Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.1683 | 0.1476 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.1683 | 0.1264 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0746 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0608 | 0.0375 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1683 | 0.1904 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.6638 | 0.6924 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.6638 | 0.7091 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.3208 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.5653 | 0.5545 |
Brugia malayi | Inositol-1 | 0.0043 | 0.6638 | 0.6554 |
Schistosoma mansoni | lamin | 0.0031 | 0.3693 | 0.3628 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.6638 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.1683 | 0.1264 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1683 | 0.1904 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.3208 | 0.2131 |
Leishmania major | DNA polymerase eta, putative | 0.0052 | 0.884 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.3208 | 0.2131 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.3208 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.6638 | 0.7091 |
Echinococcus granulosus | dna polymerase eta | 0.0052 | 0.884 | 0.968 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.3693 | 0.3628 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.9112 | 1 |
Echinococcus multilocularis | lamin | 0.0031 | 0.3693 | 0.3628 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3557 | 0.3397 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1683 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1683 | 0.1904 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0608 | 0.0375 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.1683 | 0.1264 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1683 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1683 | 0.1904 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.6638 | 0.6924 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.1683 | 0.1904 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.3693 | 0.3537 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.9112 | 0.909 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.9112 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.9112 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.9112 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.9112 | 0.909 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0052 | 0.884 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.6638 | 0.7509 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1683 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1683 | 0.1904 |
Onchocerca volvulus | 0.0031 | 0.3693 | 0.5 | |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.6638 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.6638 | 0.6554 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0052 | 0.884 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0043 | 0.6638 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1683 | 0.1904 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.3693 | 0.3537 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1683 | 0.1476 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.5653 | 0.5932 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1683 | 0.1904 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.3693 | 0.3628 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0039 | 0.555 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.6638 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0052 | 0.884 | 0.8811 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.3208 | 0.5 |
Echinococcus granulosus | lamin | 0.0031 | 0.3693 | 0.3628 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.3208 | 0.3629 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.6638 | 0.7091 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.3208 | 0.2131 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0608 | 0.0375 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1683 | 0.1264 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.6638 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.3693 | 0.3628 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.3693 | 0.3537 |
Echinococcus multilocularis | dna polymerase eta | 0.0052 | 0.884 | 0.968 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.3693 | 0.3537 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.6638 | 0.6924 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1683 | 0.1904 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.1683 | 0.1264 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0037 | 0.5101 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3693 | 0.3537 |
Leishmania major | DNA polymerase eta, putative | 0.0037 | 0.5101 | 0.4775 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.6638 | 0.7091 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.9112 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.6638 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1683 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.9112 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1683 | 0.1904 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.6638 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.884 | 0.8811 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3208 | 0.3039 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1683 | 0.1904 |
Schistosoma mansoni | DNA polymerase eta | 0.0052 | 0.884 | 0.968 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0608 | 0.0375 |
Echinococcus multilocularis | musashi | 0.0031 | 0.3693 | 0.3628 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.3693 | 0.3628 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0037 | 0.5101 | 0.5518 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.5653 | 0.5545 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.3693 | 0.3628 |
Onchocerca volvulus | 0.0031 | 0.3693 | 0.5 | |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0039 | 0.555 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1683 | 0.1264 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.9112 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.3208 | 0.3039 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.