Detailed information for compound 1165489

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.846 | Formula: C21H18ClN4O3+
  • H donors: 3 H acceptors: 3 LogP: 2.33 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NC(=O)c1cccc(c1)NC(=O)C[n+]1cccc(c1)C(=O)N
  • InChi: 1S/C21H17ClN4O3/c22-16-6-8-17(9-7-16)25-21(29)14-3-1-5-18(11-14)24-19(27)13-26-10-2-4-15(12-26)20(23)28/h1-12H,13H2,(H3-,23,24,25,27,28,29)/p+1
  • InChiKey: SUBXQVGRASWGDA-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1476 0.1693
Trichomonas vaginalis chromobox protein, putative 0.0046 0.025 0.069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.2664 0.2664
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0119 0.0119
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0205 0.2373 0.5392
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0369 0.0379
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0145 0.157 0.3581
Onchocerca volvulus 0.006 0.044 0.0359
Echinococcus granulosus tumor protein p63 0.0739 0.9518 1
Echinococcus multilocularis lamin dm0 0.0057 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0036 0.0119 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0049 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0125 0.028
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0119 0.0119
Entamoeba histolytica acyl-coA synthetase, putative 0.0205 0.2373 0.6988
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Echinococcus multilocularis cysteine protease 0.0036 0.0119 0.0119
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.007 0.007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0113 0.1152 0.1307
Brugia malayi hypothetical protein 0.0277 0.3345 0.3345
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0369 0.1958
Schistosoma mansoni hypothetical protein 0.0087 0.0794 0.1951
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0153 0.1681 0.3845
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.006 0.044 0.092
Onchocerca volvulus 0.0036 0.0119 0.0036
Mycobacterium ulcerans hypothetical protein 0.0205 0.2373 0.5392
Mycobacterium ulcerans acyl-CoA synthetase 0.006 0.044 0.0754
Brugia malayi Heterochromatin protein 1 0.0076 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0119 0.0259
Loa Loa (eye worm) hypothetical protein 0.0055 0.0369 0.0369
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0125 0.0125
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1476 0.1693
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0274 0.3295 0.3295
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0049 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.006 0.044 0.0754
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0833 0.0875
Onchocerca volvulus 0.0258 0.3083 0.3024
Echinococcus granulosus intermediate filament protein 0.0057 0.0403 0.0423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.006 0.044 0.092
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0369 0.0379
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0087 0.0794 0.0834
Onchocerca volvulus 0.0036 0.0119 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0145 0.157 0.3581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Echinococcus multilocularis geminin 0.0331 0.4069 0.4074
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0661 0.8481 1
Brugia malayi hypothetical protein 0.0035 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0043 0.0207 0.0207
Leishmania major 4-coumarate:coa ligase-like protein 0.0205 0.2373 0.2757
Brugia malayi AMP-binding enzyme family protein 0.0205 0.2373 0.2373
Schistosoma mansoni hypothetical protein 0.0087 0.0794 0.1951
Schistosoma mansoni chromobox protein 0.0076 0.0654 0.1608
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0125 0.009
Plasmodium vivax vivapain-2 0.0036 0.0119 0.0427
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.006 0.044 0.3854
Trypanosoma cruzi cruzipain precursor, putative 0.0138 0.1476 0.1693
Leishmania major acetyl-CoA synthetase, putative 0.006 0.044 0.0463
Loa Loa (eye worm) MH2 domain-containing protein 0.04 0.4981 0.4981
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0833 0.0834
Loa Loa (eye worm) ctsf protein 0.0036 0.0119 0.0119
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0087 0.0794 0.0795
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0119 0.0259
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0403 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0047 0.0047
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0125 0.0179
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.007 0.0208
Echinococcus multilocularis chromobox protein 1 0.0076 0.0654 0.0655
Onchocerca volvulus 0.006 0.044 0.0359
Entamoeba histolytica hypothetical protein 0.0277 0.3345 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0125 0.0179
Leishmania major cathepsin L-like protease 0.0036 0.0119 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Schistosoma mansoni chromobox protein 0.0076 0.0654 0.1608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0119 0.0259
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0369 0.0379
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.1293 0.1293
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0205 0.2373 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.006 0.044 0.3854
Brugia malayi AMP-binding enzyme family protein 0.0205 0.2373 0.2373
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.006 0.044 0.0754
Brugia malayi Cathepsin L-like precursor 0.0036 0.0119 0.0119
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0047 0.0047
Echinococcus granulosus GPCR family 2 0.0087 0.0794 0.0834
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0145 0.157 0.3581
Echinococcus granulosus cathepsin l1 0.0036 0.0119 0.0125
Onchocerca volvulus 0.0057 0.0403 0.0322
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.006 0.044 0.092
Loa Loa (eye worm) hypothetical protein 0.0153 0.1681 0.1681
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0661 0.8481 1
Brugia malayi AMP-binding enzyme family protein 0.0205 0.2373 0.2373
Loa Loa (eye worm) hypothetical protein 0.0033 0.0083 0.0083
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.006 0.044 0.1398
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.006 0.044 0.0754
Leishmania major acetyl-CoA synthetase, putative 0.006 0.044 0.0463
Leishmania major hypothetical protein, conserved 0.0055 0.0369 0.0379
Entamoeba histolytica hypothetical protein 0.0277 0.3345 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0125 0.028
Onchocerca volvulus 0.006 0.044 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0237 0.0582
Entamoeba histolytica hypothetical protein 0.0277 0.3345 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.006 0.044 0.0994
Loa Loa (eye worm) RNA binding protein 0.0124 0.1293 0.1293
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.006 0.044 0.0463
Brugia malayi beta-lactamase family protein 0.0037 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.0126 0.1322 0.325
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0369 0.1958
Mycobacterium tuberculosis Conserved protein 0.0037 0.0125 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Mycobacterium ulcerans acyl-CoA synthetase 0.0205 0.2373 0.5392
Brugia malayi Pre-SET motif family protein 0.0032 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0153 0.1681 0.1681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0833 0.2046
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.007 0.007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0049 0.0049
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0125 0.0179
Schistosoma mansoni hypothetical protein 0.0331 0.4069 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.006 0.044 0.0463
Brugia malayi RNA binding protein 0.0124 0.1293 0.1293
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1322 0.1389
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0093 0.088 0.0985
Entamoeba histolytica hypothetical protein 0.0277 0.3345 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0125 0.0467
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0119 0.0292
Echinococcus multilocularis musashi 0.0057 0.0403 0.0403
Mycobacterium ulcerans acyl-CoA synthetase 0.006 0.044 0.0754
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0833 0.2046
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0125 0.0132
Schistosoma mansoni lamin 0.0057 0.0403 0.099
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0125 0.009
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0126 0.1317 0.1503
Onchocerca volvulus 0.006 0.044 0.0359
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0125 0.0125
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0093 0.088 0.0985
Schistosoma mansoni hypothetical protein 0.0331 0.4069 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0119 0.0119
Echinococcus granulosus lamin dm0 0.0057 0.0403 0.0423
Loa Loa (eye worm) hypothetical protein 0.0057 0.0403 0.0403
Leishmania major cysteine peptidase A (CPA) 0.0036 0.0119 0.0083
Echinococcus multilocularis tar DNA binding protein 0.0124 0.1293 0.1295
Brugia malayi hypothetical protein 0.0055 0.0369 0.0369
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.006 0.044 0.0754
Onchocerca volvulus 0.0775 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0654 0.2019
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.006 0.044 0.092
Loa Loa (eye worm) hypothetical protein 0.0153 0.1681 0.1681
Schistosoma mansoni hypothetical protein 0.0277 0.3345 0.8221
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.5831 0.5839
Toxoplasma gondii propionate-CoA ligase 0.006 0.044 0.3854
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0654 0.0654
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0313 0.3822 0.4474
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.007 0.0172
Leishmania major mitochondrial DNA polymerase beta 0.0661 0.8481 1
Mycobacterium ulcerans acyl-CoA synthetase 0.006 0.044 0.0754
Loa Loa (eye worm) hypothetical protein 0.0153 0.1681 0.1681
Loa Loa (eye worm) AMP-binding enzyme family protein 0.006 0.044 0.044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0833 0.0833
Onchocerca volvulus 0.0205 0.2373 0.2309
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.006 0.044 0.0463
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0119 0.0036
Brugia malayi MH2 domain containing protein 0.04 0.4981 0.4981
Trypanosoma brucei acetyl-CoA synthetase, putative 0.006 0.044 0.0463
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.007 0.0172
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0125 0.009
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0125 0.028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Loa Loa (eye worm) TAR-binding protein 0.0124 0.1293 0.1293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0119 0.0119
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0087 0.0794 0.0834
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0654 0.2019
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0328 0.0657
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0119 0.0292
Loa Loa (eye worm) hypothetical protein 0.0153 0.1681 0.1681
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0125 0.0179
Toxoplasma gondii cathepsin CPL 0.0036 0.0119 0.0688
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0274 0.3295 0.3295
Loa Loa (eye worm) hypothetical protein 0.0108 0.1082 0.1082
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0277 0.3345 0.3515
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1322 0.1324
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.006 0.044 0.092
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0006 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0403 0.0403
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0119 0.0259
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0125 0.028
Schistosoma mansoni transcription factor LCR-F1 0.0277 0.3345 0.8221
Toxoplasma gondii hypothetical protein 0.0107 0.1062 1
Echinococcus granulosus tar DNA binding protein 0.0124 0.1293 0.1359
Mycobacterium tuberculosis Conserved protein 0.0037 0.0125 0.0179
Trypanosoma cruzi major cysteine proteinase, putative 0.0108 0.1082 0.1225
Loa Loa (eye worm) hypothetical protein 0.0205 0.2373 0.2373
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0207 0.0548
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0153 0.1681 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0145 0.157 0.3581
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.006 0.044 0.092
Echinococcus multilocularis chromobox protein 1 0.0076 0.0654 0.0655
Onchocerca volvulus 0.0037 0.0125 0.0042
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.006 0.044 0.092
Loa Loa (eye worm) hypothetical protein 0.0032 0.007 0.007
Mycobacterium ulcerans acetyl-CoA synthetase 0.006 0.044 0.0754
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.006 0.044 0.092
Mycobacterium ulcerans acyl-CoA synthetase 0.0205 0.2373 0.5392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.006 0.044 0.0754
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0119 0.0119
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0093 0.088 0.0985
Brugia malayi AMP-binding enzyme family protein 0.006 0.044 0.044
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0774 0.9987 1
Plasmodium vivax SET domain protein, putative 0.0032 0.007 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Brugia malayi intermediate filament protein 0.0057 0.0403 0.0403
Mycobacterium ulcerans acyl-CoA synthetase 0.006 0.044 0.0754
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0119 0.0259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Plasmodium falciparum acyl-CoA synthetase 0.0153 0.1681 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.006 0.044 0.0462
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0205 0.2373 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0205 0.2373 0.5392
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0119 0.0259
Loa Loa (eye worm) fibroinase 0.0036 0.0119 0.0119
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.5831 0.5839
Leishmania major 4-coumarate:coa ligase-like protein 0.0205 0.2373 0.2757
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0049 0.0049
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0207 0.0124
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0125 0.0179
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.006 0.044 0.0754
Onchocerca volvulus 0.0036 0.0119 0.0036
Leishmania major cathepsin L-like protease 0.0138 0.1476 0.1693
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0661 0.8481 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Schistosoma mansoni hypothetical protein 0.0087 0.0794 0.1951
Loa Loa (eye worm) latrophilin receptor protein 2 0.0087 0.0794 0.0794
Onchocerca volvulus 0.0036 0.0119 0.0036
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0087 0.0794 0.0794
Mycobacterium tuberculosis Conserved protein 0.0037 0.0125 0.0179
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.006 0.044 0.0463
Loa Loa (eye worm) oxidoreductase 0.006 0.044 0.044
Onchocerca volvulus 0.0037 0.0125 0.0042
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0125 0.0179
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0833 0.0875
Echinococcus multilocularis cysteine protease 0.0036 0.0119 0.0119
Mycobacterium ulcerans acyl-CoA synthetase 0.006 0.044 0.0754
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1476 0.1693
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1293 0.3178
Brugia malayi AMP-binding enzyme family protein 0.006 0.044 0.044
Leishmania major cathepsin L-like protease 0.0138 0.1476 0.1693
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0119 0.0259
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Brugia malayi Cathepsin L-like precursor 0.0036 0.0119 0.0119
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1293 0.3178
Loa Loa (eye worm) hypothetical protein 0.0056 0.0389 0.0389
Onchocerca volvulus 0.0108 0.1082 0.1007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0153 0.1681 0.3732
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0125 0.0308
Entamoeba histolytica acyl-CoA synthetase, putative 0.0205 0.2373 0.6988
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0205 0.2373 0.5475
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.006 0.044 0.0463
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0119 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0119 0.0259
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.007 0.0074
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.006 0.044 0.044
Leishmania major cathepsin L-like protease 0.0138 0.1476 0.1693
Loa Loa (eye worm) hypothetical protein 0.0775 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0205 0.2373 0.5392
Plasmodium vivax acetyl-CoA synthetase, putative 0.006 0.044 0.2392
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0049 0.0121
Leishmania major 4-coumarate:coa ligase-like protein 0.0205 0.2373 0.2757
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0205 0.2373 0.5392
Loa Loa (eye worm) cysteine protease 0.0036 0.0119 0.0119
Mycobacterium ulcerans acyl-CoA synthetase 0.006 0.044 0.0754
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0833 0.0833
Schistosoma mansoni acetyl-CoA synthetase 0.006 0.044 0.108
Loa Loa (eye worm) beta-lactamase 0.0037 0.0125 0.0125
Leishmania major cathepsin L-like protease 0.0036 0.0119 0.0083
Plasmodium vivax acyl-CoA synthetase, putative 0.0153 0.1681 1
Schistosoma mansoni lamin 0.0057 0.0403 0.099
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0119 0.0119
Mycobacterium tuberculosis Conserved hypothetical protein 0.0348 0.4295 1
Leishmania major cathepsin L-like protease 0.0036 0.0119 0.0083
Mycobacterium ulcerans acyl-CoA synthetase 0.006 0.044 0.0754
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.007 0.0172
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0313 0.3822 0.4474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0119 0.0259
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.006 0.044 0.1398
Leishmania major hypothetical protein, conserved 0.0037 0.0125 0.009
Brugia malayi chromobox protein homolog 3 0.0043 0.0207 0.0207
Brugia malayi Latrophilin receptor protein 2 0.0087 0.0794 0.0794
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0369 0.3154
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0054 0.0057
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.0119 0.0427
Brugia malayi AMP-binding enzyme family protein 0.006 0.044 0.044
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0049 0.0049
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.006 0.044 0.092
Echinococcus granulosus neuropeptide s receptor 0.0463 0.5831 0.6126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0833 0.2046
Echinococcus granulosus geminin 0.0331 0.4069 0.4275
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0125 0.0179
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.1293 0.1293
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.1458 0.146
Brugia malayi beta-lactamase family protein 0.0037 0.0125 0.0125
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0049 0.0049
Toxoplasma gondii ABC1 family protein 0.0037 0.0125 0.0752
Brugia malayi Calcitonin receptor-like protein seb-1 0.0274 0.3295 0.3295
Schistosoma mansoni hypothetical protein 0.0187 0.2137 0.5253
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0119 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Schistosoma mansoni intermediate filament proteins 0.0057 0.0403 0.099
Brugia malayi beta-lactamase 0.0037 0.0125 0.0125
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0119 0.0125
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0187 0.2137 0.2137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0125 0.0308
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0119 0.0125
Leishmania major cathepsin L-like protease 0.0036 0.0119 0.0083
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.006 0.044 0.0463
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1293 0.3178
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0087 0.0794 0.0795
Onchocerca volvulus 0.0036 0.0119 0.0036
Brugia malayi Cathepsin L-like precursor 0.0036 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Brugia malayi AMP-binding enzyme family protein 0.006 0.044 0.044
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.006 0.044 0.1398
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0205 0.2373 0.5392
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0833 0.0834
Echinococcus granulosus lamin 0.0057 0.0403 0.0423
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0093 0.088 0.0985
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0119 0.0259
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.006 0.044 0.092
Onchocerca volvulus 0.0036 0.0119 0.0036
Echinococcus granulosus chromobox protein 1 0.0076 0.0654 0.0687
Loa Loa (eye worm) hypothetical protein 0.006 0.044 0.044
Trichomonas vaginalis set domain proteins, putative 0.0258 0.3083 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0207 0.0548
Onchocerca volvulus 0.0036 0.0119 0.0036
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0006 0.0006
Plasmodium vivax vivapain-2 0.0036 0.0119 0.0427
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1293 0.3178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Entamoeba histolytica acyl-CoA synthetase, putative 0.0205 0.2373 0.6988
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.006 0.044 0.0754
Brugia malayi TAR-binding protein 0.0124 0.1293 0.1293
Brugia malayi acetyl-Coenzyme A synthetase 2 0.006 0.044 0.044
Brugia malayi Cathepsin L-like precursor 0.0036 0.0119 0.0119
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0274 0.3295 0.3295
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1293 0.3178
Trichomonas vaginalis esterase, putative 0.0037 0.0125 0.028
Schistosoma mansoni thyroid hormone receptor 0.0136 0.1458 0.3583
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0403 0.0403
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0119 0.0036
Leishmania major cathepsin L-like protease 0.0036 0.0119 0.0083
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0313 0.3822 0.4474
Trichomonas vaginalis antibiotic synthetase, putative 0.006 0.044 0.1313
Brugia malayi isocitrate dehydrogenase 0.0031 0.0049 0.0049
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0119 0.0083
Onchocerca volvulus 0.0057 0.0403 0.0322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1476 0.1693
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.006 0.044 0.0754
Loa Loa (eye worm) hypothetical protein 0.0205 0.2373 0.2373
Echinococcus multilocularis GPCR, family 2 0.0087 0.0794 0.0795
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.0119 0.0427
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0125
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.006 0.044 0.092
Onchocerca volvulus 0.0045 0.0237 0.0155
Trichomonas vaginalis chromobox protein, putative 0.0046 0.025 0.069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0369 0.1958
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0277 0.3345 0.335
Brugia malayi Cathepsin L-like precursor 0.0036 0.0119 0.0119
Loa Loa (eye worm) AMP-binding enzyme family protein 0.006 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.006 0.044 0.044
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0125 0.028
Brugia malayi Cathepsin L-like precursor 0.0036 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0119 0.0259
Plasmodium falciparum acetyl-CoA synthetase, putative 0.006 0.044 0.2392
Echinococcus multilocularis tumor protein p63 0.0739 0.9518 0.953
Mycobacterium ulcerans hypothetical protein 0.0348 0.4295 1
Brugia malayi Pre-SET motif family protein 0.0226 0.2664 0.2664
Echinococcus granulosus chromobox protein 1 0.0076 0.0654 0.0687
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.006 0.044 0.044
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.5831 0.6126
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.006 0.044 0.0754
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.1082 0.266
Schistosoma mansoni hypothetical protein 0.0087 0.0794 0.1951
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0205 0.2373 0.5475
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.025 0.0168
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0125 0.0125
Loa Loa (eye worm) transcription factor SMAD2 0.04 0.4981 0.4981
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0125
Trichomonas vaginalis antibiotic synthetase, putative 0.006 0.044 0.1313
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0049 0.0049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.2763 0.6393
Loa Loa (eye worm) hypothetical protein 0.0087 0.0794 0.0794
Echinococcus multilocularis lamin 0.0057 0.0403 0.0403
Onchocerca volvulus 0.0037 0.0125 0.0042
Brugia malayi latrophilin 2 splice variant baaae 0.0187 0.2137 0.2137
Schistosoma mansoni thyroid hormone receptor 0.0136 0.1458 0.3583
Loa Loa (eye worm) hypothetical protein 0.0205 0.2373 0.2373
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.0119 0.0427

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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