Detailed information for compound 1158338

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 507.578 | Formula: C28H33N3O6
  • H donors: 2 H acceptors: 4 LogP: 1.25 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOCOCCC1(O)C(=O)OCc2c1cc1c3nc4ccccc4c(c3Cn1c2=O)CCNC(C)C
  • InChi: 1S/C28H33N3O6/c1-4-35-16-36-12-10-28(34)22-13-24-25-20(14-31(24)26(32)21(22)15-37-27(28)33)18(9-11-29-17(2)3)19-7-5-6-8-23(19)30-25/h5-8,13,17,29,34H,4,9-12,14-16H2,1-3H3
  • InChiKey: ULVAEGDSHKWBSE-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi DNA-directed RNA polymerase, beta subunit family protein 0.0029 0.0018 0.0837
Loa Loa (eye worm) hypothetical protein 0.0236 0.021 1
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0009 0.0198
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0012 0.0005
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0046 0.2218
Schistosoma mansoni DNA-directed rna polymerase II subunit 0.0029 0.0018 0.0472
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.6522 0.6043 0.6038
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0215 0.019 0.9072
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0563 0.0513 0.0501
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0012 0.039
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.059
Echinococcus multilocularis DNA directed RNA polymerase II subunit RPB2 0.0029 0.0018 0.0079
Echinococcus multilocularis lysine specific demethylase 5A 0.0073 0.0058 0.026
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 1.0787 1 1
Brugia malayi AF-10 protein 0.002 0.0009 0.042
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0012 0.0005
Schistosoma mansoni jumonji domain containing protein 0.0156 0.0135 0.3631
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.1815
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0029 0.1062
Schistosoma mansoni survival motor neuron protein 0.0048 0.0035 0.0948
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0006 0.0001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0008 0.0001
Echinococcus multilocularis DNA directed RNA polymerase III subunit RPC2 0.0029 0.0018 0.0079
Loa Loa (eye worm) DNA-directed RNA polymerase II second largest subunit 0.0029 0.0018 0.0837
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0019 0.05
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.0215 0.019 0.0178
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0215 0.019 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0009 0.0186
Loa Loa (eye worm) hypothetical protein 0.0042 0.0029 0.14
Plasmodium vivax hypothetical protein, conserved 0.0021 0.001 0.0286
Plasmodium vivax hypothetical protein, conserved 0.006 0.0046 0.2218
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0009 0.0409
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0019 0.0084
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0007 0.0094
Plasmodium falciparum phd finger protein, putative 0.006 0.0046 0.2218
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0216
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0081 0.0363
Onchocerca volvulus Alhambra homolog 0.006 0.0046 0.2215
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0001 0.0006
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0215 0.019 0.5109
Schistosoma mansoni cpg binding protein 0.0031 0.0019 0.0509
Brugia malayi Pre-SET motif family protein 0.003 0.0019 0.0888
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0012 0.0007
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0015 0.0511
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0006 0.0001
Echinococcus granulosus DNA directed RNA polymerase II subunit RPB2 0.0029 0.0018 0.0472
Leishmania major hypothetical protein, conserved 0.0026 0.0015 0.0511
Schistosoma mansoni hypothetical protein 0.0048 0.0035 0.0948
Plasmodium vivax DNA-directed RNA polymerase II subunit RPB2, putative 0.0029 0.0018 0.0671
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0059 0.1596
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0015 0.0511
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 1.0787 1 1
Toxoplasma gondii DNA-directed RNA polymerase II RPB2 0.0029 0.0018 0.0671
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0019 0.0084
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0009 0.0409
Schistosoma mansoni DNA-directed RNA polymerase I subunit 0.0021 0.001 0.0267
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0015 0.0511
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0215 0.019 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0015 0.0511
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0009 0.023
Echinococcus multilocularis protein patched 0.0042 0.0029 0.0132
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0017 0.0457
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0215 0.019 0.9072
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0029 0.14
Brugia malayi jmjC domain containing protein 0.0019 0.0009 0.0409
Schistosoma mansoni hypothetical protein 0.0012 0.0001 0.0037
Brugia malayi DNA-directed RNA polymerase II second largest subunit, putative 0.0029 0.0018 0.0837
Plasmodium vivax SET domain protein, putative 0.003 0.0019 0.0728
Echinococcus multilocularis expressed conserved protein 0.0091 0.0075 0.0338
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0005 0.0138
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.0059 0.1596
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0029 0.0788
Schistosoma mansoni hypothetical protein 0.004 0.0028 0.0751
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0019 0.05
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0215 0.019 1
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0005 0.0245
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.0373 0.1671
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0012 0.0236
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0492
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0008 0.0158
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0328
Loa Loa (eye worm) DNA-directed RNA polymerase 0.0024 0.0013 0.0608
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0029 0.0788
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0019 0.05
Brugia malayi hypothetical protein 0.0017 0.0006 0.0291
Echinococcus granulosus DNA directed RNA polymerase III subunit RPC2 0.0029 0.0018 0.0472
Leishmania major hypothetical protein, conserved 0.0019 0.0009 0.0186
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0005 0.0023
Schistosoma mansoni hypothetical protein 0.004 0.0028 0.0751
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0012 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0008 0.0158
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 1.0787 1 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0009 0.0038
Schistosoma mansoni hypothetical protein 0.0412 0.0373 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0009 0.0186
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0008 0.0384
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0138 0.0118 0.0113
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbB 1.0787 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.021 0.5631
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0012 0.0005
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0029 0.0018 0.0474
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0196 0.0173 0.0774
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0006 0.0001
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0029 0.0018 0.0472
Trypanosoma brucei DNA-directed RNA polymerase III, putative 0.0029 0.0018 0.0671
Brugia malayi jmjC domain containing protein 0.0019 0.0009 0.0409
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0015 0.0511
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0033 0.0876
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0563 0.0513 1
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA2 0.0029 0.0018 0.0472
Plasmodium falciparum DNA-directed RNA polymerase I subunit RPA2, putative 0.0021 0.001 0.0261
Brugia malayi DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide 0.0029 0.0018 0.0837
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0009 0.023
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0042 0.2015
Schistosoma mansoni cpg binding protein 0.0029 0.0017 0.0468
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0009 0.023
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0209 1
Trypanosoma cruzi RNA polymerase I second largest subunit, putative 0.0021 0.001 0.0261
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0153 0.0133 0.6881
Schistosoma mansoni hypothetical protein 0.004 0.0028 0.0751
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0182 0.8688
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0409
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.059
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0046 0.0207
Trypanosoma cruzi DNA-directed RNA polymerase II subunit 2, putative 0.0019 0.0008 0.0178
Trichomonas vaginalis DNA-directed RNA polymerase III subunit, putative 0.0029 0.0018 0.0474
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0081 0.2171
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.001 0.0286
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0696
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.6522 0.6043 0.604
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0049 0.1302
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0046 0.1241
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0009 0.023
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0008 0.0216
Onchocerca volvulus 0.0048 0.0035 0.1693
Echinococcus granulosus expressed conserved protein 0.0091 0.0075 0.2024
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0215 0.019 1
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbA 1.0787 1 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.001 0.0045
Giardia lamblia PHD finger protein 15 0.006 0.0046 0.2093
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0009 0.0186
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0215 0.019 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0019 0.05
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0007 0.0094
Brugia malayi jmjC domain containing protein 0.0196 0.0173 0.8231
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0009 0.023
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0015 0.0511
Plasmodium falciparum DNA-directed RNA polymerase II subunit RPB2, putative 0.0029 0.0018 0.0671
Schistosoma mansoni hypothetical protein 0.006 0.0046 0.1241
Plasmodium vivax DNA-directed RNA polymerase III subunit, putative 0.0029 0.0018 0.0671
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0328
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0009 0.0038
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0081 0.3996
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0029 0.0018 0.0472
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0215 0.019 1
Onchocerca volvulus 0.0029 0.0017 0.0836
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0008 0.0036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0035 0.1684
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0138
Trypanosoma brucei RNA polymerase I second largest subunit 0.0021 0.001 0.0261
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0215 0.019 0.9086
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0029 0.0018 0.0521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0033 0.0146
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0046 0.2218
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0009 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0012 0.039
Onchocerca volvulus 0.0235 0.0209 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0012 0.0005
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0009 0.0186
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0033 0.0146
Leishmania major DNA-directed RNA polymerase polypeptide, putative 0.0029 0.0018 0.0671
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0009 0.0186
Echinococcus granulosus peregrin 0.006 0.0046 0.1241
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.012 0.3211
Toxoplasma gondii DNA-directed RNA polymerase I RPA2 0.0021 0.001 0.0261
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0008 0.0158
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA2 0.0029 0.0018 0.0079
Echinococcus granulosus phd:f box containing protein 0.0019 0.0009 0.023
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0009 0.0409
Onchocerca volvulus 0.0023 0.0012 0.0593
Mycobacterium ulcerans hypothetical protein 0.0023 0.0012 0.0005
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0215 0.019 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2413 0.223 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0012 0.059
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0215 0.019 1
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0018 0.0858
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 1.0787 1 1
Echinococcus granulosus dnaJ subfamily B 0.0412 0.0373 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0012 0.059
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.001 0.0271
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0409
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0081 0.3856
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0019 0.05
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0029 0.0018 0.0474
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.0215 0.019 0.0184
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0328
Toxoplasma gondii DNA-directed RNA polymerase III RPC2 0.0029 0.0018 0.0671
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0328
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0563 0.0513 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.0105 0.5024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0033 0.1555
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0023
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0008 0.0158
Entamoeba histolytica DNA-directed RNA polymerase subunit, putative 0.0029 0.0018 0.0521
Brugia malayi jmjC domain containing protein 0.0074 0.0059 0.2833
Brugia malayi PHD-finger family protein 0.006 0.0046 0.2203
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0059 0.1596
Brugia malayi jmjC domain containing protein 0.0019 0.0009 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0033 0.0876
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0005 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0023
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0008 0.0384
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0012 0.0007
Entamoeba histolytica DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide, putative 0.0029 0.0018 0.0521
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0029 0.0132
Onchocerca volvulus 0.003 0.0019 0.0892
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0008 0.0003
Trypanosoma brucei DNA-directed RNA polymerase II subunit 2, putative 0.0029 0.0018 0.0671
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0012 0.0236
Loa Loa (eye worm) hypothetical protein 0.0097 0.0081 0.3856
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0236
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0015 0.0511
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0215 0.019 1
Entamoeba histolytica DNA-directed RNA polymerase subunit, putative 0.0029 0.0018 0.0521
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0216
Brugia malayi jmjC domain containing protein 0.0019 0.0009 0.0409
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0196 0.0173 0.4635
Schistosoma mansoni hypothetical protein 0.004 0.0028 0.0751
Brugia malayi CHE-14 protein 0.0042 0.0029 0.14
Echinococcus granulosus cpg binding protein 0.0031 0.0019 0.0509
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0009 0.0038
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0215 0.019 0.0854
Plasmodium vivax DNA-directed RNA polymerase I subunit RPA2, putative 0.0021 0.001 0.0261
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 1.0787 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0082 0.2209
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0012 0.0236
Brugia malayi Bromodomain containing protein 0.006 0.0046 0.2203
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0068 0.0305
Brugia malayi Pre-SET motif family protein 0.0207 0.0182 0.8688
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0012 0.0005
Plasmodium falciparum DNA-directed RNA polymerase III subunit RPC2, putative 0.0029 0.0018 0.0671
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.059
Toxoplasma gondii exonuclease III APE 0.0019 0.0008 0.0158
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0563 0.0513 0.0506
Loa Loa (eye worm) hypothetical protein 0.006 0.0046 0.2203
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0009 0.0186
Brugia malayi hypothetical protein 0.0236 0.021 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0009 0.0198
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0009 0.023
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0009 0.023
Loa Loa (eye worm) RNA polymerase III 128kD subunit-PA 0.0029 0.0018 0.0837
Brugia malayi PHD-finger family protein 0.0021 0.001 0.0492
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0005 0.0245
Echinococcus multilocularis cpg binding protein 0.0031 0.0019 0.0085
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.021 0.0941
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0033 0.0876
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0888
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0012 0.0005
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0563 0.0513 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0215 0.019 0.0185
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0059 0.2833
Brugia malayi isocitrate dehydrogenase 0.0016 0.0005 0.0245
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0001 0.0037
Echinococcus multilocularis peregrin 0.006 0.0046 0.0207
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0033 0.1555
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0068 0.1825
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0215 0.019 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0009 0.0198
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0008 0.0158
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0009 0.0198
Plasmodium vivax JmjC domain containing protein 0.0019 0.0009 0.0186
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0009 0.023
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0215 0.019 0.5109
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.6522 0.6043 0.6041
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbC 1.0787 1 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0035 0.0156
Trypanosoma cruzi DNA-directed RNA polymerase III, putative 0.0029 0.0018 0.0671
Giardia lamblia DNA-directed RNA polymerase RPB2 0.0029 0.0018 0.0521
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0012 0.059
Brugia malayi hypothetical protein 0.0026 0.0015 0.0696
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0023
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0007 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0012 0.039
Brugia malayi CXXC zinc finger family protein 0.0029 0.0017 0.0832
Schistosoma mansoni cpg binding protein 0.0031 0.0019 0.0509
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0033 0.0876
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0021 0.001 0.0104
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0017 0.0832
Leishmania major RNA polymerase I second largest subunit, putative 0.0021 0.001 0.0261
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0033 0.0876
Schistosoma mansoni patched 1 0.0042 0.0029 0.0788
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0008 0.0158
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0328
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0046 0.1241
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0019 0.0728
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0006 0.0001
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0046 0.2203
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.012 0.0536
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0016 0.0442
Loa Loa (eye worm) hypothetical protein 0.0103 0.0086 0.4096

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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