Detailed information for compound 1159604

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 568.577 | Formula: C31H28N4O7
  • H donors: 0 H acceptors: 5 LogP: 3.12 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)c1c(c2cc(OC)c(c(c2)OC)OC)c2ccc(nc2c(=O)n1Cc1cccnc1)OCc1ccccn1
  • InChi: 1S/C31H28N4O7/c1-38-23-14-20(15-24(39-2)29(23)40-3)26-22-10-11-25(42-18-21-9-5-6-13-33-21)34-27(22)30(36)35(28(26)31(37)41-4)17-19-8-7-12-32-16-19/h5-16H,17-18H2,1-4H3
  • InChiKey: GMAUXDNVKGDACQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0218 0.1743 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0241 0.1102
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0146 0.0889
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0294 0.1104
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0033 0.0142 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0142 0.0611
Toxoplasma gondii hypothetical protein 0.0026 0.0088 0.0361
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0303 0.0921
Schistosoma mansoni hypothetical protein 0.0199 0.1578 0.4798
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0522 0.3441
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0089 0.0488
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0303 0.0921
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0146 0.0889
Plasmodium falciparum thioredoxin reductase 0.0095 0.0686 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0184 0.1447 1
Mycobacterium tuberculosis Probable lipase LipD 0.0184 0.1447 0.1399
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0019 0.0058
Echinococcus multilocularis lamin dm0 0.0029 0.0112 0.0341
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0417 0.2595
Mycobacterium tuberculosis Probable oxidoreductase 0.0242 0.1953 0.1908
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0198 0.0603
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0341
Mycobacterium tuberculosis Probable reductase 0.0218 0.1743 0.1697
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0417 0.0363
Brugia malayi Thioredoxin reductase 0.0095 0.0686 0.2084
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0522 0.3354
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0056 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0134 0.0406
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0033 0.0142 0.0738
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0146 0.065
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0146 0.065
Echinococcus multilocularis musashi 0.0029 0.0112 0.0341
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0417 0.1267
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0417 0.1267
Echinococcus granulosus intermediate filament protein 0.0029 0.0112 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0221 0.1001
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.0686 0.2084
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0084 0.0453
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0146 0.0444
Schistosoma mansoni smad 0.0025 0.0073 0.0221
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0242 0.1953 0.1908
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0058
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0522 0.3354
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0146 0.063
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3289 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0198 0.0603
Loa Loa (eye worm) Smad1 0.0025 0.0073 0.0221
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0146 0.0456
Brugia malayi TAR-binding protein 0.0397 0.3289 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0218 0.1743 0.1697
Entamoeba histolytica hypothetical protein 0.0039 0.0198 0.4734
Loa Loa (eye worm) hypothetical protein 0.0184 0.1447 0.44
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0053 0.032 0.1897
Leishmania major phosphatidylinositol 3-kinase, putative 0.0033 0.0142 0.0738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0319 0.1491
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.1768 0.5376
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0198 0.0603
Plasmodium vivax hypothetical protein, conserved 0.0184 0.1447 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0214 0.097
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0062 0.0398 0.121
Loa Loa (eye worm) hypothetical protein 0.0184 0.1447 0.44
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0397 0.3289 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0033 0.0143 0.0629
Loa Loa (eye worm) hypothetical protein 0.0026 0.0089 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0221 0.1001
Brugia malayi MH2 domain containing protein 0.0361 0.2985 0.9077
Brugia malayi MH1 domain containing protein 0.0025 0.0073 0.0221
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0124 0.0376
Echinococcus granulosus Smad4 0.0025 0.0073 0.0221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.1103 0.3352
Toxoplasma gondii thioredoxin reductase 0.0095 0.0686 0.4598
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0978 0.2975
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0142 0.0611
Trypanosoma cruzi target of rapamycin kinase 3 0.0053 0.032 0.2104
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0062 0.0398 0.2654
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0056 0.0169
Brugia malayi Pre-SET motif family protein 0.0032 0.0134 0.0406
Schistosoma mansoni smad1 5 8 and 0.0025 0.0073 0.0221
Mycobacterium ulcerans lipase LipD 0.0184 0.1447 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0146 0.065
Loa Loa (eye worm) glutathione reductase 0.0095 0.0686 0.2084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0146 0.0889
Schistosoma mansoni hypothetical protein 0.0199 0.1578 0.4798
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0522 0.1588
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.1447 0.7094
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0522 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0522 0.7288
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0218 0.1743 0.8873
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0112 0.0341
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0056 0.0963
Loa Loa (eye worm) beta-lactamase 0.0184 0.1447 0.44
Treponema pallidum NADH oxidase 0.0033 0.0146 0.1333
Loa Loa (eye worm) hypothetical protein 0.0184 0.1447 0.44
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0184 0.1447 0.1399
Loa Loa (eye worm) hypothetical protein 0.0032 0.0134 0.0406
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0522 0.2328
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0294 0.024
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0294 0.0894
Schistosoma mansoni lamin 0.0029 0.0112 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0319 0.1491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0221 0.1003
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3289 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0299 0.1393
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0417 0.2691
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0073 0.0221
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.0019 0.0058
Loa Loa (eye worm) hypothetical protein 0.0051 0.0303 0.0921
Mycobacterium tuberculosis Probable lipase LipE 0.0184 0.1447 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0299 0.1393
Schistosoma mansoni thyroid hormone receptor 0.014 0.1068 0.3248
Onchocerca volvulus 0.0184 0.1447 0.6954
Brugia malayi beta-lactamase 0.0184 0.1447 0.44
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0142 0.0611
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0978 0.2975
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.1103 0.3352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0142 0.0611
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0084 0.033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.1103 0.3352
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0033 0.0143 0.0435
Loa Loa (eye worm) RNA binding protein 0.0397 0.3289 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0033 0.0143 0.0435
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0073 0.0221
Brugia malayi beta-lactamase family protein 0.0184 0.1447 0.44
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0134 0.0406
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0218 0.1743 0.1697
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0522 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0073 0.0221
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0056 0.0169
Plasmodium falciparum thioredoxin reductase 0.0033 0.0146 0.1033
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0184 0.1447 0.44
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0062 0.0398 0.121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0299 0.1393
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0303 0.0921
Mycobacterium tuberculosis Conserved protein 0.0184 0.1447 0.1399
Echinococcus multilocularis smad 0.0025 0.0073 0.0221
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0146 0.0444
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0053 0.032 0.1997
Onchocerca volvulus 0.0032 0.0134 0.0112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0146 0.0889
Echinococcus multilocularis geminin 0.0199 0.1578 0.4798
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.1068 0.3248
Echinococcus granulosus lamin dm0 0.0029 0.0112 0.0341
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.0019 0.0058
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0062 0.0398 0.2654
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0184 0.1447 0.44
Echinococcus multilocularis serine protein kinase ATM 0.0033 0.0143 0.0435
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0033 0.0142 0.0862
Schistosoma mansoni hypothetical protein 0.0039 0.0198 0.0603
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.1103 0.3352
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.0686 0.4414
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0073 0.0221
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0062 0.0398 0.2461
Brugia malayi RNA binding protein 0.0397 0.3289 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0242 0.1953 1
Onchocerca volvulus 0.0184 0.1447 0.6954
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0146 0.0889
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.003 0.0116 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0319 0.1491
Giardia lamblia GTOR 0.0062 0.0398 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.1447 0.44
Loa Loa (eye worm) hypothetical protein 0.0035 0.0163 0.0494
Schistosoma mansoni Smad4 0.0025 0.0073 0.0221
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0417 0.1267
Loa Loa (eye worm) MH2 domain-containing protein 0.0361 0.2985 0.9077
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0691 0.21
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0294 0.024
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0146 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0398 0.1883
Brugia malayi hypothetical protein 0.0017 0.0004 0.0013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0134 0.0406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.1103 0.3352
Toxoplasma gondii target of rapamycin (TOR), putative 0.0051 0.0299 0.1859
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0146 0.0889
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0256
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0134 0.0406
Mycobacterium tuberculosis Probable dehydrogenase 0.0218 0.1743 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0299 0.1393
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0256
Schistosoma mansoni hypothetical protein 0.0035 0.0163 0.0494
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0522 0.1588
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.1447 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0056 0.0169
Echinococcus granulosus serine protein kinase ATM 0.0033 0.0143 0.0435
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0056 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0142 0.0611
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.1447 0.44
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0062 0.0398 0.2461
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0146 0.0771
Schistosoma mansoni smad1 5 8 and 0.0025 0.0073 0.0221
Loa Loa (eye worm) hypothetical protein 0.0184 0.1447 0.44
Echinococcus multilocularis tar DNA binding protein 0.0397 0.3289 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.1447 0.44
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0241 0.1102
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0146 0.0765
Trypanosoma brucei hypothetical protein, conserved 0.0184 0.1447 1
Echinococcus granulosus lamin 0.0029 0.0112 0.0341
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0146 0.0091
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0691 0.21
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.1103 0.3352
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0255
Leishmania major hypothetical protein, conserved 0.0184 0.1447 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0071 0.0114
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0056 0.0169
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.007 0.0213
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0112 0.0341
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0062 0.0398 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0522 1
Entamoeba histolytica hypothetical protein 0.0039 0.0198 0.4734
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0146 0.0444
Loa Loa (eye worm) hypothetical protein 0.0023 0.0056 0.0169
Brugia malayi MH2 domain containing protein 0.0025 0.0073 0.0221
Mycobacterium tuberculosis Conserved protein 0.0184 0.1447 0.1399
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0163 0.0494
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0417 0.2686
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0146 0.0456
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0417 0.2595
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.1447 0.7094
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0294 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0319 0.1491
Echinococcus multilocularis Smad4 0.0025 0.0073 0.0221
Toxoplasma gondii FATC domain-containing protein 0.0033 0.0143 0.0751
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0033 0.0143 0.0869
Echinococcus granulosus smad 0.0025 0.0073 0.0221
Plasmodium falciparum glutathione reductase 0.0095 0.0686 1
Brugia malayi MH2 domain containing protein 0.0025 0.0073 0.0221
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0522 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0146 0.0771
Toxoplasma gondii ABC1 family protein 0.0184 0.1447 1
Mycobacterium leprae conserved hypothetical protein 0.0184 0.1447 0.7285
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0056 0.0256
Echinococcus granulosus dna polymerase eta 0.0023 0.0056 0.0169
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0146 0.065
Brugia malayi hypothetical protein 0.0026 0.0084 0.0255
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0522 0.1588
Leishmania major DNA polymerase eta, putative 0.0023 0.0056 0.0123
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0073 0.0221
Leishmania major trypanothione reductase 0.0095 0.0686 0.4595
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0146 0.1033
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0218 0.1743 0.1697
Entamoeba histolytica hypothetical protein 0.0039 0.0198 0.4734
Trichomonas vaginalis esterase, putative 0.0184 0.1447 0.7094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0033 0.0142 0.0432
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.1103 0.3352
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0146 0.1033
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0056 0.0123
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0088 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0256
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0398 0.121
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0033 0.0142 0.0432
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0033 0.0142 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0299 0.1393
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0146 0.2641
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0056 0.0169
Echinococcus granulosus geminin 0.0199 0.1578 0.4798
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0221 0.1003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0221 0.1001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0056 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.0616
Schistosoma mansoni DNA polymerase eta 0.0023 0.0056 0.0169
Leishmania major hypothetical protein, conserved 0.0026 0.0084 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0176 0.0781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0196 0.088
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.1447 0.7094
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3289 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0319 0.1491
Onchocerca volvulus 0.0251 0.2032 1
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3289 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0522 0.3441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0398 0.1883
Echinococcus multilocularis beta LACTamase domain containing family member 0.0184 0.1447 0.44
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0146 0.0889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0299 0.1393
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0134 0.0683
Loa Loa (eye worm) transcription factor SMAD2 0.0361 0.2985 0.9077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0134 0.0406
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.1447 0.7094
Mycobacterium tuberculosis Conserved protein 0.0184 0.1447 0.1399
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0146 0.0765
Brugia malayi intermediate filament protein 0.0029 0.0112 0.0341
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0398 0.121
Mycobacterium ulcerans beta-lactamase 0.0184 0.1447 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0256
Trypanosoma brucei trypanothione reductase 0.0095 0.0686 0.4527
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0146 0.065
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0146 0.065
Echinococcus multilocularis dna polymerase eta 0.0023 0.0056 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0184 0.1447 0.1399
Loa Loa (eye worm) phosphatidylinositol 3 0.0033 0.0142 0.0432
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.1447 1
Onchocerca volvulus 0.0184 0.1447 0.6954
Schistosoma mansoni hypothetical protein 0.0129 0.0978 0.2975
Brugia malayi beta-lactamase family protein 0.0184 0.1447 0.44
Brugia malayi RNA recognition motif domain containing protein 0.0397 0.3289 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0134 0.0406
Entamoeba histolytica hypothetical protein 0.0033 0.0143 0.3273
Schistosoma mansoni smad1 5 8 and 0.0025 0.0073 0.0221
Brugia malayi hypothetical protein 0.0039 0.0198 0.0603
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0073 0.0221
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0062 0.0398 0.121
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0062 0.0398 0.2554
Leishmania major DNA polymerase kappa, putative 0.0023 0.0056 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3289 1
Schistosoma mansoni thyroid hormone receptor 0.014 0.1068 0.3248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0221 0.1003
Plasmodium vivax SET domain protein, putative 0.0032 0.0134 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0398 0.1883
Schistosoma mansoni intermediate filament proteins 0.0029 0.0112 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0275 0.1271
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0084 0.0203
Plasmodium vivax glutathione reductase, putative 0.0095 0.0686 0.4414
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0146 0.0889
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0073 0.0221
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0417 0.2595
Brugia malayi glutathione reductase 0.0095 0.0686 0.2084
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0146 0.0765
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0522 0.3217
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0056 0.0169
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.1103 0.3352
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0134 0.0406
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0146 0.063
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.0686 0.4667
Loa Loa (eye worm) hypothetical protein 0.0184 0.1447 0.44
Echinococcus multilocularis lamin 0.0029 0.0112 0.0341
Brugia malayi Probable ClpP-like protease 0.0077 0.0522 0.1588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0299 0.1393
Mycobacterium ulcerans hypothetical protein 0.0184 0.1447 1
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.1447 0.7094
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0019 0.0058
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0176 0.0781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.1103 0.3352
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0146 0.0889
Loa Loa (eye worm) TAR-binding protein 0.0397 0.3289 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0184 0.1447 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0176 0.0781
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0062 0.0398 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0221 0.1003
Mycobacterium tuberculosis Probable hydrolase 0.0184 0.1447 0.1399
Echinococcus granulosus beta LACTamase domain containing family member 0.0184 0.1447 0.44
Mycobacterium ulcerans esterase/lipase LipP 0.0184 0.1447 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0056 0.0181
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0084 0.0453
Trichomonas vaginalis set domain proteins, putative 0.0251 0.2032 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0038 0.0134
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0033 0.0142 0.0432
Brugia malayi Pre-SET motif family protein 0.0221 0.1768 0.5376
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0033 0.0142 0.0622
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0056 0.0169
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.007 0.0213
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0088 0.0071
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0146 0.0765
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0033 0.0142 0.0622
Brugia malayi Smad1 0.0025 0.0073 0.0221
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0062 0.0398 0.2554
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0146 0.0444
Plasmodium falciparum glutathione reductase 0.0033 0.0146 0.1033
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0417 0.1267
Echinococcus granulosus tar DNA binding protein 0.0397 0.3289 1
Entamoeba histolytica hypothetical protein 0.0039 0.0198 0.4734
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.0686 0.0633
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0112 0.0341
Loa Loa (eye worm) hypothetical protein 0.0077 0.0522 0.1588
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0242 0.1953 0.1908
Loa Loa (eye worm) hypothetical protein 0.0029 0.0107 0.0326
Schistosoma mansoni lamin 0.0029 0.0112 0.0341
Brugia malayi MH1 domain containing protein 0.0025 0.0073 0.0221
Mycobacterium tuberculosis Probable esterase LipL 0.0184 0.1447 0.1399
Mycobacterium leprae Probable lipase LipE 0.0184 0.1447 0.7285

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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