Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1664 | 0.1254 |
Echinococcus granulosus | cpg binding protein | 0.0067 | 0.436 | 0.8777 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.3074 | 0.3224 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.093 | 0.0899 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.093 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.093 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.4897 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.093 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.093 | 0.0959 |
Echinococcus multilocularis | cpg binding protein | 0.0067 | 0.436 | 0.8777 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4897 | 0.5202 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0489 | 0.5261 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0628 | 0.0167 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0489 | 0.5261 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0489 | 0.5261 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0489 | 0.5261 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.093 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0489 | 0.5261 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.3074 | 0.5845 |
Schistosoma mansoni | cpg binding protein | 0.0063 | 0.4095 | 0.4331 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0489 | 0.5261 |
Loa Loa (eye worm) | histone methyltransferase | 0.002 | 0.0875 | 0.0427 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.1664 | 0.263 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.4897 | 0.4555 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.4897 | 0.4646 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.012 | 0.8264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.4897 | 0.4646 |
Schistosoma mansoni | cpg binding protein | 0.0067 | 0.436 | 0.4619 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.2297 | 0.2381 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0489 | 0.5261 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.093 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.1664 | 0.1254 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4897 | 0.5202 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.093 | 0.5 |
Echinococcus multilocularis | lamin | 0.003 | 0.1664 | 0.263 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0489 | 0.5261 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.093 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.002 | 0.0875 | 0.0834 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0489 | 0.5261 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0016 | 0.0591 | 0.0186 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.093 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0489 | 0.5261 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.051 | 0.0043 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.3074 | 0.5845 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0489 | 0.5261 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0016 | 0.0591 | 0.0186 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.1664 | 0.1694 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2297 | 1 |
Onchocerca volvulus | 0.0063 | 0.4095 | 0.2916 | |
Brugia malayi | RNA binding protein | 0.0074 | 0.4897 | 0.4555 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.093 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.1664 | 0.263 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.093 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0063 | 0.4095 | 0.3804 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0489 | 0.5261 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.002 | 0.0875 | 0.0834 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0016 | 0.0591 | 0.0186 |
Echinococcus granulosus | lamin | 0.003 | 0.1664 | 0.263 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.3074 | 0.5845 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.093 | 0.5 |
Echinococcus multilocularis | musashi | 0.003 | 0.1664 | 0.263 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1623 | 0.1211 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.3074 | 0.3224 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.4897 | 1 |
Brugia malayi | intermediate filament protein | 0.003 | 0.1664 | 0.1105 |
Schistosoma mansoni | cpg binding protein | 0.0067 | 0.436 | 0.4619 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.3074 | 0.5845 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4897 | 0.5202 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.3074 | 0.261 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.093 | 0.0959 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.1664 | 0.1254 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0489 | 0.5261 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.2297 | 0.4074 |
Onchocerca volvulus | Huntingtin homolog | 0.0143 | 1 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0014 | 0.0489 | 0.5261 |
Schistosoma mansoni | lamin | 0.003 | 0.1664 | 0.1694 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0489 | 0.5261 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.093 | 0.0484 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2297 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.2297 | 0.1781 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.1664 | 0.263 |
Schistosoma mansoni | lamin | 0.003 | 0.1664 | 0.1694 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0489 | 0.5261 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2297 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.093 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0134 | 0.932 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0019 | 0.0857 | 0.0244 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0016 | 0.0591 | 0.0186 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.2297 | 0.4074 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.1664 | 0.1105 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2297 | 0.2381 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.3074 | 0.3224 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0489 | 0.5261 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4897 | 0.5202 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0489 | 0.5261 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0016 | 0.0591 | 0.0531 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.3074 | 0.2734 |
Onchocerca volvulus | Huntingtin homolog | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.4897 | 0.4646 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.093 | 0.0899 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.4897 | 0.4555 |
Brugia malayi | CXXC zinc finger family protein | 0.0063 | 0.4095 | 0.3699 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.093 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.093 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4897 | 0.5202 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.