Detailed information for compound 1162253

Basic information

Technical information
  • TDR Targets ID: 1162253
  • Name: 3-amino-5-iodo-7-methyl-2,3-dihydro-1H-inden- 4-ol
  • MW: 289.113 | Formula: C10H12INO
  • H donors: 2 H acceptors: 1 LogP: 1.87 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC1CCc2c1c(O)c(cc2C)I
  • InChi: 1S/C10H12INO/c1-5-4-7(11)10(13)9-6(5)2-3-8(9)12/h4,8,13H,2-3,12H2,1H3
  • InChiKey: OXURHOANHPGPAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-amino-5-iodo-7-methyl-indan-4-ol
  • 3-amino-5-iodo-7-methyl-4-indanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0483 0.6754 1
Onchocerca volvulus 0.0066 0.057 0.1516
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0137 0.1611 0.1558
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.057 0.0843
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0408 0.0604
Brugia malayi Pre-SET motif family protein 0.0032 0.0064 0.0094
Trypanosoma brucei Aph-1 protein, putative 0.0088 0.0897 0.1328
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.057 0.0843
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0066 0.057 0.0558
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.057 0.0843
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0483 0.6754 1
Brugia malayi MH2 domain containing protein 0.0132 0.1548 0.2292
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0408 0.0604
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0066 0.057 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0701 1 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0483 0.6754 1
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0066 0.057 0.5
Trichomonas vaginalis set domain proteins, putative 0.0257 0.34 0.4577
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.057 0.0843
Schistosoma mansoni fk506 binding protein 0.0066 0.057 0.0509
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1548 0.2292
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0137 0.1611 0.1573
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0066 0.057 1
Echinococcus multilocularis 0.0066 0.057 0.0509
Loa Loa (eye worm) hypothetical protein 0.0416 0.5767 0.8539
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0094
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0416 0.5767 0.5747
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0064 0.0018
Schistosoma mansoni immunophilin 0.0483 0.6754 0.6733
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0483 0.6754 1
Echinococcus multilocularis gamma secretase subunit aph 1 0.0227 0.2955 0.291
Loa Loa (eye worm) hypothetical protein 0.0066 0.057 0.0843
Trichomonas vaginalis fk506-binding protein, putative 0.0483 0.6754 1
Brugia malayi gamma-secretase subunit aph-1 0.0227 0.2955 0.4376
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.057 0.0843
Schistosoma mansoni hypothetical protein 0.0137 0.1611 0.1558
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0483 0.6754 1
Schistosoma mansoni thyroid hormone receptor 0.0148 0.1774 0.1722
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.057 0.0843
Loa Loa (eye worm) hypothetical protein 0.0056 0.0408 0.0604
Brugia malayi Pre-SET motif family protein 0.0226 0.2937 0.4348
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0483 0.6754 0.6733
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0483 0.6754 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0483 0.6754 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0483 0.6754 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0483 0.6754 1
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0066 0.057 0.5
Schistosoma mansoni thyroid hormone receptor 0.0148 0.1774 0.1722
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0066 0.057 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.057 0.0558
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0227 0.2955 0.4376
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0066 0.057 0.0526
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0483 0.6754 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0483 0.6754 1
Trypanosoma cruzi Aph-1 protein, putative 0.0088 0.0897 0.1328
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0066 0.057 0.5
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.057 0.0843
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0483 0.6754 1
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0066 0.057 0.0509
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0066 0.057 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0483 0.6754 0.6739
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0204 0.0141
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0066 0.057 0.0843
Leishmania major fk506-binding protein 1-like protein 0.0483 0.6754 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0483 0.6754 0.6739
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0147 0.0217
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0066 0.057 0.0843
Schistosoma mansoni hypothetical protein 0.0042 0.0204 0.0141
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0483 0.6754 1
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0066 0.057 0.0843
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0483 0.6754 1
Trypanosoma cruzi Aph-1 protein, putative 0.0088 0.0897 0.1328
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0483 0.6754 1
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0204 0.0141
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0066 0.057 0.0843
Brugia malayi hypothetical protein 0.0042 0.0204 0.0302
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0066 0.057 0.0843
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0483 0.6754 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0066 0.057 0.0843
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0066 0.057 1
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0066 0.057 0.0843
Onchocerca volvulus 0.0066 0.057 0.1516
Schistosoma mansoni gamma-secretase subunit aph-1 0.0227 0.2955 0.291
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0066 0.057 0.5
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0483 0.6754 1
Echinococcus granulosus FK506 binding protein 2 0.0066 0.057 0.0526
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0483 0.6754 0.6733
Plasmodium vivax SET domain protein, putative 0.0032 0.0064 0.0094
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0066 0.057 0.0843
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0066 0.057 0.0843
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0416 0.5767 0.574
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.2937 0.4348
Schistosoma mansoni hypothetical protein 0.0038 0.0147 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.0066 0.057 0.0843
Schistosoma mansoni hypothetical protein 0.0066 0.057 0.0509
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0217
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0483 0.6754 1
Schistosoma mansoni microtubule-associated protein tau 0.0701 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0483 0.6754 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0066 0.057 0.0843
Leishmania major peptidylprolyl isomerase-like protein 0.0483 0.6754 1
Onchocerca volvulus 0.0257 0.34 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0066 0.057 0.0843
Trichomonas vaginalis immunophilin, putative 0.0483 0.6754 1
Echinococcus multilocularis fk506 binding protein 0.0483 0.6754 0.6733
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0066 0.057 0.0843
Schistosoma mansoni immunophilin 0.0416 0.5767 0.574
Schistosoma mansoni immunophilin 0.0483 0.6754 0.6733
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0064 0.112
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0204 0.0159
Loa Loa (eye worm) FKBP5 protein 0.0483 0.6754 1
Echinococcus granulosus gamma secretase subunit aph 1 0.0227 0.2955 0.2923
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0408 0.0604
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.1774 0.1722
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1548 0.2292

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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