Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0951 | 0.0842 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0951 | 0.2825 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0208 | 0.0208 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3368 | 1 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0951 | 0.6132 | |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0951 | 0.2353 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0208 | 0.0617 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0182 | 0.916 | 0.916 |
Echinococcus granulosus | lamin | 0.0033 | 0.0951 | 0.2825 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1424 | 0.132 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0015 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.3193 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3368 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3368 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3368 | 0.3287 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0208 | 0.0617 |
Mycobacterium leprae | Possible regulatory protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0951 | 0.0951 |
Brugia malayi | PAS domain containing protein | 0.0059 | 0.2391 | 0.2299 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0951 | 0.0842 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2471 | 0.2471 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0182 | 0.916 | 0.915 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3368 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0025 | 0.0073 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.3193 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0951 | 0.2353 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0919 | 0.0919 |
Trichomonas vaginalis | adenylate cyclase, type VII, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.3193 | 0.9482 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0951 | 0.2825 |
Brugia malayi | bHLH-PAS transcription factor | 0.0043 | 0.1552 | 0.1449 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2471 | 0.238 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0208 | 0.0089 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0208 | 0.0617 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2471 | 0.2471 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1424 | 0.3848 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3368 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0208 | 0.0617 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3368 | 1 |
Echinococcus granulosus | single minded 2 | 0.0043 | 0.1552 | 0.4607 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0059 | 0.2391 | 0.691 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0951 | 0.2825 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0951 | 0.0951 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0951 | 0.2825 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.3193 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.3193 | 1 |
Onchocerca volvulus | 0.0043 | 0.1552 | 1 | |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0951 | 0.0951 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3368 | 0.3287 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3368 | 0.3368 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3368 | 0.3287 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3368 | 0.3368 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3368 | 1 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | single-minded | 0.0059 | 0.2391 | 0.691 |
Schistosoma mansoni | lamin | 0.0033 | 0.0951 | 0.2353 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0208 | 0.0089 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3368 | 0.3368 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0951 | 0.2825 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.3193 | 0.9448 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0208 | 0.0617 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0025 | 0.0073 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.3193 | 0.9448 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.3193 | 0.9482 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0208 | 0.0617 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0043 | 0.1552 | 0.4607 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1424 | 0.1424 |
Onchocerca volvulus | 0.0033 | 0.0951 | 0.6132 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.3193 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 1 | 1 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0015 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.3193 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2471 | 0.238 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.012 | 0.012 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0015 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.