Detailed information for compound 1159225

Basic information

Technical information
  • TDR Targets ID: 1159225
  • Name: 4,4-bis(4-fluorophenyl)-N-piperidin-4-ylbutan amide
  • MW: 358.425 | Formula: C21H24F2N2O
  • H donors: 2 H acceptors: 1 LogP: 3.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCNCC1)CCC(c1ccc(cc1)F)c1ccc(cc1)F
  • InChi: 1S/C21H24F2N2O/c22-17-5-1-15(2-6-17)20(16-3-7-18(23)8-4-16)9-10-21(26)25-19-11-13-24-14-12-19/h1-8,19-20,24H,9-14H2,(H,25,26)
  • InChiKey: QUCOLKNYEPAZDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4,4-bis(4-fluorophenyl)-N-(4-piperidyl)butanamide
  • 4,4-bis(4-fluorophenyl)-N-(4-piperidinyl)butanamide
  • 4,4-bis(4-fluorophenyl)-N-(4-piperidyl)butyramide
  • 4,4-bis(4-fluorophenyl)-N-piperidin-4-yl-butanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni heat shock protein 0.0012 0.0017 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.1148 0.491
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0024 0.0501 0.0171
Echinococcus multilocularis heat shock protein 90 0.0024 0.0501 0.064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0244 0.2127
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.232 1
Schistosoma mansoni hypothetical protein 0.003 0.0754 0.0996
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0335 0.292
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.1148 0.1517
Echinococcus multilocularis cysteine protease 0.0018 0.0244 0.03
Loa Loa (eye worm) beta-lactamase 0.004 0.1148 0.3326
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.2421 0.3199
Leishmania major cathepsin L-like protease 0.0018 0.0244 0.0943
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0755 0.3203
Onchocerca volvulus 0.0018 0.0244 0.2127
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0024 0.0501 1
Mycobacterium leprae Probable lipase LipE 0.004 0.1148 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0244 0.0593
Mycobacterium ulcerans beta-lactamase 0.004 0.1148 0.4393
Trypanosoma brucei heat shock protein, putative 0.003 0.0755 0.3203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0244 0.2127
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0754 0.0996
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0244 0.0708
Leishmania major cytochrome p450-like protein 0.0016 0.015 0.0553
Toxoplasma gondii ABC1 family protein 0.004 0.1148 0.4703
Echinococcus multilocularis cysteine protease 0.0018 0.0244 0.03
Trypanosoma brucei heat shock protein, putative 0.003 0.0755 0.3203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.015 0.0436
Echinococcus granulosus geminin 0.0196 0.7569 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0244 0.0323
Leishmania major cathepsin L-like protease 0.0018 0.0244 0.0943
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0244 0.2127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0754 0.0976
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0335 0.1322
Giardia lamblia Heat shock protein HSP 90-alpha 0.0024 0.0501 0.2061
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0012 0.0017 0.0042
Loa Loa (eye worm) endoplasmin 0.003 0.0755 0.2187
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.2421 0.3199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0244 0.2127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0244 0.2127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.1148 0.4393
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Mycobacterium ulcerans heat shock protein 90 0.0024 0.0501 0.1541
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0244 0.03
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.1148 1
Schistosoma mansoni hypothetical protein 0.0112 0.4117 0.544
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.1148 0.0841
Schistosoma mansoni endoplasmin 0.003 0.0755 0.0997
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0244 0.3075
Onchocerca volvulus 0.0018 0.0244 0.2127
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0244 0.0985
Onchocerca volvulus 0.0018 0.0244 0.2127
Brugia malayi Cathepsin L-like precursor 0.0018 0.0244 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Trypanosoma cruzi Heat shock protein 83, putative 0.003 0.0755 0.3203
Loa Loa (eye worm) hypothetical protein 0.0018 0.0244 0.0708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Mycobacterium leprae conserved hypothetical protein 0.004 0.1148 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0244 0.2127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Mycobacterium tuberculosis Conserved protein 0.004 0.1148 0.0841
Plasmodium falciparum heat shock protein 90 0.003 0.0755 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0754 0.0976
Trichomonas vaginalis esterase, putative 0.004 0.1148 1
Plasmodium vivax vivapain-2 0.0018 0.0244 0.2006
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.1137 0.1483
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.2421 1
Plasmodium vivax endoplasmin, putative 0.003 0.0755 0.6523
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.1148 1
Entamoeba histolytica heat shock protein 90, putative 0.003 0.0755 0.1834
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0244 0.2127
Giardia lamblia Grp94/Hsp90 0.0024 0.0501 0.2061
Plasmodium vivax vivapain-2 0.0018 0.0244 0.2006
Loa Loa (eye worm) fibroinase 0.0018 0.0244 0.0708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Leishmania major cathepsin L-like protease 0.0068 0.232 0.9579
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.1137 0.1502
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.1148 0.0841
Loa Loa (eye worm) hypothetical protein 0.0066 0.2203 0.6383
Brugia malayi beta-lactamase family protein 0.004 0.1148 0.2788
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0096 0.3452 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Schistosoma mansoni heat shock protein 0.003 0.0755 0.0997
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.1137 0.4862
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0244 0.0708
Loa Loa (eye worm) ctsf protein 0.0018 0.0244 0.0708
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.015 0.0436
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.1148 0.1517
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0244 0.0593
Schistosoma mansoni hypothetical protein 0.003 0.0754 0.0996
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.1137 0.4862
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.1137 0.1502
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.232 1
Schistosoma mansoni ap endonuclease 0.002 0.0335 0.0443
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.1148 0.0841
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.4117 0.544
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0244 0.0943
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0244 0.0593
Echinococcus granulosus cathepsin l1 0.0018 0.0244 0.0323
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0244 0.3075
Onchocerca volvulus 0.0018 0.0244 0.2127
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Entamoeba histolytica hypothetical protein 0.0112 0.4117 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Brugia malayi Cathepsin L-like precursor 0.0018 0.0244 0.0593
Echinococcus granulosus heat shock protein 90 0.003 0.0755 0.0997
Schistosoma mansoni ap endonuclease 0.002 0.0335 0.0443
Trypanosoma brucei heat shock protein, putative 0.003 0.0755 0.3203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Trypanosoma brucei cytochrome P450, putative 0.0016 0.015 0.0578
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0335 0.0814
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.1148 0.0841
Echinococcus multilocularis heat shock protein 0.003 0.0755 0.0977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.232 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0244 0.2127
Loa Loa (eye worm) hypothetical protein 0.004 0.1148 0.3326
Entamoeba histolytica cysteine protease, putative 0.0018 0.0244 0.0593
Toxoplasma gondii heat shock protein HSP90 0.003 0.0755 0.3068
Mycobacterium tuberculosis Conserved protein 0.004 0.1148 0.0841
Schistosoma mansoni hypothetical protein 0.003 0.0754 0.0996
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.1137 0.9904
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0272 0.2369
Entamoeba histolytica heat shock protein 90, putative 0.003 0.0755 0.1834
Mycobacterium tuberculosis Conserved protein 0.004 0.1148 0.0841
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0244 0.2127
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.1137 0.2762
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0244 0.2127
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.1137 0.4657
Leishmania major cathepsin L-like protease 0.0068 0.232 0.9579
Loa Loa (eye worm) hypothetical protein 0.0096 0.3452 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.1718 0.7384
Loa Loa (eye worm) hypothetical protein 0.004 0.1148 0.3326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Brugia malayi heat shock protein 90 0.003 0.0755 0.1834
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.015 0.0578
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0244 0.0323
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0335 0.0421
Brugia malayi Hsp90 protein 0.0012 0.0017 0.0042
Plasmodium vivax heat shock protein 86, putative 0.003 0.0755 0.6523
Plasmodium vivax hypothetical protein, conserved 0.004 0.1148 1
Schistosoma mansoni heat shock protein 0.003 0.0755 0.0997
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.232 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.1148 0.2788
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.2421 0.3199
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.1137 1
Brugia malayi hypothetical protein 0.0112 0.4117 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0024 0.0501 0.2009
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Brugia malayi Cytochrome P450 family protein 0.0016 0.015 0.0365
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0244 0.3075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Loa Loa (eye worm) hypothetical protein 0.004 0.1148 0.3326
Trypanosoma cruzi heat shock protein 90, putative 0.0018 0.0243 0.0979
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.1137 0.1502
Onchocerca volvulus 0.0018 0.0244 0.2127
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.4117 0.544
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0024 0.0501 0.0661
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.2421 1
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0335 0.0971
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0335 0.2811
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0335 0.0443
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0754 0.0996
Leishmania major cathepsin L-like protease 0.0018 0.0244 0.0943
Toxoplasma gondii exonuclease III APE 0.002 0.0335 0.1322
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0335 0.292
Echinococcus granulosus heat shock protein 0.003 0.0755 0.0997
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.1148 0.4393
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.1137 0.4862
Trypanosoma brucei hypothetical protein, conserved 0.004 0.1148 0.491
Echinococcus multilocularis geminin 0.0196 0.7569 1
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Toxoplasma gondii cathepsin CPL 0.0018 0.0244 0.0943
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.2421 0.3183
Trypanosoma brucei heat shock protein, putative 0.003 0.0755 0.3203
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.1148 0.0841
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0501 0.436
Trypanosoma brucei heat shock protein, putative 0.003 0.0755 0.3203
Schistosoma mansoni hypothetical protein 0.0196 0.7569 1
Mycobacterium ulcerans lipase LipD 0.004 0.1148 0.4393
Schistosoma mansoni endoplasmin 0.003 0.0755 0.0997
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.015 0.0578
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.1148 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.1137 0.9904
Brugia malayi Cathepsin L-like precursor 0.0018 0.0244 0.0593
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0096 0.3452 0.8384
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.4117 0.5429
Leishmania major hypothetical protein, conserved 0.004 0.1148 0.4703
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.1148 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0755 0.5235
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0244 0.03
Loa Loa (eye worm) CYP4Cod1 0.0016 0.015 0.0436
Onchocerca volvulus 0.0018 0.0244 0.2127
Mycobacterium ulcerans hypothetical protein 0.004 0.1148 0.4393
Schistosoma mansoni hypothetical protein 0.0066 0.2203 0.2911
Brugia malayi Cathepsin L-like precursor 0.0018 0.0244 0.0593
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Entamoeba histolytica hypothetical protein 0.0112 0.4117 1
Schistosoma mansoni hypothetical protein 0.003 0.0754 0.0996
Onchocerca volvulus 0.004 0.1148 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0335 0.138
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Leishmania major cathepsin L-like protease 0.0068 0.232 0.9579
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.1137 0.1483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Echinococcus granulosus endoplasmin 0.0024 0.0501 0.0661
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0244 0.2127
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Trichomonas vaginalis heat shock protein, putative 0.0012 0.0017 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0755 0.3203
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0244 0.2127
Onchocerca volvulus 0.004 0.1148 1
Loa Loa (eye worm) hypothetical protein 0.004 0.1148 0.3326
Trypanosoma brucei heat shock protein 90, putative 0.003 0.0755 0.3203
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1137 0.9904
Toxoplasma gondii heat shock protein 90, putative 0.003 0.0755 0.3068
Leishmania major cathepsin L-like protease 0.0018 0.0244 0.0943
Loa Loa (eye worm) heat shock protein 75 0.0012 0.0017 0.0051
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0244 0.03
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0012 0.0017 0.0152
Entamoeba histolytica hypothetical protein 0.0112 0.4117 1
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0272 0.2369
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0335 0.138
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0244 0.0323
Brugia malayi beta-lactamase 0.004 0.1148 0.2788
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0501 0.436
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0335 0.0814
Brugia malayi Calcitonin receptor-like protein seb-1 0.0096 0.3452 0.8384
Loa Loa (eye worm) hypothetical protein 0.004 0.1148 0.3326
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Echinococcus granulosus GPCR family 2 0.003 0.0754 0.0996
Trypanosoma cruzi heat shock protein 90, putative 0.0024 0.0501 0.2098
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0501 0.436
Onchocerca volvulus 0.004 0.1148 1
Trichomonas vaginalis heat shock protein, putative 0.003 0.0755 0.6576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Brugia malayi Endoplasmin precursor 0.003 0.0755 0.1834
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.2421 1
Loa Loa (eye worm) hypothetical protein 0.004 0.1137 0.3294
Echinococcus multilocularis heat shock protein 90 0.003 0.0755 0.0977
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.1148 0.0841
Loa Loa (eye worm) cysteine protease 0.0018 0.0244 0.0708
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.2421 1
Leishmania major cathepsin L-like protease 0.0018 0.0244 0.0943
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.2421 0.2159
Trypanosoma brucei heat shock protein, putative 0.003 0.0755 0.3203
Brugia malayi Latrophilin receptor protein 2 0.003 0.0754 0.1832
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.1148 0.1517
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0754 0.2185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.1148 1
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.1137 0.1483
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0335 0.0814
Plasmodium falciparum endoplasmin, putative 0.0019 0.0272 0.345
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0755 0.3203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0755 0.3203
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0244 0.03
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.1148 0.1497
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0335 0.4309
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0335 0.138
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.1148 0.3326
Loa Loa (eye worm) hypothetical protein 0.003 0.0754 0.2185
Loa Loa (eye worm) hypothetical protein 0.004 0.1148 0.3326
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.2421 1
Brugia malayi beta-lactamase family protein 0.004 0.1148 0.2788
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Mycobacterium tuberculosis Probable hydrolase 0.004 0.1148 0.0841
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.2203 0.5351
Trypanosoma brucei heat shock protein 90, putative 0.003 0.0755 0.3203
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.1148 0.491
Trypanosoma brucei heat shock protein, putative 0.003 0.0755 0.3203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0244 0.2127
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0244 0.0323
Onchocerca volvulus 0.0018 0.0244 0.2127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Brugia malayi Cathepsin L-like precursor 0.0018 0.0244 0.0593
Treponema pallidum heat shock protein 90 0.0024 0.0501 1
Echinococcus multilocularis GPCR, family 2 0.003 0.0754 0.0976
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Brugia malayi Cytochrome P450 family protein 0.0016 0.015 0.0365
Trypanosoma brucei heat shock protein, putative 0.003 0.0755 0.3203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0244 0.2127
Schistosoma mansoni hypothetical protein 0.0196 0.7569 1
Trypanosoma brucei Heat shock protein 83, putative 0.003 0.0755 0.3203
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.1137 0.1502
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Trypanosoma cruzi heat shock protein 85, putative 0.0024 0.0501 0.2098
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0244 0.2127
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.2076 0.8939
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0754 0.1832
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.1137 0.2762
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0244 0.0593
Echinococcus granulosus heat shock protein 90 0.0024 0.0501 0.0661
Loa Loa (eye worm) heat shock protein 90 0.003 0.0755 0.2187
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Entamoeba histolytica hypothetical protein 0.0112 0.4117 1
Echinococcus multilocularis endoplasmin 0.0024 0.0501 0.064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.232 1
Leishmania major heat shock protein 83-1 0.003 0.0755 0.3068
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.1137 0.1502
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0012 0.0017 0.0023

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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