Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0081 | 0.506 | 0.506 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0043 | 0.2384 | 0.2384 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1973 | 0.1973 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.2684 | 0.3066 |
Echinococcus multilocularis | lamin | 0.0081 | 0.506 | 0.578 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.506 | 0.506 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.2684 | 0.3066 |
Onchocerca volvulus | 0.0081 | 0.506 | 1 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.8754 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.2684 | 0.3333 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.6614 | 0.7555 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.2684 | 0.3066 |
Echinococcus multilocularis | musashi | 0.0081 | 0.506 | 0.578 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.8052 | 0.9197 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.2684 | 0.3066 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0133 | 0.8754 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0039 | 0.2078 | 0.2581 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4954 | 0.4954 |
Schistosoma mansoni | intermediate filament proteins | 0.0081 | 0.506 | 0.578 |
Schistosoma mansoni | lamin | 0.0081 | 0.506 | 0.578 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.015 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0081 | 0.506 | 0.578 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.7561 | 0.7561 |
Onchocerca volvulus | 0.0081 | 0.506 | 1 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.7561 | 0.7561 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.2684 | 0.3333 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.2684 | 0.3066 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.2684 | 0.2684 |
Echinococcus granulosus | intermediate filament protein | 0.0081 | 0.506 | 0.6284 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0043 | 0.2384 | 0.2384 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.2684 | 0.3066 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.8052 | 0.9197 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2078 | 0.2078 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.2684 | 0.2684 |
Echinococcus multilocularis | lamin dm0 | 0.0081 | 0.506 | 0.578 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.8052 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0103 | 0.6614 | 0.6614 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0081 | 0.506 | 0.506 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.2684 | 0.3333 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2684 | 0.2684 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.2684 | 0.3066 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1973 | 0.1973 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.2684 | 0.2684 |
Echinococcus granulosus | lamin | 0.0081 | 0.506 | 0.6284 |
Echinococcus granulosus | lamin dm0 | 0.0081 | 0.506 | 0.6284 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.015 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.8754 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0081 | 0.506 | 0.506 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.7561 | 0.7561 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0039 | 0.2078 | 0.2374 |
Brugia malayi | intermediate filament protein | 0.0081 | 0.506 | 0.506 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.6614 | 0.6614 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.