Detailed information for compound 1167573

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 303.401 | Formula: C20H21N3
  • H donors: 1 H acceptors: 0 LogP: 3.86 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1cc/c(=N\c2cccc(c2)CCc2ccccc2)/c(c1)N
  • InChi: 1S/C20H21N3/c1-23-13-12-20(19(21)15-23)22-18-9-5-8-17(14-18)11-10-16-6-3-2-4-7-16/h2-9,12-15H,10-11,21H2,1H3/b22-20+
  • InChiKey: QNWJGNVAZMKJAA-LSDHQDQOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Smad1 0.0008 0.001 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0361 0.1302
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0122 0.0439
Brugia malayi transcription factor E74 isoform 0.001 0.0031 0.0056
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.1716 0.3094
Echinococcus granulosus dna polymerase eta 0.0021 0.0153 0.0392
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Brugia malayi Ets-domain containing protein 0.0071 0.0724 0.1305
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0361 0.1302
Toxoplasma gondii exonuclease III APE 0.0018 0.0124 0.2794
Echinococcus multilocularis Smad4 0.0008 0.001 0.001
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0082 0.0296
Echinococcus multilocularis smad 0.0008 0.001 0.001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0208 0.5766
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0082 0.0231
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0082 0.0296
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0215 0.0547
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0031 0.0079
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0082 0.0231
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0149 0.1623 1
Giardia lamblia DINP protein human, muc B family 0.0021 0.0153 0.0197
Brugia malayi MH1 domain containing protein 0.0008 0.001 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0153 0.0431
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0241
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0082 0.0296
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.001 0.001
Schistosoma mansoni DNA polymerase eta 0.0021 0.0153 0.0392
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.2624 0.2624
Schistosoma mansoni hypothetical protein 0.0349 0.3918 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.1414 0.2548
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Loa Loa (eye worm) hypothetical protein 0.0318 0.3558 0.6413
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0215 0.0387
Loa Loa (eye worm) hypothetical protein 0.0036 0.0331 0.0597
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0208 0.0586
Trypanosoma brucei cytochrome P450, putative 0.0051 0.05 0.1404
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0082 0.0231
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0318 0.3558 0.908
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0215 0.0547
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0082 0.0231
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0082 0.0296
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0131 0.1414 0.2548
Onchocerca volvulus 0.0048 0.0466 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0208 0.0586
Brugia malayi Cytochrome P450 family protein 0.0015 0.0082 0.0148
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0124 0.0348
Loa Loa (eye worm) hypothetical protein 0.0039 0.0361 0.0651
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.001 0.0026
Loa Loa (eye worm) hypothetical protein 0.006 0.0607 0.1093
Mycobacterium leprae putative cytochrome p450 0.0015 0.0082 0.2272
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0361 0.0651
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0124 0.0348
Trypanosoma brucei unspecified product 0.0014 0.0079 0.0222
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0361 0.0651
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0031 0.0056
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0031 0.0056
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.001 0.0018
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0082 0.0231
Mycobacterium leprae Probable lipase LipE 0.0039 0.0361 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0208 0.0586
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0153 0.0431
Brugia malayi MH2 domain containing protein 0.0008 0.001 0.0018
Schistosoma mansoni ap endonuclease 0.0018 0.0124 0.0316
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0031 0.0031
Brugia malayi Cytochrome P450 family protein 0.0051 0.05 0.0901
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0153 0.0431
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0215 0.5371
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0208 0.0375
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0124 0.0764
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0208 0.0586
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0131 0.1414 0.3608
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0153 0.0945
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0124 0.5
Echinococcus multilocularis protein C ets 2 0.001 0.0031 0.0031
Schistosoma mansoni ets 0.001 0.0031 0.0079
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0082 0.0296
Mycobacterium ulcerans beta-lactamase 0.0039 0.0361 0.1015
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0031 0.0079
Brugia malayi beta-lactamase family protein 0.0039 0.0361 0.0651
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1333 0.2402
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0124 0.0124
Echinococcus granulosus Protein patched homolog 1 0.0131 0.1414 0.3608
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0122 0.0439
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0026
Brugia malayi MH2 domain containing protein 0.0008 0.001 0.0018
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0082 0.0231
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0361 0.1302
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0026
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.001 0.0026
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0153 0.0392
Leishmania major hypothetical protein, conserved 0.0039 0.0361 0.1015
Brugia malayi Cytochrome P450 family protein 0.0051 0.05 0.0901
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0134 0.0482
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0491 0.5548 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0153 0.0553
Echinococcus granulosus dna polymerase kappa 0.0021 0.0153 0.0392
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0215 0.1322
Brugia malayi MH2 domain containing protein 0.0124 0.1333 0.2402
Loa Loa (eye worm) CYP4Cod1 0.0051 0.05 0.0901
Schistosoma mansoni smad 0.0008 0.001 0.0026
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0399 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0082 0.0296
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.2775 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.001 0.0018
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0124 0.3103
Loa Loa (eye worm) fli-1 protein 0.0215 0.2375 0.428
Loa Loa (eye worm) Smad1 0.0008 0.001 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0122 0.0439
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0056
Schistosoma mansoni hypothetical protein 0.0015 0.0082 0.0209
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0153 0.0392
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0082 0.0231
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0082 0.0231
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0208 0.0751
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0124 0.0764
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0031 0.0079
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0153 0.0431
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0318 0.3558 0.6413
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0208 0.0586
Mycobacterium tuberculosis Conserved protein 0.0039 0.0361 0.1302
Schistosoma mansoni ets-related 0.0215 0.2375 0.6061
Brugia malayi beta-lactamase 0.0039 0.0361 0.0651
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0082 0.0231
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0082 0.0231
Brugia malayi cytochrome P450 0.0015 0.0082 0.0148
Schistosoma mansoni hypothetical protein 0.0048 0.0466 0.119
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0031 0.0031
Echinococcus granulosus sterol regulatory element binding protein 0.0131 0.1414 0.3608
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0124 0.3103
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0122 0.0439
Schistosoma mansoni survival motor neuron protein 0.0048 0.0466 0.119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.1414 0.871
Echinococcus granulosus Smad4 0.0008 0.001 0.0026
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.001 0.0026
Trichomonas vaginalis esterase, putative 0.0039 0.0361 0.2226
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0444 0.1132
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0318 0.3558 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0131 0.1414 0.1414
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0082 0.0296
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0082 0.0296
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0079 0.0222
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0375
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0215 0.4836
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0031 0.0031
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0361 0.0361
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0318 0.3558 1
Echinococcus granulosus protein C ets 2 0.001 0.0031 0.0079
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0215 0.0387
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0277
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0082 0.0296
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0082 0.2272
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0153 0.0945
Schistosoma mansoni cytochrome P450 0.0015 0.0082 0.0209
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0079
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0134 0.5
Mycobacterium ulcerans lipase LipD 0.0039 0.0361 0.1015
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0208 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0361 0.1302
Onchocerca volvulus 0.0039 0.0361 0.7749
Mycobacterium ulcerans hypothetical protein 0.0039 0.0361 0.1015
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0082 0.0296
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0124 0.0223
Loa Loa (eye worm) beta-lactamase 0.0039 0.0361 0.0651
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0399 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0082 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0361 0.1015
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.05 0.0901
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0153 0.0277
Schistosoma mansoni gabp alpha 0.0071 0.0724 0.1848
Loa Loa (eye worm) acetyltransferase 0.0157 0.1716 0.3094
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0318 0.3558 1
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0215 0.5371
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0153 0.0153
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0444 0.2733
Brugia malayi Fli-1 protein 0.0215 0.2375 0.428
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0375
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0134 0.3349
Brugia malayi Ets-domain containing protein 0.0071 0.0724 0.1305
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0153 0.0392
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0241
Echinococcus multilocularis geminin 0.0349 0.3918 0.3918
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0215 0.0604
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0153 0.3842
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0153 0.0431
Trypanosoma brucei unspecified product 0.0014 0.0079 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0079 0.0222
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0318 0.3558 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0082 0.0231
Schistosoma mansoni elf1 0.001 0.0031 0.0079
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0361 0.2226
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0361 0.0922
Loa Loa (eye worm) hypothetical protein 0.0039 0.0361 0.0651
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0215 0.4836
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0208 0.5215
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0082 0.0296
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0082 0.0296
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0031 0.0031
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0361 0.1015
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0361 0.0651
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0241
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0124 0.0447
Schistosoma mansoni patched 1 0.0131 0.1414 0.3608
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0149 0.1623 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0361 0.1302
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0208 0.5215
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0361 0.1015
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0031 0.0031
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0082 0.0231
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.1666 0.4251
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.05 0.1404
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0082 0.0231
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0361 0.2226
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0361 0.1015
Brugia malayi beta-lactamase family protein 0.0039 0.0361 0.0651
Echinococcus multilocularis 0.0015 0.0082 0.0082
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0153 0.0553
Leishmania major cytochrome p450-like protein 0.0015 0.0082 0.0231
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0208 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Echinococcus multilocularis ets variant gene 4 0.001 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0349 0.3918 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0215 0.0547
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0466 0.084
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0215 0.0387
Schistosoma mansoni Smad4 0.0008 0.001 0.0026
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0361 0.8144
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.1716 0.438
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0082 0.0296
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0153 0.0277
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0134 0.0376
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0082 0.0231
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0082 0.185
Echinococcus granulosus Niemann Pick C1 protein 0.0131 0.1414 0.3608
Leishmania major DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Mycobacterium tuberculosis Conserved protein 0.0039 0.0361 0.1302
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0375
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0082 0.0296
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0082 0.0296
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0361 0.1015
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0444 0.2733
Leishmania major cytochrome p450-like protein 0.0015 0.0082 0.0231
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.05 0.0901
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0208 0.0586
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.2624 0.6696
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0082 0.0231
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0149 0.1623 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0208 0.0586
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0361 0.0651
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0361 0.1302
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0082 0.0296
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0031 0.0056
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0124 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0153 0.0431
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0082 0.0231
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0124 0.0223
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0208 0.5215
Loa Loa (eye worm) cytochrome P450 0.0015 0.0082 0.0148
Mycobacterium ulcerans hypothetical protein 0.0026 0.0208 0.0586
Loa Loa (eye worm) hypothetical protein 0.0039 0.0361 0.0651
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0079 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Brugia malayi Ets-domain containing protein 0.001 0.0031 0.0056
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0124 0.0316
Brugia malayi hypothetical protein 0.0236 0.2624 0.4729
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0124 0.0348
Schistosoma mansoni hypothetical protein 0.001 0.0031 0.0079
Brugia malayi follicle stimulating hormone receptor 0.0491 0.5548 1
Echinococcus multilocularis dna polymerase eta 0.0021 0.0153 0.0153
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0361 0.1302
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0082 0.0231
Loa Loa (eye worm) hypothetical protein 0.0236 0.2624 0.4729
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0318 0.3558 0.908
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0724 0.1305
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0082 0.0231
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0208 0.0586
Brugia malayi Cytochrome P450 family protein 0.0015 0.0082 0.0148
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1333 0.2402
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0215 0.0215
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0153 0.0431
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0031 0.0079
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0215 0.0603
Trypanosoma brucei unspecified product 0.0021 0.0153 0.0431
Onchocerca volvulus 0.0039 0.0361 0.7749
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0318 0.3558 0.3558
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0124 0.0348
Trichomonas vaginalis chaperonin, putative 0.0026 0.0215 0.1322
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0361 0.0922
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0082 0.0231
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0215 0.0603
Leishmania major DNA polymerase eta, putative 0.0021 0.0153 0.0431
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.1716 0.1716
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0082 0.0296
Brugia malayi MH1 domain containing protein 0.0008 0.001 0.0018
Onchocerca volvulus 0.0026 0.0208 0.4468
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0031 0.0079
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0153 0.0431
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0031 0.0031
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0082 0.0231
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0361 1
Echinococcus multilocularis protein patched 0.0131 0.1414 0.1414
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.001 0.001
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0724 0.1848
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0241
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0208 0.0375
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0031 0.0056
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0124 0.2794
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0361 0.2226
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0444 1
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0318 0.3558 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0153 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.05 0.1404
Echinococcus multilocularis Niemann Pick C1 protein 0.0131 0.1414 0.1414
Leishmania major cytochrome p450-like protein 0.0051 0.05 0.1404
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0361 0.1302
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0082 0.0231
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0082 0.0296
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0361 0.2226
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0124 0.0348
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0361 0.0922
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0082 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Echinococcus granulosus geminin 0.0349 0.3918 1
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0031 0.0079
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0724 0.0724
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0082 0.0231
Onchocerca volvulus 0.0039 0.0361 0.7749
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0149 0.1623 1
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0031 0.0056
Echinococcus granulosus smad 0.0008 0.001 0.0026
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0082 0.0231
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0399 0.1837
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0215 0.0603
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0208 0.0586
Schistosoma mansoni ets-related 0.001 0.0031 0.0079
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0051 0.05 0.1404
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0082 0.0296
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0208 0.5766
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0082 0.0296
Brugia malayi CHE-14 protein 0.0131 0.1414 0.2548
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0134 0.3016
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0082 0.0209
Toxoplasma gondii ABC1 family protein 0.0039 0.0361 0.8144
Schistosoma mansoni ap endonuclease 0.0018 0.0124 0.0316
Echinococcus multilocularis protein dispatched 1 0.0131 0.1414 0.1414
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0215 0.0547
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0153 0.0431
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0082 0.0231
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0031 0.0079
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0361 0.2226
Loa Loa (eye worm) hypothetical protein 0.0039 0.0361 0.0651
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0208 0.0751

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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