Detailed information for compound 1162315

Basic information

Technical information
  • TDR Targets ID: 1162315
  • Name: 1-(4-methylphenyl)-2-phenyl-6,7,8,9-tetrahydr o-5H-imidazo[1,2-a]azepin-4-ium
  • MW: 303.421 | Formula: C21H23N2+
  • H donors: 0 H acceptors: 0 LogP: 4.9 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)[n+]1c(cn2c1CCCCC2)c1ccccc1
  • InChi: 1S/C21H23N2/c1-17-11-13-19(14-12-17)23-20(18-8-4-2-5-9-18)16-22-15-7-3-6-10-21(22)23/h2,4-5,8-9,11-14,16H,3,6-7,10,15H2,1H3/q+1
  • InChiKey: AJMZMBFVYSTERW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC01497992
  • EU-0067984
  • STOCK1S-34412
  • ChemDiv1_019456

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.014 0.0471 0.1447
Echinococcus multilocularis tumor protein p63 0.0677 0.2753 0.4742
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0179 0.0308
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0081 0.0139
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0069 0.0169 0.1411
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0069 0.0169 0.0291
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0069 0.0169 0.1411
Mycobacterium ulcerans NADH dehydrogenase 0.0069 0.0169 0.1411
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0069 0.0169 0.0554
Toxoplasma gondii thioredoxin reductase 0.0746 0.3043 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0003 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0319 0.3256
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0066 0.0159 0.0159
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0258 0.0974 0.1678
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0013 0.0032
Toxoplasma gondii NADPH-glutathione reductase 0.0258 0.0974 0.3202
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.014 0.0471 0.0812
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0069 0.0169 0.0168
Brugia malayi hypothetical protein 0.0071 0.0179 0.0446
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0081 0.0139
Echinococcus multilocularis glutamate synthase 0.0069 0.0169 0.0291
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0069 0.0169 0.1411
Brugia malayi MH1 domain containing protein 0.0066 0.0159 0.0397
Brugia malayi MH1 domain containing protein 0.0037 0.0033 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.0471 0.4822
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.014 0.0471 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.035 0.3572
Plasmodium falciparum thioredoxin reductase 0.0746 0.3043 1
Schistosoma mansoni Smad4 0.0066 0.0159 0.0159
Leishmania major NADH dehydrogenase, putative 0.0069 0.0169 0.044
Plasmodium vivax glutathione reductase, putative 0.0746 0.3043 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0069 0.0169 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0037 0.0352
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.189 0.7903 1
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0069 0.0169 0.0168
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.014 0.0471 0.0471
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0069 0.0169 0.0421
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0013 0.0032
Echinococcus multilocularis thioredoxin glutathione reductase 0.0752 0.3071 0.529
Schistosoma mansoni glutamate synthase 0.0069 0.0169 0.0169
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0077 0.0191
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0047 0.0077 0.0134
Loa Loa (eye worm) hypothetical protein 0.0148 0.0505 0.126
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0069 0.0169 0.044
Echinococcus granulosus Smad4 0.0066 0.0159 0.0274
Trypanosoma cruzi target of rapamycin kinase 3 0.0111 0.035 0.1044
Toxoplasma gondii target of rapamycin (TOR), putative 0.0104 0.0319 0.1049
Brugia malayi Smad1 0.0066 0.0159 0.0397
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0069 0.0169 0.0168
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0047 0.0077 0.0134
Echinococcus multilocularis microtubule associated protein 2 0.1396 0.5806 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0069 0.0169 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0077 0.0761
Mycobacterium tuberculosis Probable dehydrogenase 0.1701 0.7097 0.8976
Leishmania major hypothetical protein, conserved 0.0069 0.0169 0.044
Trichomonas vaginalis glutathione reductase, putative 0.0258 0.0974 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0319 0.3256
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0069 0.0169 0.0421
Echinococcus granulosus geminin 0.0343 0.1333 0.2296
Mycobacterium ulcerans monoxygenase 0.0069 0.0169 0.1411
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0223 0.0383
Brugia malayi Thioredoxin reductase 0.0746 0.3043 0.7594
Leishmania major hypothetical protein, conserved 0.0069 0.0169 0.044
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0223 0.0383
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0258 0.0974 0.312
Trichomonas vaginalis glutamate synthase, putative 0.0069 0.0169 0.1709
Plasmodium vivax thioredoxin reductase, putative 0.0746 0.3043 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1701 0.7097 0.8976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0276 0.2811
Loa Loa (eye worm) hypothetical protein 0.0081 0.0223 0.0556
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0069 0.0169 0.0291
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0258 0.0974 0.312
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.014 0.0471 0.1447
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0258 0.0974 0.312
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0077 0.0134
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0159 0.0397
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0069 0.0169 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.035 0.3572
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0069 0.0169 0.0291
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0258 0.0974 0.2432
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0258 0.0974 0.1678
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0258 0.0974 0.312
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0083
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0058 0.0124 0.0292
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0746 0.3043 0.3822
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0111 0.035 0.1044
Loa Loa (eye worm) phosphatidylinositol 3 0.014 0.0471 0.1176
Schistosoma mansoni tar DNA-binding protein 0.0583 0.2353 0.2353
Echinococcus granulosus tumor protein p63 0.0677 0.2753 0.4742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0384 0.3929
Loa Loa (eye worm) hypothetical protein 0.0069 0.0169 0.0421
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.014 0.0471 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0069 0.0169 0.044
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0258 0.0974 0.312
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0036 0.0063
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0069 0.0169 0.0554
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.0091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0258 0.0974 0.312
Plasmodium falciparum thioredoxin reductase 0.0258 0.0974 0.2803
Schistosoma mansoni hypothetical protein 0.0071 0.0179 0.0179
Entamoeba histolytica hypothetical protein 0.0071 0.0179 0.0334
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0013 0.0022
Brugia malayi MH1 domain containing protein 0.0037 0.0033 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.035 0.3572
Entamoeba histolytica hypothetical protein 0.0071 0.0179 0.0334
Mycobacterium tuberculosis Probable oxidoreductase 0.189 0.7903 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0069 0.0169 0.1709
Leishmania major hypothetical protein, conserved 0.0069 0.0169 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0198 0.2011
Echinococcus granulosus TGF beta signal transducer SmadC 0.0066 0.0159 0.0274
Entamoeba histolytica hypothetical protein 0.0071 0.0179 0.0334
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0069 0.0169 0.1709
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.189 0.7903 1
Schistosoma mansoni disulfide oxidoreductase 0.0069 0.0169 0.0169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0258 0.0974 0.312
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0003 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0081 0.0139
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0069 0.0169 0.0168
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0258 0.0974 0.312
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0258 0.0974 0.312
Echinococcus granulosus glutamate synthase 0.0069 0.0169 0.0291
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0583 0.2353 0.5874
Schistosoma mansoni smad 0.003 0.0003 0.0003
Treponema pallidum NADH oxidase 0.0258 0.0974 1
Plasmodium vivax ferrodoxin reductase, putative 0.0069 0.0169 0.0554
Schistosoma mansoni hypothetical protein 0.0032 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0077 0.0761
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.014 0.0471 0.1447
Trypanosoma brucei trypanothione reductase 0.0746 0.3043 1
Loa Loa (eye worm) Smad1 0.0066 0.0159 0.0397
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0077 0.0134
Echinococcus multilocularis geminin 0.0343 0.1333 0.2296
Schistosoma mansoni smad1 5 8 and 0.0066 0.0159 0.0159
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0003 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0198 0.2011
Toxoplasma gondii selenide, water dikinase 0.0069 0.0169 0.0554
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0077 0.0191
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0258 0.0974 0.3202
Entamoeba histolytica hypothetical protein 0.0071 0.0179 0.0334
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0179 0.0308
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0305 0.0761
Brugia malayi MH2 domain containing protein 0.003 0.0003 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0258 0.0974 0.312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0232 0.2363
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0036 0.0346
Brugia malayi Pre-SET motif family protein 0.0201 0.0731 0.1825
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0258 0.0974 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0069 0.0169 0.044
Schistosoma mansoni glutamate synthase 0.0069 0.0169 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0319 0.3256
Echinococcus multilocularis tar DNA binding protein 0.0583 0.2353 0.4053
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0069 0.0169 0.0168
Echinococcus granulosus GPCR family 2 0.0032 0.0013 0.0022
Brugia malayi MH1 domain containing protein 0.0066 0.0159 0.0397
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0258 0.0974 0.312
Schistosoma mansoni tar DNA-binding protein 0.0583 0.2353 0.2353
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0069 0.0169 0.1411
Toxoplasma gondii ABC1 family protein 0.0037 0.0036 0.0119
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0069 0.0169 0.1411
Schistosoma mansoni hypothetical protein 0.0343 0.1333 0.1333
Onchocerca volvulus 0.0099 0.0298 0.3515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0198 0.2011
Echinococcus multilocularis smad 0.0066 0.0159 0.0274
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0069 0.0169 0.1709
Brugia malayi Muscleblind-like protein 0.0302 0.1161 0.2897
Leishmania major trypanothione reductase 0.0746 0.3043 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1701 0.7097 0.8976
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0198 0.2006
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0169 0.044
Trypanosoma cruzi trypanothione reductase, putative 0.0258 0.0974 0.312
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0069 0.0169 0.0168
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0099 0.0298 0.0745
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0069 0.0169 0.0291
Loa Loa (eye worm) hypothetical protein 0.0032 0.0013 0.0032
Onchocerca volvulus 0.0229 0.0849 1
Loa Loa (eye worm) transcription factor SMAD2 0.0973 0.4006 1
Loa Loa (eye worm) programmed cell death 8 0.0069 0.0169 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0319 0.3256
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0069 0.0169 0.1709
Echinococcus granulosus muscleblind protein 0.0302 0.1161 0.1999
Brugia malayi beta-lactamase family protein 0.0037 0.0036 0.0091
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0069 0.0169 0.0291
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.0091
Loa Loa (eye worm) TAR-binding protein 0.0583 0.2353 0.5874
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.014 0.0471 1
Brugia malayi glutamate synthase 0.0069 0.0169 0.0421
Loa Loa (eye worm) beta-lactamase 0.0037 0.0036 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0198 0.2011
Loa Loa (eye worm) glutathione reductase 0.0746 0.3043 0.7594
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0069 0.0169 0.044
Trichomonas vaginalis esterase, putative 0.0037 0.0036 0.0346
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0029 0.0003 0.0009
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0258 0.0974 0.3202
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0069 0.0169 0.044
Mycobacterium ulcerans ferredoxin reductase 0.0069 0.0169 0.1411
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0258 0.0974 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1701 0.7097 0.8976
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0258 0.0974 0.2803
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0036 0.0063
Onchocerca volvulus 0.0069 0.0169 0.1987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0229 0.2327
Echinococcus granulosus mothers against decapentaplegic 5 0.0066 0.0159 0.0274
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0036 0.0091
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0036 0.0091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0036 0.0036
Leishmania major phosphatidylinositol 3-kinase, putative 0.0047 0.0077 0.0134
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0258 0.0974 0.0974
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0258 0.0974 1
Trichomonas vaginalis set domain proteins, putative 0.0229 0.0849 0.8711
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0069 0.0169 0.0554
Schistosoma mansoni smad1 5 8 and 0.0066 0.0159 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0319 0.3256
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0069 0.0169 0.044
Onchocerca volvulus Mothers against decapentaplegic homolog 0.003 0.0003 0.0039
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0111 0.035 0.1044
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0069 0.0169 0.1709
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0258 0.0974 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0077 0.0761
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0036 0.0346
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0003 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0069 0.0169 0.044
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0069 0.0169 0.0421
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.014 0.0471 0.1447
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0298 0.0298
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0047 0.0077 0.0077
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0069 0.0169 0.0554
Trichomonas vaginalis apoptosis inducing factor, putative 0.0069 0.0169 0.1709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0077 0.0761
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0223 0.0556
Echinococcus granulosus tar DNA binding protein 0.0583 0.2353 0.4053
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0069 0.0169 0.1709
Giardia lamblia GTOR 0.014 0.0471 0.3755
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0081 0.0201
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0069 0.0169 0.0554
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.0091
Schistosoma mansoni hypothetical protein 0.0032 0.0013 0.0013
Brugia malayi TAR-binding protein 0.0583 0.2353 0.5874
Schistosoma mansoni hypothetical protein 0.0343 0.1333 0.1333
Schistosoma mansoni glutamate synthase 0.0069 0.0169 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.0471 0.4822
Brugia malayi beta-lactamase family protein 0.0037 0.0036 0.0091
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0003 0.0006
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.014 0.0471 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0263 0.2679
Onchocerca volvulus 0.0037 0.0036 0.0428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0081 0.0081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0036 0.0036
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0258 0.0974 0.312
Schistosoma mansoni hypothetical protein 0.0069 0.0169 0.0169
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0069 0.0169 0.1411
Echinococcus multilocularis muscleblind protein 0.0302 0.1161 0.1999
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0069 0.0169 0.0421
Brugia malayi glutathione reductase 0.0746 0.3043 0.7594
Onchocerca volvulus 0.0148 0.0505 0.5944
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0069 0.0169 0.0291
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0047 0.0077 0.0132
Onchocerca volvulus 0.0037 0.0036 0.0428
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0069 0.0169 0.044
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0036 0.0346
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0069 0.0169 0.1709
Plasmodium falciparum glutathione reductase 0.0746 0.3043 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0069 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0198 0.2006
Trypanosoma brucei NADH dehydrogenase 0.0069 0.0169 0.044
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0069 0.0169 0.0168
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0069 0.0169 0.0291
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0258 0.0974 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.035 0.3572
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0305 0.0761
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1701 0.7097 0.8976
Echinococcus granulosus thioredoxin glutathione reductase 0.0752 0.3071 0.529
Loa Loa (eye worm) RNA binding protein 0.0583 0.2353 0.5874
Loa Loa (eye worm) hypothetical protein 0.0069 0.017 0.0424
Onchocerca volvulus 0.0081 0.0223 0.2622
Schistosoma mansoni microtubule-associated protein tau 0.1396 0.5806 0.5806
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0069 0.0169 0.044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0081 0.0139
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.0091
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0003 0.0006
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0069 0.0169 0.1709
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.019 0.0683 0.1705
Schistosoma mansoni hypothetical protein 0.0032 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0302 0.1161 0.2897
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0223 0.0223
Schistosoma mansoni sulfide quinone reductase 0.0069 0.0169 0.0169
Schistosoma mansoni smad 0.0066 0.0159 0.0159
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0258 0.0974 0.3202
Schistosoma mansoni tar DNA-binding protein 0.0583 0.2353 0.2353
Brugia malayi MH2 domain containing protein 0.0066 0.0159 0.0397
Brugia malayi MH2 domain containing protein 0.0973 0.4006 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0066 0.0159 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0198 0.2006
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0069 0.0169 0.0168
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0069 0.0169 0.0291
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1701 0.7097 0.8976
Brugia malayi RNA recognition motif domain containing protein 0.0583 0.2353 0.5874
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.0892 0.1087
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0258 0.0974 0.312
Plasmodium falciparum glutathione reductase 0.0258 0.0974 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0069 0.0169 0.1709
Schistosoma mansoni tar DNA-binding protein 0.0583 0.2353 0.2353
Echinococcus multilocularis GPCR, family 2 0.0032 0.0013 0.0022
Schistosoma mansoni hypothetical protein 0.0032 0.0013 0.0013
Schistosoma mansoni sulfide quinone reductase 0.0069 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0069 0.017 0.017
Schistosoma mansoni Smad4 0.003 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0081 0.0081
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0069 0.0169 0.044
Echinococcus granulosus smad 0.0066 0.0159 0.0274
Loa Loa (eye worm) hypothetical protein 0.0101 0.0305 0.0761
Brugia malayi MH2 domain containing protein 0.0066 0.0159 0.0397
Trichomonas vaginalis glutamate synthase, putative 0.0069 0.0169 0.1709
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0258 0.0974 0.312
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.0091
Mycobacterium tuberculosis Probable reductase 0.1701 0.7097 0.8976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0229 0.2327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0232 0.2363
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0036 0.0346
Mycobacterium ulcerans glutamate synthase subunit beta 0.0069 0.0169 0.1411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0077 0.0761
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.014 0.0471 0.0812
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0069 0.0169 0.0168
Schistosoma mansoni smad1 5 8 and 0.0066 0.0159 0.0159
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0258 0.0974 1
Brugia malayi beta-lactamase 0.0037 0.0036 0.0091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.014 0.0471 0.1176
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0069 0.0169 0.1411
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.019 0.0683 0.1705
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0319 0.3256
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0047 0.0077 0.0134
Trypanosoma cruzi NADH dehydrogenase, putative 0.0069 0.0169 0.044
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.0731 0.1825
Echinococcus multilocularis muscleblind protein 1 0.0302 0.1161 0.1999
Loa Loa (eye worm) hypothetical protein 0.0302 0.1161 0.2897
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0179 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.035 0.3572
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0258 0.0974 0.312
Echinococcus multilocularis Smad4 0.0066 0.0159 0.0274
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.189 0.7903 1
Mycobacterium ulcerans hypothetical protein 0.0069 0.0169 0.1411
Trichomonas vaginalis mercuric reductase, putative 0.0258 0.0974 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0258 0.0974 0.1192
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0069 0.0169 0.044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0013 0.0022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0013 0.0022
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0069 0.0169 0.0291
Loa Loa (eye worm) MH2 domain-containing protein 0.0973 0.4006 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0013 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0081 0.0201
Onchocerca volvulus 0.0037 0.0036 0.0428
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0258 0.0974 0.312
Brugia malayi RNA binding protein 0.0583 0.2353 0.5874
Loa Loa (eye worm) hypothetical protein 0.003 0.0003 0.0008
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0258 0.0974 0.2803
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0169 0.044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0305 0.0761
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.017 0.0424
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0069 0.0169 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0232 0.2363
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0069 0.0169 0.0291
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0036 0.0119
Mycobacterium ulcerans dehydrogenase 0.0069 0.0169 0.1411
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0069 0.0169 0.044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0081 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0036 0.0346
Schistosoma mansoni Smad4 0.003 0.0003 0.0003
Loa Loa (eye worm) nuclear factor I 0.0037 0.0033 0.0083
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0069 0.0169 0.0291
Loa Loa (eye worm) thioredoxin reductase 0.0746 0.3043 0.7594
Schistosoma mansoni tar DNA-binding protein 0.0583 0.2353 0.2353
Giardia lamblia NADH oxidase lateral transfer candidate 0.0258 0.0974 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0047 0.0077 0.0132
Echinococcus multilocularis mothers against decapentaplegic 5 0.0066 0.0159 0.0274
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0066 0.0158 0.0406
Trypanosoma cruzi trypanothione reductase, putative 0.0746 0.3043 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.0471 0.4822
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0066 0.0159 0.0274
Brugia malayi hypothetical protein 0.0148 0.0505 0.126
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0069 0.0169 0.1709
Echinococcus granulosus microtubule associated protein 2 0.1396 0.5806 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0319 0.3256

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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