Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 3 (endothelial cell) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.3485 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0051 | 0.0366 | 0.1051 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.3485 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0091 | 0.3485 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0081 | 0.2686 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.3485 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0091 | 0.3485 | 0.342 |
Brugia malayi | FAD binding domain containing protein | 0.0056 | 0.0798 | 0.1055 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0091 | 0.3485 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0053 | 0.056 | 0.0473 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0062 | 0.1217 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0062 | 0.1217 | 0.2076 |
Trypanosoma cruzi | p450 reductase, putative | 0.0091 | 0.3485 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0056 | 0.0798 | 0.2291 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0091 | 0.3485 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0166 | 0.922 | 1 |
Onchocerca volvulus | 0.0053 | 0.056 | 0.0407 | |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0091 | 0.3485 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.3485 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.3485 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0081 | 0.2686 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.3485 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0091 | 0.3485 | 0.3237 |
Leishmania major | p450 reductase, putative | 0.0091 | 0.3485 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0091 | 0.3485 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0056 | 0.0798 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.056 | 0.1607 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0084 | 0.2905 | 0.8335 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0056 | 0.0798 | 0.0449 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0091 | 0.3485 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0113 | 0.5122 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0091 | 0.3485 | 0.761 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0091 | 0.3485 | 0.342 |
Brugia malayi | flavodoxin family protein | 0.0091 | 0.3485 | 0.761 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.3485 | 0.342 |
Echinococcus multilocularis | adam 17 protease | 0.0084 | 0.2905 | 0.2754 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.3485 | 0.342 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0166 | 0.922 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0056 | 0.0798 | 0.0337 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0062 | 0.1217 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0113 | 0.5122 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0104 | 0.4464 | 0.4254 |
Echinococcus granulosus | adam 17 protease | 0.0092 | 0.3547 | 0.3491 |
Brugia malayi | Matrixin family protein | 0.0104 | 0.4464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.3485 | 0.3237 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1217 | 0.0883 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0091 | 0.3485 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.0056 | 0.0798 | 0.0337 |
Loa Loa (eye worm) | matrixin family protein | 0.0113 | 0.5122 | 0.4936 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 160000 nM | Inhibition of [3H]-(-)-Nicotine binding to recombinant rat alpha4-beta2 nAChR. | ChEMBL. | 10377228 |
IC50 (binding) | = 160000 nM | Inhibition of [3H]-(-)-Nicotine binding to recombinant rat alpha4-beta2 nAChR. | ChEMBL. | 10377228 |
IC50 (binding) | = 2.9 uM | Inhibitory activity against human inducible nitric oxide synthase | ChEMBL. | 8576908 |
IC50 (binding) | = 2.9 uM | Inhibitory activity against human inducible nitric oxide synthase | ChEMBL. | 8576908 |
IC50 (binding) | = 3.2 uM | Inhibitory activity against human Neuronal nitric oxide synthase | ChEMBL. | 8576908 |
IC50 (binding) | = 3.2 uM | Inhibitory activity against human Neuronal nitric oxide synthase | ChEMBL. | 8576908 |
IC50 (binding) | = 7.1 uM | Inhibitory activity against human Endothelial nitric oxide synthase | ChEMBL. | 8576908 |
IC50 (binding) | = 7.1 uM | Inhibitory activity against human Endothelial nitric oxide synthase | ChEMBL. | 8576908 |
Selectivity (binding) | = 1.1 | Selectivity is defined as the ratio of the IC50(hncNOS) to IC50(hiNOS) | ChEMBL. | 8576908 |
Selectivity (binding) | = 2.4 | Selectivity is defined as the ratio of the IC50(hecNOS) to IC50(hiNOS) | ChEMBL. | 8576908 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.