Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | nM | Functional activity towards human glucocorticoid receptor in genetically engineered cell line containing glucocorticoid response element and reporter gene encoding a secreted form of alkaline phosphatase | ChEMBL. | 15081010 |
IC50 (functional) | 0 nM | Functional activity towards human glucocorticoid receptor in genetically engineered cell line containing glucocorticoid response element and reporter gene encoding a secreted form of alkaline phosphatase | ChEMBL. | 15081010 |
IC50 (binding) | = 14000 nM | Binding affinity against human Glucocorticoid receptor (GR) using [3H]-dexamethasone as radioligand | ChEMBL. | 15081010 |
IC50 (binding) | = 14000 nM | Binding affinity against human Glucocorticoid receptor (GR) using [3H]-dexamethasone as radioligand | ChEMBL. | 15081010 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.