Detailed information for compound 1159639

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.444 | Formula: C18H21N3OS
  • H donors: 0 H acceptors: 2 LogP: 1.83 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(CCC21CCCN(C2)Cc1cccnc1)c1cscc1
  • InChi: 1S/C18H21N3OS/c22-17-18(6-9-21(17)16-4-10-23-13-16)5-2-8-20(14-18)12-15-3-1-7-19-11-15/h1,3-4,7,10-11,13H,2,5-6,8-9,12,14H2
  • InChiKey: MGMOLEYSAQIFTR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0879 0.1652
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0159 0.0495
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.041 0.0466
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0192 0.0218
Giardia lamblia Cathepsin B precursor 0.0053 0.0994 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0548 0.0548
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0093 0.0201
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.064 0.0868
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0093
Brugia malayi hypothetical protein 0.002 0.0193 0.0416
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0879 0.0879
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0192 0.036
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.5695 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Mycobacterium tuberculosis Conserved protein 0.0039 0.064 0.0868
Trichomonas vaginalis esterase, putative 0.0039 0.064 0.1203
Plasmodium vivax unspecified product 0.0027 0.0356 0.4054
Loa Loa (eye worm) fibroinase 0.0048 0.0879 0.0879
Onchocerca volvulus 0.0048 0.0879 0.1652
Loa Loa (eye worm) hypothetical protein 0.0039 0.064 0.064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0192 0.0596
Brugia malayi cathepsin F-like cysteine proteinase 0.0015 0.0058 0.0125
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0159 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0356 0.067
Entamoeba histolytica cysteine proteinase 1, putative 0.0027 0.0356 0.4054
Loa Loa (eye worm) hypothetical protein 0.0039 0.064 0.064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0159 0.0495
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0144 0.3215 0.3657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Echinococcus granulosus GPCR family 2 0.0016 0.0093 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.041 0.041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0879 0.1652
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0048 0.0879 0.0879
Loa Loa (eye worm) hypothetical protein 0.0119 0.2594 0.2594
Loa Loa (eye worm) hypothetical protein 0.0025 0.0309 0.0309
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.064 0.199
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.064 0.1203
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0786 0.0894
Onchocerca volvulus Cathepsin L homolog 0.0048 0.0879 0.1652
Schistosoma mansoni ap endonuclease 0.002 0.0192 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.0651
Onchocerca volvulus 0.002 0.0193 0.0362
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.064 0.0868
Schistosoma mansoni sodium/chloride dependent transporter 0.002 0.0193 0.0219
Brugia malayi Cathepsin L-like precursor 0.0034 0.0522 0.1127
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0053 0.0994 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0356 0.1553
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.002 0.0193 0.1938
Brugia malayi Cathepsin L-like precursor 0.0048 0.0879 0.1895
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0879 0.2733
Brugia malayi Cathepsin L-like precursor 0.0015 0.0058 0.0125
Leishmania major cathepsin L-like protease 0.0048 0.0879 0.8616
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.041 0.0466
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.064 0.0868
Leishmania major cathepsin L-like protease 0.0048 0.0879 0.8616
Toxoplasma gondii exonuclease III APE 0.002 0.0192 0.1928
Treponema pallidum sodium- and chloride- dependent transporter 0.0119 0.2594 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0374 0.879 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0356 0.1108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0522 0.0982
Toxoplasma gondii hypothetical protein 0.002 0.0193 0.1938
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0522 0.5946
Echinococcus multilocularis cysteine protease 0.0048 0.0879 0.1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Plasmodium falciparum amino acid transporter, putative 0.002 0.0193 0.2193
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0093 0.0201
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0309 0.3108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Loa Loa (eye worm) hypothetical protein 0.0034 0.0522 0.0522
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0939 0.0939
Echinococcus multilocularis cathepsin b 0.0144 0.3215 0.3657
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.0651
Onchocerca volvulus 0.0231 0.5318 1
Schistosoma mansoni ap endonuclease 0.002 0.0192 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Schistosoma mansoni cathepsin F (C01 family) 0.0048 0.0879 0.1
Mycobacterium ulcerans hypothetical protein 0.0039 0.064 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0027 0.0356 0.4054
Brugia malayi Sodium:neurotransmitter symporter family protein 0.002 0.0193 0.0416
Loa Loa (eye worm) hypothetical protein 0.0039 0.064 0.064
Brugia malayi Pre-SET motif family protein 0.0203 0.4636 1
Onchocerca volvulus Cathepsin F homolog 0.0048 0.0879 0.1652
Plasmodium vivax SET domain protein, putative 0.0029 0.041 0.466
Echinococcus granulosus uncharacterized sodium dependent transporter 0.002 0.0193 0.0219
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0309 0.1337
Mycobacterium tuberculosis Conserved protein 0.0039 0.064 0.0868
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.041 0.4119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Brugia malayi Cathepsin L-like precursor 0.0048 0.0879 0.1895
Loa Loa (eye worm) hypothetical protein 0.002 0.0193 0.0193
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0015 0.0058 0.0125
Echinococcus granulosus cathepsin L cysteine proteinase 0.0048 0.0879 0.1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0192 0.0192
Leishmania major cathepsin L-like protease 0.0048 0.0879 0.8616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0879 0.1652
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0879 0.1652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0192 0.2182
Loa Loa (eye worm) hypothetical protein 0.002 0.0193 0.0193
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0159 0.0495
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0356 0.0768
Schistosoma mansoni hypothetical protein 0.0016 0.0093 0.0106
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0159 0.0651
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0879 0.1652
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Echinococcus granulosus uncharacterized sodium dependent transporter 0.002 0.0193 0.0219
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.002 0.0193 0.0219
Onchocerca volvulus 0.0048 0.0879 0.1652
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.0651
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.0651
Toxoplasma gondii hypothetical protein 0.002 0.0193 0.1938
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.0651
Brugia malayi cathepsin B-like cysteine proteinase 0.0144 0.3215 0.6934
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.0651
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0383 0.0436
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0879 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.0651
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947
Brugia malayi Cathepsin L-like precursor 0.0034 0.0522 0.1127
Plasmodium vivax vivapain-2 0.0048 0.0879 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Brugia malayi cathepsin L-like precursor 0.0034 0.0522 0.1127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.064 0.0728
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0144 0.3215 0.3657
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0192 0.2182
Loa Loa (eye worm) solute carrier family 6 member 4 0.0119 0.2594 0.2594
Loa Loa (eye worm) serotonin transporter b 0.0119 0.2594 0.2594
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0576 0.0656
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.064 0.1203
Onchocerca volvulus 0.002 0.0193 0.0362
Echinococcus granulosus cathepsin L 0.0027 0.0356 0.0405
Leishmania major hypothetical protein, conserved 0.0025 0.0309 0.1793
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0192 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 0.002 0.0193 0.0416
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.041 0.0466
Leishmania major cathepsin L-like protease 0.0048 0.0879 0.8616
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0058
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0192 0.2182
Onchocerca volvulus 0.0048 0.0879 0.1652
Loa Loa (eye worm) norepinephrine transporter 0.0119 0.2594 0.2594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0879 0.1652
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0356 0.4054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0786 0.0894
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.002 0.0193 0.0219
Plasmodium vivax amine transporter, putative 0.002 0.0193 0.2193
Leishmania major hypothetical protein, conserved 0.0039 0.064 0.5754
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.064 0.0868
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0192 0.0675
Plasmodium vivax vivapain-3 0.0027 0.0356 0.4054
Brugia malayi Cathepsin L-like precursor 0.0048 0.0879 0.1895
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.064 0.0868
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0053 0.0994 0.187
Loa Loa (eye worm) beta-lactamase 0.0039 0.064 0.064
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0192 0.0218
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0356 0.0405
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0093 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Echinococcus multilocularis cysteine protease 0.0048 0.0879 0.1
Brugia malayi beta-lactamase family protein 0.0039 0.064 0.138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.064 0.0728
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0093 0.0093
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Echinococcus multilocularis serotonin transporter 0.0119 0.2594 0.2951
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.064 0.1203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0786 0.0894
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0058 0.018
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0159 0.0181
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0519 0.0975
Echinococcus granulosus cathepsin l cysteine peptidase 0.0048 0.0879 0.1
Toxoplasma gondii cathepsin CPL 0.0048 0.0879 0.8838
Plasmodium vivax hypothetical protein, conserved 0.002 0.0193 0.2193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0356 0.067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0879 0.1652
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0879 0.2733
Echinococcus granulosus dna polymerase kappa 0.0019 0.0159 0.0181
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0159 0.0651
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.002 0.0193 0.0219
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.064 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0192 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.041 0.0466
Leishmania major cysteine peptidase A (CPA) 0.0048 0.0879 0.8616
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0939 0.2025
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0159 0.0181
Trypanosoma brucei cysteine peptidase C (CPC) 0.0053 0.0994 0.4476
Schistosoma mansoni sodium-dependent amino acid transporter 0.002 0.0193 0.0219
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0159 0.0495
Plasmodium vivax unspecified product 0.0015 0.0058 0.066
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.002 0.0193 0.0219
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0093 0.0106
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0144 0.3215 0.3657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0522 0.0982
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0048 0.0879 1
Toxoplasma gondii ABC1 family protein 0.0039 0.064 0.6434
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0657 0.0747
Echinococcus granulosus cysteine protease 0.0027 0.0356 0.0405
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0309 0.0961
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.064 0.0868
Echinococcus granulosus cathepsin b 0.0144 0.3215 0.3657
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0576 0.1243
Echinococcus granulosus sodium and chloride dependent glycine 0.002 0.0193 0.0219
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0548 0.1181
Loa Loa (eye worm) hypothetical protein 0.0423 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0058
Onchocerca volvulus 0.0034 0.0522 0.0982
Onchocerca volvulus 0.0119 0.2594 0.4877
Brugia malayi hypothetical protein 0.0025 0.0309 0.0666
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0522 0.0594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0356 0.1553
Brugia malayi Pre-SET motif family protein 0.0029 0.041 0.0883
Giardia lamblia DINP protein human, muc B family 0.0019 0.0159 0.1602
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0159 0.03
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947
Onchocerca volvulus 0.0048 0.0879 0.1652
Schistosoma mansoni cathepsin F (C01 family) 0.0048 0.0879 0.1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0159 0.0344
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0192 0.0388
Plasmodium vivax hypothetical protein, conserved 0.0039 0.064 0.7281
Onchocerca volvulus 0.0039 0.064 0.1203
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.064 0.199
Mycobacterium leprae Probable lipase LipE 0.0039 0.064 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0576 0.0656
Echinococcus multilocularis cathepsin L 0.0027 0.0356 0.0405
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0356 0.0768
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.064 0.138
Plasmodium vivax vivapain-1 0.0027 0.0356 0.4054
Echinococcus multilocularis sodium and chloride dependent glycine 0.002 0.0193 0.0219
Leishmania major cathepsin L-like protease 0.0048 0.0879 0.8616
Schistosoma mansoni hypothetical protein 0.0103 0.22 0.2503
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0159 0.0159
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0309 0.3516
Loa Loa (eye worm) hypothetical protein 0.0034 0.0522 0.0522
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0048 0.0879 0.1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0159 0.03
Echinococcus granulosus cathepsin l1 0.0048 0.0879 0.1
Brugia malayi beta-lactamase family protein 0.0039 0.064 0.138
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.002 0.0193 0.0219
Brugia malayi Cathepsin L-like precursor 0.0048 0.0879 0.1895
Loa Loa (eye worm) hypothetical protein 0.002 0.0193 0.0193
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.002 0.0193 0.0219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.041 0.0466
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.002 0.0193 0.0193
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.064 0.1203
Onchocerca volvulus 0.0029 0.041 0.077
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.0651
Schistosoma mansoni DNA polymerase eta 0.0019 0.0159 0.0181
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0058
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0048 0.0879 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0192 0.0799
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.002 0.0193 0.0219
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0119 0.2594 0.2951
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.002 0.0193 0.0416
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0159 0.0344
Echinococcus granulosus cathepsin L cysteine protease 0.0027 0.0356 0.0405
Trypanosoma cruzi cruzipain precursor, putative 0.0015 0.0058 0.018
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0879 0.2733
Brugia malayi beta-lactamase 0.0039 0.064 0.138
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0309 0.3516
Schistosoma mansoni hypothetical protein 0.0374 0.879 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.064 0.064
Schistosoma mansoni sodium/chloride dependent transporter 0.0119 0.2594 0.2951
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0356 0.0405
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.064 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0356 0.4054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.4636 0.4636
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0879 0.1652
Leishmania major cathepsin L-like protease 0.0048 0.0879 0.8616
Loa Loa (eye worm) hypothetical protein 0.0039 0.064 0.064
Echinococcus multilocularis dna polymerase eta 0.0019 0.0159 0.0181
Leishmania major cathepsin L-like protease 0.0048 0.0879 0.8616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0522 0.1127
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.064 0.1203
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.041 0.0466
Echinococcus multilocularis sodium and chloride dependent glycine 0.002 0.0193 0.0219
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0159 0.0495
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0519 0.0975
Giardia lamblia Cathepsin B precursor 0.0053 0.0994 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.064 0.0728
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0144 0.3215 1
Schistosoma mansoni hypothetical protein 0.0016 0.0093 0.0106
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Trypanosoma cruzi cysteine protease, putative 0.0027 0.0356 0.1108
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.0651
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.064 0.064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0786 0.0894
Onchocerca volvulus 0.0039 0.064 0.1203
Loa Loa (eye worm) hypothetical protein 0.0039 0.064 0.064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947
Onchocerca volvulus 0.0048 0.0879 0.1652
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0048 0.0879 0.1
Loa Loa (eye worm) hypothetical protein 0.002 0.0193 0.0193
Mycobacterium tuberculosis Conserved protein 0.0039 0.064 0.0868
Plasmodium falciparum cysteine proteinase falcipain 3 0.0048 0.0879 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.002 0.0193 0.0219
Trichomonas vaginalis set domain proteins, putative 0.0231 0.5318 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0309 0.0961
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0786 0.0786
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0159 0.1813
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.064 0.2852
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0093 0.0106
Loa Loa (eye worm) hypothetical protein 0.0019 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0016 0.0093 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947
Loa Loa (eye worm) cathepsin B 0.0053 0.0994 0.0994
Onchocerca volvulus 0.002 0.0193 0.0362
Toxoplasma gondii cathepsin B 0.0053 0.0994 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0048 0.0879 0.1652
Loa Loa (eye worm) hypothetical protein 0.0144 0.3215 0.3215
Echinococcus multilocularis GPCR, family 2 0.0016 0.0093 0.0106
Loa Loa (eye worm) hypothetical protein 0.0034 0.0522 0.0522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947
Entamoeba histolytica cysteine protease, putative 0.0048 0.0879 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0356 0.0405
Loa Loa (eye worm) hypothetical protein 0.0051 0.0939 0.0939
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0356 0.1108
Plasmodium vivax vivapain-2 0.0048 0.0879 1
Echinococcus multilocularis geminin 0.0374 0.879 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0053 0.0994 0.3093
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0159 0.0651
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0356 0.4054
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0657 0.0747
Echinococcus granulosus sodium and chloride dependent glycine 0.002 0.0193 0.0219
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.002 0.0193 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Echinococcus granulosus geminin 0.0374 0.879 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0879 0.1652
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0879 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Loa Loa (eye worm) cysteine protease 0.0048 0.0879 0.0879
Trypanosoma cruzi cruzipain precursor, putative 0.0048 0.0879 0.2733
Loa Loa (eye worm) hypothetical protein 0.0031 0.0461 0.0461
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0939 0.2025
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.002 0.0193 0.1938
Echinococcus multilocularis cathepsin L cysteine protease 0.0048 0.0879 0.1
Onchocerca volvulus 0.0048 0.0879 0.1652
Trypanosoma brucei RNA helicase, putative 0.0103 0.22 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0786 0.1696
Mycobacterium leprae conserved hypothetical protein 0.0039 0.064 0.5
Entamoeba histolytica cysteine protease, putative 0.0027 0.0356 0.4054
Schistosoma mansoni cathepsin s 0.0015 0.0058 0.0066
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.002 0.0193 0.0219
Leishmania major cathepsin L-like protease 0.0048 0.0879 0.8616
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0786 0.0894
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.064 0.0868
Brugia malayi Cathepsin L-like precursor 0.0048 0.0879 0.1895
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.041 0.0466
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.002 0.0193 0.0219
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0159 0.0651
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0879 0.1895
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0192 0.036
Schistosoma mansoni hypothetical protein 0.0035 0.0548 0.0623
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0192 0.0413
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0144 0.3215 0.3657
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.002 0.0193 0.0219
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0093 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0034 0.0522 0.1625
Plasmodium falciparum transporter, putative 0.002 0.0193 0.2193
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.002 0.0193 0.0219
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0119 0.2594 0.5595
Giardia lamblia Cathepsin B precursor 0.0053 0.0994 1
Brugia malayi hypothetical protein 0.0016 0.0094 0.0202
Brugia malayi Cathepsin L-like precursor 0.0048 0.0879 0.1895
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0994 0.1131
Onchocerca volvulus 0.0039 0.064 0.1203
Loa Loa (eye worm) hypothetical protein 0.002 0.0193 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0048 0.0879 0.1652
Loa Loa (eye worm) ctsf protein 0.0048 0.0879 0.0879
Entamoeba histolytica cysteine proteinase 2 0.0027 0.0356 0.4054
Trypanosoma brucei unspecified product 0.0019 0.0159 0.0651
Mycobacterium ulcerans beta-lactamase 0.0039 0.064 1
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0879 0.2733
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0192 0.1928
Loa Loa (eye worm) hypothetical protein 0.002 0.0193 0.0193
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0027 0.0356 0.1108
Brugia malayi Sodium:neurotransmitter symporter family protein 0.002 0.0193 0.0416
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.002 0.0193 0.1938
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0058 0.0058
Mycobacterium ulcerans lipase LipD 0.0039 0.064 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0309 0.3516
Onchocerca volvulus 0.0048 0.0879 0.1652
Echinococcus granulosus cathepsin l1 0.0034 0.0522 0.0594
Schistosoma mansoni sodium/chloride dependent transporter 0.002 0.0193 0.0219
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0786 0.0894
Echinococcus multilocularis cathepsin L cysteine protease 0.0048 0.0879 0.1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0159 0.0651
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.002 0.0193 0.0193
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0356 0.4054
Echinococcus granulosus cathepsin b 0.0144 0.3215 0.3657
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0159 0.0181
Echinococcus granulosus dna polymerase eta 0.0019 0.0159 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0879 0.1652
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0786 0.0894
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.002 0.0193 0.5
Loa Loa (eye worm) hypothetical protein 0.0119 0.2594 0.2594
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0159 0.0181
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0356 0.1108
Onchocerca volvulus Cathepsin L homolog 0.0048 0.0879 0.1652
Schistosoma mansoni hypothetical protein 0.0016 0.0093 0.0106
Echinococcus granulosus serotonin transporter 0.0119 0.2594 0.2951
Echinococcus multilocularis cathepsin b 0.0144 0.3215 0.3657
Loa Loa (eye worm) hypothetical protein 0.0119 0.2594 0.2594
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0048 0.0879 0.0879
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0192 0.0596
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.064 0.0728
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0879 0.3947

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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