Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Affinity (binding) | = 0.2 % | Relative binding affinity for human progesterone receptor in MCF-7 cell cytosols compared to Org 2058 | ChEMBL. | No reference |
Affinity (binding) | = 0.2 % | Relative binding affinity for human progesterone receptor in MCF-7 cell cytosols compared to Org 2058 | ChEMBL. | No reference |
Affinity (binding) | = 98 % | Relative binding affinity for human glucocorticoid receptor in IM-9 cell cytosols compared to dexamethasone | ChEMBL. | No reference |
Affinity (binding) | = 98 % | Relative binding affinity for human glucocorticoid receptor in IM-9 cell cytosols compared to dexamethasone | ChEMBL. | No reference |
Ratio (binding) | = 490 | Ratio of compound to that of growth rate and permeability rate was determined | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.