Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lozenge | 0.0056 | 0.088 | 0.1198 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.1063 | 0.0999 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.0575 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0251 | 0.0266 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.023 | 0.4949 | 0.7228 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1063 | 0.147 |
Loa Loa (eye worm) | acetyltransferase | 0.0146 | 0.2984 | 0.2934 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0146 | 0.2984 | 0.2984 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.1852 | 0.2639 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0122 | 0.1009 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0072 | 0.0072 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0235 | 0.3888 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0142 | 0.2889 | 0.4175 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.0575 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0251 | 0.0251 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0251 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.1063 | 0.1063 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0251 | 0.0266 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0492 | 1 |
Loa Loa (eye worm) | runx1 | 0.0056 | 0.088 | 0.0814 |
Schistosoma mansoni | hypothetical protein | 0.031 | 0.6819 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0235 | 0.9116 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.1852 | 0.1852 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.0575 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1063 | 0.147 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.1063 | 0.147 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0146 | 0.2984 | 0.4317 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0122 | 0.3112 |
Echinococcus multilocularis | Protein lozenge | 0.0056 | 0.088 | 0.1198 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.0492 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.1502 | 0.1502 |
Brugia malayi | RNA binding protein | 0.0064 | 0.1063 | 0.1063 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0251 | 0.3557 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0235 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0146 | 0.2984 | 0.4317 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0235 | 0.0235 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.0575 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.1852 | 0.1793 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0235 | 0.0165 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0251 | 0.0266 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.1063 | 0.0999 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0492 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0122 | 0.1009 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0251 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1063 | 0.147 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.1852 | 0.2639 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.0575 | 0.0747 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.023 | 0.4949 | 0.7228 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0251 | 0.4265 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0251 | 0.3557 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0235 | 0.3888 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0122 | 0.121 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.1063 | 0.147 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0251 | 0.0181 |
Echinococcus granulosus | snurportin 1 | 0.031 | 0.6819 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.031 | 0.6819 | 0.6796 |
Echinococcus multilocularis | snurportin 1 | 0.031 | 0.6819 | 1 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.023 | 0.4949 | 0.7228 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.023 | 0.4949 | 0.4912 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.1063 | 0.1063 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.1852 | 0.2639 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0122 | 0.1009 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.1063 | 0.0999 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.1852 | 0.2639 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0235 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1063 | 0.147 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.1852 | 0.2639 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.0575 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1063 | 0.147 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0122 | 0.3112 |
Onchocerca volvulus | 0.0446 | 1 | 0.5 | |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0235 | 0.3243 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0235 | 1 |
Brugia malayi | hypothetical protein | 0.0106 | 0.2044 | 0.2044 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0235 | 0.3243 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.1852 | 0.2639 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.1852 | 0.2639 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.