Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0016 | 0.0234 | 0.0057 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0234 | 0.0546 |
Brugia malayi | AMP-binding enzyme family protein | 0.0054 | 0.3314 | 0.3193 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0178 | 0.0187 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0054 | 0.3314 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4528 | 0.4764 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0016 | 0.0234 | 0.0246 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.2822 | 0.2692 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0178 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0234 | 0.0057 |
Loa Loa (eye worm) | oxidoreductase | 0.0016 | 0.0234 | 0.0057 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0016 | 0.0234 | 0.0057 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0234 | 0.0057 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.4528 | 0.4764 |
Mycobacterium ulcerans | hypothetical protein | 0.0054 | 0.3314 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0036 | 0.1815 | 0.5133 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.1286 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0016 | 0.0234 | 0.0546 |
Brugia malayi | AMP-binding enzyme family protein | 0.0054 | 0.3314 | 0.3193 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0016 | 0.0234 | 0.0057 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0054 | 0.3314 | 1 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0016 | 0.0234 | 0.0546 |
Brugia malayi | AMP-binding enzyme family protein | 0.0016 | 0.0234 | 0.0057 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0178 | 0.0187 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.2034 | 0.6071 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.2034 | 0.6071 |
Schistosoma mansoni | ferritin | 0.0036 | 0.1815 | 0.191 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0054 | 0.3314 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.9506 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.4528 | 0.5192 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4528 | 0.4764 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0178 | 0.0204 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0054 | 0.3314 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0054 | 0.3314 | 1 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0016 | 0.0234 | 0.0546 |
Schistosoma mansoni | apoferritin-2 | 0.0036 | 0.1815 | 0.191 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0178 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2212 | 0.2071 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.2034 | 0.6071 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0036 | 0.1815 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.0036 | 0.1815 | 0.191 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3314 | 0.3193 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0178 | 0.0187 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0178 | 0.0187 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0016 | 0.0234 | 0.0057 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0054 | 0.3314 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.4528 | 0.4429 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.1286 | 1 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0016 | 0.0234 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2212 | 0.2071 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0036 | 0.1815 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0036 | 0.1815 | 0.5133 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0178 | 0.0187 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.9506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3314 | 0.3193 |
Brugia malayi | AMP-binding enzyme family protein | 0.0054 | 0.3314 | 0.3193 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0234 | 0.0546 |
Schistosoma mansoni | ferritin | 0.0036 | 0.1815 | 0.191 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0054 | 0.3314 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.4528 | 0.4429 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.4528 | 0.4429 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1598 | 0.1446 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0036 | 0.1815 | 0.5133 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.8721 | 0.9175 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2212 | 0.2071 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0041 | 0.2212 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1286 | 0.5319 |
Brugia malayi | hypothetical protein | 0.0029 | 0.1286 | 0.1128 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0016 | 0.0234 | 0.0057 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0054 | 0.3314 | 1 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0016 | 0.0234 | 0.0269 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0016 | 0.0234 | 0.0546 |
Schistosoma mansoni | ferritin light chain | 0.0036 | 0.1815 | 0.191 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0234 | 0.0546 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0016 | 0.0234 | 0.0246 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.2034 | 0.6071 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1598 | 0.1446 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0178 | 0.0187 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0054 | 0.3314 | 1 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0036 | 0.1815 | 0.5399 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.1286 | 0.5319 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0054 | 0.3314 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1598 | 0.1681 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0016 | 0.0234 | 0.0546 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0041 | 0.2212 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0041 | 0.2212 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.046 | 0.0287 |
Schistosoma mansoni | apoferritin-2 | 0.0036 | 0.1815 | 0.191 |
Trichomonas vaginalis | ferritin, putative | 0.0036 | 0.1815 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0054 | 0.3314 | 1 |
Echinococcus granulosus | ferritin | 0.0036 | 0.1815 | 0.2081 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1286 | 0.5319 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0054 | 0.3314 | 1 |
Echinococcus multilocularis | expressed protein | 0.0036 | 0.1815 | 0.191 |
Brugia malayi | TAR-binding protein | 0.007 | 0.4528 | 0.4429 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0054 | 0.3314 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.9506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1286 | 0.1128 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.1286 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.8721 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0178 | 0.0204 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0054 | 0.3314 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.2822 | 0.2692 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0054 | 0.3314 | 1 |
Onchocerca volvulus | 0.0054 | 0.3314 | 1 | |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0041 | 0.2212 | 0.6617 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0054 | 0.3314 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0016 | 0.0234 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3314 | 0.3193 |
Brugia malayi | AMP-binding enzyme family protein | 0.0016 | 0.0234 | 0.0057 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0036 | 0.1815 | 0.5399 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0016 | 0.0234 | 0.0546 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4528 | 0.4764 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0054 | 0.3314 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2212 | 0.2071 |
Echinococcus multilocularis | ferritin | 0.0036 | 0.1815 | 0.191 |
Schistosoma mansoni | ferritin | 0.0036 | 0.1815 | 0.191 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4528 | 0.4764 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0041 | 0.2212 | 0.6421 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.4528 | 0.4429 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.8721 | 0.9175 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2212 | 0.2071 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.1286 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.2822 | 0.2692 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2822 | 0.2692 |
Echinococcus granulosus | expressed protein | 0.0036 | 0.1815 | 0.2081 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4528 | 0.4764 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0234 | 0.0546 |
Brugia malayi | RNA binding protein | 0.007 | 0.4528 | 0.4429 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.1286 | 0.3415 |
Schistosoma mansoni | ferritin | 0.0036 | 0.1815 | 0.191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.