Detailed information for compound 1160727

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 503.639 | Formula: C26H25N5O2S2
  • H donors: 0 H acceptors: 4 LogP: 3.5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1ccc2c(c1)C[C@H](CN2Cc1cncn1C)N(S(=O)(=O)c1ccccc1)Cc1ccsc1
  • InChi: 1S/C26H25N5O2S2/c1-29-19-28-14-24(29)17-30-16-23(12-22-11-20(13-27)7-8-26(22)30)31(15-21-9-10-34-18-21)35(32,33)25-5-3-2-4-6-25/h2-11,14,18-19,23H,12,15-17H2,1H3/t23-/m1/s1
  • InChiKey: XIVVAPJAZVPZQR-HSZRJFAPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens farnesyltransferase, CAAX box, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium berghei protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium parvum farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Giardia lamblia Rab geranylgeranyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium hominis farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Theileria parva hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus granulosus protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium vivax prenyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Babesia bovis protein prenyltransferase alpha subunit repeat domain containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma mansoni protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus multilocularis protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium knowlesi protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Neospora caninum hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium falciparum protein farnesyltransferase subunit alpha Get druggable targets OG5_128459 All targets in OG5_128459
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0122 0.0122
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0024 0.0024
Plasmodium falciparum telomerase reverse transcriptase 0.0088 0.0068 0.311
Loa Loa (eye worm) hypothetical protein 0.0045 0.0028 0.0081
Mycobacterium tuberculosis Probable reductase 0.0086 0.0066 0.103
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0015 0.0044
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0023 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0108 0.0086 0.5107
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.0033 0.0095
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0015 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0067 0.0049 0.078
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0004 0.0004
Trichomonas vaginalis glutaminase, putative 0.0516 0.0463 0.2882
Schistosoma mansoni cathepsin F (C01 family) 0.0067 0.0049 0.0048
Plasmodium vivax vivapain-2 0.0067 0.0049 0.2208
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0022 0.0007 0.002
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0009 0.0026
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0021 0.006
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0088 0.1374
Trypanosoma brucei glucosidase, putative 0.0037 0.0021 0.006
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0266 0.1658
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0004 0.0004
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0004 0.0004
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0088 0.0068 0.0197
Brugia malayi Muscleblind-like protein 0.0147 0.0122 0.0354
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.0141 0.0411
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0 0.000007069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0017 0.0105
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0015 0.0015
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.025 0.0217 0.0217
Schistosoma mansoni hypothetical protein 0.0319 0.0281 0.0281
Schistosoma mansoni smad 0.0094 0.0073 0.0073
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0241 0.0209 0.0606
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.008 0.008
Schistosoma mansoni apoferritin-2 0.0051 0.0034 0.0033
Brugia malayi steroid hormone receptor 0.0031 0.0015 0.0044
Schistosoma mansoni hypothetical protein 0.0241 0.0209 0.0209
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0088 0.1374
Toxoplasma gondii hypothetical protein 0.0143 0.0118 0.5442
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.0158 0.0158
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0066 0.2919
Echinococcus multilocularis Niemann Pick C1 protein 0.1684 0.1542 0.1542
Echinococcus granulosus tar DNA binding protein 0.0065 0.0047 0.0047
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0888 0.0807 0.2344
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0021 0.0928
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0086 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0011 0.0446
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0049 0.0303
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0088 0.0547
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.322 0.296 0.296
Brugia malayi jmjC domain containing protein 0.0037 0.002 0.0059
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0017 0.0105
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0002 0.0025
Brugia malayi cathepsin L-like precursor 0.0045 0.0028 0.0081
Brugia malayi Bromodomain containing protein 0.0036 0.002 0.0058
Schistosoma mansoni peptidase Clp (S14 family) 0.025 0.0217 0.0217
Brugia malayi hypothetical protein 0.0026 0.0011 0.003
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0015 0.0245
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.005 0.0033 0.1474
Schistosoma mansoni hypothetical protein 0.0108 0.0086 0.0086
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0001 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0241 0.0209 0.0209
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0023 0.0066
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0035 0.0019 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0019 0.0922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0027 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0027 0.017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0014 0.0086
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0701 0.0634 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0297 0.0261 0.0261
Brugia malayi CXXC zinc finger family protein 0.0022 0.0007 0.0021
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0075 0.1171
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0012
Trypanosoma brucei unspecified product 0.0027 0.0012 0.0033
Mycobacterium tuberculosis Conserved protein 0.011 0.0088 0.1374
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0266 0.1658
Entamoeba histolytica cysteine proteinase 2 0.0035 0.0019 0.0922
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0002 0.0005
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.025 0.0217 1
Leishmania major DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0086 0.0086
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0091 0.0071 0.0206
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0141 0.0141
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0066 0.2743
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0021 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0009 0.013
Entamoeba histolytica hypothetical protein 0.0019 0.0004 0.0046
Loa Loa (eye worm) glutaminase 0.0516 0.0463 0.1346
Schistosoma mansoni cpg binding protein 0.0024 0.0008 0.0008
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0009 0.0337
Leishmania major cathepsin L-like protease 0.0256 0.0223 0.0647
Echinococcus granulosus GPCR family 2 0.0241 0.0209 0.0209
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.0165 0.1025
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0051 0.0034 0.1404
Plasmodium vivax vivapain-3 0.0035 0.0019 0.0816
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Loa Loa (eye worm) hypothetical protein 0.011 0.0088 0.0255
Echinococcus multilocularis expressed protein 0.0034 0.0018 0.0018
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0027 0.0027
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0088 0.0255
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.003 0.003
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0094 0.0073 0.1173
Schistosoma mansoni cathepsin F (C01 family) 0.0045 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.052 0.0467 0.1356
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0009
Onchocerca volvulus Glucosylceramidase homolog 0.0303 0.0266 0.4286
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0023 0.0057
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0193 0.0165 0.0478
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0193 0.0165 0.7579
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0015 0.0245
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.1583 0.1448 0.421
Brugia malayi Smad1 0.0209 0.018 0.0523
Loa Loa (eye worm) fibroinase 0.0067 0.0049 0.0141
Loa Loa (eye worm) hypothetical protein 0.0116 0.0094 0.0271
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0241 0.0209 0.0209
Onchocerca volvulus 0.0067 0.0049 0.078
Schistosoma mansoni alpha-glucosidase 0.0144 0.012 0.012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0015 0.0015
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0067 0.0049 0.0048
Brugia malayi MH2 domain containing protein 0.0209 0.018 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.0118
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0026
Toxoplasma gondii thioredoxin reductase 0.0038 0.0021 0.0951
Treponema pallidum hypothetical protein 0.0097 0.0077 0.3417
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0266 0.1658
Loa Loa (eye worm) hypothetical protein 0.0145 0.012 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0017 0.0105
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0047 0.0136
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0067 0.0067
Echinococcus multilocularis protein patched 0.1583 0.1448 0.1448
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Schistosoma mansoni ferritin 0.0051 0.0034 0.0033
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0025 0.0402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0002 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0023 0.0066
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0061 0.0355
Echinococcus granulosus Protein patched homolog 1 0.1583 0.1448 0.1448
Toxoplasma gondii ABC1 family protein 0.011 0.0088 0.4027
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0019 0.0922
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0067 0.0049 0.0141
Trypanosoma cruzi cysteine proteinase, putative 0.0035 0.0019 0.0053
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0004 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.052 0.0467 0.1356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.0118
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0089 0.0069 0.0069
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0027 0.1467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0068
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0009 0.0337
Plasmodium vivax unspecified product 0.0035 0.0019 0.0816
Mycobacterium ulcerans bacterioferritin BfrA 0.0051 0.0034 0.0088
Loa Loa (eye worm) MH2 domain-containing protein 0.0094 0.0073 0.0212
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0021 0.013
Mycobacterium ulcerans glutaminase 0.0516 0.0463 0.1337
Brugia malayi Cathepsin L-like precursor 0.0067 0.0049 0.0141
Trypanosoma cruzi cysteine proteinase, putative 0.0035 0.0019 0.0053
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.374 0.344 0.344
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0147 0.0122 0.0354
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0075 0.1171
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0004 0.0004
Schistosoma mansoni DNA polymerase eta 0.0066 0.0047 0.0047
Onchocerca volvulus 0.0067 0.0049 0.078
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1754 0.1607 1
Onchocerca volvulus 0.0067 0.0049 0.078
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0033 0.0095
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0082 0.0063 0.0062
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0027 0.0079
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0234 0.0202 0.0588
Schistosoma mansoni ferritin light chain 0.0051 0.0034 0.0033
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0009 0.013
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.025 0.0217 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0022 0.0022
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0015 0.0015
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0021 0.013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Mycobacterium leprae Probable lipase LipE 0.011 0.0088 0.3791
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0019 0.0115
Echinococcus granulosus cysteine protease 0.0035 0.0019 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0028 0.1516
Trypanosoma cruzi cysteine peptidase, putative 0.0256 0.0223 0.0647
Loa Loa (eye worm) hypothetical protein 0.0079 0.006 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0021 0.013
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0023 0.1192
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1754 0.1607 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0015 0.0044
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.1754 0.1607 1
Echinococcus granulosus dna polymerase eta 0.0066 0.0047 0.0047
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0049 0.0303
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0047 0.0047
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0088 0.1374
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0049 0.0303
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0011 0.0446
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0019 0.0053
Loa Loa (eye worm) hypothetical protein 0.0464 0.0415 0.1207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0019 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0049 0.0303
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0015 0.0015
Schistosoma mansoni ferritin light chain 0.0051 0.0034 0.0033
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0088 0.0255
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0088 0.0255
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0004 0.0004
Brugia malayi mothers against decapentaplegic homolog 3 0.0094 0.0073 0.0212
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0017 0.0844
Echinococcus granulosus sterol regulatory element binding protein 0.1583 0.1448 0.1448
Onchocerca volvulus 0.0022 0.0007 0.0114
Leishmania major cathepsin L-like protease 0.0256 0.0223 0.0647
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0027 0.0079
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0021 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Loa Loa (eye worm) hypothetical protein 0.1583 0.1448 0.421
Brugia malayi acetyltransferase, GNAT family protein 0.0297 0.0261 0.0758
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0164 0.0138 0.6181
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0088 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Schistosoma mansoni smad 0.0209 0.018 0.018
Trichomonas vaginalis glucosylceramidase, putative 0.0462 0.0413 0.257
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0067 0.3071
Leishmania major cathepsin L-like protease 0.0256 0.0223 0.0647
Schistosoma mansoni cathepsin s 0.0022 0.0007 0.0007
Onchocerca volvulus 0.011 0.0088 0.1413
Schistosoma mansoni hypothetical protein 0.0042 0.0025 0.0025
Brugia malayi hypothetical protein 0.0016 0.0002 0.0005
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0057 0.0056
Echinococcus multilocularis lamin dm0 0.0171 0.0144 0.0144
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0004 0.0004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0017 0.005
Schistosoma mansoni cpg binding protein 0.0022 0.0007 0.0007
Echinococcus multilocularis musashi 0.0171 0.0144 0.0144
Toxoplasma gondii cathepsin CPL 0.0067 0.0049 0.2208
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0015 0.0044
Schistosoma mansoni chromobox protein 0.0074 0.0055 0.0055
Entamoeba histolytica cysteine proteinase 1, putative 0.0035 0.0019 0.0922
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0193 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0025 0.0156
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0125 0.0102 0.0295
Trichomonas vaginalis rotamase, putative 0.0034 0.0018 0.0112
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0001 0.0002
Brugia malayi hypothetical protein 0.0019 0.0004 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0067 0.0049 0.279
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0009 0.0017
Echinococcus granulosus cathepsin l1 0.0067 0.0049 0.0048
Brugia malayi beta-lactamase family protein 0.011 0.0088 0.0255
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0341 0.0302 0.0877
Echinococcus multilocularis cathepsin L 0.0035 0.0019 0.0018
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0023 0.0066
Brugia malayi intermediate filament protein 0.0171 0.0144 0.0418
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0266 0.1658
Loa Loa (eye worm) hypothetical protein 0.0045 0.0028 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0027 0.017
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0007 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0009 0.0053
Echinococcus granulosus lamin dm0 0.0171 0.0144 0.0144
Schistosoma mansoni smad1 5 8 and 0.0209 0.018 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.042 0.0375 0.1089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0088 0.0088
Schistosoma mansoni ferritin 0.0051 0.0034 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0049 0.0303
Leishmania major cathepsin L-like protease 0.0067 0.0049 0.0141
Brugia malayi nuclear hormone receptor 0.0031 0.0015 0.0044
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.005 0.0033 0.0095
Loa Loa (eye worm) hypothetical protein 0.374 0.344 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0028 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0015 0.0015
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0009 0.0017
Onchocerca volvulus 0.0033 0.0017 0.0268
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0015 0.0015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.002 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0088 0.0547
Mycobacterium leprae conserved hypothetical protein 0.011 0.0088 0.3791
Trypanosoma cruzi major cysteine proteinase, putative 0.0201 0.0172 0.05
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0022 0.0063
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0193 0.0165 0.0165
Onchocerca volvulus 0.0171 0.0144 0.2317
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0055 0.016
Mycobacterium ulcerans beta-lactamase 0.011 0.0088 0.0246
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.005 0.0033 0.0033
Trichomonas vaginalis rotamase, putative 0.0033 0.0017 0.0108
Loa Loa (eye worm) MH1 domain-containing protein 0.0094 0.0073 0.0212
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0012
Treponema pallidum bacterioferrin (TpF1) 0.0051 0.0034 0.1404
Trichomonas vaginalis glucosylceramidase, putative 0.0462 0.0413 0.257
Entamoeba histolytica hypothetical protein 0.0019 0.0004 0.0046
Leishmania major cathepsin L-like protease 0.0067 0.0049 0.0141
Loa Loa (eye worm) hypothetical protein 0.011 0.0088 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Plasmodium falciparum cysteine proteinase falcipain 1 0.0035 0.0019 0.0816
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0028
Echinococcus multilocularis ferritin 0.0051 0.0034 0.0033
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0193 0.0165 0.1025
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0015 0.0015
Echinococcus multilocularis microtubule associated protein 2 1.0844 1 1
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.005 0.0033 0.1474
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0023 0.0347
Plasmodium vivax vivapain-2 0.0067 0.0049 0.2208
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0129
Giardia lamblia Telomerase catalytic subunit 0.0088 0.0068 0.0402
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.042 0.0375 0.1089
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0015 0.0015
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0027 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0 0.0001
Onchocerca volvulus 0.0067 0.0049 0.078
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0015 0.0044
Onchocerca volvulus 0.0171 0.0144 0.2317
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0888 0.0807 0.2344
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0047 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0 0.0001
Brugia malayi Cathepsin L-like precursor 0.0045 0.0028 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0068
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0004 0.0004
Onchocerca volvulus 0.0097 0.0076 0.1224
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.011 0.0088 0.0255
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0004 0.001
Brugia malayi jmjC domain containing protein 0.0095 0.0075 0.0217
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Echinococcus granulosus ferritin 0.0051 0.0034 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0462 0.0413 0.257
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.0158 0.0158
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0027 0.0079
Schistosoma mansoni alpha glucosidase 0.0037 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0014 0.0086
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.005 0.0033 0.1805
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0018 0.0112
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0004 0.0012
Brugia malayi PXA domain containing protein 0.0019 0.0004 0.0012
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0067 0.0049 0.0303
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.025 0.0217 1
Loa Loa (eye worm) transcription factor SMAD2 0.3074 0.2825 0.8213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0158 0.0158
Leishmania major hypothetical protein, conserved 0.0026 0.0011 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0042 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0015 0.0044
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0021 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0026
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0001 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0266 0.1658
Brugia malayi Cathepsin L-like precursor 0.0067 0.0049 0.0141
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0241 0.0209 0.0209
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0055 0.0345
Brugia malayi Calcitonin receptor-like protein seb-1 0.076 0.0689 0.2002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0021 0.0325
Brugia malayi MH1 domain containing protein 0.0209 0.018 0.0523
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.0118
Echinococcus granulosus mothers against decapentaplegic 6 0.0094 0.0073 0.0073
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0088 0.0246
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0018 0.0052
Echinococcus multilocularis muscleblind protein 0.0147 0.0122 0.0122
Echinococcus multilocularis chromobox protein 1 0.0074 0.0055 0.0055
Brugia malayi Thioredoxin reductase 0.0038 0.0021 0.0062
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0023 0.0023
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0013 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0011 0.003
Echinococcus multilocularis peptidase Clp (S14 family) 0.0164 0.0138 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0015 0.0044
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0 0.000007069
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0035 0.0019 0.0018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0125 0.0102 0.0295
Brugia malayi Cathepsin L-like cysteine proteinase 0.0045 0.0028 0.0081
Brugia malayi beta-lactamase family protein 0.011 0.0088 0.0255
Entamoeba histolytica hypothetical protein 0.0108 0.0086 0.5107
Loa Loa (eye worm) RNA binding protein 0.0065 0.0047 0.0136
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0001 0.0001
Toxoplasma gondii hypothetical protein 0.0086 0.0066 0.3011
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0021 0.1072
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.0406 0.0405
Brugia malayi Latrophilin receptor protein 2 0.0241 0.0209 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0009 0.0026
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0023 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0049 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0015 0.0044
Schistosoma mansoni intermediate filament proteins 0.0171 0.0144 0.0144
Echinococcus granulosus peptidase Clp S14 family 0.0164 0.0138 0.0137
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Schistosoma mansoni hypothetical protein 0.0335 0.0296 0.0296
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0088 0.1374
Schistosoma mansoni hypothetical protein 0.0029 0.0013 0.0013
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0125 0.0102 0.0295
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0017 0.005
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0341 0.0302 0.0877
Brugia malayi cathepsin F-like cysteine proteinase 0.0022 0.0007 0.002
Brugia malayi MH1 domain containing protein 0.0116 0.0094 0.0271
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.076 0.0689 0.2002
Onchocerca volvulus 0.0464 0.0415 0.6687
Schistosoma mansoni apoferritin-2 0.0051 0.0034 0.0033
Giardia lamblia GTOR 0.0044 0.0027 0.0147
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0143 0.0118 0.0737
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.008 0.008
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0088 0.0068 0.0197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0002 0.0002
Echinococcus granulosus dna polymerase kappa 0.0039 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0012
Entamoeba histolytica hypothetical protein 0.0108 0.0086 0.5107
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0004 0.0004
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0004 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Loa Loa (eye worm) hypothetical protein 0.0067 0.0049 0.0141
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0075 0.0075
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0019 0.0055
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0019 0.0055
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0073
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0061 0.276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.0158 0.0158
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0033 0.0095
Loa Loa (eye worm) Smad1 0.0209 0.018 0.0523
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0033 0.0095
Onchocerca volvulus Alhambra homolog 0.0029 0.0013 0.0214
Trypanosoma brucei unspecified product 0.0039 0.0023 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0028 0.0175
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0009 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0158 0.0158
Brugia malayi Blistered cuticle protein 3 0.0687 0.0621 0.1805
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0088 0.0088
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0088 0.1374
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0023 0.0142
Brugia malayi nuclear receptor RXR 0.0016 0.0002 0.0005
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0023 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0028
Leishmania major hypothetical protein, conserved 0.011 0.0088 0.0255
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0067 0.0419
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0002 0.0002
Echinococcus multilocularis tumor protein p63 0.3173 0.2916 0.2916
Loa Loa (eye worm) cysteine protease 0.0067 0.0049 0.0141
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0023 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Brugia malayi Probable ClpP-like protease 0.025 0.0217 0.063
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.0024 0.0008 0.0008
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0013 0.0582
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0075 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Echinococcus multilocularis thyroid hormone receptor alpha 0.0299 0.0263 0.0263
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0023 0.0066
Loa Loa (eye worm) beta-lactamase 0.011 0.0088 0.0255
Plasmodium falciparum thioredoxin reductase 0.0038 0.0021 0.0951
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0152 0.0127 0.0368
Onchocerca volvulus 0.005 0.0033 0.0525
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0193 0.0165 0.0478
Schistosoma mansoni microtubule-associated protein tau 1.0844 1 1
Echinococcus multilocularis chromobox protein 1 0.0074 0.0055 0.0055
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0027 0.0027
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0086 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0017 0.0105
Onchocerca volvulus 0.0152 0.0127 0.204
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0003 0.0016
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0088 0.1374
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.025 0.0217 1
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0088 0.0547
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Giardia lamblia Rab geranylgeranyltransferase 0.005 0.0033 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0021 0.006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0002 0.0025
Echinococcus multilocularis cysteine protease 0.0067 0.0049 0.0048
Echinococcus multilocularis sterol regulatory element binding protein 0.1583 0.1448 0.1448
Echinococcus granulosus Smad4 0.0209 0.018 0.018
Onchocerca volvulus 0.0067 0.0049 0.078
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0047 0.0136
Brugia malayi CHE-14 protein 0.1583 0.1448 0.421
Trypanosoma cruzi cysteine peptidase, putative 0.0256 0.0223 0.0647
Loa Loa (eye worm) glutathione reductase 0.0038 0.0021 0.0062
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0061 0.3531
Trichomonas vaginalis glucosylceramidase, putative 0.0462 0.0413 0.257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0004 0.0004
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0004 0.0012
Trypanosoma cruzi cysteine protease, putative 0.0035 0.0019 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Mycobacterium ulcerans hypothetical protein 0.0468 0.0418 0.1208
Trypanosoma brucei unspecified product 0.0027 0.0012 0.0033
Echinococcus granulosus intermediate filament protein 0.0171 0.0144 0.0144
Brugia malayi Cathepsin L-like precursor 0.0067 0.0049 0.0141
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0066 0.0047 0.0136
Brugia malayi MH2 domain containing protein 0.0209 0.018 0.0523
Brugia malayi RNA binding protein 0.0065 0.0047 0.0136
Schistosoma mansoni Smad4 0.0209 0.018 0.018
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0004 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0088 0.0088
Echinococcus granulosus TGF beta signal transducer SmadC 0.0209 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0005
Echinococcus granulosus tumor protein p63 0.3173 0.2916 0.2916
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0209 0.018 0.018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0015 0.0015
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.374 0.344 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0462 0.0413 0.12
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0193 0.0165 0.7579
Onchocerca volvulus Dual oxidase homolog 0.0687 0.0621 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0241 0.0209 0.0209
Onchocerca volvulus Cathepsin F homolog 0.0067 0.0049 0.078
Loa Loa (eye worm) latrophilin receptor protein 2 0.0241 0.0209 0.0606
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.0406 0.0405
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.374 0.344 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0004 0.001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0241 0.0209 0.0606
Echinococcus multilocularis dnaJ subfamily B 0.0319 0.0281 0.0281
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0007 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0067 0.0049 0.279
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0067 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.003
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0009 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0002 0.0005
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0004 0.0012
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.025 0.0217 1
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0266 0.1658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0 0.0001
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0001 0.0002
Schistosoma mansoni ferritin 0.0051 0.0034 0.0033
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0004 0.0004
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0006 0.0016
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0003 0.0117
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0012 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0088 0.0255
Echinococcus granulosus survival motor neuron protein 1 0.0745 0.0674 0.0674
Brugia malayi PHD-finger family protein 0.0029 0.0013 0.0039
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0003 0.0117
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.0406 0.0405
Brugia malayi hypothetical protein 0.0745 0.0674 0.196
Echinococcus multilocularis lamin 0.0171 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0009 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0009 0.0026
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0088 0.0088
Loa Loa (eye worm) MH1 domain-containing protein 0.0209 0.018 0.0523
Brugia malayi Cathepsin L-like precursor 0.0067 0.0049 0.0141
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0004 0.0004
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0022 0.0979
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.374 0.344 0.344
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0033 0.0095
Schistosoma mansoni hypothetical protein 0.0241 0.0209 0.0209
Onchocerca volvulus 0.011 0.0088 0.1413
Echinococcus multilocularis cysteine protease 0.0067 0.0049 0.0048
Entamoeba histolytica hypothetical protein 0.0097 0.0077 0.4528
Schistosoma mansoni coup transcription factor 0.0031 0.0015 0.0015
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0013 0.0039
Echinococcus granulosus expressed conserved protein 0.0095 0.0074 0.0074
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0141 0.0141
Loa Loa (eye worm) ctsf protein 0.0067 0.0049 0.0141
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0021 0.013
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0017 0.0739
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.011 0.0088 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0015 0 0.0002
Onchocerca volvulus Cathepsin L homolog 0.0067 0.0049 0.078
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Onchocerca volvulus 0.0045 0.0028 0.045
Schistosoma mansoni thyroid hormone receptor 0.0299 0.0263 0.0263
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0003 0.004
Brugia malayi Cathepsin L-like precursor 0.0067 0.0049 0.0141
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.025 0.0217 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0002 0.0002
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0004 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0171 0.0144 0.0418
Loa Loa (eye worm) glutaminase 2 0.0516 0.0463 0.1346
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0013 0.0582
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0027 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0015 0.0044
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0067 0.0049 0.0048
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0067 0.3071
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0004 0.0004
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0164 0.0138 0.2159
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0012 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0017 0.0105
Mycobacterium ulcerans lipase LipD 0.011 0.0088 0.0246
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0067 0.0049 0.2208
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0004 0.0004
Echinococcus multilocularis smad 0.0209 0.018 0.018
Echinococcus multilocularis dna polymerase eta 0.0066 0.0047 0.0047
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.0158 0.0459
Onchocerca volvulus 0.0031 0.0015 0.0245
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0004 0.0004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0004 0.001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0088 0.1374
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.0118
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.0141 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0015 0.0044
Brugia malayi nuclear receptor NHR-88 0.0031 0.0015 0.0044
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.0141 0.0141
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0023 0.0066
Leishmania major cathepsin L-like protease 0.0067 0.0049 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0068
Loa Loa (eye worm) hypothetical protein 0.0167 0.0141 0.041
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0011 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0088 0.0547
Trypanosoma brucei trypanothione reductase 0.0038 0.0021 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0049 0.0303
Trypanosoma cruzi cruzipain precursor, putative 0.0256 0.0223 0.0647
Brugia malayi hypothetical protein 0.0016 0.0002 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0013 0.0582
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0027 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0012
Brugia malayi MH1 domain containing protein 0.0116 0.0094 0.0271
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Schistosoma mansoni hypothetical protein 0.0042 0.0025 0.0025
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0047 0.0136
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0015 0.0015
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.374 0.344 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0023 0.0023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.076 0.0689 0.2002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0005
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0088 0.0246
Brugia malayi Cathepsin L-like precursor 0.0045 0.0028 0.0081
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0039
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0082 0.0063 0.0062
Schistosoma mansoni lamin 0.0171 0.0144 0.0144
Trypanosoma brucei telomerase reverse transcriptase 0.0088 0.0068 0.0197
Schistosoma mansoni glutaminase 0.0516 0.0463 0.0463
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0021 0.0062
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0027 0.0079
Echinococcus granulosus peregrin 0.0036 0.002 0.002
Toxoplasma gondii hypothetical protein 0.005 0.0033 0.1474
Brugia malayi hypothetical protein 0.0017 0.0002 0.0005
Brugia malayi beta-lactamase 0.011 0.0088 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.025 0.0217 0.0217
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0021 0.0951
Toxoplasma gondii histone lysine methyltransferase SET1 0.005 0.0032 0.146
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0009 0.0017
Schistosoma mansoni lamin 0.0171 0.0144 0.0144
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.002 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0011 0.003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.1643 0.1503 0.1503
Giardia lamblia Rab geranylgeranyltransferase 0.0193 0.0165 0.1004
Entamoeba histolytica cysteine protease, putative 0.0067 0.0049 0.279
Echinococcus multilocularis mothers against decapentaplegic 2 0.0094 0.0073 0.0073
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.005 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0044
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0015 0.0044
Echinococcus multilocularis expressed conserved protein 0.0095 0.0074 0.0074
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0001 0.0002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.002 0.002
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0021 0.1072
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.0066 0.3011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0049 0.0303
Schistosoma mansoni smad1 5 8 and 0.0209 0.018 0.018
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.025 0.0217 1
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0047 0.0136
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.002
Brugia malayi Cathepsin L-like precursor 0.0067 0.0049 0.0141
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0047 0.0136
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0021 0.0021
Echinococcus granulosus cathepsin L cysteine proteinase 0.0067 0.0049 0.0048
Giardia lamblia PHD finger protein 15 0.0029 0.0013 0.0061
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.025 0.0217 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.076 0.0689 0.2002
Loa Loa (eye worm) hypothetical protein 0.0147 0.0122 0.0354
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.374 0.344 1
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.005 0.0033 0.0095
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0066 0.103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0003 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0028
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.002 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0002 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0009 0.0053
Mycobacterium ulcerans bacterioferritin BfrB 0.0051 0.0034 0.0088
Schistosoma mansoni rotamase 0.0034 0.0018 0.0018
Loa Loa (eye worm) blistered cuticle protein 3 0.0687 0.0621 0.1805
Schistosoma mansoni hypothetical protein 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0009
Brugia malayi MH2 domain containing protein 0.0094 0.0073 0.0212
Trichomonas vaginalis ferritin, putative 0.0051 0.0034 0.0209
Brugia malayi Telomerase reverse transcriptase 0.0235 0.0203 0.0591
Mycobacterium tuberculosis Conserved protein 0.011 0.0088 0.1374
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0009 0.0053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0035 0.0019 0.0018
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0055 0.0345
Brugia malayi TAR-binding protein 0.0065 0.0047 0.0136
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0004 0.0012
Echinococcus granulosus cathepsin l1 0.0045 0.0028 0.0028
Brugia malayi glutaminase DH11.1 0.0516 0.0463 0.1346
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0051 0.0034 0.0517
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0011 0.0446
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0004 0.0004
Brugia malayi PXA domain containing protein 0.0019 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0079 0.006 0.0173
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0007 0.002
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.005 0.0033 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0009 0.0053
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0066 0.3011
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0127 0.0369
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0017 0.0758
Echinococcus granulosus smad 0.0209 0.018 0.018
Brugia malayi isocitrate dehydrogenase 0.0016 0.0001 0.0002
Schistosoma mansoni cpg binding protein 0.0024 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0019 0.0118
Brugia malayi Intermediate filament tail domain containing protein 0.0171 0.0144 0.0418
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0001 0.0001
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.005 0.0033 0.0033
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0003 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0047 0.0047
Leishmania major cysteine peptidase A (CPA) 0.0067 0.0049 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0025 0.0156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0049 0.0303
Echinococcus multilocularis cathepsin L cysteine protease 0.0067 0.0049 0.0048
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0193 0.0165 0.0165
Brugia malayi ecdysteroid receptor 0.0031 0.0015 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0028 0.0175
Brugia malayi hypothetical protein 0.0145 0.012 0.035
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0067 0.0419
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0004 0.0012
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0019 0.0055
Giardia lamblia DINP protein human, muc B family 0.0039 0.0023 0.012
Schistosoma mansoni thyroid hormone receptor 0.0299 0.0263 0.0263
Trypanosoma cruzi cysteine peptidase, putative 0.0256 0.0223 0.0647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Plasmodium falciparum phd finger protein, putative 0.0029 0.0013 0.0582
Loa Loa (eye worm) hypothetical protein 0.0033 0.0017 0.0048
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.0209 0.018 0.0523
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0051 0.0034 0.0517
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.0033 0.0095
Trichomonas vaginalis esterase, putative 0.011 0.0088 0.0547
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0004 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0017 0.0105
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0021 0.013
Onchocerca volvulus 0.0145 0.012 0.1937
Entamoeba histolytica hypothetical protein 0.0019 0.0004 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0015 0.0015
Brugia malayi MH1 domain containing protein 0.0209 0.018 0.0523
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.011 0.0088 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0888 0.0807 0.2344
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0075 0.317
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.042 0.0375 0.1089
Schistosoma mansoni Smad4 0.0094 0.0073 0.0073
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0004 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0019 0.0053
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0004 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0019 0.0922
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0 0.000007069
Echinococcus multilocularis mothers against decapentaplegic 5 0.0209 0.018 0.018
Echinococcus multilocularis GPCR, family 2 0.0241 0.0209 0.0209
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0209 0.018 0.018
Onchocerca volvulus 0.011 0.0088 0.1413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0044
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.025 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0193 0.0165 0.0478
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.002
Schistosoma mansoni patched 1 0.1583 0.1448 0.1448
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0023 0.0066
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.025 0.0217 0.0621
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0001 0.0002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0015 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0009 0.0017
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0009 0.0017
Loa Loa (eye worm) acetyltransferase 0.0297 0.0261 0.0758
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0323 0.0285 0.4587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0017 0.0105
Entamoeba histolytica hypothetical protein 0.0108 0.0086 0.5107
Plasmodium vivax hypothetical protein, conserved 0.011 0.0088 0.4027
Echinococcus granulosus histone acetyltransferase KAT2B 0.0289 0.0253 0.0253
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0019 0.0053
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0021 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0002 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0 0.0001
Plasmodium vivax glutathione reductase, putative 0.0038 0.0021 0.0951
Schistosoma mansoni hypothetical protein 0.052 0.0467 0.0466
Echinococcus granulosus expressed protein 0.0051 0.0034 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0015 0.0015
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0004 0.0004
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0004 0.0028
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0462 0.0413 0.257
Toxoplasma gondii RNA-directed DNA polymerase 0.0088 0.0068 0.311
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0086 0.0066 0.2734
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 0.0049 0.0303
Onchocerca volvulus 0.0024 0.0009 0.0144
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0013 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0019 0.0922
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0067 0.0049 0.0303
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0015 0.0015
Plasmodium falciparum cysteine proteinase falcipain 3 0.0067 0.0049 0.2208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0015 0.0044
Echinococcus granulosus cathepsin L 0.0035 0.0019 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0033 0.0095
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0021 0.013
Schistosoma mansoni hypothetical protein 0.0042 0.0025 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0013 0.0081
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0028 0.0175
Brugia malayi Heterochromatin protein 1 0.0074 0.0055 0.016
Echinococcus granulosus expressed protein 0.0034 0.0018 0.0018
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0011 0.0446
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1754 0.1607 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0021 0.013
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0015 0.0015
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0002 0.0002
Echinococcus granulosus geminin 0.0335 0.0296 0.0296
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0158 0.0158
Plasmodium vivax unspecified product 0.0022 0.0007 0.0286
Onchocerca volvulus 0.0067 0.0049 0.078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Plasmodium vivax telomerase reverse transcriptase, putative 0.0088 0.0068 0.311
Echinococcus granulosus chromobox protein 1 0.0074 0.0055 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0033 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0 0.0001
Echinococcus granulosus cathepsin l cysteine peptidase 0.0067 0.0049 0.0048
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0015 0.0245
Loa Loa (eye worm) MH2 domain-containing protein 0.3074 0.2825 0.8213
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0094 0.0073 0.0212
Echinococcus multilocularis survival motor neuron protein 1 0.0745 0.0674 0.0674
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0462 0.0413 0.12
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0066 0.103
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0021 0.0133
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0015 0.0044
Brugia malayi hypothetical protein 0.0108 0.0086 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0047 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0009 0.0053
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0027 0.0079
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0009 0.0337
Echinococcus granulosus mothers against decapentaplegic 5 0.0209 0.018 0.018
Mycobacterium ulcerans hypothetical protein 0.011 0.0088 0.0246
Leishmania major telomerase reverse transcriptase, putative 0.0088 0.0068 0.0197
Echinococcus granulosus mothers against decapentaplegic 2 0.0094 0.0073 0.0073
Leishmania major mitochondrial DNA polymerase beta 0.0888 0.0807 0.2344
Echinococcus granulosus cathepsin L cysteine protease 0.0035 0.0019 0.0018
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0066 0.103
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0004 0.0012
Echinococcus multilocularis mothers against decapentaplegic 6 0.0094 0.0073 0.0073
Echinococcus multilocularis cathepsin L cysteine protease 0.0067 0.0049 0.0048
Plasmodium vivax vivapain-1 0.0035 0.0019 0.0816
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0003 0.0016
Schistosoma mansoni hypothetical protein 0.0335 0.0296 0.0296
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0051 0.0034 0.118
Schistosoma mansoni hypothetical protein 0.0152 0.0127 0.0127
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0066 0.103
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0067 0.0049 0.0141
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0015 0.0044
Echinococcus multilocularis cpg binding protein 0.0024 0.0008 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0468 0.0418 0.6596
Schistosoma mansoni ferritin 0.0051 0.0034 0.0033
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0193 0.0165 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0268 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.025 0.0217 0.063
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.0023
Leishmania major trypanothione reductase 0.0038 0.0021 0.0062
Echinococcus granulosus protein prenyltransferase alpha subunit 0.005 0.0033 0.0033
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.374 0.344 0.344
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0004 0.0004
Schistosoma mansoni Smad4 0.0094 0.0073 0.0073
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Schistosoma mansoni survival motor neuron protein 0.0152 0.0127 0.0127
Brugia malayi Cathepsin L-like precursor 0.0022 0.0007 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0462 0.0413 0.257
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0007 0.002
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0028 0.0449
Toxoplasma gondii exonuclease III APE 0.0019 0.0004 0.0129
Brugia malayi MH2 domain containing protein 0.3074 0.2825 0.8213
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0035 0.0019 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0003 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0019 0.0053
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0341 0.0302 0.0877
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0003 0.0016
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.008 0.0233
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0021 0.013
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0028 0.0175
Brugia malayi cytoplasmic intermediate filament protein 0.0091 0.0071 0.0206
Echinococcus multilocularis expressed protein 0.0051 0.0034 0.0033
Schistosoma mansoni alpha-glucosidase 0.0144 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.002
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0004
Schistosoma mansoni cellular tumor antigen P53 0.0464 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0009 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.005 0.0033 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0009 0.0053
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0004 0.0004
Leishmania major ferric reductase, putative 0.0341 0.0302 0.0877
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.0165 0.1025
Loa Loa (eye worm) hypothetical protein 0.011 0.0088 0.0255
Trichomonas vaginalis glucosylceramidase, putative 0.0319 0.0281 0.1751
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0053 0.0036 0.0104
Leishmania major cathepsin L-like protease 0.0067 0.0049 0.0141
Loa Loa (eye worm) intermediate filament protein 0.0171 0.0144 0.0418
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0017 0.005
Brugia malayi Papain family cysteine protease containing protein 0.0067 0.0049 0.0141
Brugia malayi hypothetical protein 0.0019 0.0004 0.0012
Echinococcus multilocularis peregrin 0.0036 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0319 0.0281 0.1751
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0009 0.0026
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0066 0.103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 0.0223 0.0647
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0067 0.0049 0.2208
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0027 0.0079
Echinococcus granulosus lamin 0.0171 0.0144 0.0144
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0004 0.0012
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0125 0.0102 0.0295
Loa Loa (eye worm) hypothetical protein 0.0745 0.0674 0.196
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0015 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.0158 0.0158
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0004 0.0004
Echinococcus multilocularis protein dispatched 1 0.1589 0.1454 0.1454
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0044
Mycobacterium ulcerans hypothetical protein 0.0024 0.0009 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0021 0.006
Echinococcus granulosus neuropeptide s receptor 0.0454 0.0406 0.0405
Loa Loa (eye worm) hypothetical protein 0.0346 0.0306 0.0889
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0075 0.1171
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0028
Schistosoma mansoni hypothetical protein 0.0241 0.0209 0.0209
Brugia malayi glutathione reductase 0.0038 0.0021 0.0062
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.025 0.0217 0.0621
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0241 0.0209 0.0209
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.374 0.344 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0003 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0014 0.0086
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0004 0.0004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.0158 0.0459
Echinococcus multilocularis geminin 0.0335 0.0296 0.0296
Leishmania major cathepsin L-like protease 0.0067 0.0049 0.0141
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0004 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Leishmania major DNA polymerase eta, putative 0.0066 0.0047 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.0266 0.1658
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0015 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0023 0.0057
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0164 0.0138 0.2159
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0015 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.1583 0.1448 0.9015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Onchocerca volvulus 0.0067 0.0049 0.078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0015 0.0044
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.008 0.4751
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0268 0.0234 0.0234
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0017 0.005
Echinococcus multilocularis Smad4 0.0209 0.018 0.018
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0088 0.0547
Echinococcus granulosus muscleblind protein 0.0147 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0268 0.0234 0.0234
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0018 0.0052
Schistosoma mansoni smad1 5 8 and 0.0209 0.018 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0171 0.0144 0.0418
Loa Loa (eye worm) nuclear factor I 0.0116 0.0094 0.0271
Toxoplasma gondii hypothetical protein 0.0143 0.0119 0.5458
Loa Loa (eye worm) hypothetical protein 0.0082 0.0063 0.0181
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0067 0.3071
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0297 0.0261 0.0261
Brugia malayi chromobox protein homolog 3 0.0042 0.0025 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0012 0.0033
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0004 0.0012
Mycobacterium tuberculosis Conserved protein 0.011 0.0088 0.1374
Echinococcus granulosus expressed protein 0.0377 0.0334 0.0334
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0004 0.001
Echinococcus multilocularis expressed protein 0.0377 0.0334 0.0334
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.005 0.0033 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0023 0.0066
Echinococcus granulosus chromobox protein 1 0.0074 0.0055 0.0055
Echinococcus granulosus dnaJ subfamily B 0.0319 0.0281 0.0281
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0047 0.0136
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0015 0.0044
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0101 0.008 0.0233
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.374 0.344 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0001 0.0002
Leishmania major protein farnesyltransferase alpha subunit, putative 0.005 0.0033 0.0095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0012
Schistosoma mansoni chromobox protein 0.0074 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0015 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0015 0.0044
Echinococcus granulosus Niemann Pick C1 protein 0.1684 0.1542 0.1542
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0047 0.0047
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0049 0.0303
Leishmania major DNA polymerase eta, putative 0.0038 0.0022 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0019 0.0115
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0015 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0015 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0003 0.0016
Plasmodium falciparum glutathione reductase 0.0038 0.0021 0.0951
Entamoeba histolytica cysteine protease, putative 0.0035 0.0019 0.0922

Activities

Activity type Activity value Assay description Source Reference
Cellular reversion (functional) = 80 % Percentage cellular reversion of H-ras transformed Rat-1 cells at 100 nM ChEMBL. 15780629
IC50 (binding) = 2.8 nM Inhibition of human farnesyltransferase ChEMBL. 15780629

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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