Detailed information for compound 116464

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 335.711 | Formula: C13H18BrClNS-
  • H donors: 0 H acceptors: 0 LogP: 4.87 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCCCC1CSc1ccc(cc1)Br.[Cl-]
  • InChi: 1S/C13H18BrNS.ClH/c1-15-9-3-2-4-12(15)10-16-13-7-5-11(14)6-8-13;/h5-8,12H,2-4,9-10H2,1H3;1H/p-1
  • InChiKey: CERMIWMJXGAVJD-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.043 0.0633
Schistosoma mansoni hypothetical protein 0.0044 0.0341 0.0501
Trichomonas vaginalis esterase, putative 0.0076 0.1038 0.1702
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.228 0.4328
Mycobacterium tuberculosis Conserved protein 0.0076 0.1038 0.0962
Brugia malayi hypothetical protein 0.0035 0.0146 0.0278
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0347 0.0353
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0347 0.271
Loa Loa (eye worm) inositol-1 0.0036 0.0167 0.0317
Brugia malayi Pre-SET motif family protein 0.0034 0.0119 0.0226
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0243 0.1609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0347 0.051
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0044 0.0347 0.0659
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.1038 0.1527
Schistosoma mansoni tar DNA-binding protein 0.0132 0.228 0.3355
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0243 0.0149
Brugia malayi Bromodomain containing protein 0.0033 0.0111 0.021
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0651 0.0958
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0347 0.051
Schistosoma mansoni inositol monophosphatase 0.0036 0.0167 0.0246
Schistosoma mansoni hypothetical protein 0.0318 0.6366 0.9365
Plasmodium falciparum polyprenol reductase, putative 0.0044 0.0347 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0146 0.0215
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0173 0.0255
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.2067 0.304
Brugia malayi PHD-finger family protein 0.0053 0.0541 0.1027
Loa Loa (eye worm) MBCTL1 0.0058 0.0651 0.1235
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.4565 0.8665
Schistosoma mansoni lipoxygenase 0.0086 0.1256 0.1848
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0167 0.0246
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.1038 0.1702
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0167 0.0804
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0496 0.0729
Echinococcus multilocularis zinc finger protein 0.0042 0.0291 0.0428
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0044 0.0347 0.271
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.1057 0.1555
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1423 0.2094
Leishmania major hypothetical protein, conserved 0.0076 0.1038 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.1038 0.1969
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0651 0.1235
Loa Loa (eye worm) RNA binding protein 0.0132 0.228 0.4328
Echinococcus multilocularis muscleblind protein 0.0168 0.3061 0.4503
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0347 0.0353
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0243 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.1038 0.1969
Echinococcus granulosus peregrin 0.0033 0.0111 0.0163
Schistosoma mansoni ap endonuclease 0.0039 0.0243 0.0358
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0132 0.0194
Brugia malayi jmjC domain containing protein 0.0038 0.0221 0.042
Onchocerca volvulus Huntingtin homolog 0.0268 0.5269 0.9974
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0146 0.0215
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0243 0.0876
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0347 0.271
Loa Loa (eye worm) hypothetical protein 0.0049 0.0447 0.0848
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.1038 0.1527
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.1038 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0347 0.0659
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.0347 0.3349
Echinococcus granulosus muscleblind protein 0.0168 0.3061 0.4503
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.1038 0.1702
Loa Loa (eye worm) hypothetical protein 0.0058 0.0651 0.1235
Loa Loa (eye worm) hypothetical protein 0.007 0.0918 0.1741
Mycobacterium ulcerans beta-lactamase 0.0076 0.1038 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0347 0.051
Loa Loa (eye worm) hypothetical protein 0.0076 0.1038 0.1969
Loa Loa (eye worm) hypothetical protein 0.0168 0.3061 0.581
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0044 0.0347 0.0511
Echinococcus multilocularis geminin 0.0337 0.6797 1
Onchocerca volvulus 0.0076 0.1038 0.1964
Echinococcus granulosus histone lysine methyltransferase setb 0.007 0.0918 0.135
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0243 0.1609
Toxoplasma gondii ABC1 family protein 0.0076 0.1038 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0119 0.1147
Mycobacterium tuberculosis Conserved protein 0.0076 0.1038 0.0962
Giardia lamblia Synaptic glycoprotein SC2 0.0044 0.0347 1
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.0347 0.3349
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0167 0.0804
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.043 0.0633
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0243 1
Brugia malayi Muscleblind-like protein 0.0168 0.3061 0.581
Loa Loa (eye worm) hypothetical protein 0.0044 0.0347 0.0659
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0243 0.0358
Plasmodium vivax hypothetical protein, conserved 0.0076 0.1038 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0167 0.1022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0243 0.0161
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0243 0.0149
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0243 0.7
Brugia malayi Inositol-1 0.0036 0.0167 0.0317
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0347 0.051
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0221 0.042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0347 0.051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.1057 0.1555
Schistosoma mansoni bromodomain containing protein 0.0135 0.2338 0.3439
Schistosoma mansoni tar DNA-binding protein 0.0132 0.228 0.3355
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.2141 0.4063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0347 0.0658
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0044 0.0347 0.0511
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0243 0.0462
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0918 0.135
Schistosoma mansoni ap endonuclease 0.0039 0.0243 0.0358
Loa Loa (eye worm) hypothetical protein 0.0268 0.5269 1
Onchocerca volvulus 0.0051 0.0496 0.0938
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0167 0.0246
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0245 0.036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.1038 0.1527
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0347 0.271
Mycobacterium leprae Probable lipase LipE 0.0076 0.1038 1
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.1038 1
Echinococcus multilocularis tar DNA binding protein 0.0132 0.228 0.3355
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.3968 0.5838
Brugia malayi hypothetical protein 0.0268 0.5269 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0918 0.135
Echinococcus multilocularis muscleblind protein 1 0.0168 0.3061 0.4503
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0243 0.7
Brugia malayi mbt repeat family protein 0.0051 0.0496 0.0941
Toxoplasma gondii exonuclease III APE 0.0039 0.0243 0.2344
Loa Loa (eye worm) beta-lactamase 0.0076 0.1038 0.1969
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0341 0.0647
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0119 0.1147
Echinococcus granulosus geminin 0.0337 0.6797 1
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0347 0.3349
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.1038 0.0962
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0651 0.0958
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0173 0.0255
Schistosoma mansoni hypothetical protein 0.0337 0.6797 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0651 0.0958
Onchocerca volvulus 0.0076 0.1038 0.1964
Mycobacterium leprae conserved hypothetical protein 0.0076 0.1038 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0243 0.1609
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0496 0.0941
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0167 0.1609
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.043 0.0633
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.0347 0.3349
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0221 0.0325
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0243 0.1609
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.0347 0.0353
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0651 0.0958
Loa Loa (eye worm) hypothetical protein 0.0091 0.1371 0.2603
Onchocerca volvulus 0.0034 0.0119 0.0225
Brugia malayi Pre-SET motif family protein 0.0236 0.4565 0.8665
Loa Loa (eye worm) hypothetical protein 0.0051 0.0496 0.0941
Schistosoma mansoni tar DNA-binding protein 0.0132 0.228 0.3355
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.1038 0.0962
Mycobacterium ulcerans hypothetical protein 0.0076 0.1038 1
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0347 0.271
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.1038 0.0962
Brugia malayi beta-lactamase 0.0076 0.1038 0.1969
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0496 0.0729
Brugia malayi MH2 domain containing protein 0.0126 0.2141 0.4063
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0173 0.0255
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1038 0.1702
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1423 0.2094
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0496 0.0729
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.1038 0.0962
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0044 0.0347 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.1171 0.2223
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.1038 0.0962
Loa Loa (eye worm) hypothetical protein 0.0151 0.2686 0.5098
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0347 0.0353
Mycobacterium tuberculosis Conserved protein 0.0076 0.1038 0.0962
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.1038 0.1527
Onchocerca volvulus 0.0076 0.1038 0.1964
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0173 0.0255
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0347 0.0353
Echinococcus granulosus tar DNA binding protein 0.0132 0.228 0.3355
Loa Loa (eye worm) hypothetical protein 0.0268 0.5269 1
Brugia malayi Synaptic glycoprotein SC2 0.0044 0.0347 0.0659
Echinococcus granulosus jumonji domain containing protein 0.004 0.0245 0.036
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.1038 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0496 0.0729
Entamoeba histolytica hypothetical protein 0.0044 0.0347 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.2067 0.304
Schistosoma mansoni hypothetical protein 0.0035 0.0146 0.0215
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0243 0.0358
Loa Loa (eye worm) hypothetical protein 0.0076 0.1038 0.1969
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0347 0.0353
Brugia malayi jmjC domain containing protein 0.0093 0.1423 0.2701
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0347 0.051
Echinococcus granulosus zinc finger protein 0.0042 0.0291 0.0428
Schistosoma mansoni inositol monophosphatase 0.0036 0.0167 0.0246
Mycobacterium ulcerans hypothetical protein 0.0044 0.0347 0.2073
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0347 0.0353
Onchocerca volvulus Huntingtin homolog 0.0268 0.5269 0.9974
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.0347 0.0353
Mycobacterium ulcerans lipase LipD 0.0076 0.1038 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.1038 0.1969
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0044 0.0347 0.0511
Schistosoma mansoni hypothetical protein 0.0337 0.6797 1
Brugia malayi Bromodomain containing protein 0.016 0.2886 0.5478
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0496 0.0938
Loa Loa (eye worm) hypothetical protein 0.0076 0.1038 0.1969
Brugia malayi TAR-binding protein 0.0132 0.228 0.4328
Echinococcus granulosus synaptic glycoprotein sc2 0.0044 0.0347 0.0511
Loa Loa (eye worm) hypothetical protein 0.0076 0.1038 0.1969
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0044 0.0347 0.0511
Brugia malayi RNA binding protein 0.0132 0.228 0.4328
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0146 0.0215
Loa Loa (eye worm) hypothetical protein 0.0087 0.1282 0.2433
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0496 0.0729
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0127 0.217 0.3192
Onchocerca volvulus 0.0269 0.5283 1
Brugia malayi beta-lactamase family protein 0.0076 0.1038 0.1969
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0243 0.0462
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0496 0.0729
Onchocerca volvulus 0.0044 0.0347 0.0658
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.1038 1
Schistosoma mansoni tar DNA-binding protein 0.0132 0.228 0.3355
Loa Loa (eye worm) TAR-binding protein 0.0132 0.228 0.4328
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.1038 0.0962
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1002 0.1474
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0092 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0132 0.228 0.3355
Schistosoma mansoni hypothetical protein 0.0033 0.0091 0.0134
Brugia malayi Bromodomain containing protein 0.0082 0.1168 0.2216
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0347 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0119 0.0175
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1038 0.1702
Plasmodium vivax polyprenol reductase, putative 0.0044 0.0347 0.3349
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1038 0.1702
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0347 0.0658
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0167 0.0804
Loa Loa (eye worm) hypothetical protein 0.0168 0.3061 0.581
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.1038 0.0962
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0044 0.0347 1
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.228 0.4328
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.0347 0.0353
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.3968 0.5838
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0651 0.0958
Schistosoma mansoni zinc finger protein 0.0042 0.0291 0.0428
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.007 0.0918 0.135
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0496 0.0729
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0666 0.1264
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.2141 0.4063
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.1038 0.1969
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0044 0.0347 0.271
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0202 0.0383
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0221 0.0325
Brugia malayi beta-lactamase family protein 0.0076 0.1038 0.1969
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0243 0.4816
Brugia malayi mbt repeat family protein 0.0051 0.0496 0.0941
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0044 0.0347 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0127 0.217 0.3192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0119 0.0175
Schistosoma mansoni lipoxygenase 0.0122 0.2067 0.304
Echinococcus multilocularis synaptic glycoprotein sc2 0.0044 0.0347 0.0511
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0167 0.0804
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0243 0.2344
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0347 0.051
Echinococcus multilocularis peregrin 0.0033 0.0111 0.0163
Trichomonas vaginalis set domain proteins, putative 0.0269 0.5283 1
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0221 0.0325
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.1038 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0347 0.0659
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0119 0.0175
Schistosoma mansoni zinc finger protein 0.0033 0.0091 0.0134

Activities

Activity type Activity value Assay description Source Reference
ED40 (functional) = 159 uM kg-1 Inhibiton of dermal RPAR in rats following p.o. administration. ChEMBL. 6827539

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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