Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.1603 | 0.1879 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.2198 | 0.2577 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1934 | 0.2266 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1934 | 0.2266 |
Brugia malayi | RNA binding protein | 0.0134 | 0.8531 | 0.8531 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1934 | 0.2266 |
Loa Loa (eye worm) | RNA binding protein | 0.0134 | 0.8531 | 0.8531 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0154 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1934 | 0.2266 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.6389 | 0.6389 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0154 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.8531 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | TAR-binding protein | 0.0134 | 0.8531 | 0.8531 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1934 | 0.2266 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.2198 | 0.2577 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0105 | 0.6389 | 0.6389 |
Brugia malayi | TAR-binding protein | 0.0134 | 0.8531 | 0.8531 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1934 | 0.2266 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1934 | 0.2266 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2198 | 0.2198 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.2198 | 0.2198 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.2198 | 0.2577 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.2198 | 0.2577 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.1603 | 0.1879 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.2198 | 0.2198 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.8531 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1603 | 0.1879 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.2198 | 0.2198 |
Echinococcus multilocularis | tar DNA binding protein | 0.0134 | 0.8531 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1603 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.6389 | 0.7489 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.2198 | 0.2577 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.2198 | 0.2577 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1603 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.2198 | 0.2577 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.8531 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.2198 | 0.2577 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0134 | 0.8531 | 0.8531 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.2198 | 0.2577 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1603 | 0.1603 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.2198 | 0.2577 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0134 | 0.8531 | 0.8531 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1603 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.8531 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.1603 | 0.1879 |
Echinococcus granulosus | tar DNA binding protein | 0.0134 | 0.8531 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.8531 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1934 | 0.1934 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1603 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.