Detailed information for compound 116529

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.314 | Formula: C15H18N2O5
  • H donors: 1 H acceptors: 4 LogP: 0.89 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCCN1C1c2ccc(cc2OC([C@H]1O)(C)C)[N+](=O)[O-]
  • InChi: 1S/C15H18N2O5/c1-15(2)14(19)13(16-7-3-4-12(16)18)10-6-5-9(17(20)21)8-11(10)22-15/h5-6,8,13-14,19H,3-4,7H2,1-2H3/t13?,14-/m0/s1
  • InChiKey: VGRHXYRYQCVELV-KZUDCZAMSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni laminin gamma-3 chain 0.0018 0.0035 0.0066
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0098 0.0411
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0228 0.0433
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0092 0.0389
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.016 0.0673
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0228 0.0367
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0071 0.0136
Onchocerca volvulus 0.0272 0.2042 0.8397
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0228 0.0936
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.016 0.0583
Echinococcus multilocularis protein jagged 1 0.0018 0.0035 0.0056
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0228 0.0936
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.016 0.0258
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0101 0.0107
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.0084 0.0084
Onchocerca volvulus Huntingtin homolog 0.0121 0.0849 0.3492
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Onchocerca volvulus Slit protein homolog 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1282 1 1
Brugia malayi ecdysone receptor 0.002 0.0053 0.0217
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0149 0.0506
Echinococcus multilocularis protein jagged 1 0.0018 0.0035 0.0056
Onchocerca volvulus Huntingtin homolog 0.0121 0.0849 0.3492
Onchocerca volvulus Neurogenic locus notch homolog 0.0018 0.0035 0.0142
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0228 0.0433
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0101 0.0107
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0228 0.0433
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0071 0.0136
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0115 0.0127
Echinococcus multilocularis heat shock protein 0.0032 0.0149 0.0241
Brugia malayi Muscle positioning protein 4 0.0018 0.0035 0.0142
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0228 0.0936
Brugia malayi Nuclear hormone receptor E75 0.002 0.0053 0.0217
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0294
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0101 0.0107
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0047 0.0031
Brugia malayi hypothetical protein 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0057 0.0032
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0228 0.0367
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0035 0.0056
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0028 0.0115 0.0127
Onchocerca volvulus Peroxidase homolog 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.2379 1
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0921 0.7152 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.2299 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0228 0.0936
Onchocerca volvulus 0.002 0.0053 0.0217
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0018 0.0035 0.0066
Mycobacterium ulcerans thioesterase 0.0024 0.0084 0.006
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Brugia malayi Isocitrate dehydrogenase 0.0033 0.016 0.0659
Echinococcus multilocularis protein jagged 2 0.0018 0.0035 0.0056
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0092 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0228 0.0936
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0098 0.0279
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0098 0.0073
Leishmania major DNA polymerase kappa, putative 0.0019 0.0047 0.0195
Echinococcus granulosus fibropellin Ia 0.0018 0.0035 0.0066
Mycobacterium leprae Polyketide synthase Pks13 0.004 0.0212 0.0263
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0071 0.0294
Brugia malayi GCC2 and GCC3 family protein 0.0018 0.0035 0.0142
Echinococcus multilocularis GPCR, family 2 0.0033 0.016 0.0258
Echinococcus granulosus geminin 0.0336 0.2546 0.4839
Echinococcus granulosus neurogenic locus notch protein 4 0.0018 0.0035 0.0066
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.107 0.1048
Trichomonas vaginalis endoplasmin, putative 0.002 0.0052 0.0224
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0053 0.0217
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0728 0.2996
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0115 0.009
Brugia malayi hypothetical protein 0.002 0.0053 0.0217
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0228 0.0936
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0027 0.0107 0.0116
Mycobacterium ulcerans polyketide synthase 0.0026 0.0101 0.0076
Echinococcus multilocularis peroxidasin 0.0054 0.0324 0.0522
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0228 0.0433
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0046 0.0192
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.0084 0.0084
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0225 0.0363
Echinococcus granulosus heat shock protein 90 0.0032 0.0149 0.0283
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0057 0.0032
Echinococcus multilocularis fibropellin Ia 0.0018 0.0035 0.0056
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0149 0.0649
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0361 0.2745 0.3817
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0053 0.0085
Brugia malayi conserved hypotetical protein 0.002 0.0053 0.0217
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0825 0.3392
Onchocerca volvulus Peroxidase homolog 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Loa Loa (eye worm) blistered cuticle protein 3 0.0054 0.0324 0.1332
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0674 0.128
Leishmania major hypothetical protein, conserved 0.0025 0.0092 0.0389
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0098 0.0425
Loa Loa (eye worm) hypothetical protein 0.0106 0.0728 0.2996
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0195
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Loa Loa (eye worm) notch protein 0.0018 0.0035 0.0142
Giardia lamblia Grp94/Hsp90 0.0026 0.0098 0.0279
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0228 0.0433
Schistosoma mansoni hypothetical protein 0.0033 0.016 0.0303
Plasmodium falciparum heat shock protein 90 0.0032 0.0149 0.9316
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0228 0.0433
Mycobacterium ulcerans thioesterase TesA 0.0024 0.0084 0.006
Onchocerca volvulus 0.0018 0.0035 0.0142
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0047 0.0088
Brugia malayi Peroxidasin 0.0054 0.0324 0.1332
Brugia malayi nuclear receptor NHR-88 0.002 0.0053 0.0217
Echinococcus multilocularis notch 0.0018 0.0035 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0053 0.0217
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0071 0.0115
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0228 0.0936
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.2379 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Onchocerca volvulus 0.0054 0.0324 0.1332
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0035 0.0056
Onchocerca volvulus 0.005 0.0288 0.1185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0191
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0228 0.0936
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0228 0.0367
Loa Loa (eye worm) hypothetical protein 0.0097 0.0662 0.2722
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0047 0.0196
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0228 0.0433
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0047 0.0031
Mycobacterium ulcerans hypothetical protein 0.0166 0.1204 0.1182
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Echinococcus multilocularis X box binding protein 1 0.0284 0.2136 0.3445
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0246 0.1032
Onchocerca volvulus 0.0054 0.0324 0.1332
Mycobacterium tuberculosis Polyketide synthase Pks13 0.004 0.0212 0.0263
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.001 0.0037
Echinococcus multilocularis protein patched 0.0042 0.0225 0.0363
Loa Loa (eye worm) DR-78 0.002 0.0053 0.0217
Echinococcus granulosus neural cadherin 0.0018 0.0035 0.0066
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.107 0.1467
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0294
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Leishmania major DNA polymerase eta, putative 0.0019 0.0047 0.0195
Schistosoma mansoni nuclear hormone receptor 0.002 0.0053 0.01
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0047 0.0202
Giardia lamblia DINP protein human, muc B family 0.0019 0.0047 0.0053
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0324 0.1332
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0149 0.9316
Brugia malayi hypothetical protein 0.0025 0.0092 0.038
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0361 0.2745 1
Schistosoma mansoni septate junction protein 0.0018 0.0035 0.0066
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0047 0.0202
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0324 0.1332
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0075
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Echinococcus granulosus GPCR family 2 0.0033 0.016 0.0303
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0149 0.0649
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0149 0.0627
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0228 0.0433
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.016 0.0673
Brugia malayi Pax transcription factor protein 2 0.0272 0.2042 0.8397
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0228 0.0936
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0053 0.0217
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0228 0.0433
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Onchocerca volvulus 0.0054 0.0324 0.1332
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0021 0.0058 0.0047
Echinococcus granulosus protein jagged 2 0.0018 0.0035 0.0066
Onchocerca volvulus Dual oxidase homolog 0.0054 0.0324 0.1332
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0101 0.0107
Brugia malayi hypothetical protein 0.0016 0.0023 0.0094
Echinococcus granulosus heat shock protein 0.0032 0.0149 0.0283
Onchocerca volvulus 0.0018 0.0035 0.0142
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0053 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0228 0.0433
Onchocerca volvulus 0.0018 0.0035 0.0142
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0115 0.009
Trypanosoma brucei unspecified product 0.0019 0.0047 0.0196
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0092 0.5773
Brugia malayi nuclear hormone receptor 0.0042 0.0228 0.0936
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1071 0.4503
Brugia malayi notch-like transmembrane receptor 0.0018 0.0035 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0228 0.0936
Brugia malayi nuclear receptor NHR-88 0.0042 0.0228 0.0936
Schistosoma mansoni endoplasmin 0.0032 0.0149 0.0283
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0258
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0228 0.0367
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0196
Plasmodium falciparum endoplasmin, putative 0.002 0.0052 0.3214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Echinococcus granulosus protein jagged 1 0.0018 0.0035 0.0066
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.016 0.0657
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0115 0.0127
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0053 0.01
Brugia malayi Latrophilin receptor protein 2 0.0033 0.016 0.0657
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0035 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0228 0.0433
Schistosoma mansoni slit 0.0018 0.0035 0.0066
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0246 0.1032
Schistosoma mansoni hypothetical protein 0.0336 0.2546 0.4839
Loa Loa (eye worm) hypothetical protein 0.0121 0.0849 0.3492
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0228 0.0936
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0246 0.1032
Brugia malayi steroid hormone receptor 0.0042 0.0228 0.0936
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0053 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0228 0.0936
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0053 0.0085
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0053 0.01
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0324 0.1332
Echinococcus multilocularis slit 2 protein 0.0018 0.0035 0.0056
Brugia malayi CHE-14 protein 0.0042 0.0225 0.0925
Echinococcus granulosus neurogenic locus protein delta 0.0018 0.0035 0.0066
Schistosoma mansoni hypothetical protein 0.0336 0.2546 0.4839
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0228 0.0367
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0228 0.0433
Brugia malayi Cadherin domain containing protein 0.0018 0.0035 0.0142
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0092 0.0337
Echinococcus multilocularis protein dispatched 1 0.0048 0.0271 0.0438
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Brugia malayi heat shock protein 90 0.0032 0.0149 0.0613
Toxoplasma gondii hypothetical protein 0.0051 0.0297 0.1081
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0324 0.1332
Onchocerca volvulus 0.0322 0.2431 1
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0228 0.0367
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Loa Loa (eye worm) hypothetical protein 0.0042 0.0225 0.0925
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0228 0.0936
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0315 0.2379 1
Schistosoma mansoni cell polarity protein 0.0018 0.0035 0.0066
Schistosoma mansoni heat shock protein 0.0032 0.0149 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0195
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0053 0.0217
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.016 0.0258
Brugia malayi nuclear hormone receptor 0.002 0.0053 0.0217
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Echinococcus granulosus notch 0.0018 0.0035 0.0066
Echinococcus granulosus tumor protein p63 0.0382 0.2908 0.5527
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0028 0.0115 0.0127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0728 0.2996
Echinococcus multilocularis heat shock protein 90 0.0026 0.0098 0.0158
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0101 0.0076
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0115 0.0418
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0092 0.5773
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0088
Onchocerca volvulus 0.0018 0.0035 0.0142
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0228 0.0433
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0098 0.0425
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0149 0.0543
Loa Loa (eye worm) endoplasmin 0.0032 0.0149 0.0614
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0921 0.7152 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.2431 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0071 0.0136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0149 0.0614
Echinococcus granulosus peroxidasin 0.0054 0.0324 0.0615
Loa Loa (eye worm) hypothetical protein 0.0121 0.0849 0.3492
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0149 0.0543
Brugia malayi hypothetical protein 0.002 0.0053 0.0217
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0053 0.01
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0101 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0657
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0228 0.0936
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.099 0.1882
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0035 0.0142
Echinococcus granulosus protein jagged 2 0.0018 0.0035 0.0066
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.016 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Brugia malayi ecdysteroid receptor 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.2299 1
Echinococcus multilocularis heat shock protein 90 0.0032 0.0149 0.0241
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0053 0.0217
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0195
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0035 0.0066
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.016 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0228 0.0433
Brugia malayi hypothetical protein 0.0022 0.0071 0.0294
Echinococcus multilocularis dna polymerase eta 0.0019 0.0047 0.0075
Onchocerca volvulus Chorion peroxidase homolog 0.0054 0.0324 0.1332
Echinococcus granulosus microtubule associated protein 2 0.0681 0.5261 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0098 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0258
Loa Loa (eye worm) hypothetical protein 0.0051 0.0299 0.1229
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0035 0.0142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0361 0.2745 0.2727
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0053 0.0217
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0149 0.0627
Schistosoma mansoni DNA polymerase eta 0.0019 0.0047 0.0088
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0027 0.0107 0.0439
Schistosoma mansoni zinc finger protein 0.002 0.0053 0.01
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.016 0.0673
Onchocerca volvulus Fatty acid synthase homolog 0.0051 0.0302 0.1243
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0228 0.0936
Echinococcus multilocularis tumor protein p63 0.0382 0.2908 0.469
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0019 0.0043 0.0155
Onchocerca volvulus Putative cubilin 0.0018 0.0035 0.0142
Brugia malayi Delta serrate ligand family protein 0.0018 0.0035 0.0142
Brugia malayi nuclear receptor RXR 0.0022 0.0071 0.0294
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0324 0.1332
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0228 0.0936
Schistosoma mansoni hypothetical protein 0.0072 0.0465 0.0884
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0098 0.0103
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Echinococcus granulosus protein jagged 1 0.0018 0.0035 0.0066
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0149 0.0627
Leishmania major mitochondrial DNA polymerase beta 0.0315 0.2379 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0662 0.2722
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0092 0.0389
Loa Loa (eye worm) pax transcription factor protein 2 0.0272 0.2042 0.8397
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0225 0.0428
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0662 0.1067
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Echinococcus granulosus dna polymerase kappa 0.0019 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0053 0.0217
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0228 0.0433
Echinococcus granulosus endoplasmin 0.0026 0.0098 0.0186
Echinococcus multilocularis neural cadherin 0.0018 0.0035 0.0056
Echinococcus multilocularis expressed conserved protein 0.0091 0.0616 0.0993
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0057 0.0045
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Brugia malayi Blistered cuticle protein 3 0.0054 0.0324 0.1332
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0728 0.2996
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0107 0.0439
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.016 0.0673
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0228 0.0433
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0057 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0228 0.0936
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0071 0.0294
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Echinococcus granulosus heat shock protein 90 0.0026 0.0098 0.0186
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0662 0.1258
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0053 0.0217
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0149 0.0627
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0228 0.0936
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0053 0.0085
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0071 0.0294
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Onchocerca volvulus 0.0042 0.0228 0.0936
Brugia malayi tailless protein 0.002 0.0053 0.0217
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Brugia malayi isocitrate dehydrogenase 0.0033 0.016 0.0659
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0115 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0228 0.0936
Brugia malayi MH2 domain containing protein 0.0118 0.0825 0.3392
Loa Loa (eye worm) Notch2 0.0018 0.0035 0.0142
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.016 0.0304
Loa Loa (eye worm) fatty acid synthase 0.0028 0.0119 0.0488
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0047 0.0195
Brugia malayi Endoplasmin precursor 0.0032 0.0149 0.0613
Onchocerca volvulus 0.0056 0.0337 0.1387
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0825 0.3392
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.016 0.0303
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.038
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0035 0.0056
Schistosoma mansoni nuclear receptor 0.002 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0018 0.0035 0.0142
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Brugia malayi nuclear receptor NHR-67 0.002 0.0053 0.0217
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0228 0.0367
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Schistosoma mansoni peroxidasin 0.0054 0.0324 0.0615
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0053 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0098 0.0186
Echinococcus granulosus delta-like protein 1 0.0018 0.0035 0.0066
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1282 1 1
Brugia malayi hypothetical protein 0.0121 0.0849 0.3492
Schistosoma mansoni heat shock protein 0.0032 0.0149 0.0283
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0047 0.0191
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0092 0.5773
Echinococcus multilocularis geminin 0.0336 0.2546 0.4106
Toxoplasma gondii EGF family domain-containing protein 0.0018 0.0035 0.0126
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0228 0.0936
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0149 0.0649
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.5261 0.8485
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.016 0.0583
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0225 0.0925
Loa Loa (eye worm) hypothetical protein 0.0072 0.0465 0.1913
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0053 0.0085
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0324 0.1332
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.016 0.0673
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0053 0.0217
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0098 0.0103
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0304
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Onchocerca volvulus 0.0018 0.0035 0.0142
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0022
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0228 0.0936
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1071 0.4503
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.016 0.019
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0056 0.0337 0.1387
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.2299 1
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0324 0.1332
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0324 0.1332
Brugia malayi Cadherin domain containing protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Mycobacterium ulcerans polyketide synthase 0.0028 0.0115 0.009
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0047 0.0088
Schistosoma mansoni nuclear receptor 0.002 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0101 0.0414
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.016 1
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0337 0.0641
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0228 0.0367
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0191
Brugia malayi hypothetical protein 0.0022 0.0071 0.0294
Schistosoma mansoni hypothetical protein 0.0284 0.2136 0.406
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.1204 0.1655
Schistosoma mansoni patched 1 0.0042 0.0225 0.0428
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0196
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0098 0.0411
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0228 0.0367
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.5261 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1044
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0936
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0053 0.01
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0051 0.0302 0.1243
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Plasmodium vivax endoplasmin, putative 0.0032 0.0149 0.9316
Echinococcus granulosus expressed conserved protein 0.0091 0.0616 0.117
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.2299 0.2223
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0115 0.0127
Echinococcus granulosus X box binding protein 1 0.0284 0.2136 0.406
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0324 0.1332
Schistosoma mansoni nuclear hormone receptor 0.002 0.0053 0.01
Schistosoma mansoni hypothetical protein 0.0033 0.016 0.0303
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.016 0.0657
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.6201 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0191
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0195
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.016 0.0659
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0322 0.1353
Mycobacterium ulcerans polyketide synthase Pks13 0.004 0.0212 0.0188
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0047 0.0195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0228 0.0433
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0228 0.0433
Trichomonas vaginalis heat shock protein, putative 0.002 0.0052 0.0224
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0246 0.1032
Brugia malayi EGF-like domain containing protein 0.0018 0.0035 0.0142
Onchocerca volvulus 0.002 0.0053 0.0217
Schistosoma mansoni peroxidasin 0.0054 0.0324 0.0615
Echinococcus granulosus slit 2 protein 0.0018 0.0035 0.0066
Brugia malayi Nuclear hormone receptor E75 0.002 0.0053 0.0217
Echinococcus multilocularis fat cadherin tumor suppressor 0.0018 0.0035 0.0056
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0228 0.0433
Brugia malayi nuclear receptor RXR 0.002 0.0053 0.0217
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0627
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0047 0.0075
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0053 0.01
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0662 0.2879
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.006 0.0049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.016 0.0303
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.016 0.0258
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0228 0.0936
Schistosoma mansoni hypothetical protein 0.0033 0.016 0.0303
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0047 0.0202
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.016 0.0258
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.099 0.1597
Echinococcus multilocularis neurogenic locus notch protein 4 0.0018 0.0035 0.0056
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0053 0.0085
Brugia malayi hypothetical protein 0.0322 0.2431 1
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0098 0.0411
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0115 0.0127
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0053 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Echinococcus granulosus dna polymerase eta 0.0019 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0228 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0225 0.0978
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0294
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0324 0.1332
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0228 0.0433
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0115 0.0127
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0465 0.1913
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0324 0.1332
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.2299 1
Onchocerca volvulus 0.0027 0.0107 0.0439
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0149 0.0627
Echinococcus multilocularis endoplasmin 0.0026 0.0098 0.0158
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.004 0.0212 0.0263
Schistosoma mansoni notch 0.0018 0.0035 0.0066
Schistosoma mansoni endoplasmin 0.0032 0.0149 0.0283
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0228 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0228 0.0936
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.107 0.1467
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1332
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0627
Schistosoma mansoni coup transcription factor 0.0042 0.0228 0.0433
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.1071 0.4504
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1282 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.016 0.0303
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0225 0.0428
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196

Activities

Activity type Activity value Assay description Source Reference
Max fall in blood pressure (functional) = 12 % Maximum fall in blood pressure was evaluated at an oral dose of 0.3 mg/kg in (SHR)spontaneous hypertensive rats ChEMBL. 3783581
Max fall in blood pressure (functional) = 56 % Maximum fall in blood pressure was evaluated at an oral dose of 1.0 mg/kg in (SHR) spontaneous hypertensive rats ChEMBL. 3783581
Max fall in blood pressure (functional) = 68 % Maximum fall in blood pressure was evaluated at an oral dose of 10 mg/kg in (SHR)spontaneous hypertensive rats ChEMBL. 3783581

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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