TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 240.3 | Formula: C15H16N2O
H donors: 1 H acceptors: 1 LogP: 1.55 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: N[C@H]1C[C@@H]2CCC(=O)n3c2c(C1)c1ccccc31
InChi: 1S/C15H16N2O/c16-10-7-9-5-6-14(18)17-13-4-2-1-3-11(13)12(8-10)15(9)17/h1-4,9-10H,5-8,16H2/t9-,10-/m0/s1
InChiKey: KNVDUZNZYYTTMA-UWVGGRQHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0482	0.0669
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0732	0.2493
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0732	0.5832
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0028	0.0732	0.4023
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0482	0.3764
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.1943	0.6789
Schistosoma mansoni	hypothetical protein	0.0035	0.1016	0.1451
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0086	0.2849	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0711	0.5659
Echinococcus multilocularis	GPCR, family 2	0.0035	0.1016	0.1373
Onchocerca volvulus		0.0028	0.0732	0.1205
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0482	0.3764
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0732	0.5832
Schistosoma mansoni	cpg binding protein	0.0034	0.0967	0.138
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0028	0.0732	0.2493
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.026	0.913	0.9128
Loa Loa (eye worm)	hypothetical protein	0.0169	0.5865	0.5853
Schistosoma mansoni	peptidase Clp (S14 family)	0.0086	0.2849	0.4136
Brugia malayi	Inositol-1	0.0041	0.1234	0.1209
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0086	0.2849	1
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0096	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0021	0.048	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0021	0.048	0.0453
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0041	0.1234	0.4275
Schistosoma mansoni	hypothetical protein	0.0197	0.6851	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0112	0.378	0.3762
Schistosoma mansoni	hypothetical protein	0.0035	0.1016	0.1451
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0711	0.0684
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0037	0.1077	0.3719
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0028	0.0732	0.4023
Loa Loa (eye worm)	hypothetical protein	0.0021	0.048	0.0453
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0086	0.2849	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.1016	0.099
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0482	0.0669
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0482	0.0634
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0482	0.0455
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0482	0.3908
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0008	0.0028	0.0004
Schistosoma mansoni	hypothetical protein	0.0035	0.1016	0.1451
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0086	0.2849	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1591	0.2172
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0732	0.0705
Echinococcus granulosus	cpg binding protein	0.0034	0.0967	0.1306
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.0482	0.3764
Trypanosoma brucei	unspecified product	0.0014	0.0251	0.1844
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.1591	0.1567
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0021	0.048	0.1601
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.003	0.0808	0.2766
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2849	0.2828
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.457	0.6657
Toxoplasma gondii	hypothetical protein	0.003	0.0808	0.2766
Brugia malayi	hypothetical protein	0.0027	0.0711	0.0684
Echinococcus granulosus	geminin	0.0197	0.6851	0.9467
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.048	0.2583
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0732	0.5832
Loa Loa (eye worm)	hypothetical protein	0.0021	0.048	0.0453
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0482	0.3764
Loa Loa (eye worm)	hypothetical protein	0.0021	0.048	0.0453
Leishmania major	DNA polymerase eta, putative	0.0021	0.0482	0.3764
Loa Loa (eye worm)	inositol-1	0.0041	0.1234	0.1209
Schistosoma mansoni	hypothetical protein	0.0076	0.2501	0.3626
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0732	0.5832
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0086	0.2849	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0028	0.0732	0.2493
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0439	0.2351
Trypanosoma brucei	unspecified product	0.0021	0.0482	0.3764
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0086	0.2849	0.3916
Leishmania major	hypothetical protein, conserved	0.0027	0.0711	0.5659
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0086	0.2849	0.3916
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0482	0.0634
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0008	0.0028	0.0004
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0041	0.1234	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0134	0.457	0.4554
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.1234	1
Brugia malayi	hypothetical protein	0.0017	0.0365	0.0338
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0251	0.1844
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0037	0.1077	0.6
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.003	0.0808	0.2766
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0732	0.2493
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.1591	0.1567
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0041	0.1234	0.4275
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0732	0.0705
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1591	0.2172
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0711	0.2419
Schistosoma mansoni	cpg binding protein	0.0032	0.0901	0.1283
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.1234	1
Schistosoma mansoni	hypothetical protein	0.0035	0.1016	0.1451
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1591	0.2294
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0482	0.3908
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0112	0.378	0.3762
Echinococcus multilocularis	inositol monophosphatase 1	0.0041	0.1234	0.1676
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0207	0.7236	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0086	0.2849	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2501	0.2479
Brugia malayi	RNA binding protein	0.0134	0.457	0.4554
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0482	0.0634
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.003	0.0808	0.2766
Plasmodium vivax	acyl-CoA synthetase, putative	0.0021	0.048	0.1601
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0056	0.1776	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0028	0.0732	0.2493
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.1016	0.099
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0251	0.1844
Brugia malayi	latrophilin 2 splice variant baaae	0.0076	0.2501	0.2479
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0092	0.0064
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0711	0.5659
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0096	0.0098
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0482	0.1609
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0086	0.2849	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1591	0.2172
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0207	0.7236	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0096	0.0098
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0711	0.2419
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Schistosoma mansoni	inositol monophosphatase	0.0041	0.1234	0.1771
Trypanosoma brucei	unspecified product	0.0014	0.0251	0.1844
Schistosoma mansoni	hypothetical protein	0.0012	0.0173	0.0216
Schistosoma mansoni	cpg binding protein	0.0034	0.0967	0.138
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0028	0.023
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.1234	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1591	0.2172
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0086	0.2849	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0482	0.0455
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0482	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0134	0.457	0.4554
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0482	0.0455
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0482	0.3764
Brugia malayi	hypothetical protein	0.0169	0.5865	0.5853
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0732	0.0705
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1591	0.2294
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0732	0.0705
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0028	0.023
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1016	0.099
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0.0732	0.2493
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0482	0.2597
Brugia malayi	Probable ClpP-like protease	0.0086	0.2849	0.2828
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.1234	1
Echinococcus granulosus	inositol monophosphatase 1	0.0041	0.1234	0.1676
Echinococcus multilocularis	geminin	0.0197	0.6851	0.9467
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0173	0.0205
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0482	0.0634
Brugia malayi	TAR-binding protein	0.0134	0.457	0.4554
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0482	0.3764
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0173	0.0205
Echinococcus granulosus	tar DNA binding protein	0.0134	0.457	0.6303
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.1016	0.1373
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0711	0.2419
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Echinococcus multilocularis	cpg binding protein	0.0034	0.0967	0.1306
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.457	0.6657
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.1016	0.1373
Trichomonas vaginalis	inositol monophosphatase, putative	0.0041	0.1234	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0028	0.0732	0.2493
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0439	0.2351
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0086	0.2849	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.1016	0.099
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0056	0.1776	1
Loa Loa (eye worm)	RNA binding protein	0.0134	0.457	0.4554
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.2207	0.3196
Entamoeba histolytica	acyl-coA synthetase, putative	0.0028	0.0732	0.5832
Plasmodium falciparum	acyl-CoA synthetase	0.0021	0.048	0.1601
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0732	0.2493
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0901	0.0875
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0732	0.0705
Echinococcus multilocularis	tar DNA binding protein	0.0134	0.457	0.6303
Onchocerca volvulus		0.0169	0.5865	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.457	0.6657
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0251	0.1844
Brugia malayi	follicle stimulating hormone receptor	0.026	0.913	0.9128
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.457	0.6657
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0.0732	0.2493
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.1234	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0732	0.0705
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0056	0.1776	0.6198
Echinococcus granulosus	peptidase Clp S14 family	0.0056	0.1776	0.2428
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0901	0.0875
Schistosoma mansoni	inositol monophosphatase	0.0041	0.1234	0.1771
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0711	0.5659
Schistosoma mansoni	acetyl-CoA synthetase	0.0008	0.0028	0.0004
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0482	0.3764
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0086	0.2849	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0732	0.2493
Loa Loa (eye worm)	TAR-binding protein	0.0134	0.457	0.4554
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0482	0.0669
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0439	0.2351
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0439	0.2351
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0482	0.1609
Echinococcus granulosus	dna polymerase eta	0.0021	0.0482	0.0634
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0056	0.1776	0.2428
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0711	0.2419
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Echinococcus granulosus	GPCR family 2	0.0035	0.1016	0.1373
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.1234	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1591	0.2294
Onchocerca volvulus		0.0032	0.0901	0.1495
Schistosoma mansoni	hypothetical protein	0.0197	0.6851	1
Loa Loa (eye worm)	hypothetical protein	0.0284	1	1
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0482	0.0634
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0732	0.5832
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0482	0.0455
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.457	0.6657
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0482	0.3764
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0086	0.2849	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0482	0.2597

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1181355

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1157879