Detailed information for compound 1162892

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 277.321 | Formula: C17H15N3O
  • H donors: 1 H acceptors: 1 LogP: 3.61 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@]12Oc3ccccc3[C@H](C2)n2c(N1)nc1c2cccc1
  • InChi: 1S/C17H15N3O/c1-17-10-14(11-6-2-5-9-15(11)21-17)20-13-8-4-3-7-12(13)18-16(20)19-17/h2-9,14H,10H2,1H3,(H,18,19)/t14-,17-/m0/s1
  • InChiKey: KAUFNOCHERQJSP-YOEHRIQHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0075
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0618 0.6487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0758 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0105 0.0105
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0236 0.0236
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0618 0.0811
Toxoplasma gondii exonuclease III APE 0.0022 0.0198 0.1176
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0198 0.0147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0078 0.0087
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0114 0.0114
Brugia malayi ecdysteroid receptor 0.0024 0.0236 0.0263
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0028
Onchocerca volvulus 0.0031 0.0374 0.11
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0394 0.0394
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0528 0.0651
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0236 0.0263
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0513 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.051 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0312 0.3702
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0875 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0114 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0236 0.0263
Echinococcus multilocularis peregrin 0.0031 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0101 0.1701 0.1899
Echinococcus granulosus intermediate filament protein 0.0032 0.0387 0.0387
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0236 0.0236
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0114 0.0128
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0069 0.1096 0.1224
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0528 0.0528
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0105 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.056 0.7204
Entamoeba histolytica hypothetical protein 0.0038 0.0513 0.562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0114 0.0916
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0025 0.0025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0236 0.0236
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0147 0.2577 0.2577
Plasmodium falciparum phd finger protein, putative 0.0031 0.0372 0.4148
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.3396 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0114 0.0916
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0236 0.0236
Echinococcus granulosus jumonji domain containing protein 0.0043 0.06 0.06
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0025 0.0028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0394 0.0394
Brugia malayi hypothetical protein 0.0012 0.0025 0.0028
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0105 0.0105
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0025 0.0031
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0618 0.8027
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0236 0.0263
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0875 1
Brugia malayi steroid hormone receptor 0.0024 0.0236 0.0263
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0028
Schistosoma mansoni lamin 0.0032 0.0387 0.0477
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0236 0.0236
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0236 0.0291
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0015
Brugia malayi PHD-finger family protein 0.0031 0.0372 0.0416
Brugia malayi CXXC zinc finger family protein 0.0031 0.0374 0.0417
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.293 0.447
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1701 0.1899
Echinococcus granulosus GPCR family 2 0.0032 0.0394 0.0394
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0372 0.3375
Schistosoma mansoni hypothetical protein 0.0439 0.8105 1
Leishmania major mitochondrial DNA polymerase beta 0.035 0.6424 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.8955 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0312 0.3713
Brugia malayi PHD-finger family protein 0.0012 0.0013 0.0015
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0114 0.0014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Loa Loa (eye worm) hypothetical protein 0.0057 0.0875 0.0977
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0236 0.0291
Schistosoma mansoni cpg binding protein 0.0033 0.0407 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.051 0.6498
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1701 0.1899
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0248 0.0225
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0236 0.0263
Schistosoma mansoni hypothetical protein 0.0032 0.0394 0.0487
Echinococcus multilocularis geminin 0.0367 0.6733 0.6733
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0875 0.1218
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.06 0.06
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0198 0.2125
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0236 0.0263
Onchocerca volvulus 0.0032 0.0387 0.1139
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0758 0.0846
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0758 0.0758
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0618 0.7502
Giardia lamblia GTOR 0.0051 0.0758 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.1697 0.1697
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0236 0.0263
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0236 0.0291
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0236 0.0291
Schistosoma mansoni jumonji domain containing protein 0.008 0.1305 0.161
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.8105 0.8105
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0025 0.0028
Echinococcus multilocularis muscleblind protein 1 0.0484 0.8955 0.8955
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0618 0.0618
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0105 0.1043
Echinococcus granulosus lamin 0.0032 0.0387 0.0387
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0394 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0312 0.3713
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0105 0.0105
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0114 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0368 0.4499
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0198 0.0221
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0372 0.4148
Schistosoma mansoni cpg binding protein 0.0033 0.0407 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.051 0.6498
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0618 0.0811
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Brugia malayi hypothetical protein 0.0037 0.049 0.0548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0236 0.0263
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0618 0.8027
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0105 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.056 0.7204
Brugia malayi nuclear receptor NHR-88 0.0024 0.0236 0.0263
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Schistosoma mansoni inositol monophosphatase 0.0044 0.0618 0.0763
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0513 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0758 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0198 0.2101
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0875 1
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0387 0.0432
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0875 0.9737
Toxoplasma gondii hypothetical protein 0.0057 0.086 0.9544
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0236 0.0263
Echinococcus multilocularis neuropeptide receptor A26 0.0539 1 1
Schistosoma mansoni inositol monophosphatase 0.0044 0.0618 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0312 0.3713
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0758 0.1033
Schistosoma mansoni hypothetical protein 0.0069 0.1096 0.1352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0418 0.5205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0312 0.3702
Loa Loa (eye worm) hypothetical protein 0.0031 0.0376 0.042
Onchocerca volvulus 0.0024 0.0236 0.0693
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.6424 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0114 0.0141
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0758 0.1033
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0236 0.0263
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0025 0.0025
Brugia malayi N-terminal motif family protein 0.019 0.3396 0.3793
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0236 0.0263
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0105 0.1043
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Echinococcus multilocularis musashi 0.0032 0.0387 0.0387
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0026 0.0277 0.0341
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0114 0.0014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0198 0.0147
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0531 0.134
Echinococcus multilocularis X box binding protein 1 0.0319 0.584 0.584
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0561 0.072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.051 0.6498
Brugia malayi Bromodomain containing protein 0.0031 0.0372 0.0416
Schistosoma mansoni hypothetical protein 0.0367 0.6733 0.8308
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1701 0.1899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0114 0.0916
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0758 0.1033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0198 0.0147
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0192 0.0137
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0114 0.0014
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0236 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0236 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0368 0.4499
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0372 0.0372
Schistosoma mansoni coup transcription factor 0.0024 0.0236 0.0291
Mycobacterium ulcerans hypothetical protein 0.0185 0.3284 1
Brugia malayi jmjC domain containing protein 0.0039 0.0528 0.059
Brugia malayi intermediate filament protein 0.0032 0.0387 0.0432
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.293 0.447
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0561 0.072
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0236 0.0263
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0125 0.0154
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0387 0.0432
Brugia malayi hypothetical protein 0.0038 0.0513 0.0573
Loa Loa (eye worm) hypothetical protein 0.0053 0.0788 0.088
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0198 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0758 0.0935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.056 0.7204
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0531 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0171 0.3023 0.3023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.051 0.6498
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0198 0.0293
Echinococcus granulosus peregrin 0.0031 0.0372 0.0372
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.6424 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0236 0.0263
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0236 0.0693
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0025 0.0031
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0031 0.0372 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.056 0.7204
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0114 0.0014
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.051 0.5116
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0198 0.0221
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0495 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0236 0.0263
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0198 0.2101
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0236 0.0236
Echinococcus granulosus neuropeptide receptor A26 0.0539 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0362 0.4418
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0528 0.0651
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0105 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0236 0.0263
Trypanosoma brucei mitochondrial DNA polymerase beta 0.035 0.6424 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0105 0.0118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0236 0.0263
Echinococcus granulosus X box binding protein 1 0.0319 0.584 0.584
Onchocerca volvulus 0.0032 0.0387 0.1139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0236 0.0263
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0758 0.1033
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0372 0.0459
Echinococcus granulosus lamin dm0 0.0032 0.0387 0.0387
Echinococcus granulosus dnaJ subfamily B 0.0439 0.8105 0.8105
Mycobacterium tuberculosis Conserved hypothetical protein 0.0185 0.3284 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0105 0.0105
Schistosoma mansoni hypothetical protein 0.0367 0.6733 0.8308
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0114 0.0014
Schistosoma mansoni cpg binding protein 0.0031 0.0374 0.0461
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0372 0.3375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0439 0.5501
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0758 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.8955 1
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0236 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0362 0.4418
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0927 0.13
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0561 0.072
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0618 0.136
Loa Loa (eye worm) inositol-1 0.0044 0.0618 0.069
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.011 0.0122
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0198 0.0198
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0032 0.0387 0.0432
Echinococcus multilocularis GPCR, family 2 0.0032 0.0394 0.0394
Entamoeba histolytica hypothetical protein 0.0038 0.0513 0.562
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0166 0.293 0.447
Schistosoma mansoni hypothetical protein 0.0147 0.2577 0.318
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0236 0.0236
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0236 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.056 0.7204
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0078 0.0078
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0758 1
Brugia malayi hypothetical protein 0.0012 0.0025 0.0028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0236 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.051 0.6498
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0236 0.0236
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0723 0.0977
Brugia malayi hypothetical protein 0.0057 0.0875 0.0977
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0758 0.1033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0236 0.0236
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0158 0.0177
Schistosoma mansoni thyroid hormone receptor 0.0171 0.3023 0.373
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0025 0.0028
Entamoeba histolytica hypothetical protein 0.0038 0.0513 0.562
Entamoeba histolytica hypothetical protein 0.0038 0.0513 0.562
Giardia lamblia PHD finger protein 15 0.0031 0.0372 0.3106
Schistosoma mansoni lamin 0.0032 0.0387 0.0477
Onchocerca volvulus Alhambra homolog 0.0031 0.0372 0.1096
Schistosoma mansoni ap endonuclease 0.0022 0.0198 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0368 0.4499
Brugia malayi Inositol-1 0.0044 0.0618 0.069
Schistosoma mansoni hypothetical protein 0.0032 0.0394 0.0487
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0758 0.0846
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0374 0.0417
Echinococcus multilocularis neuropeptide s receptor 0.0539 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0394 0.044
Schistosoma mansoni hypothetical protein 0.0038 0.0513 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0114 0.0916
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0723 0.0977
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0236 0.0291
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0236 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0616 0.8002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0758 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.1697 0.1697
Echinococcus multilocularis muscleblind protein 0.0484 0.8955 0.8955
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.0263
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0618 0.8027
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0114 0.0114
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0236 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0114 0.0916
Schistosoma mansoni thyroid hormone receptor 0.0171 0.3023 0.373
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0513 0.0513
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0198 0.2125
Brugia malayi isocitrate dehydrogenase 0.0017 0.0105 0.0118
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0992 0.1108
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0236 0.0236
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0394 0.044
Echinococcus multilocularis cpg binding protein 0.0033 0.0407 0.0407
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0758 0.1033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0236 0.0263
Schistosoma mansoni intermediate filament proteins 0.0032 0.0387 0.0477
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0236 0.0693
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0875 0.1218
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0105 0.0105
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0387 0.0432
Brugia malayi jmjC domain containing protein 0.0101 0.1697 0.1895
Echinococcus granulosus cpg binding protein 0.0033 0.0407 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0236 0.0263
Schistosoma mansoni ap endonuclease 0.0022 0.0198 0.0245
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0618 0.0811
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0236 0.0263
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0147 0.2577 0.2577
Echinococcus multilocularis lamin dm0 0.0032 0.0387 0.0387
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0723 0.0977
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0618 0.0811
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.011 0.0122
Brugia malayi nuclear hormone receptor 0.0024 0.0236 0.0263
Schistosoma mansoni hypothetical protein 0.0031 0.0372 0.0459
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0236 0.0236
Leishmania major hypothetical protein, conserved 0.0057 0.0875 0.1218
Echinococcus granulosus muscleblind protein 0.0484 0.8955 0.8955
Schistosoma mansoni hypothetical protein 0.0319 0.584 0.7206
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0312 0.3713
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0394 0.0394
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1028 0.1268
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0198 0.0147
Loa Loa (eye worm) hypothetical protein 0.0032 0.0394 0.044
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0394 0.044
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0236 0.0693
Echinococcus granulosus geminin 0.0367 0.6733 0.6733
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0372 0.0372
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0044 0.0618 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.051 0.6498
Schistosoma mansoni hypothetical protein 0.0032 0.0394 0.0487
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0277 0.0277
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0236 0.0291
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0618 0.0618
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0032 0.0394 0.0487
Brugia malayi nuclear receptor RXR 0.0012 0.0025 0.0028
Loa Loa (eye worm) hypothetical protein 0.019 0.3396 0.3793
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0236 0.0291
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0896 1
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0236 0.0263
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1096 0.1224
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0528 0.059
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0236 0.0291
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0312 0.3702
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0723 0.0977
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0236 0.0263
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0078 0.0078
Echinococcus multilocularis lamin 0.0032 0.0387 0.0387
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0875 0.1218
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0277 0.0277
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0372 0.0416
Brugia malayi Muscleblind-like protein 0.0484 0.8955 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0758 0.0758

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Inhibition of kinasin spindle protein by ATPase assay ChEMBL. 20542426
Inhibition (binding) Inhibition of kinasin spindle protein in human HeLa cells assessed as inhibition of induction of mitotic arrest ChEMBL. 20542426

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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