Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.068 | 0.0796 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.623 | 0.6176 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.623 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0068 | 0.1581 | 0.146 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.623 | 0.6176 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.623 | 0.6176 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0068 | 0.1581 | 0.146 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.623 | 0.6176 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.02 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.02 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.02 | 0.006 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.068 | 0.0796 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.623 | 0.6176 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0103 | 0.3265 | 0.5082 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.02 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.02 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.623 | 0.6176 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.623 | 0.6176 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.623 | 0.6176 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.02 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.623 | 0.6176 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.623 | 0.6176 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.02 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.02 | 0.006 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.068 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1415 | 0.1292 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.623 | 0.6176 |
Onchocerca volvulus | 0.0049 | 0.068 | 0.5 | |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0068 | 0.1581 | 0.146 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.02 | 0.5 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0099 | 0.3099 | 0.3 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0068 | 0.1581 | 0.146 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0103 | 0.3265 | 0.3168 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0099 | 0.3099 | 0.3 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0103 | 0.3265 | 0.3168 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.02 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.02 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0103 | 0.3265 | 0.5082 |
Schistosoma mansoni | transient receptor potential channel | 0.0068 | 0.1581 | 0.229 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.623 | 0.6176 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0241 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.02 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.3265 | 0.3168 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.02 | 0.006 |
Brugia malayi | Inositol-1 | 0.0039 | 0.02 | 0.006 |
Schistosoma mansoni | transient receptor potential channel | 0.0068 | 0.1581 | 0.229 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.02 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.