Detailed information for compound 115971

Basic information

Technical information
  • TDR Targets ID: 115971
  • Name: (Z)-N,N-dimethyl-2-phenylethenesulfonamide
  • MW: 211.281 | Formula: C10H13NO2S
  • H donors: 0 H acceptors: 2 LogP: 1.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(S(=O)(=O)/C=C\c1ccccc1)C
  • InChi: 1S/C10H13NO2S/c1-11(2)14(12,13)9-8-10-6-4-3-5-7-10/h3-9H,1-2H3/b9-8-
  • InChiKey: NFNZBXXSRCGCIR-HJWRWDBZSA-N  

Network

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Synonyms

  • (Z)-N,N-dimethyl-2-phenyl-ethenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni notch 0.0017 0.0034 0.0177
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0099 0.0107
Brugia malayi EGF-like domain containing protein 0.0017 0.0034 0.0091
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.0605
Brugia malayi nuclear receptor RXR 0.0016 0.0027 0.006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Echinococcus multilocularis protein jagged 2 0.0017 0.0034 0.0077
Loa Loa (eye worm) pax transcription factor protein 2 0.0256 0.1963 0.8244
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1344
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0144 0.0556
Brugia malayi EGF-like domain containing protein 0.0017 0.0034 0.0091
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0144 0.1084
Toxoplasma gondii hypothetical protein 0.0049 0.0295 0.1046
Loa Loa (eye worm) blistered cuticle protein 3 0.0053 0.0325 0.1366
Brugia malayi hypothetical protein 0.0308 0.2381 1
Mycobacterium ulcerans polyketide synthase Pks13 0.0039 0.021 0.0188
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0031 0.0065
Echinococcus granulosus notch 0.0017 0.0034 0.0077
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0353 0.2744 0.2727
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0898 0.7151 1
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0055 0.017
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0105 0.044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Schistosoma mansoni hypothetical protein 0.0017 0.0031 0.0148
Echinococcus multilocularis slit 2 protein 0.0017 0.0034 0.0077
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0256 0.0873
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0031 0.0077
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0034 0.0077
Brugia malayi nuclear receptor NHR-88 0.0031 0.0144 0.0556
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0325 0.132
Onchocerca volvulus 0.0256 0.1963 0.8235
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0013 0.0053
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0031 0.0076
Onchocerca volvulus 0.0017 0.0034 0.0091
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0144 0.0556
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0256 0.2003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1067 0.4427
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0144 0.0473
Schistosoma mansoni notch 0.0017 0.0034 0.0177
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0099 0.0107
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0113 0.0126
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0031 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0144 0.0605
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0256 0.0873
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0325 0.132
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0031 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Onchocerca volvulus 0.0017 0.0034 0.0091
Mycobacterium ulcerans thioesterase 0.0023 0.0082 0.006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0323 0.1358
Brugia malayi Pax transcription factor protein 2 0.0256 0.1963 0.8235
Loa Loa (eye worm) DR-78 0.0015 0.0013 0.0053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0027 0.0116
Brugia malayi notch-like transmembrane receptor 0.0017 0.0034 0.0091
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0144 0.0473
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0144 0.0556
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0144 0.0605
Loa Loa (eye worm) hypothetical protein 0.0044 0.0251 0.1056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.0113 0.0126
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0105 0.039
Onchocerca volvulus 0.0308 0.2381 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0353 0.2744 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0112
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0256 0.0873
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2292 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0144 0.0605
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0144 0.0473
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0243 0.0908
Onchocerca volvulus Chorion peroxidase homolog 0.0053 0.0325 0.132
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0031 0.0081
Schistosoma mansoni notch 0.0017 0.0034 0.0177
Brugia malayi Muscle positioning protein 4 0.0017 0.0034 0.0091
Schistosoma mansoni peroxidasin 0.0053 0.0325 0.2574
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0144 0.0556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0256 0.2003
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0055 0.0045
Echinococcus granulosus GPCR family 2 0.0017 0.0031 0.0065
Mycobacterium ulcerans polyketide synthase 0.0027 0.0113 0.009
Schistosoma mansoni hypothetical protein 0.0165 0.1227 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0144 0.0605
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0113 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Echinococcus multilocularis protein jagged 1 0.0017 0.0034 0.0077
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0117 0.049
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0034 0.0077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.0605
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0039 0.021 0.0263
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0027 0.0051
Onchocerca volvulus 0.0048 0.0286 0.1154
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1067 0.4427
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0034 0.0093
Onchocerca volvulus 0.0017 0.0034 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0144 0.0556
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0177
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0113 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0144 0.0605
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0144 0.0473
Onchocerca volvulus 0.0053 0.0325 0.132
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0144 0.0556
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0031 0.0129
Echinococcus multilocularis GPCR, family 2 0.0017 0.0031 0.0065
Brugia malayi hypothetical protein 0.0053 0.0325 0.132
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0034 0.0091
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0013 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2292 0.5
Brugia malayi steroid hormone receptor 0.0031 0.0144 0.0556
Brugia malayi nuclear hormone receptor 0.0031 0.0144 0.0556
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.2292 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0144 0.0556
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0056 0.0047
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.2372 1
Onchocerca volvulus Fatty acid synthase homolog 0.005 0.03 0.1213
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0031 0.0128
Onchocerca volvulus 0.0053 0.0325 0.132
Onchocerca volvulus 0.0026 0.0105 0.039
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.032 0.2531
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0034 0.0091
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0034 0.0077
Brugia malayi EGF-like domain containing protein 0.0017 0.0034 0.0091
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0144 0.1084
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0325 0.132
Schistosoma mansoni hypothetical protein 0.0017 0.0031 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0144 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0256 0.2003
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.2372 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0105 0.0115
Schistosoma mansoni peroxidasin 0.0053 0.0325 0.2574
Echinococcus multilocularis neural cadherin 0.0017 0.0034 0.0077
Onchocerca volvulus 0.0017 0.0034 0.0091
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0144 0.0605
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0034 0.0177
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0113 0.0126
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.0128
Brugia malayi Cadherin domain containing protein 0.0017 0.0034 0.0091
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0144 0.0473
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.0605
Brugia malayi hypothetical protein 0.0016 0.0027 0.006
Onchocerca volvulus Dual oxidase homolog 0.0053 0.0325 0.132
Schistosoma mansoni slit 0.0017 0.0034 0.0177
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0325 0.132
Echinococcus granulosus tumor protein p63 0.0359 0.2798 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0144 0.0556
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2292 0.5
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0188 0.0789
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0034 0.0077
Mycobacterium leprae Polyketide synthase Pks13 0.0039 0.021 0.0263
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0144 0.1084
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0113 0.009
Echinococcus granulosus delta-like protein 1 0.0017 0.0034 0.0077
Brugia malayi ecdysteroid receptor 0.0031 0.0144 0.0556
Onchocerca volvulus Putative cubilin 0.0017 0.0034 0.0091
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0113 0.0126
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0325 0.1366
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0013 0.0053
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1251 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0031 0.0065
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0034 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2292 0.5
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0144 0.1084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0027 0.006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0144 0.0473
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0144 0.1084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0144 0.0605
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0144 0.0473
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0243 0.0908
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0082 0.0083
Loa Loa (eye worm) hypothetical protein 0.0308 0.2381 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0099 0.0364
Brugia malayi Blistered cuticle protein 3 0.0053 0.0325 0.132
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1066 0.1464
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0323 0.1312
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0113 0.0381
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0144 0.0473
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1066 0.1046
Echinococcus granulosus protein jagged 1 0.0017 0.0034 0.0077
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0144 0.0473
Echinococcus granulosus geminin 0.0165 0.1227 0.4359
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0325 0.132
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0113 0.009
Onchocerca volvulus 0.0017 0.0034 0.0091
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0031 0.5
Echinococcus granulosus neural cadherin 0.0017 0.0034 0.0077
Onchocerca volvulus 0.0053 0.0325 0.132
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2372 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0898 0.7151 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2292 0.5
Schistosoma mansoni hypothetical protein 0.0017 0.0031 0.0148
Schistosoma mansoni notch 0.0017 0.0034 0.0177
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0144 0.1084
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0243 0.0908
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0144 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0144 0.0556
Echinococcus multilocularis tumor protein p63 0.0359 0.2798 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0144 0.0473
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0144 0.1084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0034 0.0077
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0031 0.0065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0031 0.0065
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0034 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0027 0.006
Echinococcus granulosus protein jagged 2 0.0017 0.0034 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0144 0.0556
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0099 0.0107
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0325 0.1366
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0144 0.0473
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.2292 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Schistosoma mansoni septate junction protein 0.0017 0.0034 0.0177
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0112
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0113 0.0126
Echinococcus multilocularis fibropellin Ia 0.0017 0.0034 0.0077
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0177
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0034 0.0091
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0041 0.0118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0256 0.1074
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0082 0.0083
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0177
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0144 0.0556
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.0605
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0055 0.0032
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0099 0.0107
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0034 0.0091
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0188 0.074
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0034 0.0091
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0325 0.1366
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0034 0.0077
Echinococcus multilocularis protein jagged 1 0.0017 0.0034 0.0077
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0055 0.0032
Mycobacterium ulcerans hypothetical protein 0.0161 0.12 0.118
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0034 0.0177
Schistosoma mansoni cell polarity protein 0.0017 0.0034 0.0177
Schistosoma mansoni notch 0.0017 0.0034 0.0177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0256 0.0873
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1251 1 1
Onchocerca volvulus Peroxidase homolog 0.0053 0.0325 0.132
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0027 0.0116
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0034 0.0077
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1251 1 0.5
Echinococcus granulosus protein jagged 2 0.0017 0.0034 0.0077
Schistosoma mansoni hypothetical protein 0.0165 0.1227 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0034 0.0091
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0099 0.0076
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0144 0.1084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0144 0.0473
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2372 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0256 0.1027
Echinococcus granulosus protein jagged 1 0.0017 0.0034 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0144 0.0473
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.0605
Echinococcus granulosus peroxidasin 0.0053 0.0325 0.1122
Brugia malayi hypothetical protein 0.0016 0.0027 0.006
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0031 0.015
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.0605
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0325 0.132
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.032 0.1233
Brugia malayi EGF-like domain containing protein 0.0017 0.0034 0.0091
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.0113 0.0126
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0325 0.1366
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Echinococcus multilocularis peroxidasin 0.0053 0.0325 0.1122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0243 0.0908
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0144 0.0556
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1067 0.4427
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0323 0.1312
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Schistosoma mansoni coup transcription factor 0.0031 0.0144 0.1084
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0177
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0144 0.1084
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0099 0.0076
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0058 0.0049
Brugia malayi Peroxidasin 0.0053 0.0325 0.132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.12 0.1651
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0144 0.0473
Mycobacterium ulcerans polyketide synthase 0.0025 0.0099 0.0076
Loa Loa (eye worm) Notch2 0.0017 0.0034 0.0143
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0144 0.0556
Onchocerca volvulus Slit protein homolog 0.0017 0.0034 0.0091
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0099 0.0076
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0144 0.0473
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0144 0.0556
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0034 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0144 0.0556
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.0605
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0027 0.0112
Brugia malayi isocitrate dehydrogenase 0.0017 0.0031 0.0077
Echinococcus multilocularis geminin 0.0165 0.1227 0.4359
Echinococcus granulosus slit 2 protein 0.0017 0.0034 0.0077
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0082 0.006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Brugia malayi Delta serrate ligand family protein 0.0017 0.0034 0.0091
Onchocerca volvulus 0.0031 0.0144 0.0556
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0031 0.5
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.005 0.03 0.1213
Brugia malayi EGF-like domain containing protein 0.0017 0.0034 0.0091
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0144 0.1084
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Echinococcus granulosus fibropellin Ia 0.0017 0.0034 0.0077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0031 0.0065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2292 0.5
Onchocerca volvulus 0.0053 0.032 0.1298
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0112
Onchocerca volvulus Peroxidase homolog 0.0053 0.0325 0.132
Brugia malayi EGF-like domain containing protein 0.0017 0.0034 0.0091
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0144 0.0605
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0323 0.1358
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0099 0.0107
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0177
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0112
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0034 0.0077
Loa Loa (eye worm) hypothetical protein 0.0053 0.0325 0.1366
Brugia malayi EGF-like domain containing protein 0.0017 0.0034 0.0091
Loa Loa (eye worm) notch protein 0.0017 0.0034 0.0143
Echinococcus multilocularis notch 0.0017 0.0034 0.0077
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1066 0.1464
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0112
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.0605
Schistosoma mansoni notch 0.0017 0.0034 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0144 0.0556
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0144 0.0556
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0353 0.2744 0.3817
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0039 0.021 0.0263
Schistosoma mansoni hypothetical protein 0.0036 0.0188 0.1443
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0177
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2292 0.5
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0325 0.132
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0031 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0144 0.0556
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0144 0.0473
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.2292 1
Brugia malayi Cadherin domain containing protein 0.0017 0.0034 0.0091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2292 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0144 0.1084
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0177
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0144 0.0473
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0143
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0031 0.0081
Schistosoma mansoni hypothetical protein 0.0017 0.0031 0.0148
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0144 0.1084

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 500 uM Effective concentration of compound necessary to kill 50% of infective larvae of M. dessetae after 7 days was determined in vitro; Value ranges from 100-500 ChEMBL. 3681893
EC90 (functional) = 500 uM Effective concentration of compound necessary to kill 90% of infective larvae of M. dessetae after 7 days was determined in vitro; Value ranges from 100-500 ChEMBL. 3681893

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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