Detailed information for compound 1160295

Basic information

Technical information
  • TDR Targets ID: 1160295
  • Name: AIDS163928
  • MW: 609.713 | Formula: C32H43N5O7
  • H donors: 5 H acceptors: 5 LogP: 2.04 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](/C=C/C(=O)OCC)CCC(=O)N)Cc1ccccc1)NC(=O)OCc1ccccc1
  • InChi: 1S/C32H43N5O7/c1-2-43-29(39)19-17-25(16-18-28(34)38)35-31(41)27(21-23-11-5-3-6-12-23)36-30(40)26(15-9-10-20-33)37-32(42)44-22-24-13-7-4-8-14-24/h3-8,11-14,17,19,25-27H,2,9-10,15-16,18,20-22,33H2,1H3,(H2,34,38)(H,35,41)(H,36,40)(H,37,42)/b19-17+/t25-,26-,27-/m0/s1
  • InChiKey: XWNLLBWIUJTPNE-MWAXCLHBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-(6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-phenyl-propionylamino]-6-carbamoyl-hex-2-enoic acid, ethyl ester
  • AIDS-163928

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.1759 0.2578
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.1368 0.1554
Entamoeba histolytica Ran family GTPase 0.0022 0.0084 0.0122
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.022 0.6823 1
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.057 0.057
Giardia lamblia DNA damage repair protein 0.0029 0.0331 0.1208
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0632 0.0717
Leishmania major hypothetical protein, conserved 0.0025 0.021 0.0308
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.1 0.1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0347 0.0509
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0059 0.1368 1
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0632 0.0717
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0331 0.0485
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0331 0.0485
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0029 0.0331 0.1117
Schistosoma mansoni importin beta-1 0.0029 0.0347 0.0347
Schistosoma mansoni 6-phosphofructokinase 0.022 0.6823 0.6823
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.6823 0.7746
Mycobacterium ulcerans 6-phosphofructokinase 0.022 0.6823 0.7746
Loa Loa (eye worm) glutaminase 2 0.0278 0.8808 0.8808
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0084 0.0095
Schistosoma mansoni jumonji domain containing protein 0.0077 0.1974 0.1974
Mycobacterium ulcerans DNA polymerase IV 0.012 0.3432 0.3897
Loa Loa (eye worm) hypothetical protein 0.0049 0.1 0.1
Trypanosoma cruzi DNA polymerase kappa, putative 0.012 0.3432 0.5031
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.1368 0.1554
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0059 0.1368 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.057 0.057
Brugia malayi mbt repeat family protein 0.0049 0.1 0.1135
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0331 0.0485
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1432 0.1432
Schistosoma mansoni hypothetical protein 0.0313 1 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.1228 0.1228
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0038 0.0632 0.0632
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0084 0.0122
Brugia malayi PHD-finger family protein 0.003 0.0358 0.0406
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.017 0.0193
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0059 0.1368 0.5
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.022 0.6823 1
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0038 0.0632 0.4617
Plasmodium falciparum importin beta, putative 0.0029 0.0347 0.2536
Brugia malayi AMP-binding enzyme family protein 0.0024 0.017 0.0193
Mycobacterium ulcerans glutaminase 0.0278 0.8808 1
Brugia malayi Bromodomain containing protein 0.003 0.0358 0.0406
Brugia malayi polk-prov protein 0.0056 0.1251 0.142
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0036 0.0559 0.1887
Leishmania major DNA damage repair protein, putative 0.0029 0.0331 0.0485
Mycobacterium ulcerans hypothetical protein 0.0024 0.017 0.0193
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.017 0.0193
Entamoeba histolytica deoxycytidyl transferase, putative 0.0093 0.2512 0.3682
Trypanosoma cruzi DNA polymerase kappa, putative 0.012 0.3432 0.5031
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0084 0.0122
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0059 0.1368 0.4617
Loa Loa (eye worm) hypothetical protein 0.0051 0.1079 0.1079
Echinococcus multilocularis peregrin 0.003 0.0358 0.0358
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0632 0.0926
Schistosoma mansoni glutaminase 0.0278 0.8808 0.8808
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.017 0.0249
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0331 0.0485
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.021 0.0308
Plasmodium vivax DNA repair protein REV1, putative 0.0029 0.0331 0.2419
Leishmania major DNA polymerase eta, putative 0.0106 0.2964 0.4344
Giardia lamblia PHD finger protein 15 0.003 0.0358 0.1306
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.6823 0.7746
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.3432 0.5031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0632 0.0632
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0038 0.0632 0.4617
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.017 0.0249
Plasmodium vivax 6-phosphofructokinase, putative 0.0059 0.1368 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.1251 0.1251
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.01 0.2741 0.4017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.057 0.057
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.1228 0.1394
Brugia malayi 6-phosphofructokinase 0.022 0.6823 0.7746
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.3432 0.5031
Brugia malayi mbt repeat family protein 0.0049 0.1 0.1135
Trypanosoma brucei DNA polymerase eta, putative 0.0171 0.5145 0.7541
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0158 0.018
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.6823 0.7746
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.017 0.0193
Schistosoma mansoni 6-phosphofructokinase 0.022 0.6823 0.6823
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.1368 0.1554
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.1 0.1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0093 0.2512 0.3682
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0347 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1251 0.1834
Echinococcus multilocularis 0.0038 0.0632 0.0632
Trichomonas vaginalis dullard protein, putative 0.0038 0.0632 0.0717
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0084 0.0611
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0059 0.1368 1
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.1 0.1
Toxoplasma gondii phosphofructokinase PFKII 0.0059 0.1368 0.4617
Plasmodium vivax hypothetical protein, conserved 0.003 0.0358 0.2617
Loa Loa (eye worm) hypothetical protein 0.0037 0.0616 0.0616
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.017 0.0249
Echinococcus granulosus dna polymerase eta 0.0171 0.5145 0.5145
Trypanosoma brucei unspecified product 0.0064 0.1531 0.2244
Echinococcus granulosus importin subunit beta 1 0.0029 0.0347 0.0347
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0331 0.0485
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.021 0.0308
Loa Loa (eye worm) hypothetical protein 0.0025 0.021 0.021
Brugia malayi RNA, U transporter 1 0.0083 0.2186 0.2482
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0753 0.0753
Trypanosoma brucei chrX additional, unordered contigs 0.0029 0.0331 0.0485
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0084 0.0084
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.017 0.0249
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.1228 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.3432 0.5031
Brugia malayi ImpB/MucB/SamB family protein 0.0171 0.5145 0.5842
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0093 0.2512 0.2512
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0059 0.1368 0.2006
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.1228 0.1228
Brugia malayi 6-phosphofructokinase 0.022 0.6823 0.7746
Trypanosoma brucei DNA polymerase IV, putative 0.012 0.3432 0.5031
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.5984 0.5984
Entamoeba histolytica phosphofructokinase, putative 0.022 0.6823 1
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0038 0.0632 0.0632
Mycobacterium ulcerans hypothetical protein 0.0029 0.0331 0.0376
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0632 0.0717
Echinococcus granulosus dna polymerase kappa 0.012 0.3432 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.3432 0.5031
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0331 0.0485
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0038 0.0632 0.0632
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0106 0.2964 1
Schistosoma mansoni hypothetical protein 0.0299 0.9514 0.9514
Giardia lamblia DINP protein human, muc B family 0.01 0.2741 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0038 0.0632 0.0632
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0358 0.0358
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0038 0.0632 0.0717
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.017 0.0193
Echinococcus granulosus peregrin 0.003 0.0358 0.0358
Schistosoma mansoni DNA polymerase eta 0.0171 0.5145 0.5145
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.1228 0.1228
Brugia malayi AMP-binding enzyme family protein 0.0024 0.017 0.0193
Mycobacterium ulcerans DNA polymerase IV 0.012 0.3432 0.3897
Leishmania major DNA polymerase kappa, putative 0.0029 0.0331 0.0485
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0093 0.2512 0.2512
Trichomonas vaginalis dullard protein, putative 0.0038 0.0632 0.0717
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0059 0.1368 0.4993
Entamoeba histolytica phosphofructokinase, putative 0.022 0.6823 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.017 0.0249
Echinococcus granulosus CTD small phosphatase protein like 0.0038 0.0632 0.0632
Schistosoma mansoni hypothetical protein 0.003 0.0358 0.0358
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0331 0.0485
Brugia malayi jmjC domain containing protein 0.0036 0.057 0.0647
Trichomonas vaginalis DNA polymerase eta, putative 0.012 0.3432 0.3897
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.017 0.0193
Plasmodium vivax importin-beta 2, putative 0.0029 0.0347 0.2536
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.1368 0.1554
Trypanosoma cruzi DNA polymerase eta, putative 0.0171 0.5145 0.7541
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0038 0.0632 0.2305
Onchocerca volvulus Alhambra homolog 0.003 0.0358 0.227
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.022 0.6823 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.5145 0.5145
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0038 0.0632 0.4617
Brugia malayi ImpB/MucB/SamB family protein 0.0093 0.2512 0.2853
Loa Loa (eye worm) hypothetical protein 0.0029 0.0347 0.0347
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.021 0.0709
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0632 0.0717
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0158 0.018
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.1 0.1
Schistosoma mansoni DNA polymerase IV / kappa 0.0029 0.0331 0.0331
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0347 0.1171
Echinococcus granulosus 6 phosphofructokinase 0.022 0.6823 0.6823
Loa Loa (eye worm) MBCTL1 0.0055 0.1228 0.1228
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.017 0.0249
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0084 0.0305
Schistosoma mansoni ran 0.0022 0.0084 0.0084
Echinococcus multilocularis snurportin 1 0.0313 1 1
Onchocerca volvulus 0.0049 0.1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.021 0.1536
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.012 0.3432 0.3897
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.5984 0.5984
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.3432 0.5031
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.1 0.1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.2653 0.2653
Schistosoma mansoni hypothetical protein 0.0037 0.0616 0.0616
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0358 0.0358
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.017 0.0193
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.017 0.0249
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.017 0.0249
Loa Loa (eye worm) hypothetical protein 0.0024 0.017 0.017
Loa Loa (eye worm) 6-phosphofructokinase 0.022 0.6823 0.6823
Trypanosoma brucei DNA polymerase IV, putative 0.012 0.3432 0.5031
Loa Loa (eye worm) hypothetical protein 0.0055 0.1228 0.1228
Brugia malayi hypothetical protein 0.0025 0.021 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1251 0.1834
Entamoeba histolytica phosphofructokinase, putative 0.022 0.6823 1
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.1368 0.1554
Trypanosoma cruzi DNA polymerase eta, putative 0.0106 0.2964 0.4344
Trypanosoma brucei unspecified product 0.0113 0.3204 0.4696
Trypanosoma cruzi DNA polymerase kappa, putative 0.012 0.3432 0.5031
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0084 0.0611
Brugia malayi AMP-binding enzyme family protein 0.0024 0.017 0.0193
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.2653 0.2653
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0358 0.1208
Leishmania major ATP-dependent phosphofructokinase 0.022 0.6823 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.1 0.1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0347 0.0509
Brugia malayi jmjC domain containing protein 0.0097 0.2653 0.3012
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0084 0.0282
Schistosoma mansoni terminal deoxycytidyl transferase 0.0093 0.2512 0.2512
Echinococcus multilocularis 6 phosphofructokinase 0.022 0.6823 0.6823
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0331 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.1759 0.2578
Trichomonas vaginalis glutaminase, putative 0.0278 0.8808 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.017 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.3432 0.5031
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.1368 0.1554
Leishmania major importin beta-1 subunit, putative 0.0024 0.0158 0.0232
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.057 0.057
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0093 0.2512 0.2512
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.3432 0.5031
Loa Loa (eye worm) hypothetical protein 0.003 0.0358 0.0358
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0158 0.018
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.022 0.6823 1
Loa Loa (eye worm) 6-phosphofructokinase 0.022 0.6823 0.6823
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.1 0.1
Trypanosoma brucei unspecified product 0.0064 0.1531 0.2244
Leishmania major DNA polymerase eta, putative 0.0171 0.5145 0.7541
Echinococcus multilocularis dna polymerase eta 0.0171 0.5145 0.5145
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.1228 0.1228
Brugia malayi Importin beta-1 subunit 0.0029 0.0347 0.0394
Brugia malayi glutaminase DH11.1 0.0278 0.8808 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.017 0.017
Plasmodium falciparum DNA repair protein REV1, putative 0.0029 0.0331 0.2419
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0753 0.0753
Trichomonas vaginalis ran, putative 0.0022 0.0084 0.0095
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0158 0.0232
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0084 0.0122
Loa Loa (eye worm) hypothetical protein 0.0024 0.017 0.017
Leishmania major hypothetical protein, conserved 0.0038 0.0632 0.0926
Toxoplasma gondii 6-phosphofructokinase 0.0059 0.1368 0.4617
Schistosoma mansoni ran 0.0022 0.0084 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.3432 0.5031
Trichomonas vaginalis dullard protein, putative 0.0038 0.0632 0.0717
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.021 0.0308
Leishmania major GTP-binding protein, putative 0.0022 0.0084 0.0122
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.022 0.6823 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.021 0.1536
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.1 0.1
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.1759 0.2578
Loa Loa (eye worm) phosphofructokinase 0.022 0.6823 0.6823
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0038 0.0632 0.0926
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0084 0.0084
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.3204 0.4696
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0093 0.2512 0.2512
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0059 0.1368 0.2006
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0084 0.0084
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0358 0.0358
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0358 0.1208
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0059 0.1368 0.1554
Trypanosoma cruzi DNA polymerase kappa, putative 0.012 0.3432 0.5031
Plasmodium vivax 6-phosphofructokinase, putative 0.0059 0.1368 1
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0038 0.0632 0.2131
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.021 0.1536
Echinococcus multilocularis dna polymerase kappa 0.012 0.3432 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.3432 0.5031
Entamoeba histolytica hypothetical protein 0.0024 0.0158 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.2741 0.4017
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0358 0.0358
Loa Loa (eye worm) glutaminase 0.0278 0.8808 0.8808
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0038 0.0632 0.0926
Leishmania major DNA polymerase kappa, putative 0.01 0.2741 0.4017
Plasmodium falciparum phd finger protein, putative 0.003 0.0358 0.2617
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.01 0.2741 0.4017
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.057 0.057
Brugia malayi phosphofructokinase 0.022 0.6823 0.7746
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.6823 0.7746

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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