Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.038 | 0.038 |
Mycobacterium leprae | putative cytochrome p450 | 0.0055 | 0.055 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.3238 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0118 | 0.2787 | 1 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0055 | 0.055 | 0.1974 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0694 | 0.0694 |
Brugia malayi | cytochrome P450 | 0.0055 | 0.055 | 0.055 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0118 | 0.2787 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0118 | 0.2787 | 0.2787 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0118 | 0.2787 | 0.2367 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0055 | 0.055 | 0.1974 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0118 | 0.2787 | 0.2787 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0039 | 0 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.038 | 0.038 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.0694 | 0.0694 |
Leishmania major | cytochrome p450-like protein | 0.0118 | 0.2787 | 1 |
Brugia malayi | hypothetical protein | 0.013 | 0.3238 | 0.3238 |
Loa Loa (eye worm) | cytochrome P450 | 0.0055 | 0.055 | 0.055 |
Trichomonas vaginalis | glutaminase, putative | 0.0321 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.3238 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0055 | 0.055 | 0.1974 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0055 | 0.055 | 0.1974 |
Brugia malayi | Cytochrome P450 family protein | 0.0118 | 0.2787 | 0.2787 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0118 | 0.2787 | 0.2787 |
Leishmania major | cytochrome p450-like protein | 0.0055 | 0.055 | 0.1974 |
Schistosoma mansoni | cytochrome P450 | 0.0055 | 0.055 | 0.055 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.3238 | 0.3238 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.3238 | 0.3238 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0118 | 0.2787 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0132 | 0.3275 | 0.3275 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0855 | 0.0855 |
Mycobacterium ulcerans | glutaminase | 0.0321 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0244 | 0.7256 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0055 | 0.055 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.055 | 0.055 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0132 | 0.3275 | 0.3275 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0055 | 0.055 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0055 | 0.055 | 0.0758 |
Loa Loa (eye worm) | glutaminase | 0.0321 | 1 | 1 |
Echinococcus multilocularis | 0.0055 | 0.055 | 0.0758 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0118 | 0.2787 | 0.2787 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.038 | 0.038 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0055 | 0.055 | 0.1974 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.7256 | 0.7256 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0244 | 0.7256 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0245 | 0.7292 | 1 |
Brugia malayi | hypothetical protein | 0.0244 | 0.7256 | 0.7256 |
Loa Loa (eye worm) | glutaminase 2 | 0.0321 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0055 | 0.055 | 0.1974 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0037 | 0.0037 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.055 | 0.055 |
Schistosoma mansoni | glutaminase | 0.0321 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.