Detailed information for compound 1165843

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 336.388 | Formula: C19H20N4O2
  • H donors: 3 H acceptors: 3 LogP: 2.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNCCn1nc2c3c1ccc(c3c(=O)c1c2cccc1)NC
  • InChi: 1S/C19H20N4O2/c1-20-14-6-7-15-17-16(14)19(25)13-5-3-2-4-12(13)18(17)22-23(15)10-8-21-9-11-24/h2-7,20-21,24H,8-11H2,1H3
  • InChiKey: AJKDHIYJSHMPTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0043 0.0081
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0025 0.0185 0.023
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0028
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1517 0.328
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0065 0.0081
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0445 0.0891
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0682 0.7915 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0173 0.1927 0.1927
Trypanosoma cruzi trypanothione reductase, putative 0.0269 0.3057 0.67
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0614 0.7109 0.8958
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0453 0.1357
Onchocerca volvulus 0.0173 0.1927 0.4187
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0613 0.0761
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0614 0.7109 0.8958
Trichomonas vaginalis hypothetical protein 0.0013 0.0043 0.0008
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0169 0.0357
Echinococcus granulosus tar DNA binding protein 0.0061 0.0613 0.0761
Schistosoma mansoni notch 0.0023 0.0159 0.0159
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0396 0.4544 1
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0159 0.0198
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0049 0.0466 0.0363
Brugia malayi Delta serrate ligand family protein 0.0023 0.0159 0.0336
Echinococcus granulosus neural cadherin 0.0023 0.0159 0.0198
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.8057 0.8057
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0049 0.0466 0.3489
Leishmania major importin beta-1 subunit, putative 0.0026 0.0197 0.0348
Schistosoma mansoni slit 0.0023 0.0159 0.0159
Mycobacterium ulcerans hypothetical protein 0.0025 0.0185 0.0271
Echinococcus granulosus transmembrane protease serine 3 0.0021 0.0143 0.0177
Echinococcus multilocularis tissue type plasminogen activator 0.0152 0.1678 0.2083
Schistosoma mansoni notch 0.0023 0.0159 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0241 0.0241
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0049 0.0466 0.3489
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0185 0.0185
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0043 0.0121
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0093 0.099 0.3224
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.17 0.1961
Schistosoma mansoni kinase 0.0201 0.2257 0.2257
Mycobacterium ulcerans hypothetical protein 0.0154 0.17 1
Echinococcus granulosus cpg binding protein 0.0034 0.0292 0.0362
Onchocerca volvulus 0.0021 0.0143 0.0221
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0167 0.0282
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0185 0.0585
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0303 0.0153
Giardia lamblia Glutamate synthase 0.0025 0.0185 0.0393
Echinococcus granulosus L aminoadipate semialdehyde 0.0173 0.1927 0.2392
Schistosoma mansoni hypothetical protein 0.0025 0.0185 0.0185
Onchocerca volvulus 0.0013 0.0043 0.000000031551
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.099 0.211
Onchocerca volvulus 0.0023 0.0159 0.0257
Giardia lamblia NADH oxidase lateral transfer candidate 0.0093 0.099 0.2168
Brugia malayi Trypsin family protein 0.0021 0.0143 0.03
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0466 0.1402
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0339 0.3876 0.8529
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0093 0.099 0.2168
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0169 0.0357
Entamoeba histolytica hypothetical protein 0.0013 0.0043 0.0008
Entamoeba histolytica hypothetical protein 0.0049 0.0466 0.0946
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0303 0.0153
Loa Loa (eye worm) hypothetical protein 0.0025 0.0185 0.0393
Trichomonas vaginalis CAMK family protein kinase 0.0396 0.4544 1
Loa Loa (eye worm) Notch2 0.0023 0.0159 0.0336
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Onchocerca volvulus 0.0034 0.0295 0.0559
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0303 0.0303
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0143 0.0177
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0224 0.0714
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0303 0.0584
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0093 0.099 0.1042
Onchocerca volvulus 0.0042 0.0391 0.0772
Echinococcus granulosus microtubule associated protein 2 0.0694 0.8057 1
Toxoplasma gondii EGF family domain-containing protein 0.0023 0.0159 0.05
Loa Loa (eye worm) beta-lactamase 0.0035 0.0303 0.0653
Entamoeba histolytica hypothetical protein 0.0026 0.0197 0.0348
Mycobacterium ulcerans dehydrogenase 0.0025 0.0185 0.0271
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.099 0.211
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0303 0.0153
Schistosoma mansoni DNA helicase recq5 0.001 0.0007 0.0007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0247 0.0531
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0453 0.0917
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0241 0.0299
Loa Loa (eye worm) hypothetical protein 0.003 0.0241 0.0517
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0007 0.0008
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0185 0.0323
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0065 0.008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0303 0.0653
Echinococcus granulosus lamin dm0 0.003 0.0247 0.0307
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0128
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0093 0.099 0.544
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0076 0.0228
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0093 0.099 0.211
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0159 0.0198
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Trichomonas vaginalis CAMK family protein kinase 0.0396 0.4544 1
Onchocerca volvulus Putative cubilin 0.0023 0.0159 0.0257
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0267 0.0505
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0025 0.0185 0.023
Onchocerca volvulus 0.0152 0.1678 0.3632
Schistosoma mansoni hypothetical protein 0.004 0.0359 0.0359
Echinococcus multilocularis slit 2 protein 0.0023 0.0159 0.0198
Loa Loa (eye worm) hypothetical protein 0.0117 0.1266 0.2776
Trypanosoma cruzi polo-like protein kinase, putative 0.0396 0.4544 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0093 0.099 0.211
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0083 0.0169
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0065 0.0081
Giardia lamblia High cysteine protein 0.0023 0.0159 0.0336
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0185 0.0323
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0807 0.1703
Loa Loa (eye worm) glutathione reductase 0.0269 0.3057 0.6724
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0256 0.0481
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0613 0.0613
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0043 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0376 0.0747
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0682 0.7915 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Loa Loa (eye worm) hypothetical protein 0.0034 0.0295 0.0636
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0083 0.0096
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0078 0.0116
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0169 0.0531
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0453 0.0562
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0173 0.1927 0.4234
Brugia malayi Calcium binding EGF domain containing protein 0.0023 0.0159 0.0336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.03
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0025 0.0185 0.023
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0359 0.0359
Brugia malayi TAR-binding protein 0.0061 0.0613 0.1337
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0021 0.0143 0.0177
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0065 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.1678 0.3638
Leishmania major hypothetical protein, conserved 0.0025 0.0185 0.0323
Brugia malayi Thioredoxin reductase 0.0269 0.3057 0.6724
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0093 0.099 0.211
Leishmania major hypothetical protein, conserved 0.0035 0.0303 0.0584
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Entamoeba histolytica hypothetical protein 0.004 0.0359 0.071
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0303 0.0153
Echinococcus granulosus enteropeptidase 0.0021 0.0143 0.0177
Trichomonas vaginalis CAMK family protein kinase 0.0396 0.4544 1
Schistosoma mansoni chromobox protein 0.0013 0.0043 0.0043
Entamoeba histolytica hypothetical protein 0.0013 0.0043 0.0008
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0025 0.0185 0.0323
Schistosoma mansoni hypothetical protein 0.0013 0.0043 0.0043
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0169 0.0209
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0035 0.0303 0.0653
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Mycobacterium ulcerans ferredoxin reductase 0.0025 0.0185 0.0271
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0224 0.0714
Trichomonas vaginalis apoptosis inducing factor, putative 0.0025 0.0185 0.0323
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0197 0.0348
Brugia malayi hypothetical protein 0.0018 0.0107 0.0222
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0093 0.099 0.211
Echinococcus granulosus Mastin 0.0021 0.0143 0.0177
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0359 0.0446
Onchocerca volvulus 0.003 0.0247 0.0453
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0152 0.1678 0.5424
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0129 0.0198
Mycobacterium ulcerans hypothetical protein 0.0035 0.0303 0.1027
Echinococcus granulosus glutamate synthase 0.0025 0.0185 0.023
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0025 0.0185 0.023
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0303 0.0153
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1517 0.328
Echinococcus granulosus geminin 0.0189 0.2114 0.2624
Onchocerca volvulus 0.0025 0.0185 0.0315
Echinococcus granulosus thioredoxin glutathione reductase 0.0271 0.3076 0.3817
Schistosoma mansoni hypothetical protein 0.0152 0.1678 0.1678
Mycobacterium tuberculosis Conserved protein 0.0035 0.0303 0.0153
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0043 0.0043
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0406 0.0813
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0069 0.0699 0.1527
Leishmania major hypothetical protein, conserved 0.0152 0.1678 0.3638
Brugia malayi Cadherin domain containing protein 0.0023 0.0159 0.0336
Echinococcus granulosus intermediate filament protein 0.003 0.0247 0.0307
Echinococcus granulosus tissue type plasminogen activator 0.0152 0.1678 0.2083
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0025 0.0185 0.023
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0303 0.1027
Brugia malayi EGF-like domain containing protein 0.0023 0.0159 0.0336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0129 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.2196 0.4787
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0224 0.041
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0159 0.0159
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0267 0.0854
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0043 0.0008
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0185 0.0185
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0023 0.0159 0.0336
Loa Loa (eye worm) acetyltransferase 0.0162 0.1793 0.3938
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0185 0.0323
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0143 0.0143
Schistosoma mansoni notch 0.0023 0.0159 0.0159
Echinococcus multilocularis Mastin 0.0021 0.0143 0.0177
Loa Loa (eye worm) hypothetical protein 0.0035 0.0303 0.0653
Onchocerca volvulus 0.0035 0.0303 0.0576
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0081
Brugia malayi CHD4 protein 0.0015 0.0065 0.0129
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0025 0.0185 0.0271
Brugia malayi Kringle domain containing protein 0.0152 0.1678 0.3684
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0043 0.0054
Loa Loa (eye worm) hypothetical protein 0.0035 0.0303 0.0653
Echinococcus multilocularis chromobox protein 2 0.0013 0.0043 0.0054
Brugia malayi glutamate synthase 0.0025 0.0185 0.0393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0241 0.0241
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0224 0.041
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0303 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0303 0.0653
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0129 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0613 0.0613
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0183 0.2048 0.2048
Entamoeba histolytica hypothetical protein 0.0013 0.0043 0.0008
Echinococcus granulosus neurogenic locus notch protein 4 0.0023 0.0159 0.0198
Leishmania major NADH dehydrogenase, putative 0.0025 0.0185 0.0323
Echinococcus granulosus glycoprotein Antigen 5 0.0021 0.0143 0.0177
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0093 0.099 0.544
Loa Loa (eye worm) hypothetical protein 0.0014 0.0058 0.0114
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0482 0.0982
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0396 0.4544 0.564
Echinococcus multilocularis glycoprotein Antigen 5 0.0021 0.0143 0.0177
Mycobacterium ulcerans monoxygenase 0.0025 0.0185 0.0271
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.3324 0.7291
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Echinococcus multilocularis chromobox protein 1 0.0078 0.0807 0.1002
Brugia malayi SET domain containing protein 0.0014 0.0064 0.0127
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0025 0.0185 0.023
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Mycobacterium tuberculosis Probable reductase 0.0614 0.7109 0.8958
Brugia malayi Calcium binding EGF domain containing protein 0.0023 0.0159 0.0336
Schistosoma mansoni serine/threonine protein kinase 0.0396 0.4544 0.4544
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0376 0.0747
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0081
Entamoeba histolytica hypothetical protein 0.004 0.0359 0.071
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0143 0.0143
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2266 0.4979
Brugia malayi EGF-like domain containing protein 0.0023 0.0159 0.0336
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0303 0.0584
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0025 0.0185 0.0585
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0167 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0406 0.0813
Brugia malayi Heterochromatin protein 1 0.0078 0.0807 0.1764
Treponema pallidum NADH oxidase 0.0093 0.099 1
Echinococcus granulosus protein jagged 1 0.0023 0.0159 0.0198
Plasmodium vivax SET domain protein, putative 0.003 0.0241 0.0656
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0043 0.0043
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0185 0.0323
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Schistosoma mansoni hypothetical protein 0.0023 0.0159 0.0159
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0025 0.0185 0.0323
Loa Loa (eye worm) hypothetical protein 0.0152 0.1678 0.3684
Echinococcus granulosus protein jagged 1 0.0023 0.0159 0.0198
Loa Loa (eye worm) hypothetical protein 0.0173 0.1927 0.4234
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0185 0.0323
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0185 0.0323
Schistosoma mansoni hypothetical protein 0.0023 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0339 0.3876 0.3876
Echinococcus multilocularis musashi 0.003 0.0247 0.0307
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0025 0.0185 0.0323
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0025 0.0185 0.0323
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0021 0.0033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0093 0.099 0.211
Echinococcus multilocularis neurogenic locus notch protein 4 0.0023 0.0159 0.0198
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0129 0.0198
Schistosoma mansoni notch 0.0023 0.0159 0.0159
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0224 0.06
Brugia malayi Trypsin family protein 0.0021 0.0143 0.03
Onchocerca volvulus 0.0035 0.0303 0.0576
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0466 0.0363
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.3324 0.7291
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.1793 0.2226
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0185 0.0323
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0043 0.0121
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0396 0.4544 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0185 0.0393
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0043 0.0121
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143
Echinococcus multilocularis geminin 0.0189 0.2114 0.2624
Leishmania major hypothetical protein, conserved 0.0025 0.0185 0.0323
Leishmania major trypanothione reductase 0.0269 0.3057 0.67
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Plasmodium falciparum cysteine repeat modular protein 1 0.0152 0.1678 0.5479
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0376 0.0747
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.8057 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0185 0.0323
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0185 0.0323
Schistosoma mansoni hypothetical protein 0.0023 0.0159 0.0159
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0185 0.0323
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0025 0.0185 0.0271
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0169 0.0415
Onchocerca volvulus 0.0021 0.0143 0.0221
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0185 0.023
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0247 0.0531
Echinococcus multilocularis L aminoadipate semialdehyde 0.0173 0.1927 0.2392
Loa Loa (eye worm) hypothetical protein 0.0044 0.0406 0.088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.099 0.211
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0043 0.0043
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0043 0.0008
Trypanosoma brucei polo-like protein kinase 0.0396 0.4544 1
Echinococcus granulosus notch 0.0023 0.0159 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.03
Echinococcus multilocularis lamin 0.003 0.0247 0.0307
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0303 0.1027
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0025 0.0185 0.0585
Schistosoma mansoni glutamate synthase 0.0025 0.0185 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0008
Schistosoma mansoni notch 0.0023 0.0159 0.0159
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0023 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0185 0.0323
Schistosoma mansoni hypothetical protein 0.0023 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0021 0.0143 0.0143
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0025 0.0185 0.0271
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0169 0.0357
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.027 0.0581
Toxoplasma gondii hypothetical protein 0.0047 0.0447 0.1444
Onchocerca volvulus 0.0023 0.0159 0.0257
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0007 0.00000000016799
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0081
Echinococcus granulosus lamin 0.003 0.0247 0.0307
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0043 0.0121
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0614 0.7109 0.8958
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0023 0.0159 0.0159
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0025 0.0185 0.0271
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0185 0.023
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0185 0.0323
Schistosoma mansoni hypothetical protein 0.0189 0.2114 0.2114
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0269 0.3057 0.3716
Brugia malayi Protein cec-1. 0.0013 0.0043 0.0081
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0049 0.0466 0.2074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.099 0.211
Echinococcus multilocularis protein jagged 2 0.0023 0.0159 0.0198
Onchocerca volvulus 0.0023 0.0159 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0256 0.0481
Schistosoma mansoni hypothetical protein 0.0023 0.0159 0.0159
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.1793 0.3938
Schistosoma mansoni cpg binding protein 0.0032 0.027 0.027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0043 0.0008
Trypanosoma brucei NADH dehydrogenase 0.0025 0.0185 0.0323
Loa Loa (eye worm) TK/ROR protein kinase 0.0152 0.1678 0.3684
Schistosoma mansoni chromobox protein 0.0013 0.0043 0.0043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.099 0.211
Onchocerca volvulus 0.0021 0.0143 0.0221
Mycobacterium tuberculosis Conserved protein 0.0035 0.0303 0.0153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0129 0.0198
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0093 0.099 0.3224
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0143 0.0143
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0093 0.099 0.3141
Entamoeba histolytica hypothetical protein 0.004 0.0359 0.071
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0303 0.0153
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0807 0.1764
Loa Loa (eye worm) trypsin family protein 0.0021 0.0143 0.03
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0267 0.0505
Brugia malayi Protein kinase domain containing protein 0.0152 0.1678 0.3684
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0093 0.099 0.3141
Brugia malayi hypothetical protein 0.0028 0.0224 0.048
Brugia malayi RNA, U transporter 1 0.009 0.0955 0.209
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0303 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0406 0.0813
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0221 0.0274
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.03
Mycobacterium ulcerans glutamate synthase subunit beta 0.0025 0.0185 0.0271
Onchocerca volvulus 0.003 0.0247 0.0453
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0406 0.0805
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0129 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0396 0.4544 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0025 0.0185 0.047
Mycobacterium ulcerans lipase LipD 0.0035 0.0303 0.1027
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0185 0.0271
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0185 0.0323
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0049 0.0466 0.1506
Schistosoma mansoni hypothetical protein 0.0189 0.2114 0.2114
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0093 0.099 0.211
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0043 0.00000000015396
Loa Loa (eye worm) notch protein 0.0023 0.0159 0.0336
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0613 0.1337
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0466 0.0946
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0453 0.0917
Brugia malayi Pre-SET motif family protein 0.003 0.0241 0.0517
Giardia lamblia Kinase, PLK 0.0396 0.4544 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0025 0.0185 0.0323
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0143 0.0143
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0093 0.099 0.211
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0043 0.0008
Trichomonas vaginalis mercuric reductase, putative 0.0093 0.099 0.211
Loa Loa (eye worm) hypothetical protein 0.0032 0.0267 0.0574
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0185 0.0323
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.174 0.216
Leishmania major hypothetical protein, conserved 0.0025 0.0185 0.0323
Schistosoma mansoni importin beta-1 0.0032 0.0267 0.0267
Trichomonas vaginalis CAMK family protein kinase 0.0396 0.4544 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0093 0.099 1
Echinococcus multilocularis snurportin 1 0.0339 0.3876 0.4811
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0303 0.0584
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0093 0.099 0.544
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.2196 0.4787
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0008
Brugia malayi Calcium binding EGF domain containing protein 0.0023 0.0159 0.0336
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0043 0.0121
Echinococcus granulosus bloom syndrome protein 0.0023 0.0167 0.0207
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Schistosoma mansoni lamin 0.003 0.0247 0.0247
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0049 0.0466 0.3489
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0159 0.0198
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Brugia malayi beta-lactamase family protein 0.0035 0.0303 0.0653
Echinococcus multilocularis neurogenic locus protein delta 0.0023 0.0159 0.0198
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0453 0.1462
Echinococcus multilocularis lamin dm0 0.003 0.0247 0.0307
Brugia malayi EGF-like domain containing protein 0.0023 0.0159 0.0336
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0396 0.4544 0.564
Schistosoma mansoni hypothetical protein 0.0013 0.0042 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0089 0.011
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0303 0.0584
Brugia malayi hypothetical protein 0.0021 0.0143 0.03
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0025 0.0185 0.0393
Echinococcus granulosus slit 2 protein 0.0023 0.0159 0.0198
Echinococcus multilocularis protein jagged 1 0.0023 0.0159 0.0198
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0093 0.099 0.3224
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0093 0.099 1
Echinococcus multilocularis protein jagged 1 0.0023 0.0159 0.0198
Brugia malayi Importin beta-1 subunit 0.0032 0.0267 0.0574
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0359 0.0446
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.03
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0025 0.0185 0.0323
Echinococcus multilocularis fibropellin Ia 0.0023 0.0159 0.0198
Schistosoma mansoni glutamate synthase 0.0025 0.0185 0.0185
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0023 0.0159 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0396 0.4544 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0406 0.1309
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0089 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0008
Schistosoma mansoni ran 0.0023 0.0169 0.0169
Echinococcus granulosus chromobox protein 2 0.0013 0.0043 0.0054
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0169 0.0286
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0093 0.099 0.211
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143
Brugia malayi EGF-like domain containing protein 0.0023 0.0159 0.0336
Trichomonas vaginalis ran, putative 0.0023 0.0169 0.0286
Echinococcus multilocularis transmembrane protease serine 3 0.0021 0.0143 0.0177
Loa Loa (eye worm) RNA binding protein 0.0061 0.0613 0.1337
Mycobacterium ulcerans NADH dehydrogenase 0.0025 0.0185 0.0271
Leishmania major phosphopantetheinyl transferase-like protein 0.0049 0.0466 0.0946
Brugia malayi Trypsin-like protease protein 5 0.0021 0.0143 0.03
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0129 0.0198
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0043 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0008
Echinococcus granulosus chromobox protein 1 0.0078 0.0807 0.1002
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0025 0.0185 0.0393
Onchocerca volvulus 0.0035 0.0303 0.0576
Toxoplasma gondii selenide, water dikinase 0.0025 0.0185 0.0585
Echinococcus multilocularis fat cadherin tumor suppressor 0.0023 0.0159 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0396 0.4544 1
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0185 0.0585
Schistosoma mansoni hypothetical protein 0.0023 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Schistosoma mansoni ran 0.0023 0.0169 0.0169
Plasmodium falciparum glutathione reductase 0.0269 0.3057 1
Brugia malayi EGF-like domain containing protein 0.0023 0.0159 0.0336
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0042 0.0052
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0614 0.7109 0.8958
Brugia malayi Pre-SET motif family protein 0.0202 0.2266 0.4979
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0025 0.0185 0.023
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0025 0.0185 0.0271
Brugia malayi GCC2 and GCC3 family protein 0.0023 0.0159 0.0336
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0042 0.0052
Brugia malayi beta-lactamase family protein 0.0035 0.0303 0.0653
Entamoeba histolytica disulphide oxidoreductase, putative 0.0025 0.0185 0.0323
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0081
Plasmodium falciparum thioredoxin reductase 0.0269 0.3057 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0025 0.0185 0.0323
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.03
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0185 0.0323
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0267 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0008
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0613 0.1337
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0159 0.0198
Echinococcus granulosus neurogenic locus protein delta 0.0023 0.0159 0.0198
Echinococcus granulosus delta-like protein 1 0.0023 0.0159 0.0198
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0043 0.0008
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0083 0.0169
Schistosoma mansoni DNA helicase recq1 0.001 0.0007 0.0007
Echinococcus granulosus importin subunit beta 1 0.0032 0.0267 0.0331
Brugia malayi glutathione reductase 0.0269 0.3057 0.6724
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Echinococcus multilocularis Chromo domain 0.0013 0.0043 0.0054
Trypanosoma cruzi polo-like protein kinase, putative 0.0396 0.4544 1
Loa Loa (eye worm) programmed cell death 8 0.0025 0.0185 0.0393
Mycobacterium tuberculosis Probable oxidoreductase 0.0682 0.7915 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0185 0.0323
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0167 0.0353
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0028
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0134 0.0416
Brugia malayi notch-like transmembrane receptor 0.0023 0.0159 0.0336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.03
Brugia malayi beta-lactamase 0.0035 0.0303 0.0653
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0185 0.047
Echinococcus granulosus protein jagged 2 0.0023 0.0159 0.0198
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0185 0.0585
Echinococcus granulosus Chromobox protein 3 0.0013 0.0043 0.0054
Plasmodium falciparum thioredoxin reductase 0.0093 0.099 0.3224
Schistosoma mansoni cell polarity protein 0.0023 0.0159 0.0159
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0197 0.0348
Echinococcus granulosus snurportin 1 0.0339 0.3876 0.4811
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0807 0.1703
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.3324 0.7291
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0303 0.0584
Giardia lamblia Thioredoxin reductase 0.0025 0.0185 0.0393
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0049 0.0466 0.1506
Loa Loa (eye worm) RecQ helicase 0.0023 0.0167 0.0353
Echinococcus multilocularis notch 0.0023 0.0159 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0613 0.0613
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0169 0.0209
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0043 0.0008
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0081
Schistosoma mansoni disulfide oxidoreductase 0.0025 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0035 0.0303 0.0653
Echinococcus granulosus chromobox protein 1 0.0078 0.0807 0.1002
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0043 0.0081
Entamoeba histolytica Ran family GTPase 0.0023 0.0169 0.0286
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0049 0.0466 0.2074
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0021 0.0143 0.0177
Entamoeba histolytica serine/threonine protein kinase, putative 0.0396 0.4544 1
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0445 0.0899
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0065 0.0065
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0445 0.0899
Brugia malayi RNA binding protein 0.0061 0.0613 0.1337
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Schistosoma mansoni cpg binding protein 0.0034 0.0292 0.0292
Plasmodium falciparum ferrodoxin reductase-like protein 0.0025 0.0185 0.0585
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0185 0.0323
Loa Loa (eye worm) thioredoxin reductase 0.0269 0.3057 0.6724
Loa Loa (eye worm) helicase 0.0013 0.0043 0.0081
Entamoeba histolytica hypothetical protein 0.004 0.0359 0.071
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0021 0.0143 0.0143
Brugia malayi EGF-like domain containing protein 0.0023 0.0159 0.0336
Echinococcus multilocularis chromobox protein 1 0.0078 0.0807 0.1002
Brugia malayi hypothetical protein 0.0013 0.0043 0.0081
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0093 0.099 0.1229
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0169 0.0286
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0185 0.0323
Plasmodium vivax ferrodoxin reductase, putative 0.0025 0.0185 0.047
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0406 0.088
Onchocerca volvulus Serine\/threonine kinase homolog 0.0396 0.4544 1
Loa Loa (eye worm) intermediate filament protein 0.003 0.0247 0.0531
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0043 0.0081
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0081
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0025 0.0185 0.0393
Trypanosoma brucei trypanothione reductase 0.0269 0.3057 0.67
Brugia malayi CXXC zinc finger family protein 0.0032 0.027 0.0581
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0169 0.0286
Echinococcus multilocularis enteropeptidase 0.0021 0.0143 0.0177
Onchocerca volvulus 0.0032 0.027 0.0504
Brugia malayi Trypsin family protein 0.0021 0.0143 0.03
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0167 0.0282
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0043 0.0121
Brugia malayi Trypsin family protein 0.0021 0.0143 0.03
Echinococcus granulosus fibropellin Ia 0.0023 0.0159 0.0198
Trichomonas vaginalis glutathione reductase, putative 0.0093 0.099 0.211
Loa Loa (eye worm) hypothetical protein 0.0035 0.0303 0.0653
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2506 0.3003
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0007 0.0008
Schistosoma mansoni septate junction protein 0.0023 0.0159 0.0159
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0241 0.0299
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0303 0.0153
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0185 0.023
Echinococcus multilocularis thioredoxin glutathione reductase 0.0271 0.3076 0.3817
Brugia malayi chromobox protein homolog 3 0.0044 0.0406 0.088
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0613 0.1337
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0109 0.0109
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0682 0.7915 1
Echinococcus granulosus protein jagged 2 0.0023 0.0159 0.0198
Onchocerca volvulus Slit protein homolog 0.0023 0.0159 0.0257
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.099 0.211
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0093 0.099 0.211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0129 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0224 0.048
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143
Trichomonas vaginalis esterase, putative 0.0035 0.0303 0.0584
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0025 0.0185 0.023
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0185 0.0323
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0185 0.0393
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0303 0.0584
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0093 0.099 0.1229
Loa Loa (eye worm) hypothetical protein 0.0014 0.0058 0.0114
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.003 0.0241 0.0517
Schistosoma mansoni intermediate filament proteins 0.003 0.0247 0.0247
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0303 0.0303
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0093 0.099 0.211
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0025 0.0185 0.0585
Toxoplasma gondii NADPH-glutathione reductase 0.0093 0.099 0.3224
Mycobacterium ulcerans beta-lactamase 0.0035 0.0303 0.1027
Toxoplasma gondii thioredoxin reductase 0.0269 0.3057 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0021 0.0143 0.0177
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0169 0.0531
Schistosoma mansoni cpg binding protein 0.0034 0.0292 0.0292
Onchocerca volvulus 0.0021 0.0143 0.0221
Onchocerca volvulus 0.0021 0.0143 0.0221
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0224 0.041
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0007 0.0008
Echinococcus granulosus Chromo domain 0.0013 0.0043 0.0054
Schistosoma mansoni hypothetical protein 0.0021 0.0143 0.0143
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0613 0.0613
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0241 0.0241
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0303 0.0376
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0185 0.0323
Brugia malayi EGF-like domain containing protein 0.0023 0.0159 0.0336
Schistosoma mansoni chromobox protein 0.0078 0.0807 0.0807
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0376 0.0747
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0143 0.0143
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0453 0.1462
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0043 0.0054
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0303 0.0653
Trichomonas vaginalis set domain proteins, putative 0.023 0.2592 0.5667
Onchocerca volvulus 0.0023 0.0159 0.0257
Entamoeba histolytica thioredoxin reductase, putative 0.0025 0.0185 0.0323
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0241 0.0769
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0021 0.0143 0.03
Onchocerca volvulus 0.0023 0.0159 0.0257
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.3324 0.7291
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0008
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0224 0.0714
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0043 0.0008
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0185 0.0585
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0093 0.099 0.211
Mycobacterium tuberculosis Probable dehydrogenase 0.0614 0.7109 0.8958
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0043 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.03
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0241 0.0299
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0143 0.0143
Echinococcus multilocularis neural cadherin 0.0023 0.0159 0.0198
Echinococcus multilocularis neurogenic locus protein delta 0.0023 0.0159 0.0198
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0093 0.099 0.099
Brugia malayi hypothetical protein 0.004 0.0359 0.0778
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0197 0.0348
Plasmodium vivax importin-beta 2, putative 0.0032 0.0267 0.0742
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0303 0.0861
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0069 0.0699 0.1527
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0303 0.0376
Brugia malayi Muscle positioning protein 4 0.0023 0.0159 0.0336
Brugia malayi serine/threonine-protein kinase plk-2 0.0396 0.4544 1
Schistosoma mansoni glutamate synthase 0.0025 0.0185 0.0185
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0185 0.023
Schistosoma mansoni chromobox protein 0.0078 0.0807 0.0807
Echinococcus multilocularis glutamate synthase 0.0025 0.0185 0.023
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0466 0.1506
Brugia malayi intermediate filament protein 0.003 0.0247 0.0531
Brugia malayi Cadherin domain containing protein 0.0023 0.0159 0.0336
Onchocerca volvulus Neurogenic locus notch homolog 0.0023 0.0159 0.0257
Schistosoma mansoni lamin 0.003 0.0247 0.0247
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0185 0.0323
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0614 0.7109 0.8958
Leishmania major GTP-binding protein, putative 0.0023 0.0169 0.0286
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0043 0.0081
Toxoplasma gondii kringle domain-containing protein 0.0152 0.1678 0.5479
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0197 0.0348
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0666 0.2161
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0705 0.0705
Plasmodium vivax thioredoxin reductase, putative 0.0269 0.3057 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0081
Echinococcus multilocularis cpg binding protein 0.0034 0.0292 0.0362
Plasmodium falciparum importin beta, putative 0.0032 0.0267 0.0854
Mycobacterium leprae Probable lipase LipE 0.0035 0.0303 0.0153
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0303 0.0584
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.1793 0.1793
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1517 0.328
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0185 0.0323
Plasmodium vivax glutathione reductase, putative 0.0269 0.3057 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0303 0.0153
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0185 0.0323
Onchocerca volvulus 0.023 0.2592 0.5663
Schistosoma mansoni notch 0.0023 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0336
Schistosoma mansoni hypothetical protein 0.0023 0.0159 0.0159
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0043 0.0008
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0185 0.0323
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0185 0.0323
Onchocerca volvulus 0.0021 0.0143 0.0221
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0025 0.0185 0.0323
Toxoplasma gondii ABC1 family protein 0.0035 0.0303 0.0971
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0093 0.099 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0065 0.0129
Plasmodium falciparum glutathione reductase 0.0093 0.099 0.3224
Leishmania major hypothetical protein, conserved 0.0028 0.0224 0.041
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0185 0.0271
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0143 0.0143

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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