
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0016 0.0037 0.0037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0119 0.0178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0093 0.0093
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0093 0.0093
Schistosoma mansoni protein kinase 0.0016 0.0037 0.0037
Onchocerca volvulus 0.0015 0.0033 0.0033
Trypanosoma brucei protein kinase, putative 0.0016 0.0037 0.0037
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0095 0.0095
Loa Loa (eye worm) SRC-1 0.0152 0.1204 0.1204
Echinococcus multilocularis N chimaerin 0.0015 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0093 0.0093
Brugia malayi Tensin 0.0015 0.0033 0.0033
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0015 0.0033 0.0033
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0093 0.0093
Echinococcus granulosus tar DNA binding protein 0.0076 0.0549 0.0549
Mycobacterium ulcerans hypothetical protein 0.0025 0.0119 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.003 0.003
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0015 0.003 0.003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0095 0.0095
Schistosoma mansoni coup transcription factor 0.0022 0.0093 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0093 0.0093
Schistosoma mansoni tyrosine kinase 0.0152 0.1204 0.1204
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0064 0.0064
Brugia malayi hypothetical protein 0.0015 0.0033 0.0033
Entamoeba histolytica protein kinase, putative 0.0027 0.013 0.013
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0119 1
Schistosoma mansoni tyrosine kinase 0.002 0.007 0.007
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0412 0.0412
Echinococcus multilocularis Spectrin alpha actinin 0.0015 0.003 0.003
Loa Loa (eye worm) guanylate kinase 0.0015 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.002 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0152 0.1204 0.1204
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0119 0.0119
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0152 0.1204 0.1204
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0093 0.0093
Schistosoma mansoni growth factor receptor-bound protein 0.003 0.016 0.016
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0917 0.0917
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0015 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0064
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.003 0.003
Echinococcus multilocularis tyrosine protein kinase shark 0.002 0.007 0.007
Schistosoma mansoni sorting nexin 0.0015 0.003 0.003
Onchocerca volvulus 0.0022 0.0093 0.0093
Schistosoma mansoni tensin 0.0015 0.0033 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0056 0.0083
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1182 1 1
Onchocerca volvulus 0.002 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Echinococcus multilocularis nostrin 0.0015 0.003 0.003
Echinococcus granulosus SH2 domain containing protein 7 0.0015 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.003 0.003
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.003 0.016 0.016
Onchocerca volvulus 0.0025 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.003 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0093 0.0093
Schistosoma mansoni tensin-related 0.0015 0.0033 0.0033
Onchocerca volvulus 0.0015 0.0033 0.0033
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0015 0.003 0.003
Echinococcus granulosus src region 0.0015 0.003 0.003
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1182 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0093 0.0093
Echinococcus granulosus nostrin 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0119 0.0178
Schistosoma mansoni apoptosis stimulating of P53 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0095 0.5
Leishmania major protein kinase, putative 0.0015 0.0033 0.0033
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0095 0.0095
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0119 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.003 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0093 0.0093
Brugia malayi SH2 domain containing protein 0.0015 0.0033 0.0033
Echinococcus granulosus suppressor of cytokine signaling 6 0.0015 0.0033 0.0033
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1182 1 1
Trypanosoma brucei conserved protein 0.0015 0.003 0.003
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0015 0.0033 0.0033
Echinococcus granulosus expressed protein 0.0015 0.003 0.003
Loa Loa (eye worm) SH2 domain-containing protein 0.0015 0.0033 0.0033
Entamoeba histolytica BAR/SH3 domain containing protein 0.0015 0.003 0.003
Brugia malayi hypothetical protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) TK protein kinase 0.0138 0.1077 0.1077
Giardia lamblia Kinase, CMGC GSK 0.1182 1 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0122 0.0947 0.0947
Brugia malayi Guanylate kinase family protein 0.0015 0.003 0.003
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.0033 0.0033
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0033 0.0033
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.002 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Echinococcus granulosus tyrosine protein kinase Blk 0.0138 0.1077 0.1077
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Schistosoma mansoni tyrosine kinase 0.002 0.007 0.007
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0093 0.0093
Schistosoma mansoni tensin 0.0015 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.003
Schistosoma mansoni sorbin 0.0015 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0019 0.0064 0.0064
Echinococcus multilocularis tyrosine protein kinase Srms 0.0138 0.1077 0.1077
Entamoeba histolytica hypothetical protein 0.0015 0.003 0.003
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0152 0.1204 0.1204
Leishmania major protein kinase, putative 0.0015 0.0033 0.0033
Echinococcus multilocularis protein kinase shaggy 0.1182 1 1
Brugia malayi SH2 domain containing protein 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Schistosoma mansoni suppressor of cytokine signaling 0.0015 0.0033 0.0033
Onchocerca volvulus 0.002 0.007 0.007
Schistosoma mansoni shc transforming protein 0.0015 0.0033 0.0033
Entamoeba histolytica hypothetical protein 0.0015 0.003 0.003
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0033 0.0033
Echinococcus granulosus c src tyrosine kinase 0.0034 0.0197 0.0197
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.0033 0.0033
Brugia malayi SH2 domain containing protein 0.0015 0.0033 0.0033
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0152 0.1204 0.1204
Onchocerca volvulus 0.002 0.007 0.007
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0152 0.1204 0.1204
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0119 0.0178
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0015 0.003 0.003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0095 0.0095
Trichomonas vaginalis p67phox protein, putative 0.0015 0.003 0.003
Echinococcus granulosus epidermal growth factor receptor kinase 0.0015 0.003 0.003
Echinococcus granulosus endophilin A3 0.0015 0.003 0.003
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0015 0.0033 0.0033
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0093 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.007 0.007
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0119 0.0178
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0093 0.0093
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0152 0.1204 0.1204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0093
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0093 0.0093
Entamoeba histolytica hypothetical protein 0.0015 0.003 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0093 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Brugia malayi Variant SH3 domain containing protein 0.0015 0.003 0.003
Echinococcus multilocularis tyrosine protein kinase Blk 0.0138 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) STAT protein 0.0015 0.0033 0.0033
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0095 0.0142
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0096 0.0096
Loa Loa (eye worm) sex muscle abnormal protein 5 0.003 0.016 0.016
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0015 0.0033 0.0033
Brugia malayi cytokine inducible SH2-containing protein 5 0.0015 0.0033 0.0033
Echinococcus granulosus SH2 motif 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.018 0.1436 0.1436
Schistosoma mansoni ap endonuclease 0.0022 0.0095 0.0095
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0064 0.0096
Echinococcus multilocularis SH2 motif 0.0015 0.0033 0.0033
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0133 0.1041 0.1041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Brugia malayi Protein kinase domain containing protein 0.002 0.007 0.007
Brugia malayi Protein kinase domain containing protein 0.002 0.007 0.007
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.003 0.003
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0004 0.0004
Echinococcus multilocularis SH2 motif 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0119
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase HCK 0.0122 0.0947 0.0947
Schistosoma mansoni hypothetical protein 0.0015 0.0033 0.0033
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0064 1
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0093 0.0093
Plasmodium falciparum cGMP-dependent protein kinase 0.0015 0.0033 0.0033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0095 0.0095
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0095 0.0095
Echinococcus granulosus tyrosine protein kinase Fyn 0.0152 0.1204 0.1204
Entamoeba histolytica protein kinase domain containing protein 0.1182 1 1
Schistosoma mansoni hypothetical protein 0.0015 0.0033 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0119 0.0119
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.003 0.003
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0119 0.0119
Plasmodium falciparum protein kinase, putative 0.0016 0.0037 0.0037
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0093 0.0093
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0015 0.0033 0.0033
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0015 0.003 0.003
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0015 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0093 0.0093
Schistosoma mansoni tyrosine kinase 0.0034 0.0197 0.0197
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0064 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0056 0.0083
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0093 0.0093
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0119 0.0119
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0015 0.0033 0.0033
Schistosoma mansoni growth factor receptor-bound protein 0.003 0.016 0.016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0093 0.0093
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0138 0.1077 0.1077
Echinococcus multilocularis tyrosine protein kinase ABL1 0.002 0.007 0.007
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0015 0.003 0.003
Echinococcus granulosus activin receptor type 0.0016 0.0037 0.0037
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0095 0.0095
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0064 0.0096
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0093 0.0093
Brugia malayi Egg laying defective protein 4 0.0015 0.0033 0.0033
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0093 0.0093
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0015 0.003 0.003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0119 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0093 0.0093
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0033 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0093 0.0093
Entamoeba histolytica protein kinase, putative 0.0122 0.0947 0.0947
Echinococcus granulosus Spectrin alpha actinin 0.0015 0.003 0.003
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0015 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0019 0.0064 0.0064
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0152 0.1204 0.1204
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0015 0.0033 0.0033
Schistosoma mansoni protein kinase 0.0016 0.0037 0.0037
Brugia malayi RhoGAP domain containing protein 0.0015 0.0033 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0119 0.0119
Trichomonas vaginalis CMGC family protein kinase 0.1182 1 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0064 0.0064
Brugia malayi nuclear receptor RXR 0.0012 0.0004 0.0004
Echinococcus granulosus intersectin 2 0.0015 0.003 0.003
Echinococcus granulosus cGMP dependent protein kinase 0.0015 0.0033 0.0033
Schistosoma mansoni adapter molecule crk 0.003 0.016 0.016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0093 0.0093
Echinococcus multilocularis transfer RNA-Ala 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.007 0.007
Brugia malayi SH2 domain containing protein 0.002 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Brugia malayi N-terminal motif family protein 0.018 0.1436 0.1436
Onchocerca volvulus 0.0015 0.0033 0.0033
Echinococcus multilocularis SHC transforming protein 3 0.0015 0.0033 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0119 0.0119
Brugia malayi SH3 domain containing protein 0.0015 0.003 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0093 0.0093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0056 0.0083
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Echinococcus granulosus signal transduction protein lnk realted 0.0015 0.0033 0.0033
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0016 0.0037 0.0037
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Entamoeba histolytica protein kinase, putative 0.1182 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0251 0.0251
Brugia malayi Variant SH3 domain containing protein 0.0015 0.003 0.003
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0093 0.0093
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0093 0.0093
Echinococcus granulosus tyrosine protein kinase Fyn 0.0152 0.1204 0.1204
Echinococcus granulosus tyrosine protein kinase Fps85D 0.002 0.007 0.007
Brugia malayi Protein kinase domain containing protein 0.002 0.007 0.007
Onchocerca volvulus 0.002 0.007 0.007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0095 0.0095
Brugia malayi RNA binding protein 0.0076 0.0549 0.0549
Echinococcus multilocularis c src tyrosine kinase 0.0034 0.0197 0.0197
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0033 0.0033
Brugia malayi ecdysteroid receptor 0.0022 0.0093 0.0093
Echinococcus granulosus tyrosine protein kinase Fyn 0.0152 0.1204 0.1204
Brugia malayi Spectrin alpha chain 0.0015 0.003 0.003
Echinococcus granulosus tyrosine protein kinase Src42A 0.0133 0.1041 0.1041
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0033 0.0033
Loa Loa (eye worm) protein-tyrosine kinase 0.0015 0.003 0.003
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0033 0.0033
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0015 0.003 0.003
Loa Loa (eye worm) thyroid receptor interactor 0.0015 0.003 0.003
Echinococcus multilocularis SH2 domain containing protein 7 0.0015 0.0033 0.0033
Onchocerca volvulus 0.002 0.007 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0119 0.0178
Schistosoma mansoni tyrosine kinase 0.0034 0.0197 0.0197
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0037 0.0037
Brugia malayi Fes/CIP4 homology domain containing protein 0.0015 0.003 0.003
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0004 0.0004

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.013 ug ml-1 Compound was evaluated in vitro for antimicrobial activity against Escherichia coli DC 2 ChEMBL. 10866383
MIC (functional) = 0.025 ug ml-1 Compound was evaluated in vitro for antimicrobial activity against Escherichia coli 055 ChEMBL. 10866383
MIC (functional) = 0.025 ug ml-1 Compound was evaluated in vitro for antimicrobial activity against Escherichia coli DC 0 ChEMBL. 10866383
MIC (functional) = 0.098 ug ml-1 Compound was evaluated in vitro for antimicrobial activity against Escherichia coli TEM ChEMBL. 10866383
MIC (functional) = 0.098 ug ml-1 Compound was evaluated in vitro for antimicrobial activity against Escherichia coli 1507E ChEMBL. 10866383

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.