Detailed information for compound 1162555

Basic information

Technical information
  • TDR Targets ID: 1162555
  • Name: 2-[3-(2-bromophenyl)-5-methyl-4H-1,2-oxazol-5 -yl]-5-(3-chlorophenyl)-1,3,4-oxadiazole
  • MW: 418.672 | Formula: C18H13BrClN3O2
  • H donors: 0 H acceptors: 2 LogP: 4.35 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)c1nnc(o1)C1(C)ON=C(C1)c1ccccc1Br
  • InChi: 1S/C18H13BrClN3O2/c1-18(10-15(23-25-18)13-7-2-3-8-14(13)19)17-22-21-16(24-17)11-5-4-6-12(20)9-11/h2-9H,10H2,1H3
  • InChiKey: VVLSXKTUIRSWLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-(2-bromophenyl)-5-methyl-4H-isoxazol-5-yl]-5-(3-chlorophenyl)-1,3,4-oxadiazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0306 0.0395
Brugia malayi Pre-SET motif family protein 0.0029 0.0282 0.0288
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1277 0.2707
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0306 0.0313
Onchocerca volvulus 0.0074 0.127 0.2692
Echinococcus granulosus geminin 0.0164 0.3237 0.4432
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0282 0.0432
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0411 0.0539
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.127 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0306 0.0293
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0729 0.5641
Echinococcus granulosus tumor protein p63 0.035 0.728 1
Schistosoma mansoni alpha glucosidase 0.0075 0.1277 0.2071
Plasmodium vivax hypothetical protein, conserved 0.0074 0.127 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.126 0.267
Loa Loa (eye worm) hypothetical protein 0.003 0.0306 0.0293
Onchocerca volvulus 0.003 0.0306 0.0617
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.127 0.0381
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0729 0.5641
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0306 0.0395
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0256 0.0509
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.127 1
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.127 0.0381
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.1043 0.1686
Schistosoma mansoni bromodomain containing protein 0.0129 0.2474 0.4043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0706 0.0702
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0306 0.0313
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.1254 0.17
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Brugia malayi Bromodomain containing protein 0.0078 0.1359 0.139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0306 0.0293
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0924 0.0945
Onchocerca volvulus 0.0029 0.0282 0.0565
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.126 0.9844
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0306 0.0395
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0306 0.0472
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1012 0.1634
Loa Loa (eye worm) hypothetical protein 0.0074 0.127 0.1281
Leishmania major cathepsin L-like protease 0.0065 0.1058 0.8261
Loa Loa (eye worm) hypothetical protein 0.0055 0.0856 0.0857
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.127 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0306 0.0472
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0729 0.0977
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1012 0.1016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0839 0.0839
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.127 0.0381
Brugia malayi Pre-SET motif family protein 0.0202 0.4056 0.4146
Schistosoma mansoni hypothetical protein 0.0033 0.0372 0.058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1012 0.1634
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0306 0.0313
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0075 0.1277 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.071 0.1485
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0256 0.188
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0181 0.3592 0.3659
Brugia malayi Glycosyl hydrolases family 31 protein 0.0336 0.6981 0.7136
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.1277 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0306 0.0313
Onchocerca volvulus 0.0074 0.127 0.2692
Echinococcus multilocularis lysosomal alpha glucosidase 0.0336 0.6981 0.9588
Brugia malayi PHD-finger family protein 0.0051 0.0762 0.0779
Brugia malayi MAP kinase sur-1 0.0049 0.0729 0.0745
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0075 0.1277 0.1288
Brugia malayi TAR-binding protein 0.0062 0.1012 0.1034
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0256 0.0509
Schistosoma mansoni zinc finger protein 0.0031 0.0333 0.0516
Mycobacterium ulcerans lipase LipD 0.0074 0.127 1
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0729 0.0977
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0306 0.0617
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0259 0.0329
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.127 0.2692
Echinococcus granulosus neutral alpha glucosidase AB 0.0075 0.1277 0.1732
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.002
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.1277 0.2707
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.071 0.0707
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.3592 0.492
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0306 0.0472
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0192 0.1377
Echinococcus granulosus tar DNA binding protein 0.0062 0.1012 0.1366
Loa Loa (eye worm) hypothetical protein 0.0028 0.0256 0.0242
Loa Loa (eye worm) hypothetical protein 0.0074 0.127 0.1281
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0306 0.0313
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.126 0.1708
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.1058 0.8261
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0924 0.1246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0306 0.0293
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0306 0.0395
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.126 0.267
Loa Loa (eye worm) hypothetical protein 0.0145 0.2806 0.2854
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0856 0.1378
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.126 0.9866
Loa Loa (eye worm) hypothetical protein 0.0051 0.0767 0.0765
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.3592 0.492
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0306 0.0395
Loa Loa (eye worm) MBCTL1 0.0055 0.0856 0.0857
Loa Loa (eye worm) hypothetical protein 0.0048 0.0706 0.0702
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0306 0.0395
Loa Loa (eye worm) hypothetical protein 0.003 0.0306 0.0293
Trypanosoma cruzi ISWI complex protein 0.0031 0.0333 0.2491
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0306 0.0395
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.3825 0.5242
Loa Loa (eye worm) hypothetical protein 0.0033 0.0372 0.036
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0256 0.188
Loa Loa (eye worm) hypothetical protein 0.003 0.0306 0.0293
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0464 0.9783 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.127 0.1281
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0729 0.0726
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0306 0.0313
Trypanosoma brucei ISWI complex protein 0.0031 0.0333 0.13
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.1058 0.8261
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0306 0.0313
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.127 0.9947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0306 0.0293
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0757 0.5864
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0306 0.0472
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0256 0.0509
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0372 0.038
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.071 0.1136
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0729 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0181 0.3592 0.3672
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0306 0.0313
Schistosoma mansoni hypothetical protein 0.0164 0.3237 0.53
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Loa Loa (eye worm) hypothetical protein 0.0074 0.127 0.1281
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.127 0.9947
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1012 0.1634
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.1043 0.141
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0306 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0306 0.0313
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0282 0.0361
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.126 0.1708
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.127 0.2692
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.127 0.1722
Trichomonas vaginalis sucrase-isomaltase, putative 0.0075 0.1277 0.2707
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0729 0.5641
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.127 0.2692
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0706 0.0721
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0336 0.6981 0.713
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0729 0.4949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.071 0.095
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0306 0.0395
Onchocerca volvulus 0.023 0.4664 1
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0306 0.0395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.3592 0.492
Schistosoma mansoni alpha-glucosidase 0.0289 0.596 0.9785
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1012 0.1634
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0729 0.0977
Leishmania major hypothetical protein, conserved 0.0074 0.127 0.9947
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.3592 0.5884
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1012 0.1634
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0656 0.0877
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0256 0.0509
Echinococcus multilocularis tumor protein p63 0.035 0.728 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0924 0.7196
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.1091 0.0184
Mycobacterium leprae Probable lipase LipE 0.0074 0.127 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0856 0.1152
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0924 0.149
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.127 0.9938
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0856 0.0875
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0856 0.1152
Brugia malayi RNA binding protein 0.0062 0.1012 0.1034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0306 0.0313
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0729 0.5641
Brugia malayi Inositol-1 0.0074 0.126 0.1288
Loa Loa (eye worm) beta-lactamase 0.0074 0.127 0.1281
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0256 0.0262
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0306 0.0395
Echinococcus multilocularis geminin 0.0164 0.3237 0.4432
Mycobacterium ulcerans hypothetical protein 0.0074 0.127 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0075 0.1277 0.1305
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0306 0.0313
Mycobacterium tuberculosis Conserved protein 0.0074 0.127 0.0381
Onchocerca volvulus 0.0074 0.127 0.2692
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0306 0.0472
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0306 0.0472
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0192 0.1369
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0256 0.0509
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.127 0.1281
Brugia malayi mbt repeat family protein 0.0049 0.071 0.0726
Brugia malayi beta-lactamase family protein 0.0074 0.127 0.1298
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0411 0.0645
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0122 0.2314 0.3161
Brugia malayi Bromodomain containing protein 0.0153 0.2997 0.3064
Trichomonas vaginalis esterase, putative 0.0074 0.127 0.2692
Leishmania major cathepsin L-like protease 0.0065 0.1058 0.8261
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0729 0.1527
Schistosoma mansoni thyroid hormone receptor 0.003 0.0306 0.0472
Brugia malayi nuclear hormone receptor 0.003 0.0306 0.0313
Onchocerca volvulus 0.0051 0.0767 0.1609
Loa Loa (eye worm) hypothetical protein 0.003 0.0306 0.0293
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0306 0.0395
Onchocerca volvulus 0.0049 0.071 0.1485
Loa Loa (eye worm) hypothetical protein 0.0064 0.1043 0.1048
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1012 0.1034
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0256 0.0591
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.127 0.206
Brugia malayi hypothetical protein 0.0025 0.0192 0.0196
Echinococcus multilocularis lysosomal alpha glucosidase 0.0336 0.6981 0.9588
Schistosoma mansoni hypothetical protein 0.0295 0.6091 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1277 0.2707
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0306 0.0472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0306 0.0293
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0571 0.0565
Leishmania major hypothetical protein, conserved 0.0031 0.0333 0.2491
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.126 0.9866
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0706 0.0721
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.1277 0.2707
Mycobacterium tuberculosis Conserved protein 0.0074 0.127 0.0381
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.127 0.1298
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1277 0.2707
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0856 0.1152
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1277 0.2707
Brugia malayi beta-lactamase family protein 0.0074 0.127 0.1298
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0306 0.0313
Loa Loa (eye worm) hypothetical protein 0.0074 0.127 0.1281
Schistosoma mansoni inositol monophosphatase 0.0074 0.126 0.2043
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0306 0.0472
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0306 0.0395
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.127 0.0381
Plasmodium vivax SET domain protein, putative 0.0029 0.0282 0.2098
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.126 0.9866
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.071 0.1136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0729 0.0977
Mycobacterium tuberculosis Conserved protein 0.0074 0.127 0.0381
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.126 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0192 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.127 0.1281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0306 0.0293
Onchocerca volvulus 0.0194 0.389 0.8333
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0411 0.0645
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0767 0.1231
Leishmania major cathepsin L-like protease 0.0065 0.1058 0.8261
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0729 0.1527
Echinococcus multilocularis neutral alpha glucosidase AB 0.0075 0.1277 0.1732
Toxoplasma gondii ABC1 family protein 0.0074 0.127 0.9947
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0729 0.5641
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.127 0.206
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.071 0.1136
Trypanosoma brucei glucosidase, putative 0.0075 0.1277 1
Brugia malayi follicle stimulating hormone receptor 0.0464 0.9783 1
Schistosoma mansoni coup transcription factor 0.003 0.0306 0.0472
Brugia malayi steroid hormone receptor 0.003 0.0306 0.0313
Mycobacterium leprae conserved hypothetical protein 0.0074 0.127 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0282 0.2087
Loa Loa (eye worm) hypothetical protein 0.0087 0.1553 0.1571
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0729 0.5641
Trichomonas vaginalis set domain proteins, putative 0.023 0.4664 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.1058 0.8261
Loa Loa (eye worm) inositol-1 0.0074 0.126 0.127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.3592 0.5884
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.126 0.9866
Brugia malayi nuclear receptor NHR-88 0.003 0.0306 0.0313
Loa Loa (eye worm) hypothetical protein 0.003 0.0306 0.0293
Loa Loa (eye worm) hypothetical protein 0.0049 0.071 0.0707
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0306 0.0313
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.1043 0.141
Schistosoma mansoni nuclear hormone receptor 0.003 0.0306 0.0472
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0256 0.0509
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0656 0.0877
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.3592 0.492
Loa Loa (eye worm) hypothetical protein 0.0025 0.0192 0.0176
Schistosoma mansoni zinc finger protein 0.004 0.0524 0.083
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0256 0.0509
Leishmania major alpha glucosidase II subunit, putative 0.0075 0.1277 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.071 0.095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.1058 0.8261
Trypanosoma cruzi ISWI complex protein 0.0031 0.0333 0.2491
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.127 0.2692
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.071 0.095
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.002
Echinococcus granulosus zinc finger protein 0.004 0.0524 0.0694
Echinococcus granulosus FTZ F1 alpha 0.003 0.0306 0.0395
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0256 0.188
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0192 0.1369
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0306 0.0313
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0306 0.0313
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.127 0.0381
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0439 0.0429
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.126 0.9704
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0306 0.0293
Schistosoma mansoni inositol monophosphatase 0.0074 0.126 0.2043
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0256 0.0509
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0122 0.2314 0.3161
Echinococcus multilocularis zinc finger protein 0.004 0.0524 0.0694
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0192 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0306 0.0293
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.127 0.1722
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.127 0.0381
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0256 0.188
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.126 0.267
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1277 1
Schistosoma mansoni hypothetical protein 0.0042 0.0571 0.0908
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0306 0.0395
Brugia malayi ecdysteroid receptor 0.003 0.0306 0.0313
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1012 0.1366
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0856 0.1152
Loa Loa (eye worm) hypothetical protein 0.0083 0.1468 0.1484
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0656 0.1048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0306 0.0395
Schistosoma mansoni hypothetical protein 0.0164 0.3237 0.53
Brugia malayi mbt repeat family protein 0.0049 0.071 0.0726
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0729 0.5641
Loa Loa (eye worm) hypothetical protein 0.003 0.0306 0.0293
Loa Loa (eye worm) hypothetical protein 0.003 0.0306 0.0293
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0936 0.7289
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0256 0.0509
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0306 0.0617
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.071 0.095
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.1277 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0306 0.0395
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.002
Mycobacterium ulcerans beta-lactamase 0.0074 0.127 1
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0306 0.0293
Leishmania major hypothetical protein, conserved 0.0025 0.0192 0.1369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.1043 0.1686
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.002
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.127 0.2692
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0411 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0282 0.0432
Trypanosoma brucei protein kinase, putative 0.0049 0.0729 0.4949
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.3592 0.5884
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.1254 0.17
Loa Loa (eye worm) RNA binding protein 0.0062 0.1012 0.1016
Schistosoma mansoni hypothetical protein 0.0031 0.0333 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0306 0.0313
Brugia malayi beta-lactamase 0.0074 0.127 0.1298
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1277 0.2707
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.4056 0.4134
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0924 0.1246
Schistosoma mansoni thyroid hormone receptor 0.003 0.0306 0.0472
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0306 0.0472
Loa Loa (eye worm) hypothetical protein 0.0078 0.1363 0.1375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1058 0.7985
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.126 0.9866
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1277 1
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0306 0.0617
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0729 0.1168
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0306 0.0395
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0192 0.1369
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0729 0.1527
Echinococcus granulosus lysosomal alpha glucosidase 0.0336 0.6981 0.9588
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.3825 0.5242
Trichomonas vaginalis maltase-glucoamylase, putative 0.0075 0.1277 0.2707
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1012 0.1016
Schistosoma mansoni alpha-glucosidase 0.0289 0.596 0.9785
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0729 0.1527

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.037 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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