Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0428 | 0.074 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0231 | 0.0399 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0231 | 0.0231 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0053 | 0.0399 | 0.4725 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0067 | 0.0588 | 0.0588 |
Brugia malayi | TAR-binding protein | 0.0216 | 0.2512 | 0.4345 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0213 | 0.247 | 0.3505 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0231 | 0.0399 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0213 | 0.247 | 0.3505 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0588 | 0.1017 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0067 | 0.0588 | 0.0588 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0213 | 0.247 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0121 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.214 | 0.3702 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0121 | 0.0121 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0053 | 0.0399 | 0.0754 |
Echinococcus multilocularis | expressed protein | 0.0411 | 0.5031 | 0.5031 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0254 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0231 | 0.0399 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0428 | 0.074 |
Schistosoma mansoni | lamin | 0.0031 | 0.0121 | 0.0121 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0053 | 0.0399 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0053 | 0.0399 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0067 | 0.0588 | 0.0588 |
Plasmodium vivax | SET domain protein, putative | 0.0067 | 0.0588 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0067 | 0.0588 | 0.0588 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0065 | 0.0556 | 0.0556 |
Onchocerca volvulus | 0.0056 | 0.0437 | 0.0486 | |
Echinococcus multilocularis | lamin | 0.0031 | 0.0121 | 0.0121 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0103 | 0.1051 | 0.1818 |
Mycobacterium ulcerans | glutaminase | 0.0301 | 0.3609 | 1 |
Schistosoma mansoni | kinase | 0.0108 | 0.1117 | 0.1117 |
Loa Loa (eye worm) | glutaminase | 0.0301 | 0.3609 | 0.6243 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0213 | 0.247 | 0.3505 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0231 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0231 | 0.0399 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0216 | 0.2512 | 0.4345 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.1051 | 0.1051 |
Onchocerca volvulus | 0.004 | 0.0231 | 0.0168 | |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0658 | 0.1907 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0794 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.1051 | 0.1051 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0231 | 0.0399 |
Echinococcus multilocularis | tar DNA binding protein | 0.0216 | 0.2512 | 0.2512 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0073 | 0.0658 | 0.1907 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0213 | 0.247 | 0.3505 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0213 | 0.247 | 0.3615 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0437 | 0.0756 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0437 | 0.0437 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0428 | 0.074 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.108 | 0.133 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0658 | 0.1907 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0794 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0067 | 0.0588 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0254 | 0.0254 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0428 | 0.074 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0187 | 0.214 | 0.214 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0213 | 0.247 | 0.247 |
Schistosoma mansoni | tar DNA-binding protein | 0.0216 | 0.2512 | 0.2512 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0231 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0231 | 0.0399 |
Schistosoma mansoni | tar DNA-binding protein | 0.0216 | 0.2512 | 0.2512 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0213 | 0.247 | 0.3505 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0231 | 0.0231 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0253 | 0.2992 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0254 | 0.0254 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0121 | 0.021 |
Schistosoma mansoni | tar DNA-binding protein | 0.0216 | 0.2512 | 0.2512 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0067 | 0.0588 | 0.0588 |
Entamoeba histolytica | hypothetical protein | 0.0053 | 0.0399 | 0.0655 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0187 | 0.214 | 0.3702 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0213 | 0.247 | 0.3505 |
Schistosoma mansoni | tar DNA-binding protein | 0.0216 | 0.2512 | 0.2512 |
Onchocerca volvulus | 0.0067 | 0.0588 | 0.0718 | |
Onchocerca volvulus | 0.004 | 0.0231 | 0.0168 | |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0053 | 0.0399 | 0.0611 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0121 | 0.0121 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0231 | 0.0231 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0231 | 0.0231 |
Onchocerca volvulus | 0.0187 | 0.214 | 0.3107 | |
Loa Loa (eye worm) | glutaminase 2 | 0.0301 | 0.3609 | 0.6243 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0073 | 0.0658 | 0.1821 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0121 | 0.0121 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0067 | 0.0588 | 0.0588 |
Echinococcus multilocularis | geminin | 0.0381 | 0.4655 | 0.4655 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0203 | 0.0352 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.197 | 0.3407 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0437 | 0.0437 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.0658 | 0.0658 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 0.1051 | 0.1051 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0272 | 0.3241 | 0.3241 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0053 | 0.0399 | 0.05 |
Brugia malayi | beta-lactamase | 0.004 | 0.0231 | 0.0399 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0254 | 0.0254 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0067 | 0.0588 | 0.0588 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 0.1051 | 0.1051 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0053 | 0.0399 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0411 | 0.5031 | 0.5031 |
Brugia malayi | Pre-SET motif family protein | 0.0468 | 0.5782 | 1 |
Onchocerca volvulus | 0.0533 | 0.6619 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0381 | 0.4655 | 0.4655 |
Echinococcus granulosus | tar DNA binding protein | 0.0216 | 0.2512 | 0.2512 |
Onchocerca volvulus | 0.004 | 0.0231 | 0.0168 | |
Echinococcus granulosus | lamin | 0.0031 | 0.0121 | 0.0121 |
Brugia malayi | RNA binding protein | 0.0216 | 0.2512 | 0.4345 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 0.1051 | 0.1051 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0053 | 0.0399 | 0.05 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0121 | 0.0121 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0073 | 0.0658 | 0.1138 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0121 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0231 | 0.0399 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0053 | 0.0399 | 0.4725 |
Brugia malayi | hypothetical protein | 0.0174 | 0.197 | 0.3407 |
Brugia malayi | hypothetical protein | 0.0272 | 0.3241 | 0.5607 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.0262 | 0.0262 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0272 | 0.3241 | 0.3241 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0213 | 0.247 | 1 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0053 | 0.0399 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0381 | 0.4655 | 0.4655 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.0262 | 0.0262 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0053 | 0.0399 | 0.0754 |
Brugia malayi | glutaminase DH11.1 | 0.0301 | 0.3609 | 0.6243 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.108 | 0.133 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0254 | 0.0254 |
Schistosoma mansoni | glutaminase | 0.0301 | 0.3609 | 0.3609 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0231 | 0.0399 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.0658 | 0.0658 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0187 | 0.214 | 0.214 |
Schistosoma mansoni | tar DNA-binding protein | 0.0216 | 0.2512 | 0.2512 |
Echinococcus granulosus | geminin | 0.0381 | 0.4655 | 0.4655 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0216 | 0.2512 | 0.4345 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.0658 | 0.0658 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0203 | 0.0203 |
Trichomonas vaginalis | set domain proteins, putative | 0.0533 | 0.6619 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0213 | 0.247 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0053 | 0.0399 | 0.4725 |
Trypanosoma brucei | polo-like protein kinase | 0.0213 | 0.247 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0468 | 0.5782 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.0121 | 0.0121 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0213 | 0.247 | 0.247 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0213 | 0.247 | 0.247 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0213 | 0.247 | 0.3505 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0121 | 0.021 |
Trichomonas vaginalis | glutaminase, putative | 0.0301 | 0.3609 | 0.5289 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0231 | 0.0399 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0103 | 0.1051 | 0.1818 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0114 | 0.0197 |
Brugia malayi | Pre-SET motif family protein | 0.0067 | 0.0588 | 0.1017 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0203 | 0.0352 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0121 | 0.021 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0213 | 0.247 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0213 | 0.247 | 0.4272 |
Giardia lamblia | Kinase, PLK | 0.0213 | 0.247 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.1051 | 0.1051 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 0.1051 | 0.1051 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0658 | 0.1907 |
Loa Loa (eye worm) | RNA binding protein | 0.0216 | 0.2512 | 0.4345 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.3241 | 0.5607 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0053 | 0.0399 | 0.5 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0187 | 0.214 | 0.214 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.0658 | 0.1138 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0213 | 0.247 | 0.4272 |
Loa Loa (eye worm) | TAR-binding protein | 0.0216 | 0.2512 | 0.4345 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0121 | 0.021 |
Onchocerca volvulus | 0.0174 | 0.197 | 0.2844 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.