Detailed information for compound 1161441

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 356.462 | Formula: C20H28N4O2
  • H donors: 0 H acceptors: 3 LogP: 1.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC2(N1Cc1cccc(n1)C)CCN(CC2)C(=O)N1CCCC1
  • InChi: 1S/C20H28N4O2/c1-16-5-4-6-17(21-16)15-24-18(25)7-8-20(24)9-13-23(14-10-20)19(26)22-11-2-3-12-22/h4-6H,2-3,7-15H2,1H3
  • InChiKey: FSLUGSRWHBWCHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0158 0.0158
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0031 0.0031
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0049 0.0018
Schistosoma mansoni hypothetical protein 0.0429 0.2065 0.2065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0019 0.005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0031 0.008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0031 0.0075
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0525 0.0401
Brugia malayi beta-lactamase family protein 0.0042 0.0158 0.0128
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0158 0.0158
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.0714
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.012 0.0089
Toxoplasma gondii ABC1 family protein 0.0042 0.0158 0.003
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0158 0.0158
Plasmodium falciparum dihydroorotate dehydrogenase 0.2037 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0507 0.131
Leishmania major hypothetical protein, conserved 0.0053 0.0212 0.0054
Schistosoma mansoni dihydroorotate dehydrogenase 0.2037 1 1
Loa Loa (eye worm) glutaminase 0.0269 0.1279 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0795 0.3875 1
Onchocerca volvulus 0.0036 0.0129 0.0763
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0314 0.0314
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.012 0.031
Schistosoma mansoni thyroid hormone receptor 0.0034 0.012 0.012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.012 0.0089
Echinococcus granulosus FTZ F1 alpha 0.0034 0.012 0.031
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.005 0.0121
Brugia malayi nuclear receptor NHR-88 0.0034 0.012 0.0089
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0795 0.3875 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0299 0.0721
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.012 0.0694
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0299 0.0299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0019 0.005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0019 0.005
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0031 0.008
Echinococcus multilocularis cpg binding protein 0.0064 0.0268 0.0646
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0212 0.0054
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0158 0.0382
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2037 1 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0795 0.3875 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.012 0.031
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.2037 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0158 0.0409
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0158 0.0409
Schistosoma mansoni hypothetical protein 0.0024 0.0068 0.0068
Schistosoma mansoni nuclear receptor 0.0016 0.0031 0.0031
Schistosoma mansoni thyroid hormone receptor 0.0034 0.012 0.012
Brugia malayi glutaminase DH11.1 0.0269 0.1279 0.1252
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0795 0.3875 1
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.2037 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.005 0.013
Brugia malayi ecdysteroid receptor 0.0034 0.012 0.0089
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.0785
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0158 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.012 0.0089
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.012 0.012
Brugia malayi hypothetical protein 0.0018 0.0041 0.001
Brugia malayi nuclear receptor RXR 0.0018 0.0041 0.001
Onchocerca volvulus 0.0276 0.1315 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0795 0.3875 0.9338
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0507 0.0507
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0212 0.0084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.012 0.031
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0158 0.0158
Schistosoma mansoni nuclear hormone receptor 0.0034 0.012 0.012
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0031 0.0031
Brugia malayi Pre-SET motif family protein 0.0243 0.115 0.1123
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.012 0.029
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0129 0.0311
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.012 0.031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0076
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.2037 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.0451 0.1164
Echinococcus granulosus geminin 0.0521 0.2522 0.6507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.102
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.012 0.012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0158 0.0158
Trichomonas vaginalis set domain proteins, putative 0.0276 0.1315 0.3393
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0031 0.008
Schistosoma mansoni hypothetical protein 0.0521 0.2522 0.2522
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.0714
Trichomonas vaginalis glutaminase, putative 0.0269 0.1279 0.3301
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0299 0.0299
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.012 0.031
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0314 0.2269
Loa Loa (eye worm) histone methyltransferase 0.002 0.005 0.0155
Mycobacterium ulcerans beta-lactamase 0.0042 0.0158 0.0158
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0212 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.0451 0.1087
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0507 0.1223
Brugia malayi hypothetical protein 0.0053 0.0212 0.0182
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.012 0.029
Schistosoma mansoni glutaminase 0.0269 0.1279 0.1279
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.012 0.012
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0158 0.0409
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0158 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.012 0.0714
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0212 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0129 0.0129
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.012 0.029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.012 0.012
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2037 1 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0314 0.0314
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0158 0.0158
Schistosoma mansoni zinc finger protein 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.102
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0019 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0019 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.012 0.031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.012 0.0714
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0041 0.0105
Echinococcus granulosus tar DNA binding protein 0.0074 0.0314 0.0811
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0299 0.0299
Mycobacterium tuberculosis Conserved protein 0.0042 0.0158 0.0158
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0019 0.005
Brugia malayi beta-lactamase 0.0042 0.0158 0.0128
Trichomonas vaginalis esterase, putative 0.0042 0.0158 0.0409
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0129 0.0129
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0031 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0019 0.005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.012 0.0089
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.012 0.0714
Onchocerca volvulus 0.0042 0.0158 0.0992
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0076
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.012 0.029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0593 0.0593
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0041 0.0076
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.0714
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.012 0.029
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0299 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.005
Onchocerca volvulus 0.0061 0.0251 0.1713
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0068 0.0165
Loa Loa (eye worm) beta-lactamase 0.0042 0.0158 0.102
Mycobacterium tuberculosis Conserved protein 0.0042 0.0158 0.0158
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0299 0.0299
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0795 0.3875 1
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.2037 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.012 0.0089
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0031 0.0031
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.012 0.029
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0212 0.0054
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0041 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.0451 0.1164
Schistosoma mansoni hypothetical protein 0.0113 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.0714
Brugia malayi nuclear hormone receptor 0.0034 0.012 0.0089
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0041 0.0041
Brugia malayi hypothetical protein 0.0034 0.012 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.012 0.0714
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2037 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.102
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.012 0.031
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0032 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.005
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.012 0.0089
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0031 0.0075
Loa Loa (eye worm) RNA binding protein 0.0074 0.0314 0.2269
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.0714
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.012 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0129 0.0311
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0158 0.0128
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.2037 1 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0314 0.0314
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0031 0.0075
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0851 0.415 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0032 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0158 0.003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0251 0.1761
Mycobacterium leprae Probable lipase LipE 0.0042 0.0158 0.0158
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0795 0.3875 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.102
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0314 0.0757
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0591 0.4483
Brugia malayi Zinc finger, C2H2 type family protein 0.0795 0.3875 0.3856
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0591 0.4483
Loa Loa (eye worm) glutaminase 2 0.0269 0.1279 1
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0031 0.0031
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0158 0.0409
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.0714
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0031 0.0075
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0795 0.3875 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.012 0.029
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0795 0.3875 1
Brugia malayi MH2 domain containing protein 0.013 0.0591 0.0561
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.0451 0.0421
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.102
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0032 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0158 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.012 0.0089
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.012 0.0694
Trichomonas vaginalis helicase, putative 0.0014 0.0019 0.005
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0314 0.0314
Schistosoma mansoni cpg binding protein 0.0061 0.0251 0.0251
Schistosoma mansoni coup transcription factor 0.0034 0.012 0.012
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.012 0.0694
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0451 0.0451
Schistosoma mansoni nuclear receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.0451 0.3366
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0032 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.012 0.0089
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.005
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.012 0.0714
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.012 0.0714
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.0714
Onchocerca volvulus 0.0042 0.0158 0.0992
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.0451 0.1087
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0032 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.012 0.0714
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0299 0.0143
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0041 0.001
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0158 0.0158
Echinococcus multilocularis geminin 0.0521 0.2522 0.6076
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0001 0.0001
Brugia malayi RNA binding protein 0.0074 0.0314 0.0284
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0795 0.3875 0.3777
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.012 0.0089
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2037 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0268 0.1274 0.1274
Brugia malayi steroid hormone receptor 0.0034 0.012 0.0089
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.012 0.012
Echinococcus granulosus cpg binding protein 0.0064 0.0268 0.0691
Brugia malayi beta-lactamase family protein 0.0042 0.0158 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.005
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0068 0.0176
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0031 0.0075
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0031 0.008
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.0714
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.012 0.0089
Onchocerca volvulus 0.0042 0.0158 0.0992
Onchocerca volvulus 0.0034 0.012 0.0694
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.2037 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0314 0.2269
Brugia malayi hypothetical protein 0.0113 0.0507 0.0478
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0158 0.0409
Mycobacterium ulcerans lipase LipD 0.0042 0.0158 0.0158
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0299 0.0172
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0314 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.012 0.0089
Schistosoma mansoni cpg binding protein 0.0064 0.0268 0.0268
Brugia malayi CXXC zinc finger family protein 0.0061 0.0251 0.0221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0451 0.0451
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0451 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.012 0.012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0053 0.0212 0.145
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0795 0.3875 0.9338
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.005
Mycobacterium tuberculosis Conserved protein 0.0042 0.0158 0.0158
Echinococcus multilocularis dnaJ subfamily B 0.0429 0.2065 0.4977
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0076
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.115 0.8966
Brugia malayi Pre-SET motif family protein 0.0036 0.0129 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.012 0.0714
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0041 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.012 0.0089
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0019 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.005
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0041 0.001
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.012 0.012
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0795 0.3875 1
Schistosoma mansoni cpg binding protein 0.0064 0.0268 0.0268
Leishmania major dihydroorotate dehydrogenase 0.2037 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.012 0.0089
Brugia malayi hypothetical protein 0.0018 0.0041 0.001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0299 0.0772
Schistosoma mansoni hypothetical protein 0.0521 0.2522 0.2522
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0031 0.0075
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.012 0.031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.012 0.0089
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.012 0.029
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0116 0.03
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.012 0.0089
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.012 0.029
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0129 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0158 0.102
Treponema pallidum bacterioferrin (TpF1) 0.001 0 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0158 0.0158
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0031 0.008
Mycobacterium ulcerans hypothetical protein 0.0042 0.0158 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0129 0.0129
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0158 0.0158
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.012 0.012
Echinococcus granulosus dnaJ subfamily B 0.0429 0.2065 0.533
Brugia malayi TAR-binding protein 0.0074 0.0314 0.0284
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.2037 1 1
Mycobacterium ulcerans glutaminase 0.0269 0.1279 0.1279

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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