Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0231 | 0.4529 | 0.6712 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0074 | 0.0963 | 0.1124 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0963 | 0.1124 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.0963 | 0.1309 |
Onchocerca volvulus | 0.0059 | 0.0617 | 0.0626 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0963 | 0.1124 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.0963 | 0.1309 |
Schistosoma mansoni | hypothetical protein | 0.0257 | 0.5124 | 0.8777 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0292 | 0.5912 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0409 | 0.8567 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0074 | 0.0963 | 0.1427 |
Trichomonas vaginalis | set domain proteins, putative | 0.0466 | 0.9849 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0329 | 0.6747 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0059 | 0.0617 | 0.1057 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0231 | 0.4529 | 0.5287 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.2776 | 0.2006 |
Brugia malayi | beta-lactamase | 0.0074 | 0.0963 | 0.1124 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0231 | 0.4529 | 0.6712 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0963 | 0.1124 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.5912 | 1 |
Onchocerca volvulus | 0.0466 | 0.9849 | 1 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0057 | 0.0568 | 0.0842 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0617 | 0.072 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.2776 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.2422 | 0.2948 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0963 | 0.1124 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0231 | 0.4529 | 0.7758 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.2422 | 0.3871 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0257 | 0.5124 | 0.7594 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0074 | 0.0963 | 0.1309 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0289 | 0.5838 | 0.8653 |
Onchocerca volvulus | 0.0074 | 0.0963 | 0.0978 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.009 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.009 | 0.0134 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0231 | 0.4529 | 0.7758 |
Onchocerca volvulus | 0.0074 | 0.0963 | 0.0978 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0074 | 0.0963 | 0.1124 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0231 | 0.4529 | 0.6712 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0059 | 0.0617 | 0.0914 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0059 | 0.0617 | 0.1057 |
Onchocerca volvulus | 0.0074 | 0.0963 | 0.0978 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0292 | 0.5912 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0059 | 0.0617 | 0.1057 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0963 | 0.1649 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0059 | 0.0617 | 0.4316 |
Mycobacterium leprae | conserved hypothetical protein | 0.0074 | 0.0963 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0963 | 0.1124 |
Schistosoma mansoni | thyroid hormone receptor | 0.0289 | 0.5838 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0059 | 0.0617 | 0.1057 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.217 | 0.2533 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.009 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0231 | 0.4529 | 0.6712 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0378 | 0.0441 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.217 | 0.2533 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0421 | 0.0358 |
Brugia malayi | hypothetical protein | 0.0035 | 0.009 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0963 | 0.1124 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.5912 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0378 | 0.0647 |
Onchocerca volvulus | 0.0048 | 0.0378 | 0.0384 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.009 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0074 | 0.0963 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0231 | 0.4529 | 0.7758 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0409 | 0.8567 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.217 | 0.2533 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0257 | 0.5124 | 0.7594 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.009 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0963 | 0.1124 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0059 | 0.0617 | 0.0914 |
Plasmodium vivax | hypothetical protein, conserved | 0.0074 | 0.0963 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0059 | 0.0617 | 0.0914 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0074 | 0.0963 | 0.1427 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0963 | 0.1124 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0231 | 0.4529 | 0.5287 |
Schistosoma mansoni | thyroid hormone receptor | 0.0289 | 0.5838 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.009 | 0.0155 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0963 | 0.1649 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.2422 | 0.3871 |
Brugia malayi | Pre-SET motif family protein | 0.0059 | 0.0617 | 0.072 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.009 | 0.0134 |
Echinococcus multilocularis | tumor protein p63 | 0.0329 | 0.6747 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.009 | 0.0155 |
Loa Loa (eye worm) | beta-lactamase | 0.0074 | 0.0963 | 0.1124 |
Mycobacterium leprae | Probable lipase LipE | 0.0074 | 0.0963 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.