Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0015 | 0.036 | 0.0684 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Trypanosoma cruzi | putative prolyl carboxypeptidase, putative | 0.002 | 0.0653 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3341 | 0.6349 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3341 | 0.6349 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0.036 | 0.5 |
Trichomonas vaginalis | lysosomal pro-X carboxypeptidase, putative | 0.002 | 0.0653 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3341 | 0.3341 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0.036 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2236 | 0.2236 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2236 | 0.2236 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.0092 | 0.5263 | 0.5263 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5263 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0092 | 0.5263 | 0.5263 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.002 | 0.0653 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.036 | 0.0684 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0653 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3341 | 0.6349 |
Brugia malayi | Cytochrome P450 family protein | 0.0015 | 0.036 | 0.0684 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3341 | 0.3341 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.002 | 0.0653 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Giardia lamblia | Serine peptidase, putative | 0.002 | 0.0653 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2236 | 0.425 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3341 | 0.3341 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2236 | 0.2236 |
Brugia malayi | Serine protease Z688.6 precursor | 0.002 | 0.0653 | 0.1241 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.002 | 0.0653 | 0.0653 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.002 | 0.0653 | 0.0653 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2236 | 0.2236 |
Toxoplasma gondii | serine carboxypeptidase s28 protein | 0.002 | 0.0653 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3341 | 0.6349 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.002 | 0.0653 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0653 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0.036 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.002 | 0.0653 | 0.0653 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2236 | 0.2236 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.036 | 0.0684 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3341 | 0.6349 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0015 | 0.036 | 0.0684 |
Onchocerca volvulus | 0.002 | 0.0653 | 1 | |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2236 | 0.2236 |
Brugia malayi | Cytochrome P450 family protein | 0.0025 | 0.1007 | 0.1914 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3341 | 0.3341 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.002 | 0.0653 | 0.5 |
Echinococcus multilocularis | geminin | 0.0165 | 1 | 1 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.002 | 0.0653 | 1 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.002 | 0.0653 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0092 | 0.5263 | 0.5263 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.002 | 0.0653 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0653 | 0.1241 |
Brugia malayi | Serine carboxypeptidase S28 family protein | 0.0092 | 0.5263 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2236 | 0.425 |
Giardia lamblia | Thymus-specific serine protease precursor | 0.002 | 0.0653 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.1007 | 0.1914 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Brugia malayi | Serine protease Z688.6 precursor | 0.002 | 0.0653 | 0.1241 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.002 | 0.0653 | 0.5 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3341 | 0.6349 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3341 | 0.3341 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3341 | 0.3341 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2236 | 0.2236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.