Detailed information for compound 1167352

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.353 | Formula: C17H12F5N3O2S
  • H donors: 2 H acceptors: 3 LogP: 4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)c1[nH]c(nc1c1ccc(cc1)F)S(=O)(=O)C(C(F)F)(F)F
  • InChi: 1S/C17H12F5N3O2S/c18-11-5-1-9(2-6-11)13-14(10-3-7-12(23)8-4-10)25-16(24-13)28(26,27)17(21,22)15(19)20/h1-8,15H,23H2,(H,24,25)
  • InChiKey: JSZFOPYQNRDZQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0026 0.0026
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0036 0.0153
Schistosoma mansoni hypothetical protein 0.0083 0.0461 0.0921
Echinococcus granulosus smad 0.0035 0.0134 0.0134
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0406 0.6325
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0452 0.2997 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0084 0.0156
Loa Loa (eye worm) hypothetical protein 0.0028 0.0084 0.0156
Echinococcus multilocularis tumor protein p63 0.1472 1 1
Echinococcus multilocularis GPCR, family 2 0.0083 0.0461 0.0461
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0066
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0452 0.2997 0.2997
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0121 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0461 0.0461
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0406 0.6325
Schistosoma mansoni cellular tumor antigen P53 0.0215 0.1371 0.2739
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0026 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0084 0.0124
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0105 0.0105
Brugia malayi MH1 domain containing protein 0.0035 0.0134 0.0249
Echinococcus granulosus GPCR family 2 0.0083 0.0461 0.0461
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0036 0.0017
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.1161
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0406 0.6325
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0134 0.0134
Onchocerca volvulus 0.002 0.0026 0.0154
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0262 0.1691 0.3137
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0134 0.0134
Mycobacterium ulcerans hypothetical protein 0.0028 0.0084 0.0826
Onchocerca volvulus Cathepsin L homolog 0.002 0.0026 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0192 0.1207 0.241
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0134 0.0249
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0461 0.0461
Schistosoma mansoni smad 0.0035 0.0134 0.0268
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0026 0.0026
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.015 0.03
Schistosoma mansoni Smad4 0.0035 0.0134 0.0268
Echinococcus granulosus Smad4 0.0035 0.0134 0.0134
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0626 0.1251
Schistosoma mansoni smad1 5 8 and 0.0035 0.0134 0.0268
Schistosoma mansoni smad1 5 8 and 0.0035 0.0134 0.0268
Brugia malayi MH2 domain containing protein 0.0035 0.0134 0.0249
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0405 0.6321
Brugia malayi hypothetical protein 0.0801 0.5391 1
Onchocerca volvulus 0.0107 0.0626 0.3661
Brugia malayi beta-lactamase 0.0107 0.0626 0.1161
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0026 0.0049
Brugia malayi TAR-binding protein 0.0192 0.1207 0.2238
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.1207 0.2238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0105 0.021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0461 0.0855
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0084 0.0826
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.1489 0.2763
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0048
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0626 1
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0626 0.1313
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0626 0.1313
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0026 0.0026
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0626 0.0626
Mycobacterium tuberculosis Conserved protein 0.0107 0.0626 0.1313
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0461 0.0855
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0053 0.0258 0.0479
Onchocerca volvulus 0.002 0.0026 0.0154
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0033 0.0121 0.0224
Loa Loa (eye worm) beta-lactamase 0.0107 0.0626 0.1161
Brugia malayi Pre-SET motif family protein 0.0233 0.1489 0.2763
Loa Loa (eye worm) MH2 domain-containing protein 0.0519 0.3458 0.6415
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0084 0.0156
Onchocerca volvulus 0.0265 0.171 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0197 0.0393
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0084 0.0826
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.1161
Echinococcus granulosus microtubule associated protein 2 0.0745 0.5006 0.5006
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0405 0.6321
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0163 0.1013 0.2024
Brugia malayi Pre-SET motif family protein 0.0033 0.0121 0.0224
Schistosoma mansoni hypothetical protein 0.0452 0.2997 0.5987
Echinococcus multilocularis Smad4 0.0035 0.0134 0.0134
Brugia malayi beta-lactamase family protein 0.0107 0.0626 0.1161
Schistosoma mansoni tar DNA-binding protein 0.0192 0.1207 0.241
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0105 0.1317
Leishmania major hypothetical protein, conserved 0.0075 0.0405 0.6321
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0066
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.1207 0.2238
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0121 0.1571
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0197 0.0365
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0592 0.0592
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0626 0.1313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0626 1
Schistosoma mansoni smad1 5 8 and 0.0035 0.0134 0.0268
Mycobacterium ulcerans lipase LipD 0.0107 0.0626 1
Brugia malayi Smad1 0.0035 0.0134 0.0249
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.015 0.0279
Brugia malayi Cathepsin L-like precursor 0.002 0.0026 0.0049
Brugia malayi Cathepsin L-like precursor 0.002 0.0026 0.0049
Brugia malayi MH1 domain containing protein 0.002 0.0026 0.0048
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0163 0.1013 0.1879
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0405 1
Onchocerca volvulus 0.0215 0.1371 0.8017
Brugia malayi Cathepsin L-like precursor 0.002 0.0026 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0626 0.3562
Echinococcus multilocularis cysteine protease 0.002 0.0026 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0192 0.1207 0.241
Trichomonas vaginalis esterase, putative 0.0107 0.0626 0.3562
Onchocerca volvulus 0.002 0.0026 0.0154
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0626 0.1313
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0105 0.0195
Loa Loa (eye worm) hypothetical protein 0.0801 0.5391 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0084 0.0124
Mycobacterium tuberculosis Conserved protein 0.0107 0.0626 0.1313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0197 0.0197
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0626 0.1313
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0036 0.5
Brugia malayi MH2 domain containing protein 0.0035 0.0134 0.0249
Toxoplasma gondii ABC1 family protein 0.0107 0.0626 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0684 0.4585 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0626 0.1161
Brugia malayi Bromodomain containing protein 0.0031 0.0105 0.0195
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0026 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0262 0.1691 0.3137
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.015 0.015
Brugia malayi Cathepsin L-like precursor 0.002 0.0026 0.0049
Loa Loa (eye worm) hypothetical protein 0.0179 0.1122 0.2081
Schistosoma mansoni hypothetical protein 0.0083 0.0461 0.0921
Echinococcus multilocularis peregrin 0.0031 0.0105 0.0105
Echinococcus granulosus peregrin 0.0031 0.0105 0.0105
Onchocerca volvulus 0.0163 0.1013 0.5924
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0452 0.2997 0.2997
Mycobacterium ulcerans hypothetical protein 0.0107 0.0626 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0075 0.0405 0.0752
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0361 0.5581
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0084 0.0826
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0626 1
Loa Loa (eye worm) nuclear factor I 0.002 0.0026 0.0048
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0105 0.0105
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.015 0.015
Entamoeba histolytica hypothetical protein 0.0452 0.2997 1
Schistosoma mansoni microtubule-associated protein tau 0.0745 0.5006 1
Brugia malayi MH1 domain containing protein 0.002 0.0026 0.0048
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0626 0.3562
Schistosoma mansoni survival motor neuron protein 0.0163 0.1013 0.2024
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0296 0.449
Brugia malayi jmjC domain containing protein 0.0038 0.015 0.0279
Brugia malayi Cathepsin L-like precursor 0.002 0.0026 0.0049
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0105 0.1317
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0461 0.0855
Schistosoma mansoni hypothetical protein 0.0179 0.1122 0.2241
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0084 0.0195
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0448 0.0895
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0084 0.0195
Echinococcus granulosus tar DNA binding protein 0.0192 0.1207 0.1207
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0405 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0084 0.0967
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0197 0.0365
Brugia malayi MH1 domain containing protein 0.0035 0.0134 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0192 0.1207 0.241
Onchocerca volvulus Cathepsin L homolog 0.002 0.0026 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0121 0.0241
Schistosoma mansoni hypothetical protein 0.0083 0.0461 0.0921
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0333 0.0618
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0084 0.0156
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0105 0.1317
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0626 0.1161
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0405 0.6321
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0406 0.6325
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0084 0.0826
Mycobacterium ulcerans beta-lactamase 0.0107 0.0626 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0084 0.0826
Brugia malayi Cathepsin L-like precursor 0.002 0.0026 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0626 0.1251
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0626 0.1313
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0026 0.0026
Schistosoma mansoni transcription factor LCR-F1 0.0452 0.2997 0.5987
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0026 0.0053
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0134 0.0249
Loa Loa (eye worm) RNA binding protein 0.0192 0.1207 0.2238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0197 0.0393
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0084 0.0826
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.1161
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0461 0.0461
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0626 0.3562
Plasmodium falciparum phd finger protein, putative 0.0031 0.0105 0.2083
Entamoeba histolytica hypothetical protein 0.0452 0.2997 1
Echinococcus multilocularis survival motor neuron protein 1 0.0801 0.5391 0.5391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0197 0.0393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0121 0.0241
Brugia malayi RNA binding protein 0.0192 0.1207 0.2238
Loa Loa (eye worm) transcription factor SMAD2 0.0519 0.3458 0.6415
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0121 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Leishmania major cathepsin L-like protease 0.0075 0.0406 0.6325
Onchocerca volvulus 0.002 0.0026 0.0154
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0626 0.3562
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.015 0.03
Onchocerca volvulus 0.002 0.0026 0.0154
Onchocerca volvulus 0.002 0.0026 0.0154
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0066
Loa Loa (eye worm) hypothetical protein 0.0215 0.1371 0.2543
Schistosoma mansoni hypothetical protein 0.0034 0.0122 0.0244
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0122 0.0122
Onchocerca volvulus 0.0028 0.0084 0.0493
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0262 0.1691 0.3137
Plasmodium vivax SET domain protein, putative 0.0033 0.0121 0.1571
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0066
Mycobacterium tuberculosis Conserved protein 0.0107 0.0626 0.1313
Loa Loa (eye worm) hypothetical protein 0.0031 0.0105 0.0195
Mycobacterium leprae Probable lipase LipE 0.0107 0.0626 1
Brugia malayi hypothetical protein 0.0048 0.0223 0.0414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Echinococcus multilocularis cysteine protease 0.002 0.0026 0.0026
Leishmania major hypothetical protein, conserved 0.0107 0.0626 1
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0626 1
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0626 1
Loa Loa (eye worm) Smad1 0.0035 0.0134 0.0249
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0405 0.6321
Schistosoma mansoni hypothetical protein 0.0031 0.0105 0.021
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0592 0.0592
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Brugia malayi PHD-finger family protein 0.0031 0.0105 0.0195
Brugia malayi jmjC domain containing protein 0.0102 0.0592 0.1098
Echinococcus granulosus cathepsin l1 0.002 0.0026 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0626 1
Schistosoma mansoni hypothetical protein 0.0083 0.0461 0.0921
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0036 0.0242
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0121 0.0121
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0626 0.1313
Echinococcus multilocularis microtubule associated protein 2 0.0745 0.5006 0.5006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0197 0.0197
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0197 0.0197
Leishmania major cathepsin L-like protease 0.0075 0.0406 0.6325
Loa Loa (eye worm) fibroinase 0.002 0.0026 0.0049
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0134 0.0268
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0134 0.0134
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0026 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0084 0.0156
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0084 0.0967
Onchocerca volvulus 0.0107 0.0626 0.3661
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0626 0.3562
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.1161
Echinococcus multilocularis tar DNA binding protein 0.0192 0.1207 0.1207
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0084 0.0826
Brugia malayi MH2 domain containing protein 0.0519 0.3458 0.6415
Loa Loa (eye worm) TAR-binding protein 0.0192 0.1207 0.2238
Onchocerca volvulus 0.002 0.0026 0.0154
Loa Loa (eye worm) cysteine protease 0.002 0.0026 0.0049
Entamoeba histolytica hypothetical protein 0.0452 0.2997 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0121 0.0121
Brugia malayi hypothetical protein 0.0075 0.0405 0.0752
Trichomonas vaginalis set domain proteins, putative 0.0265 0.171 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0406 0.0011
Loa Loa (eye worm) ctsf protein 0.002 0.0026 0.0049
Loa Loa (eye worm) hypothetical protein 0.0083 0.0461 0.0855
Schistosoma mansoni tar DNA-binding protein 0.0192 0.1207 0.241
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.1161
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0084 0.0195
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0262 0.1691 0.3137
Onchocerca volvulus Alhambra homolog 0.0031 0.0105 0.0616
Onchocerca volvulus Cathepsin F homolog 0.002 0.0026 0.0154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0084 0.0967
Brugia malayi latrophilin 2 splice variant baaae 0.0179 0.1122 0.2081
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.1161
Echinococcus multilocularis smad 0.0035 0.0134 0.0134
Onchocerca volvulus 0.0033 0.0121 0.0705
Leishmania major cathepsin L-like protease 0.0075 0.0406 0.6325
Onchocerca volvulus 0.0107 0.0626 0.3661
Loa Loa (eye worm) hypothetical protein 0.0028 0.0084 0.0156
Brugia malayi hypothetical protein 0.0452 0.2997 0.556
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0626 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0112 0.0112
Brugia malayi beta-lactamase family protein 0.0107 0.0626 0.1161
Giardia lamblia PHD finger protein 15 0.0031 0.0105 0.5
Echinococcus granulosus survival motor neuron protein 1 0.0801 0.5391 0.5391

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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