Detailed information for compound 1161102

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 394.47 | Formula: C21H26N6O2
  • H donors: 4 H acceptors: 0 LogP: 0.48 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1cc(ccc1OCCCOc1ccc(cc1N)C1=NCCN1)C1=NCCN1
  • InChi: 1S/C21H26N6O2/c22-16-12-14(20-24-6-7-25-20)2-4-18(16)28-10-1-11-29-19-5-3-15(13-17(19)23)21-26-8-9-27-21/h2-5,12-13H,1,6-11,22-23H2,(H,24,25)(H,26,27)
  • InChiKey: VLOYXVRUCXLBDZ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0154 0.02
Entamoeba histolytica hypothetical protein 0.0147 0.1099 0.3707
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0057 0.1645
Mycobacterium tuberculosis Conserved protein 0.0037 0.0154 0.0643
Loa Loa (eye worm) hypothetical protein 0.0037 0.0154 0.02
Echinococcus granulosus protein kinase shaggy 0.0047 0.0244 0.0241
Echinococcus multilocularis microtubule associated protein 2 0.0777 0.6502 0.6501
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0069 0.0434 0.1152
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0154 0.0643
Loa Loa (eye worm) nuclear receptor nhr-7B 0.006 0.0355 0.0478
Schistosoma mansoni endoplasmin 0.0032 0.0112 0.011
Loa Loa (eye worm) RNA binding protein 0.0865 0.7261 1
Schistosoma mansoni smad1 5 8 and 0.0033 0.012 0.0118
Schistosoma mansoni lamin 0.0053 0.0295 0.0292
Trypanosoma brucei RNA helicase, putative 0.0101 0.0706 0.2125
Echinococcus multilocularis tar DNA binding protein 0.0865 0.7261 0.726
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.0691 0.0943
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0195 0.0671
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0157 1
Echinococcus granulosus lamin 0.0053 0.0295 0.0292
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0388 0.0386
Brugia malayi hypothetical protein 0.0055 0.0308 0.0416
Toxoplasma gondii NAC domain-containing protein 0.0357 0.2903 1
Schistosoma mansoni inositol monophosphatase 0.0042 0.0195 0.0192
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0195 0.0192
Echinococcus multilocularis smad 0.0033 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Loa Loa (eye worm) hypothetical protein 0.0128 0.0934 0.1276
Loa Loa (eye worm) hypothetical protein 0.0036 0.0147 0.0191
Echinococcus granulosus tar DNA binding protein 0.0865 0.7261 0.726
Loa Loa (eye worm) hypothetical protein 0.0053 0.0295 0.0395
Schistosoma mansoni glutaminase 0.0306 0.2465 0.2463
Echinococcus granulosus transcription factor btf3 0.0357 0.2903 0.2901
Echinococcus multilocularis lamin dm0 0.0053 0.0295 0.0292
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0112 0.0387
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0154 1
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0195 0.065
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0308 0.106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0013 0.0011
Brugia malayi MH1 domain containing protein 0.0033 0.012 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1483 0.1481
Schistosoma mansoni hypothetical protein 0.1184 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0069 0.0434 0.0431
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0154 0.0151
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0388 0.0386
Schistosoma mansoni transient receptor potential channel 0.0097 0.067 0.0667
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Giardia lamblia Kinase, CMGC GSK 0.0047 0.0244 1
Schistosoma mansoni transient receptor potential channel 0.0064 0.0388 0.0386
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0128 0.0934 0.0931
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0443 0.044
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0128 0.0934 0.0931
Trypanosoma brucei protein kinase, putative 0.0047 0.0244 0.047
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0244 0.0819
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0057 0.0054
Echinococcus granulosus lamin dm0 0.0053 0.0295 0.0292
Toxoplasma gondii exonuclease III APE 0.0037 0.0154 0.015
Brugia malayi Latrophilin receptor protein 2 0.0099 0.0691 0.0943
Brugia malayi nuclear receptor RXR 0.0067 0.0417 0.0566
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0057 0.0109
Schistosoma mansoni nuclear hormone receptor 0.006 0.0355 0.0352
Onchocerca volvulus Protein ultraspiracle homolog 0.0128 0.0934 0.3633
Loa Loa (eye worm) hypothetical protein 0.0128 0.0934 0.1276
Schistosoma mansoni endoplasmin 0.0032 0.0112 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.1563 0.5372
Echinococcus granulosus ecdysone induced protein 78C 0.0128 0.0934 0.0931
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.0691 0.0941
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0112 0.0387
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0388 0.0386
Schistosoma mansoni thyroid hormone receptor 0.0128 0.0934 0.0931
Brugia malayi nuclear hormone receptor family member nhr-6 0.006 0.0355 0.0481
Plasmodium falciparum heat shock protein 90 0.0032 0.0112 0.0366
Brugia malayi hypothetical protein 0.0138 0.1021 0.1399
Echinococcus granulosus nuclear receptor nhr 48 0.006 0.0355 0.0352
Loa Loa (eye worm) hypothetical protein 0.0037 0.0154 0.02
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1474 0.5068
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0128 0.0934 0.0931
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0154 0.0532
Loa Loa (eye worm) nuclear hormone receptor 0.006 0.0355 0.0478
Loa Loa (eye worm) hypothetical protein 0.0061 0.0361 0.0485
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0195 0.065
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0128 0.0934 0.1279
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0128 0.0934 0.0931
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0244 0.0722
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0154 0.0511
Loa Loa (eye worm) hypothetical protein 0.0164 0.125 0.1711
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0191 0.0188
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.067 0.0667
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0154 0.0152
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0154 0.0203
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0147 0.0145
Loa Loa (eye worm) glutaminase 0.0306 0.2465 0.3387
Schistosoma mansoni hypothetical protein 0.0405 0.3317 0.3316
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0084 0.0081
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0128 0.0934 0.0931
Loa Loa (eye worm) hypothetical protein 0.0097 0.067 0.0912
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0154 0.0643
Schistosoma mansoni smad1 5 8 and 0.0033 0.012 0.0118
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0129 0.0949 0.3181
Schistosoma mansoni tar DNA-binding protein 0.0865 0.7261 0.726
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Giardia lamblia Kinase, CMGC GSK 0.0047 0.0244 1
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0295 0.0398
Loa Loa (eye worm) ICD-1 protein 0.0357 0.2903 0.3992
Mycobacterium leprae Probable lipase LipE 0.0037 0.0154 0.97
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0154 0.0482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1483 0.1481
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0191 0.0281
Echinococcus granulosus heat shock protein 0.0032 0.0112 0.011
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0069 0.0434 0.0431
Schistosoma mansoni transcription factor btf3 0.0357 0.2903 0.2901
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0128 0.0934 0.0931
Schistosoma mansoni hypothetical protein 0.0041 0.0189 0.0186
Loa Loa (eye worm) hypothetical protein 0.0067 0.0417 0.0563
Loa Loa (eye worm) hypothetical protein 0.0067 0.0417 0.0563
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.012 0.0118
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0013 0.0011
Schistosoma mansoni hypothetical protein 0.0099 0.0691 0.0688
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0069 0.0434 0.1495
Echinococcus multilocularis cpg binding protein 0.0063 0.0375 0.0372
Schistosoma mansoni hypothetical protein 0.0215 0.168 0.1678
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0865 0.7261 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0128 0.0934 0.0931
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0154 0.0201
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0112 0.0264
Loa Loa (eye worm) hypothetical protein 0.0037 0.0154 0.02
Brugia malayi hypothetical protein 0.0147 0.1099 0.1507
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0157 0.0663
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.067 0.0667
Schistosoma mansoni tar DNA-binding protein 0.0865 0.7261 0.726
Brugia malayi Bromodomain containing protein 0.0043 0.0208 0.0278
Trypanosoma cruzi transcription factor btf3, putative 0.0357 0.2903 1
Loa Loa (eye worm) glutaminase 2 0.0306 0.2465 0.3387
Brugia malayi photoreceptor-specific nuclear receptor 0.0128 0.0934 0.1279
Echinococcus multilocularis zinc finger protein 0.0025 0.0055 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0128 0.0934 0.1276
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0191 0.0538
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2332 0.8028
Brugia malayi nuclear receptor NHR-88 0.0128 0.0934 0.1279
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0059 0.0056
Echinococcus multilocularis musashi 0.0053 0.0295 0.0292
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0154 0.0529
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0128 0.0934 0.0931
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0128 0.0934 0.1279
Brugia malayi hypothetical protein 0.0067 0.0417 0.0566
Schistosoma mansoni nuclear receptor nhr-48 0.006 0.0355 0.0352
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2332 0.8028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0128 0.0934 0.1276
Echinococcus multilocularis lamin 0.0053 0.0295 0.0292
Schistosoma mansoni smad 0.0033 0.012 0.0118
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0271 0.0365
Onchocerca volvulus 0.0047 0.0244 0.0838
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0057 0.0195
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0878 0.0876
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1474 0.5068
Onchocerca volvulus 0.0037 0.0154 0.0474
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0128 0.0934 0.0931
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0799 0.6692 0.9216
Loa Loa (eye worm) hypothetical protein 0.0799 0.6692 0.9216
Loa Loa (eye worm) hypothetical protein 0.0311 0.2506 0.3444
Schistosoma mansoni cpg binding protein 0.0063 0.0375 0.0372
Schistosoma mansoni hypothetical protein 0.0147 0.1099 0.1097
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0328 0.0441
Loa Loa (eye worm) hypothetical protein 0.0043 0.0209 0.0276
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Onchocerca volvulus 0.006 0.0355 0.1289
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0355 0.0352
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0128 0.0934 0.1276
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2332 0.8028
Toxoplasma gondii ABC1 family protein 0.0037 0.0154 0.0148
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0154 0.0511
Echinococcus granulosus zinc finger protein 0.0025 0.0055 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1474 0.5068
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0112 0.0387
Mycobacterium ulcerans hypothetical protein 0.0037 0.0154 0.0482
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0067 0.0417 0.0414
Echinococcus granulosus smad 0.0033 0.012 0.0118
Echinococcus granulosus dnaJ subfamily B 0.0405 0.3317 0.3316
Schistosoma mansoni steroid hormone receptor ad4bp 0.0128 0.0934 0.0931
Brugia malayi Nuclear hormone receptor E75 0.006 0.0355 0.0481
Schistosoma mansoni cpg binding protein 0.0057 0.0328 0.0326
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0154 0.0511
Brugia malayi Inositol-1 0.0042 0.0195 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0357 0.2903 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0128 0.0934 0.0931
Brugia malayi Calcitonin receptor-like protein seb-1 0.0314 0.2533 0.3483
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Schistosoma mansoni inositol monophosphatase 0.0042 0.0195 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0128 0.0934 0.1279
Schistosoma mansoni hypothetical protein 0.0101 0.0706 0.0703
Echinococcus multilocularis protein kinase shaggy 0.0047 0.0244 0.0241
Schistosoma mansoni hypothetical protein 0.0099 0.0691 0.0688
Leishmania major hypothetical protein, conserved 0.0037 0.0154 0.0408
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.1563 0.5372
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0154 0.0643
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0128 0.0934 0.0931
Trichomonas vaginalis conserved hypothetical protein 0.0357 0.2903 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0195 0.0551
Loa Loa (eye worm) TAR-binding protein 0.0865 0.7261 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0154 0.0509
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0128 0.0934 0.0931
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1474 0.5068
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0154 0.0643
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0154 0.0509
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0185 0.0182
Brugia malayi MH2 domain containing protein 0.0033 0.012 0.0157
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.012 0.0118
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.1855 1
Schistosoma mansoni heat shock protein 0.0032 0.0112 0.011
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0355 0.0352
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0138 0.1021 0.1396
Loa Loa (eye worm) steroid hormone receptor 0.0128 0.0934 0.1276
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.1961 0.1958
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0128 0.0934 0.0931
Onchocerca volvulus 0.0053 0.0295 0.1046
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0047 0.0244 0.0324
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0642 0.064
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1474 0.5068
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0128 0.0934 0.1279
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.0949 0.2996
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0057 0.0173
Toxoplasma gondii isocitrate dehydrogenase 0.0069 0.0434 0.1152
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0308 0.07
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2332 0.8028
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0057 0.0173
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0154 0.0647
Brugia malayi hypothetical protein 0.0067 0.0417 0.0566
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0129 0.0949 0.0946
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.006 0.0355 0.0352
Onchocerca volvulus Huntingtin homolog 0.0138 0.1021 0.3987
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0154 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2332 0.8028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0128 0.0934 0.0931
Loa Loa (eye worm) inositol-1 0.0042 0.0195 0.0257
Echinococcus granulosus muscleblind protein 0.0164 0.125 0.1247
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.3317 0.3316
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0154 0.0204
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0067 0.0417 0.0563
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0129 0.0949 0.0946
Brugia malayi beta-NAC-like protein 0.0357 0.2903 0.3994
Brugia malayi tailless protein 0.006 0.0355 0.0481
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.1099 0.1097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1483 0.1481
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.0057
Schistosoma mansoni survival motor neuron protein 0.005 0.0271 0.0268
Schistosoma mansoni smad1 5 8 and 0.0033 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0215 0.168 0.2305
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0083 0.0102
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Echinococcus multilocularis muscleblind protein 0.0164 0.125 0.1247
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0067 0.0417 0.0414
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0191 0.0637
Loa Loa (eye worm) beta-lactamase 0.0037 0.0154 0.02
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0128 0.0934 0.1279
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0244 0.0722
Mycobacterium tuberculosis Conserved protein 0.0037 0.0154 0.0643
Schistosoma mansoni tar DNA-binding protein 0.0865 0.7261 0.726
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0154 0.0411
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0417 0.0566
Echinococcus multilocularis isocitrate dehydrogenase 0.0069 0.0434 0.0431
Loa Loa (eye worm) hypothetical protein 0.0051 0.0278 0.0371
Loa Loa (eye worm) hypothetical protein 0.0128 0.0934 0.1276
Loa Loa (eye worm) hypothetical protein 0.0052 0.0287 0.0384
Loa Loa (eye worm) endoplasmin 0.0032 0.0112 0.0143
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0047 0.0244 0.0241
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0295 0.0395
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0128 0.0934 0.3633
Schistosoma mansoni bromodomain containing protein 0.0074 0.0477 0.0475
Onchocerca volvulus 0.0037 0.0154 0.0474
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0154 0.0643
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0128 0.0934 0.1279
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0069 0.0434 0.0431
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0154 0.0509
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0191 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0128 0.0934 0.1279
Loa Loa (eye worm) nuclear receptor NHR-67 0.006 0.0355 0.0478
Brugia malayi steroid hormone receptor 0.0128 0.0934 0.1279
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0154 0.5229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.1099 0.1097
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0195 0.0192
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0185 0.0182
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Brugia malayi TAR-binding protein 0.0865 0.7261 1
Entamoeba histolytica hypothetical protein 0.0147 0.1099 0.3707
Onchocerca volvulus 0.0037 0.0154 0.0474
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.006 0.0355 0.0352
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0084 0.0081
Plasmodium vivax basic transcription factor 3b, putative 0.0357 0.2903 1
Brugia malayi intermediate filament protein 0.0053 0.0295 0.0398
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0154 0.0509
Brugia malayi conserved hypotetical protein 0.006 0.0355 0.0481
Echinococcus multilocularis heat shock protein 90 0.0025 0.0057 0.0054
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0191 0.0538
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.006 0.0355 0.0481
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Entamoeba histolytica hypothetical protein 0.0357 0.2903 1
Echinococcus multilocularis muscleblind protein 1 0.0164 0.125 0.1247
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0154 0.0152
Schistosoma mansoni cpg binding protein 0.0063 0.0375 0.0372
Plasmodium falciparum glycogen synthase kinase 3 0.0047 0.0244 0.0819
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0069 0.0434 0.1386
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.012 0.0118
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Brugia malayi nuclear hormone receptor 0.006 0.0355 0.0481
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0584 0.485 0.4848
Echinococcus multilocularis FTZ F1 alpha 0.0128 0.0934 0.0931
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0291 0.2332 0.3204
Loa Loa (eye worm) MH2 domain-containing protein 0.0483 0.3984 0.5482
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Echinococcus multilocularis heat shock protein 0.0032 0.0112 0.011
Loa Loa (eye worm) hypothetical protein 0.008 0.0521 0.0707
Brugia malayi heat shock protein 90 0.0032 0.0112 0.0146
Brugia malayi nuclear hormone receptor family member odr-7 0.006 0.0355 0.0481
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0417 0.0566
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0057 0.0069
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Brugia malayi glutaminase DH11.1 0.0306 0.2465 0.339
Brugia malayi orphan nuclear receptor NR2E1 0.006 0.0355 0.0481
Loa Loa (eye worm) DR-78 0.006 0.0355 0.0478
Loa Loa (eye worm) isocitrate dehydrogenase 0.0069 0.0434 0.0587
Mycobacterium ulcerans glutaminase 0.0306 0.2465 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.006 0.0355 0.0352
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0057 0.0173
Onchocerca volvulus 0.0053 0.0295 0.1046
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0191 0.0637
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.012 0.0154
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.067 0.0667
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0112 0.0366
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.0949 0.3268
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0388 0.0386
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1474 0.5068
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0128 0.0934 0.0931
Schistosoma mansoni transient receptor potential channel 0.0064 0.0388 0.0386
Schistosoma mansoni zinc finger protein 0.0025 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0039
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0191 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0128 0.0934 0.1279
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0154 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0154 0.0148
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.012 0.0118
Brugia malayi intracellular kinase 0.0047 0.0244 0.0327
Loa Loa (eye worm) hypothetical protein 0.0067 0.0417 0.0563
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0069 0.0434 0.1152
Schistosoma mansoni Smad4 0.0033 0.012 0.0118
Echinococcus multilocularis endoplasmin 0.0025 0.0057 0.0054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0154 0.0643
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0642 0.064
Brugia malayi Bromodomain containing protein 0.0088 0.059 0.0805
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Echinococcus multilocularis transcription factor btf3 0.0357 0.2903 0.2901
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.006 0.0355 0.0352
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0865 0.7261 0.726
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0191 0.0188
Schistosoma mansoni lamin 0.0053 0.0295 0.0292
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0129 0.0949 0.1296
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0112 0.0264
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0128 0.0934 0.0931
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.006 0.0355 0.0352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1483 0.1481
Schistosoma mansoni nuclear receptor 0.006 0.0355 0.0352
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.012 0.0118
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0067 0.0417 0.0563
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0154 0.015
Brugia malayi isocitrate dehydrogenase 0.0069 0.0434 0.059
Brugia malayi nuclear hormone receptor 0.0128 0.0934 0.1279
Echinococcus granulosus endoplasmin 0.0025 0.0057 0.0054
Brugia malayi Smad1 0.0033 0.012 0.0157
Loa Loa (eye worm) hypothetical protein 0.0128 0.0934 0.1276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0154 0.02
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0195 0.0551
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0191 0.0188
Loa Loa (eye worm) hypothetical protein 0.0033 0.012 0.0153
Onchocerca volvulus 0.006 0.0355 0.1289
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0129 0.0949 0.3181
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0059 0.0056
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0195 0.0671
Brugia malayi beta-lactamase family protein 0.0037 0.0154 0.0203
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0069 0.0434 0.1152
Onchocerca volvulus Huntingtin homolog 0.0138 0.1021 0.3987
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0128 0.0934 0.1279
Brugia malayi MH1 domain containing protein 0.0033 0.012 0.0157
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0047 0.0244 0.0241
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.0949 0.3268
Loa Loa (eye worm) hypothetical protein 0.0067 0.0417 0.0563
Schistosoma mansoni coup transcription factor 0.0128 0.0934 0.0931
Brugia malayi hypothetical protein 0.0311 0.2506 0.3446
Echinococcus granulosus heat shock protein 90 0.0025 0.0057 0.0054
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.0691 0.0688
Schistosoma mansoni nuclear receptor 0.006 0.0355 0.0352
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0308 0.104
Onchocerca volvulus 0.005 0.0271 0.0949
Echinococcus granulosus intermediate filament protein 0.0053 0.0295 0.0292
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0083 0.0106
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0047 0.0244 0.0722
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0191 0.0657
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0191 0.7174
Echinococcus multilocularis thyroid hormone receptor alpha 0.0128 0.0934 0.0931
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0195 1
Schistosoma mansoni ap endonuclease 0.0037 0.0154 0.0152
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.012 0.0154
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0355 0.0352
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0195 0.0295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0128 0.0934 0.1279
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0069 0.0434 0.1495
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0154 0.0529
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0067 0.0417 0.0414
Brugia malayi latrophilin 2 splice variant baaae 0.0215 0.168 0.2307
Schistosoma mansoni nuclear hormone receptor 0.006 0.0355 0.0352
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0129 0.0949 0.0946
Entamoeba histolytica hypothetical protein 0.0147 0.1099 0.3707
Brugia malayi Endoplasmin precursor 0.0032 0.0112 0.0146
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0147 0.0195
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0047 0.0244 0.084
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0047 0.0244 0.0241
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0013 0.0011
Brugia malayi beta-lactamase 0.0037 0.0154 0.0203
Brugia malayi PHD-finger family protein 0.0031 0.0107 0.0138
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0154 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0128 0.0934 0.1276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1483 0.1481
Echinococcus granulosus microtubule associated protein 2 0.0777 0.6502 0.6501
Schistosoma mansoni heat shock protein 0.0032 0.0112 0.011
Loa Loa (eye worm) hypothetical protein 0.0164 0.125 0.1711
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.2332 0.8028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0128 0.0934 0.1276
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0154 0.0643
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.1099 0.1097
Schistosoma mansoni thyroid hormone receptor 0.0128 0.0934 0.0931
Echinococcus multilocularis heat shock protein 90 0.0032 0.0112 0.011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0128 0.0934 0.0931
Echinococcus granulosus GPCR family 2 0.0099 0.0691 0.0688
Brugia malayi RNA binding protein 0.0865 0.7261 1
Echinococcus granulosus transcription factor Dp 1 0.0075 0.0481 0.0478
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0037 0.004
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0154 0.015
Echinococcus multilocularis geminin 0.1184 1 1
Brugia malayi hypothetical protein 0.006 0.0355 0.0481
Onchocerca volvulus Glucosylceramidase homolog 0.0191 0.1474 0.5823
Entamoeba histolytica transcription factor BTF3, putative 0.0357 0.2903 1
Brugia malayi MH2 domain containing protein 0.0033 0.012 0.0157
Echinococcus granulosus cpg binding protein 0.0063 0.0375 0.0372
Schistosoma mansoni ap endonuclease 0.0037 0.0154 0.0152
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0084 0.0081
Brugia malayi ecdysone receptor 0.006 0.0355 0.0481
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0128 0.0934 0.0931
Loa Loa (eye worm) Smad1 0.0033 0.012 0.0154
Mycobacterium ulcerans beta-lactamase 0.0037 0.0154 0.0482
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0069 0.0434 0.0431
Trypanosoma brucei transcription factor BTF3, putative 0.0357 0.2903 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0355 0.0352
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0191 0.0637
Plasmodium falciparum basic transcription factor 3b, putative 0.0357 0.2903 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0013 0.0011
Trypanosoma cruzi transcription factor btf3, putative 0.0357 0.2903 1
Onchocerca volvulus 0.0128 0.0934 0.3633
Loa Loa (eye worm) hypothetical protein 0.0046 0.0231 0.0307
Loa Loa (eye worm) hypothetical protein 0.0037 0.0154 0.02
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0112 0.0143
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0244 0.0819
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0195 0.065
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0191 0.0188
Brugia malayi Nuclear hormone receptor-like 1 0.0128 0.0934 0.1279
Brugia malayi Nuclear hormone receptor E75 0.006 0.0355 0.0481
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0443 0.044
Onchocerca volvulus 0.0057 0.0328 0.1182
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0154 0.0482
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0154 0.0509
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0355 0.0352
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0154 0.0485
Brugia malayi ecdysteroid receptor 0.0128 0.0934 0.1279
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1483 0.1481
Echinococcus multilocularis nuclear receptor nhr 48 0.006 0.0355 0.0352
Echinococcus granulosus heat shock protein 90 0.0032 0.0112 0.011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0128 0.0934 0.1279
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0191 0.0188
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0191 0.0657
Brugia malayi Steroid receptor seven-up type 2 0.0128 0.0934 0.1279
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0112 0.0387
Trichomonas vaginalis esterase, putative 0.0037 0.0154 0.0509
Loa Loa (eye worm) hypothetical protein 0.0128 0.0934 0.1276
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.079 0.2428
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0128 0.0934 0.0931
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0308 0.106
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.0691 0.0688
Schistosoma mansoni nuclear hormone receptor 0.0128 0.0934 0.0931
Trichomonas vaginalis glutaminase, putative 0.0306 0.2465 0.8488
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0112 0.0387
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0128 0.0934 0.1279
Brugia malayi beta-lactamase family protein 0.0037 0.0154 0.0203
Mycobacterium ulcerans lipase LipD 0.0037 0.0154 0.0482
Leishmania major hypothetical protein, conserved 0.0055 0.0308 0.0945
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0128 0.0934 0.1279
Schistosoma mansoni hypothetical protein 0.005 0.0271 0.0268
Schistosoma mansoni tar DNA-binding protein 0.0865 0.7261 0.726
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Mycobacterium tuberculosis Conserved protein 0.0037 0.0154 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0357 0.2903 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.1961 0.2692
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0195 0.0651
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0129 0.0949 0.1299
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0308 0.07
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0355 0.1289
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0047 0.0244 0.0324
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0039
Loa Loa (eye worm) hypothetical protein 0.0055 0.0308 0.0412
Loa Loa (eye worm) hypothetical protein 0.0041 0.0191 0.0251
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0195 0.0295
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1474 0.5068
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0147 0.0145
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0069 0.0434 0.0431
Schistosoma mansoni zinc finger protein 0.006 0.0355 0.0352
Brugia malayi RNA recognition motif domain containing protein 0.0865 0.7261 1
Echinococcus granulosus FTZ F1 alpha 0.0128 0.0934 0.0931
Loa Loa (eye worm) hypothetical protein 0.0099 0.0691 0.0941
Schistosoma mansoni hypothetical protein 0.0099 0.0691 0.0688
Schistosoma mansoni RAR-like nuclear receptor 0.0128 0.0934 0.0931
Brugia malayi hypothetical protein 0.0035 0.0141 0.0186
Entamoeba histolytica hypothetical protein 0.0147 0.1099 0.3707
Entamoeba histolytica protein kinase, putative 0.0047 0.0244 0.0722
Echinococcus multilocularis GPCR, family 2 0.0099 0.0691 0.0688
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0355 0.1289
Brugia malayi MH2 domain containing protein 0.0483 0.3984 0.5483
Schistosoma mansoni hypothetical protein 0.0099 0.0691 0.0688
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0291 0.2332 0.3206
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0308 0.07
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0069 0.0434 0.2185
Brugia malayi nuclear receptor NHR-67 0.006 0.0355 0.0481
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0154 0.0411
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.1483 0.2036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0128 0.0934 0.1276
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0154 0.97
Onchocerca volvulus Bile acid receptor homolog 0.0128 0.0934 0.3633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0128 0.0934 0.1276
Schistosoma mansoni microtubule-associated protein tau 0.0777 0.6502 0.6501
Onchocerca volvulus 0.0311 0.2506 1
Leishmania major heat shock protein 83-1 0.0032 0.0112 0.0264
Schistosoma mansoni hypothetical protein 0.0023 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Echinococcus granulosus Smad4 0.0033 0.012 0.0118
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0049 0.0046
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0057 0.0195
Loa Loa (eye worm) hypothetical protein 0.0128 0.0934 0.1276
Schistosoma mansoni hypothetical protein 0.0025 0.0049 0.0046
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0047 0.0244 0.047
Schistosoma mansoni retinoic acid receptor RXR 0.0128 0.0934 0.0931
Brugia malayi nuclear receptor RXR 0.006 0.0355 0.0481
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0042
Brugia malayi Muscleblind-like protein 0.0164 0.125 0.1714
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0154 0.0151
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0154 0.7085
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.1961 0.1958
Loa Loa (eye worm) hypothetical protein 0.0128 0.0934 0.1276
Loa Loa (eye worm) hypothetical protein 0.0138 0.1021 0.1396
Echinococcus granulosus thyroid hormone receptor alpha 0.006 0.0355 0.0352
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0355 0.0352
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0069 0.0434 0.0431
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.1483 0.2033
Echinococcus multilocularis Smad4 0.0033 0.012 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0128 0.0934 0.0931
Schistosoma mansoni intermediate filament proteins 0.0053 0.0295 0.0292
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0295 0.0395
Plasmodium vivax glycogen synthase kinase 3, putative 0.0047 0.0244 0.047
Toxoplasma gondii isocitrate dehydrogenase 0.0069 0.0434 0.1152
Loa Loa (eye worm) hypothetical protein 0.0037 0.0154 0.02
Brugia malayi CXXC zinc finger family protein 0.0057 0.0328 0.0444
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Brugia malayi Isocitrate dehydrogenase 0.0069 0.0434 0.059
Brugia malayi hypothetical protein 0.006 0.0355 0.0481
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0112 0.2986
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0191 0.0188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1483 0.1481
Echinococcus multilocularis transcription factor Dp 1 0.0075 0.0481 0.0478
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0067 0.0417 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0478
Schistosoma mansoni hypothetical protein 0.1184 1 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0191 0.0188
Brugia malayi hypothetical protein 0.0247 0.1961 0.2694
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0314 0.2533 0.3481
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0069 0.0434 0.1476
Brugia malayi nuclear receptor NHR-88 0.006 0.0355 0.0481
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0584 0.485 0.4848
Leishmania major basic transcription factor 3a, putative 0.0357 0.2903 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0308 0.104
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.0057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0154 0.0532
Loa Loa (eye worm) hypothetical protein 0.0128 0.0934 0.1276
Loa Loa (eye worm) transcription factor SMAD2 0.0483 0.3984 0.5482

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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