Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0617 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.3192 | 0.4791 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0953 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0617 | 0.0925 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0617 | 0.0925 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0617 | 0.0925 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.2821 | 0.4234 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0617 | 0.0925 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.2821 | 0.8559 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0617 | 1 |
Onchocerca volvulus | 0.0036 | 0.0617 | 0.5 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0617 | 0.0925 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3422 | 0.3422 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0617 | 0.1802 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0617 | 0.0925 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0953 | 0.143 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.2821 | 0.4234 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0617 | 0.5 | |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0953 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0617 | 0.0617 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.3422 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0953 | 0.1199 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.2821 | 0.4234 |
Onchocerca volvulus | 0.0036 | 0.0617 | 0.5 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3129 | 0.8955 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0617 | 0.1802 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.3422 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0617 | 0.6471 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0953 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0617 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0617 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0953 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0617 | 0.0617 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0953 | 0.2785 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0617 | 0.0925 |
Schistosoma mansoni | hypothetical protein | 0.0335 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3422 | 0.3422 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0617 | 0.6471 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0617 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0617 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.2821 | 0.4234 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.3422 | 0.3422 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.3422 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.2821 | 0.4234 |
Treponema pallidum | NADH oxidase | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0335 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3422 | 0.3422 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0953 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0617 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0953 | 0.1199 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0953 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3129 | 0.8955 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.3192 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0617 | 0.6471 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.3422 | 0.3422 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0617 | 0.1802 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0617 | 0.0925 |
Echinococcus multilocularis | geminin | 0.0335 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0617 | 0.6471 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0617 | 0.0617 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0953 | 0.0953 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0953 | 0.2785 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0953 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.3192 | 0.4791 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0617 | 0.6471 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3129 | 0.9143 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.2821 | 0.4234 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0617 | 0.0617 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0617 | 0.6471 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.3192 | 0.4791 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0953 | 0.0953 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3422 | 0.3422 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.3422 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.3422 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3422 | 0.3422 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.6662 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0617 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0953 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0617 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0617 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0617 | 0.0925 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0617 | 0.1802 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0617 | 0.0925 |
Brugia malayi | RNA binding protein | 0.0125 | 0.3422 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0617 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.