TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 335.418 | Formula: C21H22FN3
H donors: 0 H acceptors: 1 LogP: 3.9 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCc2c(C1)c(nn2C(c1ccccc1)C)c1ccc(cc1)F
InChi: 1S/C21H22FN3/c1-15(16-6-4-3-5-7-16)25-20-12-13-24(2)14-19(20)21(23-25)17-8-10-18(22)11-9-17/h3-11,15H,12-14H2,1-2H3
InChiKey: PTKRTEFVBRMDQU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	somatostatin receptor	0.0017	0.0421	0.0506
Brugia malayi	Serotonin receptor	0.0017	0.0421	0.0421
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.3444	0.4319
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0017	0.0421	0.0421
Echinococcus granulosus	allatostatin A receptor	0.0017	0.0421	0.0506
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0017	0.0421	0.0506
Echinococcus multilocularis	calpain A	0.0066	0.3444	0.4136
Schistosoma mansoni	histamine h1 receptor	0.0017	0.0421	0.0528
Echinococcus granulosus	sex peptide receptor	0.0017	0.0421	0.0506
Loa Loa (eye worm)	G-protein coupled receptor	0.0017	0.0421	0.0421
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0017	0.0421	0.0506
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0542	0.5
Echinococcus multilocularis	calpain	0.0019	0.0542	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0019	0.0542	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0017	0.0421	0.2004
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.3349	0.3349
Schistosoma mansoni	adenoreceptor	0.0017	0.0421	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Brugia malayi	hypothetical protein	0.0017	0.0421	0.0421
Brugia malayi	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0017	0.0421	0.0528
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0542	0.5
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0019	0.0542	0.5
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2101	0.2101
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0017	0.0421	0.0506
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.3026	0.5
Onchocerca volvulus		0.0017	0.0421	0.2004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0017	0.0421	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus granulosus	7tm_1 domain containing protein	0.0017	0.0421	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0542	0.5
Onchocerca volvulus		0.0017	0.0421	0.2004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0421	0.0528
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0017	0.0421	0.0528
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	neuropeptide F-like receptor	0.0017	0.0421	0.0528
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.3026	0.3795
Onchocerca volvulus		0.0017	0.0421	0.2004
Schistosoma mansoni	hypothetical protein	0.0017	0.0421	0.0528
Brugia malayi	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.3349	0.42
Echinococcus multilocularis	somatostatin receptor	0.0017	0.0421	0.0506
Schistosoma mansoni	biogenic amine (5HT) receptor	0.014	0.7974	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.5497	0.5497
Echinococcus multilocularis	muscleblind protein	0.0146	0.8326	1
Loa Loa (eye worm)	calpain family protein 1	0.0044	0.2101	0.2101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0421	0.0528
Brugia malayi	Dopamine receptor	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0017	0.0421	0.0506
Brugia malayi	calpain family protein 1	0.0063	0.3247	0.3247
Loa Loa (eye worm)	calpain 5	0.0019	0.0542	0.0542
Echinococcus multilocularis	g protein coupled receptor	0.0017	0.0421	0.0506
Brugia malayi	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.6871	0.6871
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0017	0.0421	0.0421
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.3349	0.42
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3247	0.3247
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0017	0.0421	0.0506
Schistosoma mansoni	amine GPCR	0.0017	0.0421	0.0528
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.1326	0.1593
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0017	0.0421	0.0528
Brugia malayi	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	amine GPCR	0.0017	0.0421	0.0528
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0017	0.0421	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	amine GPCR	0.0017	0.0421	0.0528
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0542	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.4957	0.6216
Echinococcus multilocularis	neuropeptide Y receptor	0.0017	0.0421	0.0506
Schistosoma mansoni	hypothetical protein	0.0068	0.3567	0.4473
Echinococcus multilocularis	orexin receptor type 2	0.0017	0.0421	0.0506
Echinococcus multilocularis	neuropeptide Y receptor	0.0017	0.0421	0.0506
Schistosoma mansoni	amine GPCR	0.0017	0.0421	0.0528
Schistosoma mansoni	biogenic amine receptor	0.0017	0.0421	0.0528
Schistosoma mansoni	hypothetical protein	0.0017	0.0421	0.0528
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Echinococcus granulosus	tm gpcr rhodopsin	0.0017	0.0421	0.0506
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0421	0.0528
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0421	0.0528
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.1326	0.1593
Brugia malayi	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	neuropeptide f receptor 76f	0.0017	0.0421	0.0528
Echinococcus granulosus	calpain A	0.0019	0.0542	0.0651
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0542	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0017	0.0421	0.0506
Echinococcus granulosus	orexin receptor type 2	0.0017	0.0421	0.0506
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0017	0.0421	0.2004
Echinococcus multilocularis	calpain 5	0.0019	0.0542	0.0651
Schistosoma mansoni	hypothetical protein	0.0017	0.0421	0.0528
Onchocerca volvulus		0.0017	0.0421	0.2004
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0542	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0017	0.0421	0.0506
Loa Loa (eye worm)	calpain family protein 1	0.0063	0.3247	0.3247
Brugia malayi	calpain family protein 1	0.0063	0.3247	0.3247
Brugia malayi	sulfakinin receptor protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.1326	0.1326
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0542	0.5
Brugia malayi	TAR-binding protein	0.0065	0.3349	0.3349
Echinococcus granulosus	biogenic amine 5HT receptor	0.014	0.7974	0.9577
Brugia malayi	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0421	0.0528
Echinococcus multilocularis	fmrfamide receptor	0.0017	0.0421	0.0506
Schistosoma mansoni	neuropeptide F-like receptor	0.0017	0.0421	0.0528
Echinococcus granulosus	serotonin receptor	0.0017	0.0421	0.0506
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0017	0.0421	0.0506
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.3026	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.3349	0.4023
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0017	0.0421	0.0506
Schistosoma mansoni	hypothetical protein	0.0032	0.1326	0.1663
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0542	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0017	0.0421	0.0506
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Brugia malayi	Melatonin receptor type 1A	0.0017	0.0421	0.0421
Echinococcus multilocularis	g-protein coupled receptor	0.0017	0.0421	0.0506
Echinococcus granulosus	hypothetical protein	0.0017	0.0421	0.0506
Echinococcus granulosus	neuropeptide receptor	0.0017	0.0421	0.0506
Onchocerca volvulus		0.0017	0.0421	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus granulosus	neuropeptides capa receptor	0.0017	0.0421	0.0506
Echinococcus granulosus	muscleblind protein	0.0146	0.8326	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0542	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0017	0.0421	0.0421
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Brugia malayi	G protein-coupled receptor F59B2.13	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0017	0.0421	0.0528
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.4957	0.5954
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0421	0.0528
Echinococcus granulosus	G protein coupled receptor 139	0.0017	0.0421	0.0506
Brugia malayi	Dopamine receptor protein 2	0.0017	0.0421	0.0421
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0017	0.0421	0.0421
Echinococcus granulosus	neuropeptide Y receptor	0.0017	0.0421	0.0506
Onchocerca volvulus		0.0044	0.2101	1
Echinococcus granulosus	calpain A	0.0066	0.3444	0.4136
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.014	0.7974	0.7974
Onchocerca volvulus		0.0017	0.0421	0.2004
Trypanosoma cruzi	kinesin, putative	0.0019	0.0542	0.5
Brugia malayi	AKH receptor	0.0017	0.0421	0.0421
Brugia malayi	calpain 7	0.0019	0.0542	0.0542
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.4957	0.6216
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Trypanosoma cruzi	kinesin, putative	0.0019	0.0542	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0017	0.0421	0.0506
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.971	0.5
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0063	0.3247	0.4072
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0017	0.0421	0.0506
Echinococcus granulosus	tm gpcr rhodopsin	0.0017	0.0421	0.0506
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.1326	0.1326
Schistosoma mansoni	opsin-like receptor	0.0017	0.0421	0.0528
Brugia malayi	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.6871	0.6871
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0017	0.0421	0.0506
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0017	0.0421	0.0528
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0017	0.0421	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Echinococcus granulosus	neuropeptide s receptor	0.0017	0.0421	0.0506
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.3026	0.5
Brugia malayi	RNA binding protein	0.0065	0.3349	0.3349
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0017	0.0421	0.0506
Brugia malayi	G-protein coupled receptor	0.0017	0.0421	0.0421
Onchocerca volvulus		0.0017	0.0421	0.2004
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0017	0.0421	0.0528
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0017	0.0421	0.0506
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.5497	0.5497
Brugia malayi	Dopamine receptor protein 1	0.0017	0.0421	0.0421
Loa Loa (eye worm)	TYRA-2 protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0068	0.3567	0.3567
Plasmodium vivax	calpain, putative	0.0019	0.0542	0.5
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0542	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0017	0.0421	0.0528
Echinococcus granulosus	neuropeptide Y receptor	0.0017	0.0421	0.0506
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.5497	0.5497
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0017	0.0421	0.0506
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0542	0.5
Onchocerca volvulus		0.0017	0.0421	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0174	1	1
Schistosoma mansoni	myosin xvIII	0.0017	0.0421	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0421	0.0528
Schistosoma mansoni	opsin-like receptor	0.0017	0.0421	0.0528
Brugia malayi	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Brugia malayi	putative neuropeptide receptor NPR1	0.0017	0.0421	0.0421
Echinococcus multilocularis	neuropeptides capa receptor	0.0017	0.0421	0.0506
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0542	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0017	0.0421	0.0506
Onchocerca volvulus		0.0017	0.0421	0.2004
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0066	0.3444	0.4136
Loa Loa (eye worm)	calpain	0.0019	0.0542	0.0542
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0017	0.0421	0.0506
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.4957	0.4957
Schistosoma mansoni	biogenic amine receptor	0.0017	0.0421	0.0528
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0017	0.0421	0.0506
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0017	0.0421	0.0528
Onchocerca volvulus		0.0017	0.0421	0.2004
Echinococcus granulosus	g protein coupled receptor	0.0017	0.0421	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0044	0.2101	0.2101
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.3026	0.3634
Echinococcus granulosus	g protein coupled receptor	0.0017	0.0421	0.0506
Brugia malayi	G protein-coupled receptor	0.0017	0.0421	0.0421
Onchocerca volvulus		0.0017	0.0421	0.2004
Brugia malayi	larval opioid receptor	0.0017	0.0421	0.0421
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Schistosoma mansoni	amine GPCR	0.0017	0.0421	0.0528
Trypanosoma brucei	antigen, putative	0.0019	0.0542	0.5
Entamoeba histolytica	protein kinase, putative	0.0019	0.0542	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Brugia malayi	neuropeptide F receptor	0.0017	0.0421	0.0421
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.4957	0.5954
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0017	0.0421	0.0506
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.1326	0.1593
Echinococcus granulosus	GPCR family 2	0.0032	0.1326	0.1593
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.3026	0.3795
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0017	0.0421	0.0421
Schistosoma mansoni	calpain (C02 family)	0.0019	0.0542	0.0679
Brugia malayi	neuropeptide F receptor	0.0017	0.0421	0.0421
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0017	0.0421	0.0528
Brugia malayi	putative neuropeptide receptor	0.0017	0.0421	0.0421
Echinococcus multilocularis	GPCR, family 2	0.0032	0.1326	0.1593
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0017	0.0421	0.0528
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0017	0.0421	0.0506
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0019	0.0542	0.0679
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0019	0.0542	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.3567	0.3567
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0066	0.3444	0.4136
Brugia malayi	Muscleblind-like protein	0.0146	0.8326	0.8326
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0017	0.0421	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus granulosus	fmrfamide receptor	0.0017	0.0421	0.0506
Echinococcus multilocularis	neuropeptide receptor	0.0017	0.0421	0.0506
Echinococcus multilocularis	neuropeptides capa receptor	0.0017	0.0421	0.0506
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.3026	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0542	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0017	0.0421	0.0506
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0017	0.0421	0.0421
Echinococcus multilocularis	neuropeptide receptor A26	0.0017	0.0421	0.0506
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0017	0.0421	0.0506
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0017	0.0421	0.0506
Loa Loa (eye worm)	neuropeptide F receptor	0.0017	0.0421	0.0421
Echinococcus granulosus	tar DNA binding protein	0.0065	0.3349	0.4023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.8326	1
Onchocerca volvulus		0.0017	0.0421	0.2004
Echinococcus multilocularis	calpain family protein 1, d	0.0044	0.2101	0.2523
Echinococcus granulosus	neuropeptides capa receptor	0.0017	0.0421	0.0506
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0017	0.0421	0.0506
Echinococcus granulosus	neuropeptide FF receptor 2	0.0017	0.0421	0.0506
Echinococcus multilocularis	serotonin receptor	0.014	0.7974	0.9577
Loa Loa (eye worm)	hypothetical protein	0.014	0.7974	0.7974
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.4957	0.4957
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0017	0.0421	0.0506
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.1326	0.1593
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus multilocularis	allatostatin A receptor	0.0017	0.0421	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.4957	0.5954
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0017	0.0421	0.0528
Loa Loa (eye worm)	neuropeptide F receptor	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0017	0.0421	0.0421
Echinococcus granulosus	biogenic amine 5HT receptor	0.0017	0.0421	0.0506
Echinococcus granulosus	calpain	0.0019	0.0542	0.0651
Echinococcus multilocularis	calpain 7 (C02 family)	0.0019	0.0542	0.0651
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0542	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0017	0.0421	0.0506
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.3026	0.3634
Echinococcus granulosus	neuropeptide receptor A26	0.0017	0.0421	0.0506
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0017	0.0421	0.0528
Brugia malayi	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus multilocularis	neuropeptide s receptor	0.0017	0.0421	0.0506
Schistosoma mansoni	hypothetical protein	0.0032	0.1326	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Onchocerca volvulus		0.0017	0.0421	0.2004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0421	0.0528
Echinococcus multilocularis	dro:myosuppressin receptor	0.0017	0.0421	0.0506
Echinococcus granulosus	calpain 7 C02 family	0.0019	0.0542	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1326	0.1326
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Onchocerca volvulus		0.0017	0.0421	0.2004
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.3444	0.4319
Brugia malayi	GnHR receptor homolog	0.0017	0.0421	0.0421
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0542	0.0679
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.3349	0.42
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0421	0.0528
Echinococcus granulosus	g protein coupled receptor	0.0017	0.0421	0.0506
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Brugia malayi	calpain 5	0.0019	0.0542	0.0542
Schistosoma mansoni	hypothetical protein	0.0017	0.0421	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0146	0.8326	0.8326
Onchocerca volvulus		0.0017	0.0421	0.2004
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.3026	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.3349	0.42
Echinococcus granulosus	7TM GPCR rhodopsin	0.0017	0.0421	0.0506
Schistosoma mansoni	biogenic amine receptor	0.0017	0.0421	0.0528
Schistosoma mansoni	calpain C (C02 family)	0.0019	0.0542	0.0679
Schistosoma mansoni	hypothetical protein	0.0032	0.1326	0.1663
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0421	0.0528
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0421	0.0528
Loa Loa (eye worm)	RNA binding protein	0.0065	0.3349	0.3349
Echinococcus granulosus	dro:myosuppressin receptor	0.0017	0.0421	0.0506
Brugia malayi	ORL1-like opioid receptor	0.0017	0.0421	0.0421
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.4957	0.5954
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0542	0.0679
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Loa Loa (eye worm)	melatonin receptor type 1A	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.3349	0.3349
Trypanosoma brucei	kinesin, putative	0.0019	0.0542	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0017	0.0421	0.0506
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0017	0.0421	0.0528
Schistosoma mansoni	opsin-like receptor	0.0017	0.0421	0.0528
Onchocerca volvulus		0.0017	0.0421	0.2004
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.3349	0.42
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0017	0.0421	0.0528
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.4957	0.6216
Brugia malayi	follicle stimulating hormone receptor	0.0017	0.0421	0.0421
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Echinococcus multilocularis	serotonin receptor	0.014	0.7974	0.9577
Schistosoma mansoni	hypothetical protein	0.0032	0.1326	0.1663
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0017	0.0421	0.0506
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0017	0.0421	0.0421
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.3026	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0017	0.0421	0.0421
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0421	0.0528
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0017	0.0421	0.0421
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.1326	0.1326
Brugia malayi	G-protein coupled receptor	0.0017	0.0421	0.0421
Echinococcus multilocularis	sex peptide receptor	0.0017	0.0421	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.3349	0.3349
Onchocerca volvulus		0.0017	0.0421	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0146	0.8326	0.8326
Loa Loa (eye worm)	hypothetical protein	0.01	0.5497	0.5497
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3247	0.3247
Brugia malayi	Serotonin receptor	0.0017	0.0421	0.0421
Brugia malayi	RE15519p	0.0017	0.0421	0.0421
Echinococcus multilocularis	hypothetical protein	0.0019	0.0542	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus multilocularis	G protein coupled receptor 139	0.0017	0.0421	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0421	0.0506
Echinococcus granulosus	calpain 5	0.0019	0.0542	0.0651
Brugia malayi	MH2 domain containing protein	0.0122	0.6871	0.6871
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0421	0.0528
Echinococcus granulosus	neuropeptide receptor	0.0017	0.0421	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0421	0.0421
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0421	0.0506

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1197097

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1160229