TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.521 | Formula: C19H32N10O5
H donors: 7 H acceptors: 7 LogP: -5.42 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: NC(=N)NCCCCN(C[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N)CC[C@@H](C(=O)O)N
InChi: 1S/C19H32N10O5/c20-10(18(32)33)3-6-28(5-2-1-4-24-19(22)23)7-11-13(30)14(31)17(34-11)29-9-27-12-15(21)25-8-26-16(12)29/h8-11,13-14,17,30-31H,1-7,20H2,(H,32,33)(H2,21,25,26)(H4,22,23,24)/t10-,11+,13+,14+,17+/m0/s1
InChiKey: DLOOVRFFQLSQMA-YRGUDCOPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0303	0.1333
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0303	0.1333
Onchocerca volvulus		0.005	0.0428	0.1966
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.0303	0.067
Schistosoma mansoni	high-affinity choline transporter	0.0375	0.42	1
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0428	0.0626
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0119	0.1222	1
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0428	0.0626
Echinococcus granulosus	intermediate filament protein	0.0028	0.0176	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1222	0.291
Loa Loa (eye worm)	MBCTL1	0.0057	0.0508	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0006	0.0014
Schistosoma mansoni	hypothetical protein	0.0172	0.1837	0.4128
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0023	0.0056
Schistosoma mansoni	DNA polymerase eta	0.0039	0.0303	0.0317
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0105	0.1067	0.2122
Schistosoma mansoni	inositol monophosphatase	0.0043	0.035	0.0433
Trypanosoma cruzi	hypothetical protein, conserved	0.0119	0.1222	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0119	0.1222	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0298	0.1134
Schistosoma mansoni	sodium/solute symporter	0.0041	0.0328	0.0378
Trypanosoma brucei	unspecified product	0.0039	0.0303	0.1333
Entamoeba histolytica	hypothetical protein	0.0039	0.0298	0.1134
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0303	0.0014
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0467	0.0724
Toxoplasma gondii	ABC1 family protein	0.0119	0.1222	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0303	0.0125
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.035	0.0624
Echinococcus granulosus	sodium:glucose cotransporter	0.0041	0.0328	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1457	0.347
Entamoeba histolytica	hypothetical protein	0.0039	0.0298	0.1134
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0039	0.0303	0.0014
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0105	0.1067	0.2216
Mycobacterium tuberculosis	Probable lipase LipE	0.0119	0.1222	0.1116
Echinococcus multilocularis	polycomb protein SCMH1	0.005	0.0428	0.0422
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0057	0.0508	0.0502
Loa Loa (eye worm)	hypothetical protein	0.005	0.0428	0.1018
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0105	0.1067	0.1062
Trypanosoma brucei	DNA polymerase eta, putative	0.0039	0.0303	0.1333
Trichomonas vaginalis	inositol monophosphatase, putative	0.0043	0.035	0.0624
Brugia malayi	hypothetical protein	0.0039	0.0298	0.0658
Mycobacterium ulcerans	lipase LipD	0.0119	0.1222	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0119	0.1222	0.1116
Leishmania major	hypothetical protein, conserved	0.0119	0.1222	1
Echinococcus granulosus	SAM and MBT domain containing protein	0.005	0.0428	0.0843
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0053	0.0467	0.1885
Plasmodium vivax	hypothetical protein, conserved	0.0119	0.1222	1
Onchocerca volvulus	Huntingtin homolog	0.0139	0.1457	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0039	0.0303	0.0125
Mycobacterium tuberculosis	Conserved protein	0.0119	0.1222	0.1116
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.0303	0.067
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0176	0.0418
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0292	0.1224
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0205	0.2222	0.2217
Leishmania major	DNA polymerase kappa, putative	0.0039	0.0303	0.0125
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0292	0.0286
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0303	0.1333
Echinococcus granulosus	solute carrier family 5	0.0041	0.0328	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0176	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1222	0.291
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0292	0.0642
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0303	0.1333
Trichomonas vaginalis	penicillin-binding protein, putative	0.0119	0.1222	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0119	0.1222	0.2601
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0303	0.0125
Mycobacterium tuberculosis	Probable hydrolase	0.0119	0.1222	0.1116
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0041	0.0328	0.0643
Echinococcus granulosus	geminin	0.0172	0.1837	0.366
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0467	0.1885
Leishmania major	DNA polymerase eta, putative	0.0039	0.0303	0.0125
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0039	0.0303	0.0722
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0041	0.0328	0.0322
Echinococcus granulosus	histone acetyltransferase MYST2	0.0057	0.0508	0.1003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0303	0.1333
Brugia malayi	MH2 domain containing protein	0.0135	0.1416	0.3335
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0053	0.0467	0.0461
Giardia lamblia	Kinase, CMGC MAPK	0.0053	0.0467	1
Echinococcus granulosus	dna polymerase kappa	0.0039	0.0303	0.0594
Echinococcus granulosus	FTZ F1 alpha	0.0445	0.5008	1
Trypanosoma brucei	hypothetical protein, conserved	0.0119	0.1222	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0298	0.1134
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0053	0.0467	0.1112
Mycobacterium ulcerans	DNA polymerase IV	0.0039	0.0303	0.0125
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0292	0.0571
Loa Loa (eye worm)	transcription factor SMAD2	0.0135	0.1416	0.3372
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0043	0.035	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0328	0.0781
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0467	0.1885
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0292	0.0694
Echinococcus multilocularis	lamin	0.0028	0.0176	0.017
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0757	0.8628	1
Echinococcus multilocularis	dna polymerase kappa	0.0039	0.0303	0.0297
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0053	0.0467	0.1885
Brugia malayi	mbt repeat family protein	0.005	0.0428	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1222	0.291
Echinococcus multilocularis	high affinity choline transporter 1	0.0375	0.42	0.4196
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.005	0.0428	0.1966
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0039	0.0303	0.0125
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0053	0.0467	0.2878
Echinococcus multilocularis	lamin dm0	0.0028	0.0176	0.017
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.035	0.0624
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.035	0.1772
Echinococcus granulosus	inositol monophosphatase 1	0.0043	0.035	0.0687
Echinococcus granulosus	lamin dm0	0.0028	0.0176	0.0339
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0039	0.0303	0.0317
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0057	0.0508	0.0826
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0303	0.1333
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0119	0.1222	0.1116
Echinococcus granulosus	mitogen activated protein kinase	0.0053	0.0467	0.0922
Mycobacterium ulcerans	hypothetical protein	0.0119	0.1222	1
Brugia malayi	hypothetical protein	0.0139	0.1457	0.3433
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0205	0.2222	0.443
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0053	0.0467	0.1885
Loa Loa (eye worm)	MH2 domain-containing protein	0.0135	0.1416	0.3372
Trichomonas vaginalis	DNA polymerase eta, putative	0.0039	0.0303	0.0125
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0303	0.1333
Echinococcus multilocularis	inositol monophosphatase 1	0.0043	0.035	0.0344
Onchocerca volvulus		0.0041	0.0328	0.1188
Onchocerca volvulus		0.0119	0.1222	0.8167
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0057	0.0508	0.0502
Schistosoma mansoni	inositol transporter	0.0041	0.0328	0.0378
Trypanosoma cruzi	hypothetical protein, conserved	0.0119	0.1222	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0043	0.035	1
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0467	0.1885
Echinococcus granulosus	beta LACTamase domain containing family member	0.0119	0.1222	0.2431
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0467	0.1885
Schistosoma mansoni	inositol monophosphatase	0.0043	0.035	0.0433
Mycobacterium ulcerans	esterase/lipase LipP	0.0119	0.1222	1
Echinococcus granulosus	lamin	0.0028	0.0176	0.0339
Onchocerca volvulus		0.0119	0.1222	0.8167
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0043	0.035	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0508	0.1209
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0119	0.1222	0.1116
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0053	0.0467	0.1885
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1222	0.291
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0039	0.0303	0.1998
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0119	0.1222	0.2871
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0303	0.0125
Trypanosoma brucei	protein kinase, putative	0.0053	0.0467	0.2878
Brugia malayi	Sodium:solute symporter family protein	0.0041	0.0328	0.0729
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0303	0.1333
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0176	0.0364
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0041	0.0328	0.0643
Loa Loa (eye worm)	beta-lactamase	0.0119	0.1222	0.291
Brugia malayi	mbt repeat family protein	0.005	0.0428	0.0968
Echinococcus multilocularis	geminin	0.0172	0.1837	0.1832
Loa Loa (eye worm)	hypothetical protein	0.0028	0.017	0.0404
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0298	0.0305
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0039	0.0297	0.0007
Schistosoma mansoni	inositol transporter	0.0041	0.0328	0.0378
Schistosoma mansoni	hypothetical protein	0.0312	0.3461	0.8166
Giardia lamblia	DINP protein human, muc B family	0.0039	0.0303	0.0662
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0039	0.0303	0.0317
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0303	0.1333
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0105	0.1067	0.25
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0105	0.1067	0.2541
Brugia malayi	GH02984p	0.0375	0.42	1
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0043	0.035	0.0624
Brugia malayi	beta-lactamase family protein	0.0119	0.1222	0.2871
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0303	0.1333
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0119	0.1222	0.2601
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0105	0.1067	0.2216
Echinococcus granulosus	dna polymerase eta	0.0039	0.0303	0.0594
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0105	0.1067	0.1062
Mycobacterium ulcerans	beta-lactamase	0.0119	0.1222	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0119	0.1222	0.291
Echinococcus multilocularis	musashi	0.0028	0.0176	0.017
Mycobacterium tuberculosis	Conserved protein	0.0119	0.1222	0.1116
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0041	0.0328	0.0643
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0298	0.0584
Schistosoma mansoni	hypothetical protein	0.0172	0.1837	0.4128
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0041	0.0328	0.0322
Trichomonas vaginalis	D-aminoacylase, putative	0.0119	0.1222	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0039	0.0303	0.0297
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0467	0.1885
Brugia malayi	Inositol-1	0.0043	0.035	0.0781
Onchocerca volvulus		0.0119	0.1222	0.8167
Brugia malayi	beta-lactamase	0.0119	0.1222	0.2871
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0303	0.0722
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0303	0.1333
Trichomonas vaginalis	esterase, putative	0.0119	0.1222	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0105	0.1067	0.2122
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0039	0.0303	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1222	0.291
Echinococcus multilocularis	dna polymerase eta	0.0039	0.0303	0.0297
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.035	0.0624
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0057	0.0508	0.116
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1457	0.347
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0467	0.1885
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0041	0.0328	0.0322
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0303	0.1333
Trichomonas vaginalis	D-aminoacylase, putative	0.0119	0.1222	1
Onchocerca volvulus	Huntingtin homolog	0.0139	0.1457	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.005	0.0428	0.0626
Schistosoma mansoni	hypothetical protein	0.0039	0.0298	0.0305
Mycobacterium tuberculosis	Probable lipase LipD	0.0119	0.1222	0.1116
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.035	0.0624
Echinococcus multilocularis	mitogen activated protein kinase	0.0053	0.0467	0.0461
Echinococcus granulosus	high affinity choline transporter 1	0.0375	0.42	0.8384
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1222	0.291
Mycobacterium leprae	conserved hypothetical protein	0.0119	0.1222	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0105	0.1067	0.2216
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.035	0.0624
Schistosoma mansoni	ap endonuclease	0.0038	0.0292	0.0288
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0303	0.1333
Mycobacterium leprae	Probable lipase LipE	0.0119	0.1222	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0053	0.0467	0.1885
Brugia malayi	beta-lactamase family protein	0.0119	0.1222	0.2871
Trichomonas vaginalis	penicillin-binding protein, putative	0.0119	0.1222	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0176	0.0418
Echinococcus multilocularis	solute carrier family 5	0.0041	0.0328	0.0322
Schistosoma mansoni	ap endonuclease	0.0038	0.0292	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0375	0.42	1
Brugia malayi	intermediate filament protein	0.0028	0.0176	0.0364
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0057	0.0508	0.1003
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0298	0.0292
Loa Loa (eye worm)	mbt repeat family protein	0.005	0.0428	0.1018
Loa Loa (eye worm)	inositol-1	0.0043	0.035	0.0833
Mycobacterium tuberculosis	Conserved protein	0.0119	0.1222	0.1116
Echinococcus multilocularis	SAM and MBT domain containing protein	0.005	0.0428	0.0422
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0041	0.0328	0.0388
Echinococcus granulosus	mitogen activated protein kinase 3	0.0053	0.0467	0.0922
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0292	0.5
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0292	0.5
Trypanosoma cruzi	DNA polymerase eta, putative	0.0039	0.0303	0.0125
Brugia malayi	MAP kinase sur-1	0.0053	0.0467	0.1062
Mycobacterium tuberculosis	Probable esterase LipL	0.0119	0.1222	0.1116
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0119	0.1222	0.1217
Echinococcus granulosus	polycomb protein SCMH1	0.005	0.0428	0.0843
Mycobacterium ulcerans	DNA polymerase IV	0.0039	0.0303	0.0125
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0303	0.0125

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1199012

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Detailed information for compound 1161372