Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.5153 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0082 | 0.0523 | 0.0523 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0082 | 0.0523 | 0.0392 |
Entamoeba histolytica | protein kinase, putative | 0.0082 | 0.0523 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0969 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.5153 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.0523 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0054 | 0.0224 | 0.0089 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0235 | 0.0235 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0054 | 0.0224 | 0.0224 |
Entamoeba histolytica | protein kinase, putative | 0.0082 | 0.0523 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 0.0523 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.5153 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0046 | 0.0136 | 0.0136 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Echinococcus granulosus | dual specificity | 0.0082 | 0.0523 | 0.0523 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0969 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0174 | 0.1508 | 0.1508 |
Schistosoma mansoni | dihydrofolate reductase | 0.0969 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0046 | 0.0136 | 0.0136 |
Brugia malayi | Dihydrofolate reductase | 0.0969 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0969 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0519 | 0.0388 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0054 | 0.0224 | 0.0224 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0969 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Echinococcus granulosus | thymidylate synthase | 0.0116 | 0.0883 | 0.0883 |
Echinococcus multilocularis | thymidylate synthase | 0.0116 | 0.0883 | 0.0883 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0969 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0054 | 0.0224 | 0.0224 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0116 | 0.0883 | 0.0664 |
Echinococcus granulosus | dihydrofolate reductase | 0.0969 | 1 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0082 | 0.0523 | 0.0587 |
Echinococcus multilocularis | dual specificity | 0.0082 | 0.0523 | 0.0523 |
Brugia malayi | jmjC domain containing protein | 0.0054 | 0.0224 | 0.0224 |
Schistosoma mansoni | P2X receptor subunit | 0.0174 | 0.1508 | 0.1508 |
Schistosoma mansoni | P2X receptor subunit | 0.0174 | 0.1508 | 0.1508 |
Onchocerca volvulus | 0.0116 | 0.0883 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.5153 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0116 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0969 | 1 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0082 | 0.0523 | 0.0587 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0054 | 0.0224 | 0.0224 |
Schistosoma mansoni | jumonji domain containing protein | 0.0054 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | thymidylate synthase | 0.0116 | 0.0883 | 0.0757 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0054 | 0.0224 | 0.0224 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0054 | 0.0224 | 0.0224 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.5153 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Brugia malayi | Protein kinase domain containing protein | 0.0082 | 0.0523 | 0.0523 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0515 | 0.5153 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0174 | 0.1508 | 0.1508 |
Brugia malayi | thymidylate synthase | 0.0116 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0519 | 0.0388 |
Brugia malayi | jmjC domain containing protein | 0.0054 | 0.0224 | 0.0224 |
Schistosoma mansoni | P2X receptor subunit | 0.0174 | 0.1508 | 0.1508 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0.0235 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 191 uM | Inhibition of Phenylethylamine N-Methyltransferase (PNMT) using radiochemical assay | ChEMBL. | 3681889 |
Ki (binding) | = 191 uM | Inhibition of Phenylethylamine N-Methyltransferase (PNMT) using radiochemical assay | ChEMBL. | 3681889 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.