Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0187 | 0.0593 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0241 | 0.1112 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0115 | 0.0029 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0434 | 0.0399 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0091 | 0.0059 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0091 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0187 | 0.0112 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0483 | 0.3118 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0187 | 0.0112 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.1426 | 0.6587 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.1138 | 0.5502 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0558 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0091 | 0.0059 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.1138 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0997 | 0.1052 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1574 | 0.727 |
Brugia malayi | Inositol-1 | 0.0041 | 0.1138 | 0.1217 |
Trichomonas vaginalis | set domain proteins, putative | 0.0241 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0483 | 0.4266 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0483 | 0.0456 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0558 | 0.7889 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0091 | 0.0059 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1574 | 0.1723 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0483 | 0.3118 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.1426 | 0.6587 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1574 | 0.7768 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0558 | 0.0542 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0657 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0558 | 0.4898 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1778 | 0.1959 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0997 | 0.1052 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0483 | 0.4247 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0187 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0483 | 0.0456 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0483 | 0.3118 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0187 | 0.0112 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0483 | 0.0456 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0327 | 0.151 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.1138 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0091 | 0.0418 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0327 | 0.1287 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0091 | 0.0418 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0657 | 0.1709 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.1778 | 0.1959 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.2694 | 0.3024 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0079 | 0.0366 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2004 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2004 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.2165 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.1138 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1574 | 0.7768 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0107 | 0.0019 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0091 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0483 | 0.0456 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0193 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1426 | 0.1551 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.0947 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1148 | 0.1228 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1574 | 0.727 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.1138 | 0.5502 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.1138 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0037 | 0.0947 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0241 | 0.0174 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0483 | 0.4247 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1234 | 0.1328 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.1138 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0607 | 0.2743 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0327 | 0.1287 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0558 | 0.0542 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1574 | 0.7768 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0483 | 0.3118 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0048 | 0.1426 | 0.7 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0193 | 0.0891 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0483 | 0.0456 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0483 | 0.4266 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0931 | 0.4427 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1574 | 0.1723 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.1138 | 0.1217 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0091 | 0.0059 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0483 | 0.0456 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0657 | 0.3033 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0931 | 0.4427 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.1138 | 0.5256 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0657 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0187 | 0.0112 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.1138 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0558 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1038 | 0.11 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1041 | 0.1104 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0483 | 0.3118 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.8702 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0483 | 0.3118 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.1138 | 0.5256 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0193 | 0.0592 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.1778 | 0.1959 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0048 | 0.1426 | 0.7 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1574 | 0.7768 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0483 | 0.3118 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0079 | 0.0366 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.1778 | 0.1959 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1574 | 0.727 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0483 | 0.4247 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0558 | 0.4898 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0558 | 0.4898 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0997 | 0.4603 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0091 | 0.0418 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0657 | 0.3001 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0187 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.8702 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0657 | 0.0658 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.1138 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0091 | 0.0418 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.1138 | 1 |
Onchocerca volvulus | 0.003 | 0.0657 | 0.0182 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0483 | 0.3118 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0558 | 0.4898 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2501 | 0.2799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.