TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 395.458 | Formula: C20H25N7O2
H donors: 2 H acceptors: 3 LogP: 2.45 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nc(nn1c1ccccn1)Nc1ccc(cc1)OCCCN1CCOCC1
InChi: 1S/C20H25N7O2/c21-19-24-20(25-27(19)18-4-1-2-9-22-18)23-16-5-7-17(8-6-16)29-13-3-10-26-11-14-28-15-12-26/h1-2,4-9H,3,10-15H2,(H3,21,23,24,25)
InChiKey: NIPJQRGYPGKSQY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fms-related tyrosine kinase 3	Starlite/ChEMBL	References
Homo sapiens	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	Get druggable targets OG5_132967	All targets in OG5_132967

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	beta-lactamase	0.0035	0.0364	0.1052
Leishmania major	cathepsin L-like protease	0.0016	0.0082	0.0797
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0771	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0012	0.0022	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0082	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0063
Loa Loa (eye worm)	TAR-binding protein	0.0125	0.1735	0.5016
Onchocerca volvulus		0.0016	0.0082	0.1419
Leishmania major	hypothetical protein, conserved	0.0035	0.0364	0.4564
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0567	0.1639
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0527	0.8862
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0364	0.1052
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0063
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0082	0.0236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0067	0.0195
Brugia malayi	Cathepsin L-like precursor	0.0011	0	0.0001
Echinococcus granulosus	roundabout 2	0.0037	0.0404	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0364	0.1052
Brugia malayi	beta-lactamase family protein	0.0035	0.0364	0.1052
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Brugia malayi	RNA recognition motif domain containing protein	0.0125	0.1735	0.5016
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0082	0.1541
Echinococcus granulosus	cathepsin l1	0.0016	0.0082	0.0082
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0364	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0239	0.3459	1
Onchocerca volvulus		0.0012	0.0022	0.038
Schistosoma mansoni	hypothetical protein	0.0015	0.0067	0.0202
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1735	0.5209
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0067	0.0195
Onchocerca volvulus		0.0016	0.0082	0.1419
Echinococcus granulosus	neuroglian	0.0037	0.0404	0.0404
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0364	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0011	0	0.0001
Toxoplasma gondii	ABC1 family protein	0.0035	0.0364	0.6001
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0012	0.0022	0.0066
Brugia malayi	acetyltransferase, GNAT family protein	0.0155	0.2185	0.6316
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Brugia malayi	beta-lactamase family protein	0.0035	0.0364	0.1052
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0082	0.1541
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.023	0.333	0.9629
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0527	0.8862
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0082	0.1541
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0082	0.173
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0592	1
Plasmodium vivax	vivapain-2	0.0016	0.0082	0.1048
Brugia malayi	TAR-binding protein	0.0125	0.1735	0.5016
Onchocerca volvulus		0.0016	0.0082	0.1419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0527	0.0527
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0082	0.0236
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.3207	1
Brugia malayi	RNA binding protein	0.0125	0.1735	0.5016
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0012	0.0022	0.0406
Schistosoma mansoni	hypothetical protein	0.0033	0.0336	0.1008
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0082	0.1419
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0037	0.0404	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0364	0.1052
Schistosoma mansoni	nephrin	0.0037	0.0404	0.1214
Onchocerca volvulus		0.0011	0	0.0008
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0364	0.1052
Brugia malayi	hypothetical protein	0.0037	0.0404	0.1169
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0012	0.0022	0.0406
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0041	0.0456	0.1318
Onchocerca volvulus		0.0049	0.0575	1
Echinococcus multilocularis	tar DNA binding protein	0.0125	0.1735	0.5016
Trichomonas vaginalis	esterase, putative	0.0035	0.0364	0.6902
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0364	0.6902
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0771	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0364	0.6902
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0067	0.0067
Echinococcus granulosus	defective proboscis extension response	0.0037	0.0404	0.0404
Toxoplasma gondii	cathepsin CPL	0.0016	0.0082	0.1048
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.0456	0.1318
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0404	0.1169
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0082	0.0236
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0082	0.1419
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0567	0.1639
Echinococcus granulosus	survival motor neuron protein 1	0.0239	0.3459	0.3459
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0364	0.6902
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0082	0.0236
Loa Loa (eye worm)	cysteine protease	0.0016	0.0082	0.0236
Onchocerca volvulus		0.0016	0.0082	0.1419
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0	0.0001
Onchocerca volvulus		0.0016	0.0082	0.1419
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0082	0.1048
Echinococcus multilocularis	survival motor neuron protein 1	0.0239	0.3459	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0082	0.1541
Echinococcus multilocularis	roundabout 2	0.0037	0.0404	0.1169
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0067	0.0195
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0037	0.0404	0.1214
Echinococcus multilocularis	aminopeptidase N	0.0012	0.0022	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0404	0.1169
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0567	0.1639
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0063
Brugia malayi	hypothetical protein	0.0106	0.1443	0.4171
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0364	0.6902
Loa Loa (eye worm)	hypothetical protein	0.0011	0	0.0001
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0592	0.7607
Leishmania major	cathepsin L-like protease	0.0016	0.0082	0.0797
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0022
Onchocerca volvulus		0.0012	0.0022	0.038
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0575	0.1663
Onchocerca volvulus		0.0016	0.0082	0.1419
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0082	0.1048
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0364	0.0364
Plasmodium falciparum	histone acetyltransferase GCN5	0.0042	0.0469	0.7852
Brugia malayi	hypothetical protein	0.0032	0.0324	0.0937
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0037	0.0404	0.0404
Schistosoma mansoni	vesicular amine transporter	0.0037	0.0404	0.1214
Brugia malayi	hypothetical protein	0.0012	0.0022	0.0063
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0012	0.0022	0.0066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Onchocerca volvulus		0.0035	0.0364	0.6326
Echinococcus granulosus	twitchin	0.0037	0.0404	0.0404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0082	0.0082
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0336	0.097
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.069	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0011	0	0.0001
Leishmania major	cathepsin L-like protease	0.0016	0.0082	0.0797
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0022	0.0063
Leishmania major	hypothetical protein, conserved	0.005	0.0592	0.7607
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.023	0.333	1
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1735	0.5209
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0082	0.173
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0082	0.0236
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0012	0.0022	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0404	0.1169
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0364	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0067	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0404	0.1169
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0155	0.2185	0.6316
Leishmania major	cathepsin L-like protease	0.0016	0.0082	0.0797
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0364	0.6001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0592	0.7607
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0771	1
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0364	0.1052
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0022
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0082	0.0245
Echinococcus multilocularis	cysteine protease	0.0016	0.0082	0.0236
Brugia malayi	TATA binding protein associated factor	0.0012	0.0022	0.0063
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1735	0.5209
Schistosoma mansoni	hypothetical protein	0.0049	0.0575	0.1727
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0082	0.0236
Onchocerca volvulus		0.0016	0.0082	0.1419
Brugia malayi	follicle stimulating hormone receptor	0.0224	0.323	0.9339
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.0527	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0404	0.1169
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0022	0.0063
Echinococcus multilocularis	cysteine protease	0.0016	0.0082	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0404	0.1169
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0527	0.8862
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0067	0.0195
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0404	0.1169
Brugia malayi	Cathepsin L-like precursor	0.0011	0	0.0001
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0067	0.0195
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0364	0.4564
Onchocerca volvulus		0.0035	0.0364	0.6326
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0082	0.173
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0575	0.1727
Schistosoma mansoni	hypothetical protein	0.0015	0.0067	0.0202
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0082	0.1541
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0364	1
Mycobacterium ulcerans	lipase LipD	0.0035	0.0364	1
Loa Loa (eye worm)	TATA binding protein associated factor	0.0012	0.0022	0.0063
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0082	0.0236
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Loa Loa (eye worm)	ctsf protein	0.0016	0.0082	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0364	0.1052
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0067	0.0067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0364	0.1052
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0336	0.097
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0404	0.1169
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0592	0.7607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0082	0.1541
Echinococcus granulosus	tar DNA binding protein	0.0125	0.1735	0.1735
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Echinococcus multilocularis	neuroglian	0.0037	0.0404	0.1169
Schistosoma mansoni	hypothetical protein	0.0015	0.0067	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0771	1
Onchocerca volvulus		0.0012	0.0022	0.038
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0082	0.0236
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0012	0.0022	0.0063
Entamoeba histolytica	aminopeptidase, putative	0.0012	0.0022	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0063
Brugia malayi	hypothetical protein	0.005	0.0592	0.1711
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0364	0.1052
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0364	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0155	0.2185	0.656
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0082	0.0797
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0125	0.1735	0.5016
Echinococcus granulosus	leukotriene A 4 hydrolase	0.023	0.333	0.333
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0082	0.0082
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0082	0.1541
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0592	1
Echinococcus granulosus	Immunoglobulin	0.0037	0.0404	0.0404
Echinococcus granulosus	GPCR family 2	0.0015	0.0067	0.0067
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0082	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0567	0.1639
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0022
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0012	0.0022	0.0066
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0082	0.1419
Echinococcus granulosus	histone acetyltransferase KAT2B	0.015	0.2119	0.2119
Loa Loa (eye worm)	aminopeptidase N	0.0012	0.0022	0.0063
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0022
Leishmania major	cathepsin L-like protease	0.0062	0.0771	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0224	0.323	0.9339
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.0527	1
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0037	0.0404	0.1214
Leishmania major	cathepsin L-like protease	0.0062	0.0771	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0082	0.1541
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0569	0.1646
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0063
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0082	0.1541
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0082	0.1048
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0	0.0001
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0082	0.0236
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0022	0.0022
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0364	0.5
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.023	0.333	0.9629
Schistosoma mansoni	cell adhesion molecule	0.0037	0.0404	0.1214
Schistosoma mansoni	hypothetical protein	0.0022	0.0175	0.0526
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0175	0.0175
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0082	0.0236
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0364	1
Brugia malayi	hypothetical protein	0.0012	0.0022	0.0063
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0012	0.0022	0.0063
Echinococcus multilocularis	Immunoglobulin	0.0037	0.0404	0.1169
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0364	0.4564
Brugia malayi	Fibronectin type III domain containing protein	0.0037	0.0404	0.1169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0082	0.1541
Onchocerca volvulus		0.0035	0.0364	0.6326
Plasmodium vivax	vivapain-2	0.0016	0.0082	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0404	0.1169
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0592	1
Leishmania major	cathepsin L-like protease	0.0016	0.0082	0.0797
Loa Loa (eye worm)	hypothetical protein	0.005	0.0592	0.1711
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0364	0.6902
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.0469	1
Brugia malayi	cathepsin L-like precursor	0.0011	0	0.0001
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0082	0.0236
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0592	1
Brugia malayi	hypothetical protein	0.0239	0.3459	1
Echinococcus multilocularis	Immunoglobulin	0.0037	0.0404	0.1169
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0082	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0195
Loa Loa (eye worm)	RNA binding protein	0.0125	0.1735	0.5016
Giardia lamblia	Histone acetyltransferase GCN5	0.0042	0.0469	0.5
Trypanosoma cruzi	major cysteine proteinase, putative	0.0048	0.0571	0.7329
Leishmania major	cathepsin L-like protease	0.0062	0.0771	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0082	0.0236
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0364	0.1052
Loa Loa (eye worm)	fibroinase	0.0016	0.0082	0.0236
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0082	0.1541
Echinococcus granulosus	aminopeptidase N	0.0012	0.0022	0.0022
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0175	0.0506
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0022	0.0063
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0082	0.1541
Schistosoma mansoni	hypothetical protein	0.0015	0.0067	0.0202
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1735	0.5209
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0771	1
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0569	0.1646
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0364	0.4564
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1735	0.5209
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0404	0.1169
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0364	0.1092
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0082	0.0236
Loa Loa (eye worm)	acetyltransferase	0.0155	0.2185	0.6316

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 12 nM	Displacement of [33P]ATP from human recombinant FLT3 domain after 20 mins by scintillation counting	ChEMBL.	21970471
Ki (binding)	< 50 nM	Displacement of [33P]ATP from human recombinant c-KIT domain after 20 mins by scintillation counting	ChEMBL.	21970471

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1835751

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1161093