Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0055 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0103 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0103 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Onchocerca volvulus | 0.0103 | 1 | 1 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0103 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0103 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0103 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0103 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0055 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0103 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0103 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0103 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0103 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0103 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0103 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0103 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0103 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0103 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0103 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1071 | 0.1071 |
Schistosoma mansoni | thyroid hormone receptor | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0103 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0055 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0103 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0055 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0103 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0103 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0103 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0055 | 0.1071 | 0.1071 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0103 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0103 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0103 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0103 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0103 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0103 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0103 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0103 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0103 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0103 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0103 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0103 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0103 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0055 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0055 | 0.1071 | 0.1071 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1071 | 0.1071 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0103 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0055 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0055 | 0.1071 | 0.1071 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0055 | 0.1071 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.14 uM | Inhibition of Prostaglandin G/H synthase 2 in human whole blood | ChEMBL. | 10465547 |
IC50 (binding) | = 0.14 uM | Inhibition of Prostaglandin G/H synthase 2 in human whole blood | ChEMBL. | 10465547 |
IC50 (binding) | = 25 uM | Inhibitory activity against Human Prostaglandin G/H synthase 1 in U937 Microsome COX-1 assay | ChEMBL. | 10465547 |
IC50 (binding) | = 25 uM | Inhibitory activity against Human Prostaglandin G/H synthase 1 in U937 Microsome COX-1 assay | ChEMBL. | 10465547 |
IC50 (binding) | > 100 uM | Inhibitory activity against Prostaglandin G/H synthase 1 in human whole blood | ChEMBL. | 10465547 |
IC50 (binding) | > 100 uM | Inhibitory activity against Prostaglandin G/H synthase 1 in human whole blood | ChEMBL. | 10465547 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.