Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1885 | 0.2153 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0298 | 0.0289 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.1689 | 0.1681 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.1018 | 0.1561 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0491 | 0.056 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0491 | 0.0698 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0014 | 0.0297 | 0.0339 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0014 | 0.0297 | 0.0339 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0016 | 0.0406 | 0.0577 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0027 | 0.0922 | 0.1311 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0055 | 0.2161 | 0.3313 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1658 | 0.2358 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.015 | 0.6522 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0297 | 0.0456 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0298 | 0.0289 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0055 | 0.2161 | 0.3628 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0016 | 0.0406 | 0.0622 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.002 | 0.0573 | 0.0815 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1018 | 0.1163 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0016 | 0.0406 | 0.0577 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0491 | 0.0698 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0491 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0491 | 0.0753 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0298 | 0.0289 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0491 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0048 | 0.1885 | 0.268 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0298 | 0.0289 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0298 | 0.0289 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0055 | 0.2161 | 0.3313 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.1522 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0298 | 0.0289 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.103 | 0.117 |
Trichomonas vaginalis | set domain proteins, putative | 0.0227 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0043 | 0.1639 | 0.1872 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0113 | 0.4823 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.1689 | 0.2604 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4823 | 0.5509 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0048 | 0.1885 | 0.268 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0048 | 0.1885 | 0.2153 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0491 | 0.0482 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0491 | 0.0753 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.103 | 0.1464 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0298 | 0.0289 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.006 | 0.2422 | 0.2766 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.103 | 0.1176 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0199 | 0.8754 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0491 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0014 | 0.0297 | 0.0422 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0491 | 0.3227 |
Schistosoma mansoni | patched 1 | 0.0048 | 0.1885 | 0.289 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.1689 | 0.2604 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0491 | 0.1018 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1658 | 0.2358 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.103 | 0.1464 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0298 | 0.0289 |
Schistosoma mansoni | cpg binding protein | 0.0064 | 0.2578 | 0.3953 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0298 | 0.0289 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0298 | 0.0289 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0055 | 0.2161 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0298 | 0.0289 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0055 | 0.2161 | 0.3073 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1805 | 0.2768 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0014 | 0.0297 | 0.0422 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0029 | 0.1018 | 0.1163 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0014 | 0.0297 | 0.0422 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0014 | 0.0297 | 0.0339 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0298 | 0.0289 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1658 | 0.2542 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0113 | 0.4823 | 0.6859 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0491 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0014 | 0.0297 | 0.0422 |
Schistosoma mansoni | cpg binding protein | 0.006 | 0.2422 | 0.3713 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.1689 | 0.1681 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1805 | 0.2768 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0055 | 0.2161 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0129 | 0.5548 | 0.8506 |
Schistosoma mansoni | bromodomain containing protein | 0.0007 | 0 | 0.0001 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1658 | 0.2358 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0491 | 0.0482 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0043 | 0.1639 | 0.1872 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.103 | 0.1464 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.103 | 0.1579 |
Loa Loa (eye worm) | histone methyltransferase | 0.002 | 0.0573 | 0.0654 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.015 | 0.6522 | 0.745 |
Loa Loa (eye worm) | acetyltransferase | 0.015 | 0.6522 | 0.745 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0161 | 0.7031 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.015 | 0.6522 | 0.9276 |
Echinococcus multilocularis | expressed conserved protein | 0.0106 | 0.4511 | 0.6415 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0491 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0298 | 0.0289 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0298 | 0.0289 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0019 | 0.0562 | 0.0642 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.1522 | 0.3155 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0016 | 0.0406 | 0.0577 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0491 | 0.056 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.103 | 0.1579 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0055 | 0.2161 | 0.3073 |
Echinococcus granulosus | cpg binding protein | 0.0064 | 0.2578 | 0.3667 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0298 | 0.0289 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1658 | 0.1894 |
Trichomonas vaginalis | helicase, putative | 0.0014 | 0.0298 | 0.0289 |
Echinococcus multilocularis | cpg binding protein | 0.0064 | 0.2578 | 0.3667 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0055 | 0.2161 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0297 | 0.0456 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0298 | 0.0289 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0016 | 0.0406 | 0.0577 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.1689 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0064 | 0.2578 | 0.3953 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.103 | 0.1579 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1658 | 0.2542 |
Echinococcus multilocularis | protein dispatched 1 | 0.0055 | 0.2197 | 0.3124 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0146 | 0.633 | 0.9003 |
Brugia malayi | CXXC zinc finger family protein | 0.006 | 0.2422 | 0.2766 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.103 | 0.1579 |
Brugia malayi | Pre-SET motif family protein | 0.0199 | 0.8754 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0007 | 0 | 0.0001 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0119 | 0.5093 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0297 | 0.0456 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0014 | 0.0297 | 0.0422 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0113 | 0.4823 | 0.5509 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1658 | 0.1894 |
Echinococcus granulosus | GPCR family 2 | 0.0014 | 0.0297 | 0.0422 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.001 | 0.0117 | 0.018 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0113 | 0.4823 | 0.6859 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1805 | 0.2768 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0055 | 0.2161 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1658 | 0.2358 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1805 | 0.2768 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0297 | 0.0456 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0048 | 0.1885 | 0.268 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0161 | 0.7031 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0048 | 0.1885 | 0.268 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0115 | 0.4902 | 0.7516 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0298 | 0.0289 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.1522 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.002 | 0.0573 | 0.0815 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.1885 | 0.1877 |
Schistosoma mansoni | zinc finger protein | 0.0007 | 0 | 0.0001 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0055 | 0.2161 | 1 |
Onchocerca volvulus | 0.006 | 0.2422 | 0.1552 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1658 | 0.2542 |
Brugia malayi | CHE-14 protein | 0.0048 | 0.1885 | 0.2153 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0043 | 0.1639 | 0.1872 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1639 | 0.1872 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.103 | 0.4494 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2382 | 0.272 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.103 | 0.1176 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.1689 | 0.2402 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0297 | 0.0339 |
Echinococcus granulosus | expressed conserved protein | 0.0106 | 0.4511 | 0.6415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.