Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.2508 | 0.1573 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.1131 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.7353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.9879 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.1131 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0154 | 0.9879 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.6321 | 0.8342 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.6321 | 0.8342 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.1131 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.2508 | 0.2538 |
Brugia malayi | glutathione reductase | 0.0049 | 0.1131 | 0.1145 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.1131 | 0.1145 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.2508 | 0.2538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2508 | 0.2508 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2508 | 0.2508 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.2508 | 0.2538 |
Echinococcus granulosus | muscleblind protein | 0.0154 | 0.9879 | 1 |
Leishmania major | trypanothione reductase | 0.0049 | 0.1131 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2508 | 0.2508 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1351 | 0.1368 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.6321 | 0.8342 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.1131 | 0.1145 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1351 | 0.1368 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.1131 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1351 | 0.1368 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2508 | 0.2508 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.6321 | 0.8342 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.7353 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1351 | 0.1368 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.7353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.9879 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0154 | 0.9879 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.1131 | 0.1145 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.1131 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.6321 | 0.8342 |
Brugia malayi | Muscleblind-like protein | 0.0154 | 0.9879 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.2508 | 0.1573 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.7353 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.2508 | 0.2538 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.1131 | 0.5 |
Brugia malayi | RNA binding protein | 0.0065 | 0.2508 | 0.2538 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.6321 | 0.8342 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.2508 | 0.2538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2508 | 0.2508 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.1131 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.