Detailed information for compound 116529

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.314 | Formula: C15H18N2O5
  • H donors: 1 H acceptors: 4 LogP: 0.89 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCCN1C1c2ccc(cc2OC([C@H]1O)(C)C)[N+](=O)[O-]
  • InChi: 1S/C15H18N2O5/c1-15(2)14(19)13(16-7-3-4-12(16)18)10-6-5-9(17(20)21)8-11(10)22-15/h5-6,8,13-14,19H,3-4,7H2,1-2H3/t13?,14-/m0/s1
  • InChiKey: VGRHXYRYQCVELV-KZUDCZAMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0115 0.009
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0047 0.0195
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0324 0.1332
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0098 0.0103
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.5261 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0228 0.0433
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0228 0.0433
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0101 0.0414
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Brugia malayi Nuclear hormone receptor E75 0.002 0.0053 0.0217
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0304
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.016 0.0258
Onchocerca volvulus 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0072 0.0465 0.1913
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.016 1
Mycobacterium ulcerans hypothetical protein 0.0166 0.1204 0.1182
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0092 0.0389
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.1204 0.1655
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0149 0.0506
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0149 0.9316
Schistosoma mansoni nuclear hormone receptor 0.002 0.0053 0.01
Onchocerca volvulus Huntingtin homolog 0.0121 0.0849 0.3492
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Leishmania major DNA polymerase kappa, putative 0.0019 0.0047 0.0195
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0228 0.0433
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0028 0.0115 0.0127
Loa Loa (eye worm) blistered cuticle protein 3 0.0054 0.0324 0.1332
Echinococcus granulosus neural cadherin 0.0018 0.0035 0.0066
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0071 0.0294
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0092 0.5773
Brugia malayi hypothetical protein 0.0016 0.0023 0.0094
Schistosoma mansoni hypothetical protein 0.0033 0.016 0.0303
Brugia malayi hypothetical protein 0.002 0.0053 0.0217
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0053 0.01
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0228 0.0936
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0035 0.0056
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0228 0.0433
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0228 0.0367
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0047 0.0202
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.016 0.019
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0047 0.0196
Mycobacterium ulcerans thioesterase 0.0024 0.0084 0.006
Echinococcus granulosus notch 0.0018 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0121 0.0849 0.3492
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.016 0.0303
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0361 0.2745 1
Brugia malayi CHE-14 protein 0.0042 0.0225 0.0925
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0053 0.0085
Brugia malayi tailless protein 0.002 0.0053 0.0217
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0196
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0149 0.0543
Echinococcus granulosus protein jagged 2 0.0018 0.0035 0.0066
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0322 0.1353
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0149 0.0627
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0047 0.0031
Echinococcus multilocularis X box binding protein 1 0.0284 0.2136 0.3445
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0027 0.0107 0.0439
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.016 0.0673
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.2379 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0098 0.0411
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0071 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0228 0.0936
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0225 0.0978
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Giardia lamblia Grp94/Hsp90 0.0026 0.0098 0.0279
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0115 0.0418
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0035 0.0056
Leishmania major hypothetical protein, conserved 0.0025 0.0092 0.0389
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0294
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.016 0.0673
Schistosoma mansoni coup transcription factor 0.0042 0.0228 0.0433
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0228 0.0433
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0324 0.1332
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.016 0.0304
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0149 0.0543
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0115 0.0127
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0101 0.0107
Trichomonas vaginalis heat shock protein, putative 0.002 0.0052 0.0224
Schistosoma mansoni peroxidasin 0.0054 0.0324 0.0615
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.107 0.1048
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.016 0.0673
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.016 0.0258
Onchocerca volvulus Fatty acid synthase homolog 0.0051 0.0302 0.1243
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) fatty acid synthase 0.0028 0.0119 0.0488
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0228 0.0433
Echinococcus granulosus heat shock protein 0.0032 0.0149 0.0283
Echinococcus granulosus protein jagged 2 0.0018 0.0035 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0228 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Plasmodium falciparum heat shock protein 90 0.0032 0.0149 0.9316
Echinococcus multilocularis endoplasmin 0.0026 0.0098 0.0158
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0228 0.0936
Brugia malayi steroid hormone receptor 0.0042 0.0228 0.0936
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0324 0.1332
Echinococcus granulosus heat shock protein 90 0.0026 0.0098 0.0186
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0228 0.0936
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.2379 1
Onchocerca volvulus 0.002 0.0053 0.0217
Brugia malayi hypothetical protein 0.0025 0.0092 0.038
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Echinococcus granulosus slit 2 protein 0.0018 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0121 0.0849 0.3492
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0228 0.0433
Echinococcus multilocularis neurogenic locus notch protein 4 0.0018 0.0035 0.0056
Onchocerca volvulus 0.0018 0.0035 0.0142
Schistosoma mansoni heat shock protein 0.0032 0.0149 0.0283
Echinococcus multilocularis protein jagged 1 0.0018 0.0035 0.0056
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Echinococcus granulosus neurogenic locus notch protein 4 0.0018 0.0035 0.0066
Brugia malayi Endoplasmin precursor 0.0032 0.0149 0.0613
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0092 0.0389
Onchocerca volvulus Huntingtin homolog 0.0121 0.0849 0.3492
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0149 0.0627
Echinococcus multilocularis protein jagged 2 0.0018 0.0035 0.0056
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0021 0.0058 0.0047
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.004 0.0212 0.0263
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0921 0.7152 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0272 0.2042 0.8397
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0191
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0246 0.1032
Brugia malayi MH2 domain containing protein 0.0118 0.0825 0.3392
Echinococcus multilocularis heat shock protein 0.0032 0.0149 0.0241
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0046 0.0192
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1071 0.4503
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0053 0.01
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Onchocerca volvulus Slit protein homolog 0.0018 0.0035 0.0142
Loa Loa (eye worm) Notch2 0.0018 0.0035 0.0142
Loa Loa (eye worm) notch protein 0.0018 0.0035 0.0142
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0921 0.7152 1
Onchocerca volvulus 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0294
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.2299 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0228 0.0433
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0258
Schistosoma mansoni hypothetical protein 0.0284 0.2136 0.406
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0294
Brugia malayi hypothetical protein 0.002 0.0053 0.0217
Echinococcus granulosus GPCR family 2 0.0033 0.016 0.0303
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0191
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0053 0.0217
Echinococcus granulosus endoplasmin 0.0026 0.0098 0.0186
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Brugia malayi Delta serrate ligand family protein 0.0018 0.0035 0.0142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0228 0.0433
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0228 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0075
Brugia malayi nuclear hormone receptor 0.0042 0.0228 0.0936
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0071 0.0136
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Loa Loa (eye worm) endoplasmin 0.0032 0.0149 0.0614
Loa Loa (eye worm) hypothetical protein 0.0042 0.0225 0.0925
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0228 0.0433
Brugia malayi nuclear receptor RXR 0.0022 0.0071 0.0294
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.016 0.0303
Onchocerca volvulus Neurogenic locus notch homolog 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Echinococcus granulosus fibropellin Ia 0.0018 0.0035 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0053 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0228 0.0367
Onchocerca volvulus 0.0322 0.2431 1
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0047 0.0075
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0053 0.0085
Onchocerca volvulus 0.0018 0.0035 0.0142
Echinococcus multilocularis slit 2 protein 0.0018 0.0035 0.0056
Giardia lamblia DINP protein human, muc B family 0.0019 0.0047 0.0053
Brugia malayi hypothetical protein 0.0121 0.0849 0.3492
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0035 0.0142
Echinococcus multilocularis dna polymerase eta 0.0019 0.0047 0.0075
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0098 0.0425
Schistosoma mansoni nuclear hormone receptor 0.002 0.0053 0.01
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0195
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.016 0.0258
Echinococcus granulosus microtubule associated protein 2 0.0681 0.5261 1
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0825 0.3392
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Echinococcus multilocularis heat shock protein 90 0.0032 0.0149 0.0241
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0035 0.0142
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.099 0.1882
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0092 0.0337
Schistosoma mansoni cell polarity protein 0.0018 0.0035 0.0066
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0053 0.0217
Onchocerca volvulus 0.0042 0.0228 0.0936
Schistosoma mansoni slit 0.0018 0.0035 0.0066
Schistosoma mansoni endoplasmin 0.0032 0.0149 0.0283
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.016 0.0673
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0053 0.0085
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0106 0.0728 0.2996
Echinococcus granulosus protein jagged 1 0.0018 0.0035 0.0066
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0195
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0228 0.0367
Brugia malayi Cadherin domain containing protein 0.0018 0.0035 0.0142
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0115 0.0127
Trypanosoma brucei unspecified product 0.0019 0.0047 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0195
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0228 0.0433
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Brugia malayi hypothetical protein 0.0322 0.2431 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0657
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0071 0.0294
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Schistosoma mansoni nuclear receptor 0.002 0.0053 0.01
Echinococcus granulosus protein jagged 1 0.0018 0.0035 0.0066
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0053 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0322 0.2431 1
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0195
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0246 0.1032
Toxoplasma gondii EGF family domain-containing protein 0.0018 0.0035 0.0126
Schistosoma mansoni endoplasmin 0.0032 0.0149 0.0283
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0022
Plasmodium vivax endoplasmin, putative 0.0032 0.0149 0.9316
Schistosoma mansoni zinc finger protein 0.002 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0115 0.0127
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0228 0.0433
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0228 0.0936
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.016 0.0657
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0053 0.0085
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.016 0.0657
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0225 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0228 0.0936
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0115 0.0127
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0053 0.01
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0115 0.0127
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0228 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0097 0.0662 0.2722
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0225 0.0925
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.0084 0.0084
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0246 0.1032
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0022
Brugia malayi nuclear receptor RXR 0.002 0.0053 0.0217
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0098 0.0103
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0324 0.1332
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0098 0.0073
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.2299 0.2223
Onchocerca volvulus 0.005 0.0288 0.1185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Echinococcus granulosus peroxidasin 0.0054 0.0324 0.0615
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.016 0.0659
Echinococcus multilocularis heat shock protein 90 0.0026 0.0098 0.0158
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0246 0.1032
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0051 0.0302 0.1243
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0035 0.0066
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0228 0.0936
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0047 0.0195
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0228 0.0936
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0053 0.0085
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0149 0.0627
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0071 0.0136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0662 0.2879
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.038
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0035 0.0066
Echinococcus granulosus tumor protein p63 0.0382 0.2908 0.5527
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0018 0.0035 0.0142
Echinococcus multilocularis protein dispatched 1 0.0048 0.0271 0.0438
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0056 0.0337 0.1387
Brugia malayi heat shock protein 90 0.0032 0.0149 0.0613
Brugia malayi conserved hypotetical protein 0.002 0.0053 0.0217
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.099 0.1597
Echinococcus multilocularis protein patched 0.0042 0.0225 0.0363
Echinococcus granulosus delta-like protein 1 0.0018 0.0035 0.0066
Mycobacterium leprae Polyketide synthase Pks13 0.004 0.0212 0.0263
Toxoplasma gondii hypothetical protein 0.0051 0.0297 0.1081
Mycobacterium ulcerans polyketide synthase Pks13 0.004 0.0212 0.0188
Schistosoma mansoni septate junction protein 0.0018 0.0035 0.0066
Onchocerca volvulus Peroxidase homolog 0.0054 0.0324 0.1332
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0053 0.01
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Schistosoma mansoni peroxidasin 0.0054 0.0324 0.0615
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.107 0.1467
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0674 0.128
Brugia malayi hypothetical protein 0.0022 0.0071 0.0294
Mycobacterium ulcerans polyketide synthase 0.0026 0.0101 0.0076
Onchocerca volvulus 0.0056 0.0337 0.1387
Echinococcus multilocularis geminin 0.0336 0.2546 0.4106
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0053 0.01
Echinococcus granulosus dna polymerase eta 0.0019 0.0047 0.0088
Mycobacterium ulcerans thioesterase TesA 0.0024 0.0084 0.006
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0196
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1282 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0228 0.0936
Leishmania major mitochondrial DNA polymerase beta 0.0315 0.2379 1
Onchocerca volvulus 0.0054 0.0324 0.1332
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0057 0.0032
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0662 0.2722
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0101 0.0107
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Brugia malayi Muscle positioning protein 4 0.0018 0.0035 0.0142
Echinococcus multilocularis fat cadherin tumor suppressor 0.0018 0.0035 0.0056
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0149 0.0627
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0057 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0033 0.016 0.0657
Onchocerca volvulus 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Echinococcus multilocularis neural cadherin 0.0018 0.0035 0.0056
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0228 0.0367
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0825 0.3392
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0294
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.016 0.0258
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0047 0.0031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0098 0.0411
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0662 0.1258
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0324 0.1332
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0101 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0098 0.0425
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.006 0.0049
Echinococcus multilocularis protein jagged 1 0.0018 0.0035 0.0056
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0092 0.5773
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0101 0.0107
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0196
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.2299 1
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Echinococcus multilocularis GPCR, family 2 0.0033 0.016 0.0258
Echinococcus granulosus neurogenic locus protein delta 0.0018 0.0035 0.0066
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0225 0.0363
Echinococcus granulosus X box binding protein 1 0.0284 0.2136 0.406
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0088
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0047 0.0202
Mycobacterium ulcerans polyketide synthase 0.0028 0.0115 0.009
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Echinococcus multilocularis notch 0.0018 0.0035 0.0056
Schistosoma mansoni hypothetical protein 0.0033 0.016 0.0303
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0092 0.0389
Brugia malayi Cadherin domain containing protein 0.0018 0.0035 0.0142
Brugia malayi isocitrate dehydrogenase 0.0033 0.016 0.0659
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0027 0.0107 0.0116
Brugia malayi nuclear receptor NHR-88 0.002 0.0053 0.0217
Brugia malayi Peroxidasin 0.0054 0.0324 0.1332
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.016 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0101 0.0076
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0149 0.0627
Schistosoma mansoni hypothetical protein 0.0336 0.2546 0.4839
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0228 0.0367
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0053 0.01
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0018 0.0035 0.0066
Brugia malayi Pax transcription factor protein 2 0.0272 0.2042 0.8397
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0228 0.0433
Schistosoma mansoni hypothetical protein 0.0033 0.016 0.0303
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0662 0.1067
Brugia malayi notch-like transmembrane receptor 0.0018 0.0035 0.0142
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0324 0.1332
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0053 0.01
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0098 0.0186
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0053 0.0217
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Echinococcus granulosus geminin 0.0336 0.2546 0.4839
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0361 0.2745 0.2727
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0228 0.0936
Onchocerca volvulus 0.002 0.0053 0.0217
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0228 0.0433
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0053 0.0217
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0028 0.0115 0.0127
Onchocerca volvulus 0.0027 0.0107 0.0439
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0092 0.5773
Loa Loa (eye worm) hypothetical protein 0.0051 0.0299 0.1229
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0018 0.0035 0.0142
Brugia malayi nuclear hormone receptor 0.002 0.0053 0.0217
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Schistosoma mansoni laminin gamma-3 chain 0.0018 0.0035 0.0066
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0324 0.1332
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0149 0.0649
Onchocerca volvulus 0.0272 0.2042 0.8397
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0071 0.0115
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0728 0.2996
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Mycobacterium tuberculosis Polyketide synthase Pks13 0.004 0.0212 0.0263
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0258
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0324 0.1332
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0053 0.0085
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0053 0.01
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0047 0.0191
Schistosoma mansoni heat shock protein 0.0032 0.0149 0.0283
Onchocerca volvulus Peroxidase homolog 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Brugia malayi Isocitrate dehydrogenase 0.0033 0.016 0.0659
Loa Loa (eye worm) DR-78 0.002 0.0053 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0228 0.0936
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0228 0.0433
Brugia malayi hypothetical protein 0.0054 0.0324 0.1332
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0035 0.0142
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0071 0.0294
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0337 0.0641
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0107 0.0439
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0728 0.2996
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Onchocerca volvulus Dual oxidase homolog 0.0054 0.0324 0.1332
Schistosoma mansoni hypothetical protein 0.0336 0.2546 0.4839
Schistosoma mansoni DNA polymerase eta 0.0019 0.0047 0.0088
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0228 0.0433
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0294
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0047 0.0088
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0057 0.0206
Echinococcus multilocularis peroxidasin 0.0054 0.0324 0.0522
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.5261 0.8485
Brugia malayi Nuclear hormone receptor E75 0.002 0.0053 0.0217
Echinococcus granulosus heat shock protein 90 0.0032 0.0149 0.0283
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.107 0.1467
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0225 0.0428
Schistosoma mansoni patched 1 0.0042 0.0225 0.0428
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0228 0.0367
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0228 0.0433
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0324 0.1332
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0101 0.0107
Echinococcus multilocularis fibropellin Ia 0.0018 0.0035 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0228 0.0936
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0465 0.1913
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0035 0.0056
Schistosoma mansoni nuclear receptor 0.002 0.0053 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0228 0.0936
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0098 0.0411
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0149 0.0614
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1071 0.4503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0228 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Brugia malayi GCC2 and GCC3 family protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0053 0.0217
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Brugia malayi hypothetical protein 0.0022 0.0071 0.0294
Brugia malayi nuclear receptor NHR-67 0.002 0.0053 0.0217
Echinococcus granulosus expressed conserved protein 0.0091 0.0616 0.117
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0228 0.0433
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0228 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Echinococcus granulosus dna polymerase kappa 0.0019 0.0047 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.016 0.0583
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0149 0.0649
Leishmania major DNA polymerase eta, putative 0.0019 0.0047 0.0195
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.2299 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0228 0.0936
Onchocerca volvulus 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0228 0.0936
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0149 0.0627
Schistosoma mansoni hypothetical protein 0.0033 0.016 0.0303
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0115 0.009
Brugia malayi ecdysteroid receptor 0.0042 0.0228 0.0936
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0149 0.0627
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0035 0.0056
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0115 0.0127
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.016 0.0673
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.016 0.0583
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0098 0.0279
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1282 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0228 0.0936
Trichomonas vaginalis endoplasmin, putative 0.002 0.0052 0.0224
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0053 0.0217
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0258
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0053 0.0217
Onchocerca volvulus Chorion peroxidase homolog 0.0054 0.0324 0.1332
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0053 0.0217
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0228 0.0433
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0228 0.0433
Schistosoma mansoni hypothetical protein 0.0072 0.0465 0.0884
Plasmodium falciparum endoplasmin, putative 0.002 0.0052 0.3214
Echinococcus multilocularis tumor protein p63 0.0382 0.2908 0.469
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0019 0.0043 0.0155
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0315 0.2379 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0228 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.6201 1
Echinococcus multilocularis expressed conserved protein 0.0091 0.0616 0.0993
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0228 0.0936
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.1071 0.4504
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0361 0.2745 0.3817
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0228 0.0936
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0228 0.0433
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0149 0.0627
Onchocerca volvulus Putative cubilin 0.0018 0.0035 0.0142
Brugia malayi ecdysone receptor 0.002 0.0053 0.0217
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0047 0.0202
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0228 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0191
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0098 0.0425
Brugia malayi nuclear receptor NHR-88 0.0042 0.0228 0.0936
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1282 1 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0057 0.0045
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.001 0.0037
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1044
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0728 0.2996
Brugia malayi Blistered cuticle protein 3 0.0054 0.0324 0.1332
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0149 0.0649
Onchocerca volvulus 0.0054 0.0324 0.1332

Activities

Activity type Activity value Assay description Source Reference
Max fall in blood pressure (functional) = 12 % Maximum fall in blood pressure was evaluated at an oral dose of 0.3 mg/kg in (SHR)spontaneous hypertensive rats ChEMBL. 3783581
Max fall in blood pressure (functional) = 56 % Maximum fall in blood pressure was evaluated at an oral dose of 1.0 mg/kg in (SHR) spontaneous hypertensive rats ChEMBL. 3783581
Max fall in blood pressure (functional) = 68 % Maximum fall in blood pressure was evaluated at an oral dose of 10 mg/kg in (SHR)spontaneous hypertensive rats ChEMBL. 3783581

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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