Detailed information for compound 1166918

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.459 | Formula: C22H26FN3O2
  • H donors: 1 H acceptors: 2 LogP: 3.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(CCCN1CCN(CC1)c1nccc2c1cc(o2)C)O
  • InChi: 1S/C22H26FN3O2/c1-16-15-19-21(28-16)8-9-24-22(19)26-13-11-25(12-14-26)10-2-3-20(27)17-4-6-18(23)7-5-17/h4-9,15,20,27H,2-3,10-14H2,1H3
  • InChiKey: JCIQDYFHWCYNKW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0035 0.0196 0.062
Leishmania major NADH dehydrogenase, putative 0.0035 0.0196 0.0425
Schistosoma mansoni hypothetical protein 0.0084 0.0593 0.0581
Echinococcus multilocularis nibrin 0.002 0.0072 0.0109
Entamoeba histolytica hypothetical protein 0.0073 0.0505 0.2907
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0035 0.0196 0.0296
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0072 0.002
Trichomonas vaginalis glutamate synthase, putative 0.0035 0.0196 0.0428
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0072 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0133 0.1 0.3109
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0099 0.0222
Giardia lamblia Replication factor C, subunit 1 0.002 0.0072 0.0031
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0133 0.1 0.0988
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0069 0.0204
Echinococcus multilocularis snurportin 1 0.0344 0.2728 0.4124
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.0192
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0133 0.1 0.3109
Trypanosoma cruzi hypothetical protein, conserved 0.0214 0.1666 0.5333
Brugia malayi beta-lactamase family protein 0.0035 0.0195 0.0534
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0196 0.0428
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0106 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0072 0.0118
Mycobacterium ulcerans monoxygenase 0.0035 0.0196 0.068
Mycobacterium tuberculosis Conserved protein 0.0025 0.0108 0.0082
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0069 0.0204
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0035 0.0196 0.062
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0253 0.057
Onchocerca volvulus 0.0504 0.4042 1
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.0106 0.0125
Brugia malayi RNA, U transporter 1 0.0092 0.0657 0.1842
Leishmania major hypothetical protein, conserved 0.0035 0.0196 0.0425
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0035 0.0196 0.068
Trichomonas vaginalis apoptosis inducing factor, putative 0.0035 0.0196 0.0428
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0505 0.0763
Entamoeba histolytica hypothetical protein 0.0026 0.012 0.0341
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.007
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0253 0.057
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0052 0.007
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0098 0.0709 0.1989
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0099 0.0303
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0976 0.7911 1
Leishmania major DNA damage repair protein, putative 0.0024 0.0106 0.0125
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0108 0.0265
Schistosoma mansoni hypothetical protein 0.005 0.0314 0.0301
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0035 0.0196 0.0425
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0035 0.0196 0.062
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.012 0.0238
Entamoeba histolytica hypothetical protein 0.0024 0.0099 0.0201
Onchocerca volvulus 0.0024 0.0102 0.0252
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0196 0.0428
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0035 0.0196 0.0193
Brugia malayi hypothetical protein 0.002 0.0072 0.0185
Echinococcus multilocularis chromobox protein 1 0.007 0.0482 0.0729
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0133 0.1 0.281
Brugia malayi CHE-14 protein 0.0087 0.0619 0.1733
Mycobacterium ulcerans dehydrogenase 0.0035 0.0196 0.068
Brugia malayi Heterochromatin protein 1 0.007 0.0482 0.1346
Trichomonas vaginalis DNA polymerase eta, putative 0.0079 0.0553 0.1315
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0195 0.0425
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0072 0.0214
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0385 0.3063 0.3837
Mycobacterium leprae Probable lipase LipE 0.0035 0.0195 0.0157
Schistosoma mansoni hypothetical protein 0.005 0.0314 0.0301
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.0553 0.2366
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0072 0.0109
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.0553 0.1545
Entamoeba histolytica hypothetical protein 0.0073 0.0505 0.2907
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0431 0.0652
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0196 0.0428
Loa Loa (eye worm) hypothetical protein 0.0108 0.0788 0.2211
Trypanosoma cruzi NADH dehydrogenase, putative 0.0035 0.0196 0.0425
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.0425
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0482 0.1346
Echinococcus granulosus dna polymerase kappa 0.0079 0.0553 0.1789
Treponema pallidum NADH oxidase 0.0133 0.1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0035 0.0196 0.0428
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0072 0.0214
Brugia malayi Thioredoxin reductase 0.0385 0.3063 0.8648
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0133 0.1 0.325
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0102 0.011
Echinococcus granulosus chromobox protein 1 0.007 0.0482 0.1561
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0878 0.7108 0.8978
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0035 0.0196 0.0425
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0195 0.0534
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0505 0.0492
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0106 0.0125
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0035 0.0196 0.0158
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0432
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0133 0.1 0.448
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0035 0.0196 0.062
Chlamydia trachomatis DNA ligase 0.002 0.0072 0.0207
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0099 0.0303
Trypanosoma brucei hypothetical protein, conserved 0.0214 0.1666 0.5333
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0035 0.0196 0.0296
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0072 0.0119
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0035 0.0196 0.068
Onchocerca volvulus 0.0012 0.0006 0.0016
Schistosoma mansoni hypothetical protein 0.0084 0.0593 0.0581
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0072 0.0185
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0079 0.0553 0.1315
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0102 0.0073
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0196 0.0428
Schistosoma mansoni importin beta-1 0.0032 0.017 0.0157
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.1196 0.3367
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0072 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0196 0.0425
Loa Loa (eye worm) hypothetical protein 0.0104 0.0757 0.2125
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0108 0.0132
Brugia malayi Niemann-Pick C1 protein precursor 0.0203 0.1568 0.4417
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0099 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0072 0.0118
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0195 0.0192
Mycobacterium ulcerans hypothetical protein 0.0035 0.0195 0.0676
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0108 0.0265
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0195 0.0192
Trichomonas vaginalis set domain proteins, putative 0.0504 0.4042 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0069 0.0079
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0878 0.7108 0.8978
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0102 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0352 0.0945
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0079 0.0553 0.054
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0035 0.0196 0.0158
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0195 0.0192
Schistosoma mansoni cpg binding protein 0.003 0.015 0.0137
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0035 0.0196 0.068
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0035 0.0196 0.0428
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Brugia malayi glutaminase DH11.1 0.0276 0.2167 0.6114
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0035 0.0196 0.0635
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0072 0.0118
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0619 0.0936
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0431 0.1397
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0229 0.0566
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0069 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0076 0.0526 0.0513
Onchocerca volvulus 0.0035 0.0195 0.0483
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0035 0.0196 0.0848
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0035 0.0196 0.1366
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0035 0.0196 0.1366
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0035 0.0196 0.0425
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0344 0.2728 0.77
Brugia malayi Pre-SET motif family protein 0.0443 0.3541 1
Brugia malayi DKFZp564C0469 protein 0.002 0.0072 0.0185
Plasmodium falciparum thioredoxin reductase 0.0385 0.3063 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0229 0.0509
Leishmania major importin beta-1 subunit, putative 0.0026 0.012 0.0171
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0072 0.0118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.1196 0.3367
Schistosoma mansoni hypothetical protein 0.0108 0.0788 0.0776
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0079 0.0553 0.1789
Trichomonas vaginalis glutamate synthase, putative 0.0035 0.0196 0.0428
Mycobacterium ulcerans beta-lactamase 0.0035 0.0195 0.0676
Echinococcus granulosus geminin 0.0166 0.1268 0.4105
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0035 0.0196 0.0635
Loa Loa (eye worm) hypothetical protein 0.0039 0.0229 0.0629
Schistosoma mansoni DNA ligase IV 0.002 0.0072 0.0059
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0035 0.0196 0.0425
Schistosoma mansoni DNA polymerase eta 0.0104 0.0757 0.0745
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0072 0.0118
Trichomonas vaginalis importin beta-1, putative 0.0026 0.012 0.0238
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0035 0.0196 0.0193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0195 0.0182
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0102 0.0219
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0106 0.0327
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0619 0.1733
Trichomonas vaginalis chromobox protein, putative 0.007 0.0482 0.1139
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0035 0.0196 0.0848
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0137 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0134 0.0274
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0035 0.0196 0.0296
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0035 0.0196 0.062
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0035 0.0196 0.062
Toxoplasma gondii NADPH-glutathione reductase 0.0133 0.1 0.325
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0407 0.1318
Trichomonas vaginalis chromobox protein, putative 0.007 0.0482 0.1139
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0106 0.0327
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0102 0.0038
Trypanosoma cruzi DNA polymerase eta, putative 0.0104 0.0757 0.2299
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0035 0.0196 0.1366
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0035 0.0196 0.0537
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0311 0.0809
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.0192
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.007
Onchocerca volvulus 0.0012 0.0006 0.0016
Mycobacterium ulcerans hypothetical protein 0.0025 0.0108 0.0265
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0505 0.1634
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0195 0.0192
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.017 0.0535
Mycobacterium ulcerans hypothetical protein 0.0035 0.0196 0.068
Schistosoma mansoni glutamate synthase 0.0035 0.0196 0.0183
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0106 0.0125
Loa Loa (eye worm) hypothetical protein 0.0032 0.017 0.0463
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0553 0.1615
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0035 0.0196 0.0296
Trichomonas vaginalis esterase, putative 0.0035 0.0195 0.0425
Trypanosoma brucei NADH dehydrogenase 0.0035 0.0196 0.0425
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0079 0.0553 0.0646
Echinococcus multilocularis protein patched 0.0087 0.0619 0.0936
Schistosoma mansoni disulfide oxidoreductase 0.0035 0.0196 0.0183
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0098 0.0709 0.1989
Mycobacterium tuberculosis Probable oxidoreductase 0.0976 0.7911 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0431 0.0419
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0133 0.1 1
Brugia malayi CHD4 protein 0.0013 0.0013 0.0019
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0195 0.0632
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0035 0.0196 0.0635
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.0421
Mycobacterium ulcerans hypothetical protein 0.0024 0.0106 0.0256
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0134 0.0274
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0106 0.0125
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0072 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0352 0.0945
Plasmodium vivax SET domain protein, putative 0.0064 0.0431 0.139
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0072 0.0059
Leishmania major trypanothione reductase 0.0385 0.3063 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0106 0.0125
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0976 0.7911 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0102 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0106 0.0125
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.007
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0035 0.0196 0.0425
Giardia lamblia DNA damage repair protein 0.0024 0.0106 0.0403
Loa Loa (eye worm) thioredoxin reductase 0.0385 0.3063 0.8648
Onchocerca volvulus Protein patched homolog 0.0012 0.0006 0.0016
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.0553 0.0646
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0069 0.0104
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0072 0.0214
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0362 0.1164
Trypanosoma brucei unspecified product 0.0054 0.0352 0.0945
Echinococcus granulosus GPCR family 2 0.005 0.0314 0.1017
Entamoeba histolytica hypothetical protein 0.002 0.0072 0.002
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0035 0.0196 0.0425
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0102 0.0234
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0553 0.1615
Schistosoma mansoni hypothetical protein 0.0073 0.0505 0.0492
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0195 0.0182
Echinococcus multilocularis Niemann Pick C1 protein 0.0289 0.2281 0.3448
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0619 0.2004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.027
Schistosoma mansoni cpg binding protein 0.0028 0.0137 0.0124
Echinococcus granulosus Niemann Pick C1 protein 0.0289 0.2281 0.7385
Onchocerca volvulus 0.0084 0.0594 0.1468
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0196 0.0428
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0133 0.1 0.3109
Trypanosoma brucei unspecified product 0.0079 0.0553 0.1615
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0035 0.0196 0.0425
Schistosoma mansoni glutamate synthase 0.0035 0.0196 0.0183
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0035 0.0196 0.0425
Brugia malayi beta-lactamase 0.0035 0.0195 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0619 0.148
Plasmodium falciparum importin beta, putative 0.0032 0.017 0.0535
Plasmodium vivax thioredoxin reductase, putative 0.0385 0.3063 1
Leishmania major DNA polymerase kappa, putative 0.0024 0.0106 0.0125
Onchocerca volvulus 0.0012 0.0006 0.0016
Onchocerca volvulus 0.0012 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0185
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.0106 0.0327
Echinococcus multilocularis Niemann Pick C1 protein 0.0203 0.1568 0.237
Mycobacterium ulcerans NADH dehydrogenase 0.0035 0.0196 0.068
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0035 0.0196 0.0635
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0534
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0102 0.0234
Plasmodium falciparum ferrodoxin reductase-like protein 0.0035 0.0196 0.062
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0534
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0099 0.0303
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0195 0.0295
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0035 0.0196 0.062
Schistosoma mansoni glutamate synthase 0.0035 0.0196 0.0183
Schistosoma mansoni hypothetical protein 0.005 0.0314 0.0301
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0035 0.0196 0.0537
Loa Loa (eye worm) hypothetical protein 0.005 0.0314 0.087
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0102 0.027
Onchocerca volvulus Protein patched homolog 0.0012 0.0006 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0133 0.1 0.3109
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0102 0.0219
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0069 0.0111
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0102 0.0219
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0035 0.0196 0.0193
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0594 0.1922
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Brugia malayi hypothetical protein 0.0073 0.0505 0.1409
Echinococcus multilocularis cpg binding protein 0.003 0.015 0.0226
Treponema pallidum DNA ligase (lig) 0.002 0.0072 0.0031
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0099 0.0324
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0133 0.1 0.325
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0102 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.007
Schistosoma mansoni chromobox protein 0.007 0.0482 0.047
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0052 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0133 0.1 0.325
Loa Loa (eye worm) hypothetical protein 0.0087 0.0619 0.1733
Toxoplasma gondii thioredoxin reductase 0.0385 0.3063 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.013
Entamoeba histolytica thioredoxin reductase, putative 0.0035 0.0196 0.0848
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0195 0.0676
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0099 0.0101
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0099 0.007
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0133 0.1 0.325
Echinococcus multilocularis thioredoxin glutathione reductase 0.0388 0.3089 0.4669
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0185
Schistosoma mansoni chromobox protein 0.007 0.0482 0.047
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.0421
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0133 0.1 0.3237
Plasmodium vivax importin-beta 2, putative 0.0032 0.017 0.0535
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.0192
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0133 0.1 0.3109
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0108 0.0132
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0035 0.0196 0.0296
Giardia lamblia Glutamate synthase 0.0035 0.0196 0.1366
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0229 0.0509
Leishmania major hypothetical protein, conserved 0.0035 0.0196 0.0425
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0069 0.0177
Treponema pallidum thioredoxin reductase (trxB) 0.0035 0.0196 0.1366
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0102 0.027
Loa Loa (eye worm) hypothetical protein 0.0203 0.1568 0.4417
Toxoplasma gondii selenide, water dikinase 0.0035 0.0196 0.062
Echinococcus granulosus nibrin 0.002 0.0072 0.0233
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0035 0.0196 0.0425
Brugia malayi Latrophilin receptor protein 2 0.005 0.0314 0.087
Echinococcus granulosus dna polymerase eta 0.0104 0.0757 0.2452
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0594 0.0897
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0035 0.0196 0.0425
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0013 0.002
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0133 0.1 0.1215
Echinococcus multilocularis dna polymerase kappa 0.0079 0.0553 0.0835
Schistosoma mansoni hypothetical protein 0.0344 0.2728 0.2718
Schistosoma mansoni hypothetical protein 0.0166 0.1268 0.1256
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0035 0.0196 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0072 0.0118
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0195 0.0192
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0035 0.0196 0.062
Loa Loa (eye worm) beta-lactamase 0.0035 0.0195 0.0534
Echinococcus multilocularis glutamate synthase 0.0035 0.0196 0.0296
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0108 0.0209
Treponema pallidum oxidoreductase 0.0035 0.0196 0.1366
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.013
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0253 0.0627
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0035 0.0196 0.0848
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0028 0.001
Onchocerca volvulus 0.002 0.0072 0.0178
Schistosoma mansoni hypothetical protein 0.0084 0.0593 0.0581
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0035 0.0196 0.068
Echinococcus granulosus expressed conserved protein 0.019 0.1467 0.4749
Mycobacterium ulcerans glutamate synthase subunit beta 0.0035 0.0196 0.068
Loa Loa (eye worm) glutaminase 0.0276 0.2167 0.6114
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0102 0.011
Chlamydia trachomatis thioredoxin reductase 0.0035 0.0196 0.1518
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0314 0.0475
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0431 0.0419
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0108 0.0082
Entamoeba histolytica disulphide oxidoreductase, putative 0.0035 0.0196 0.0848
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0099 0.0101
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.012 0.0171
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0196 0.0425
Onchocerca volvulus 0.0031 0.0159 0.0393
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0314 0.087
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0035 0.0196 0.0158
Echinococcus multilocularis expressed conserved protein 0.019 0.1467 0.2218
Echinococcus granulosus cpg binding protein 0.003 0.015 0.0485
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0035 0.0196 0.0537
Mycobacterium ulcerans glutaminase 0.0276 0.2167 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0013 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0102 0.011
Trypanosoma cruzi trypanothione reductase, putative 0.0385 0.3063 1
Schistosoma mansoni sulfide quinone reductase 0.0035 0.0196 0.0183
Loa Loa (eye worm) hypothetical protein 0.0157 0.1196 0.3367
Echinococcus granulosus importin subunit beta 1 0.0032 0.017 0.055
Schistosoma mansoni cpg binding protein 0.003 0.015 0.0137
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0196 0.0428
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.012 0.0238
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0099 0.0324
Giardia lamblia Thioredoxin reductase 0.0035 0.0196 0.1366
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0108 0.0164
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0133 0.1 0.3109
Entamoeba histolytica hypothetical protein 0.0073 0.0505 0.2907
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0099 0.0303
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0069 0.0223
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0106 0.0125
Brugia malayi chromobox protein homolog 3 0.0039 0.0229 0.0629
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0106 0.0125
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0099 0.0495
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0108 0.0351
Toxoplasma gondii exonuclease III APE 0.002 0.0069 0.0204
Schistosoma mansoni terminal deoxycytidyl transferase 0.0079 0.0553 0.054
Brugia malayi glutamate synthase 0.0035 0.0196 0.0537
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0133 0.1 0.3109
Mycobacterium ulcerans lipase LipD 0.0035 0.0195 0.0676
Plasmodium falciparum glutathione reductase 0.0385 0.3063 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0133 0.1 0.448
Echinococcus granulosus snurportin 1 0.0344 0.2728 0.8832
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0195 0.0676
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0185
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Brugia malayi Importin beta-1 subunit 0.0032 0.017 0.0463
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0314 0.1017
Schistosoma mansoni hypothetical protein 0.0166 0.1268 0.1256
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0069 0.0031
Schistosoma mansoni sulfide quinone reductase 0.0035 0.0196 0.0183
Mycobacterium ulcerans ferredoxin reductase 0.0035 0.0196 0.068
Trypanosoma cruzi NADH dehydrogenase, putative 0.0035 0.0196 0.0425
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0314 0.1017
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0195 0.0192
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0035 0.0196 0.0193
Loa Loa (eye worm) glutathione reductase 0.0385 0.3063 0.8648
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0035 0.0196 0.0428
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0133 0.1 0.3109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0133 0.1 0.3109
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0035 0.0196 0.0296
Trypanosoma cruzi trypanothione reductase, putative 0.0133 0.1 0.3109
Entamoeba histolytica hypothetical protein 0.0073 0.0505 0.2907
Giardia lamblia NADH oxidase lateral transfer candidate 0.0133 0.1 1
Onchocerca volvulus 0.0035 0.0196 0.0485
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.017 0.0338
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0106 0.0125
Onchocerca volvulus 0.0076 0.0526 0.1301
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0133 0.1 0.325
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0553 0.1615
Onchocerca volvulus 0.0035 0.0195 0.0483
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0314 0.087
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0102 0.0234
Onchocerca volvulus 0.0012 0.0006 0.0016
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0035 0.0196 0.0848
Onchocerca volvulus 0.0035 0.0195 0.0483
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0195 0.0534
Schistosoma mansoni ap endonuclease 0.002 0.0069 0.0056
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0035 0.0196 0.0158
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0035 0.0196 0.068
Loa Loa (eye worm) hypothetical protein 0.0084 0.0594 0.1661
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0133 0.1 0.3109
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0185
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0035 0.0196 0.068
Schistosoma mansoni glutaminase 0.0276 0.2167 0.2157
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0195 0.0421
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0203 0.1568 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0195 0.0425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0133 0.1 0.3109
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0099 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0352 0.0945
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0035 0.0196 0.0635
Brugia malayi hypothetical protein 0.002 0.0072 0.0185
Toxoplasma gondii ABC1 family protein 0.0035 0.0195 0.0617
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0878 0.7108 0.8978
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0133 0.1 0.3109
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.0106 0.0327
Plasmodium vivax ferrodoxin reductase, putative 0.0035 0.0196 0.062
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0035 0.0196 0.0635
Leishmania major DNA polymerase eta, putative 0.0104 0.0757 0.2299
Brugia malayi polk-prov protein 0.0024 0.0106 0.0283
Trypanosoma brucei DNA polymerase eta, putative 0.0104 0.0757 0.2299
Trypanosoma brucei unspecified product 0.0054 0.0352 0.0945
Echinococcus multilocularis GPCR, family 2 0.005 0.0314 0.0475
Mycobacterium tuberculosis Probable reductase 0.0878 0.7108 0.8978
Echinococcus granulosus thioredoxin glutathione reductase 0.0388 0.3089 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0195 0.0617
Mycobacterium tuberculosis Probable dehydrogenase 0.0878 0.7108 0.8978
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0079 0.0553 0.1615
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0106 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0072 0.001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0431 0.0652
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.0553 0.2366
Brugia malayi SET domain containing protein 0.0014 0.0024 0.005
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0133 0.1 0.3109
Leishmania major DNA polymerase eta, putative 0.0049 0.0311 0.0809
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0035 0.0196 0.068
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0102 0.0234
Leishmania major hypothetical protein, conserved 0.0214 0.1666 0.5333
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0069 0.0177
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0052 0.001
Leishmania major DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0185
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.0425
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0195 0.0157
Trichomonas vaginalis glutathione reductase, putative 0.0133 0.1 0.2428
Brugia malayi glutathione reductase 0.0385 0.3063 0.8648
Brugia malayi CXXC zinc finger family protein 0.0028 0.0137 0.0368
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0072 0.001
Brugia malayi Pre-SET motif family protein 0.0064 0.0431 0.1202
Plasmodium falciparum thioredoxin reductase 0.0133 0.1 0.325
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.027
Leishmania major hypothetical protein, conserved 0.0035 0.0195 0.0421
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0013 0.0043
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0052 0.007
Onchocerca volvulus 0.0012 0.0006 0.0016
Echinococcus granulosus replication factor c subunit 1 0.002 0.0072 0.0233
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0133 0.1 0.1511
Mycobacterium ulcerans hypothetical protein 0.0025 0.0108 0.0265
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0878 0.7108 0.8978
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0443 0.3541 1
Schistosoma mansoni patched 1 0.0087 0.0619 0.0607
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0035 0.0196 0.0537
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.1196 0.3367
Echinococcus multilocularis geminin 0.0166 0.1268 0.1917
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0072 0.0119
Loa Loa (eye worm) hypothetical protein 0.0106 0.0779 0.2187
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0035 0.0196 0.0425
Entamoeba histolytica deoxycytidyl transferase, putative 0.0079 0.0553 0.3227
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0196 0.0425
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0415 0.0402
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0052 0.015
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0072 0.0093
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.6615 1
Onchocerca volvulus 0.0028 0.0137 0.0338
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0035 0.0196 0.0193
Loa Loa (eye worm) hypothetical protein 0.0064 0.0431 0.1202
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.013
Trichomonas vaginalis mercuric reductase, putative 0.0133 0.1 0.2428
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0788 0.2211
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0108 0.0265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0196 0.0537
Mycobacterium ulcerans hypothetical protein 0.0024 0.0102 0.0234
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0594 0.0581
Giardia lamblia DINP protein human, muc B family 0.0079 0.0553 0.5196
Plasmodium falciparum glutathione reductase 0.0133 0.1 0.325
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0133 0.1 0.3109
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0976 0.7911 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.0311 0.0997
Echinococcus granulosus chromobox protein 1 0.007 0.0482 0.1561
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0108 0.0132
Onchocerca volvulus 0.0012 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0534
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0534
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0102 0.0234
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0072 0.001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0079 0.0553 0.1545
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0878 0.7108 0.8975
Echinococcus multilocularis chromobox protein 1 0.007 0.0482 0.0729
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0072 0.0119
Brugia malayi topoisomerase 0.002 0.0072 0.0185
Brugia malayi beta-lactamase family protein 0.0035 0.0195 0.0534
Schistosoma mansoni ap endonuclease 0.002 0.0069 0.0056
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0206 0.1593 0.1582
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0431 0.139
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0035 0.0196 0.0428
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0133 0.1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0214 0.1666 0.5333
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0133 0.1 0.448
Trichomonas vaginalis glutaminase, putative 0.0276 0.2167 0.5334
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0133 0.1 0.3109
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0619 0.2004
Echinococcus granulosus glutamate synthase 0.0035 0.0196 0.0635
Leishmania major hypothetical protein, conserved 0.0035 0.0196 0.0425
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0195 0.0192
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0431 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0028 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.017 0.0338
Echinococcus multilocularis importin subunit beta 1 0.0032 0.017 0.0257
Loa Loa (eye worm) programmed cell death 8 0.0035 0.0196 0.0537
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0102 0.027
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0072 0.0214
Echinococcus multilocularis dna polymerase eta 0.0104 0.0757 0.1145
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0102 0.0073
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0035 0.0196 0.1366
Brugia malayi ImpB/MucB/SamB family protein 0.0104 0.0757 0.2125
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0035 0.0196 0.0848
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1755 0.2175
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0072 0.0118
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0314 0.0475
Schistosoma mansoni hypothetical protein 0.005 0.0314 0.0301
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0133 0.1 0.3109
Trypanosoma brucei trypanothione reductase 0.0385 0.3063 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0283
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0133 0.1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0106 0.0125
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0594 0.1661
Schistosoma mansoni hypothetical protein 0.0035 0.0196 0.0183
Schistosoma mansoni topbp1 0.002 0.0072 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0553 0.1615
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0035 0.0196 0.0193
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0534
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.007
Echinococcus multilocularis protein dispatched 1 0.0099 0.072 0.1088
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0072 0.001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0079 0.0553 0.0835
Schistosoma mansoni topbp1 0.002 0.0072 0.0059
Echinococcus granulosus Niemann Pick C1 protein 0.0203 0.1568 0.5076
Loa Loa (eye worm) glutaminase 2 0.0276 0.2167 0.6114
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.027
Schistosoma mansoni hypothetical protein 0.0084 0.0593 0.0581
Plasmodium vivax glutathione reductase, putative 0.0385 0.3063 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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