Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.8593 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.8593 | 0.5 |
Echinococcus granulosus | lamin | 0.0026 | 1 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 1 | 0.5 |
Echinococcus multilocularis | musashi | 0.0026 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.8593 | 0.8593 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.8593 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.8593 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.8593 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.8593 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.8593 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.8593 | 0.5 |
Echinococcus multilocularis | lamin | 0.0026 | 1 | 0.5 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9606 | 0.9606 |
Brugia malayi | hypothetical protein | 0.0016 | 0.1458 | 0.1458 |
Brugia malayi | hypothetical protein | 0.0024 | 0.8593 | 0.8593 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.