Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3123 | 0.3123 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0049 | 0.0472 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0472 | 0.0472 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0427 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0056 | 0.07 | 0.07 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0129 | 0.3123 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.3535 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.07 | 0.2242 |
Loa Loa (eye worm) | MBCTL1 | 0.0056 | 0.07 | 0.2242 |
Schistosoma mansoni | hypothetical protein | 0.0335 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0129 | 0.3123 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0546 | 0.1749 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0527 | 0.0358 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3123 | 0.3123 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0546 | 0.1749 |
Echinococcus granulosus | tar DNA binding protein | 0.0129 | 0.3123 | 0.2783 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0472 | 0.151 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3123 | 0.3123 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3123 | 0.3123 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0056 | 0.07 | 0.024 |
Brugia malayi | RNA binding protein | 0.0129 | 0.3123 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0056 | 0.07 | 0.024 |
Echinococcus multilocularis | tar DNA binding protein | 0.0129 | 0.3123 | 0.2783 |
Loa Loa (eye worm) | RNA binding protein | 0.0129 | 0.3123 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0472 | 0.0472 |
Echinococcus multilocularis | geminin | 0.0335 | 1 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0056 | 0.07 | 0.024 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0199 | 0.5454 | 0.5229 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0056 | 0.07 | 0.024 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0049 | 0.0472 | 0.0472 |
Mycobacterium ulcerans | hypothetical protein | 0.0157 | 0.4068 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0472 | 0.151 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0472 | 0.151 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0056 | 0.07 | 0.2242 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3123 | 0.3123 |
Brugia malayi | TAR-binding protein | 0.0129 | 0.3123 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.3535 | 0.3871 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0157 | 0.4068 | 0.5 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0199 | 0.5454 | 0.5229 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.8986 | 0.8986 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0546 | 0.1749 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0298 | 0.8783 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0298 | 0.8783 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.8783 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0049 | 0.0472 | 0.151 |
Schistosoma mansoni | hypothetical protein | 0.0335 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.8783 | 1 |
Onchocerca volvulus | 0.0049 | 0.0472 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0546 | 0.1749 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0129 | 0.3123 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.