Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.3694 | 1 | 0.5 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0274 | 0.0729 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.001 | 0.0007 |
Loa Loa (eye worm) | intermediate filament protein | 0.0018 | 0.0036 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0036 | 0.0033 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.1777 | 0.4803 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.3694 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0018 | 0.0036 | 0.0075 |
Schistosoma mansoni | cpg binding protein | 0.002 | 0.0042 | 0.0088 |
Onchocerca volvulus | 0.0019 | 0.0039 | 0.0003 | |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.3694 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0035 | 0.0032 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.3694 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0006 | 0.0003 | 0.0007 |
Brugia malayi | CXXC zinc finger family protein | 0.0019 | 0.0039 | 0.0036 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.001 | 0.0013 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0274 | 0.0729 | 0.1518 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.1777 | 0.4803 | 0.4801 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0018 | 0.0036 | 0.0033 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.1777 | 0.4803 | 0.4801 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.1777 | 0.4803 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0041 | 0.0098 | 0.0203 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0009 | 0.0011 | 0.0022 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.001 | 0.0013 | 0.001 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.3694 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0011 | 0.0007 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.1777 | 0.4803 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0018 | 0.0036 | 0.0075 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.1777 | 0.4803 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.1777 | 0.4803 | 1 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.1777 | 0.4803 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0018 | 0.0036 | 0.0075 |
Schistosoma mansoni | lamin | 0.0018 | 0.0036 | 0.0075 |
Echinococcus granulosus | cpg binding protein | 0.002 | 0.0042 | 0.0088 |
Echinococcus multilocularis | lamin | 0.0018 | 0.0036 | 0.0075 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.1777 | 0.4803 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.3694 | 1 | 1 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.3694 | 1 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0009 | 0.0011 | 0.0022 |
Schistosoma mansoni | cpg binding protein | 0.0019 | 0.0039 | 0.0082 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.1777 | 0.4803 | 0.4801 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.1777 | 0.4803 | 1 |
Echinococcus granulosus | dnaJ subfamily B | 0.0274 | 0.0729 | 0.1518 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.3694 | 1 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.1777 | 0.4803 | 1 |
Onchocerca volvulus | 0.3694 | 1 | 1 | |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.3694 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.1777 | 0.4803 | 1 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.3694 | 1 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0006 | 0.0003 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.001 | 0.0007 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0019 | 0.0039 | 0.0036 |
Echinococcus granulosus | lamin | 0.0018 | 0.0036 | 0.0075 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.3694 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.002 | 0.0042 | 0.0088 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.1777 | 0.4803 | 0.4801 |
Schistosoma mansoni | intermediate filament proteins | 0.0018 | 0.0036 | 0.0075 |
Echinococcus multilocularis | musashi | 0.0018 | 0.0036 | 0.0075 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.3694 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0018 | 0.0036 | 0.0033 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0018 | 0.0036 | 0.0033 |
Echinococcus multilocularis | cpg binding protein | 0.002 | 0.0042 | 0.0088 |
Schistosoma mansoni | lamin | 0.0018 | 0.0036 | 0.0075 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.